ID   HAT2_GIBZE              Reviewed;         423 AA.
AC   Q4I7L0;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Histone acetyltransferase type B subunit 2;
DE            EC=2.3.1.48;
GN   Name=HAT2; ORFNames=FG06798;
OS   Gibberella zeae (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Gibberella.
OX   NCBI_TaxID=5518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / NRRL 31084;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G.,
RA   Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G.,
RA   Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D.,
RA   Gale L.R., Gnerre S., Goswami R.S., Hammond-Kosack K., Harris L.J.,
RA   Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G.,
RA   Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G.,
RA   Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W.,
RA   Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
CC   -!- FUNCTION: Component of the histone acetylase B (HAT-B) complex.
CC       The complex acetylates 'Lys-12' of histone H4 which is required
CC       for telomeric silencing (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + histone = CoA + acetylhistone.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1
CC       and HAT2. The HAT-B complex binds to histone H4 tail (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC   -!- SIMILARITY: Contains 6 WD repeats.
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DR   EMBL; AACM01000276; EAA76730.1; -; Genomic_DNA.
DR   RefSeq; XP_386974.1; -.
DR   GeneID; 2788868; -.
DR   KEGG; fgr:FG06798.1; -.
DR   BRENDA; 2.3.1.48; 74326.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:EC.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019782; WD40_repeat_2.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_region.
DR   InterPro; IPR019781; WD40_repeat_sg.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   Pfam; PF00400; WD40; 5.
DR   ProDom; PD000018; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Chromatin regulator; Cytoplasm; DNA damage;
KW   DNA repair; Nucleus; Repeat; Transferase; WD repeat.
FT   CHAIN         1    423       Histone acetyltransferase type B subunit
FT                                2.
FT                                /FTId=PRO_0000227740.
FT   REPEAT      121    161       WD 1.
FT   REPEAT      174    214       WD 2.
FT   REPEAT      224    264       WD 3.
FT   REPEAT      271    311       WD 4.
FT   REPEAT      315    355       WD 5.
FT   REPEAT      372    412       WD 6.
SQ   SEQUENCE   423 AA;  47397 MW;  948167F15C9BCFE4 CRC64;
     MDVDMIHDEE DDQGERLINE EYKTWKKNSP FLTALTWPTL TVQWFPDVKE PEGKNYKIHR
     LLLGTHTSDE SPNYLQIADV QIPKVVAPNP DDYDEERGEI GGYGKSGDVA AIKCDIVQRI
     EHPGEVNKAR YQPQNPDILA TLCVDGKILI FDRTKHPLDP TSTGKVNAQI ELVGHEAEGF
     GLNWNPHEEG CLASGSEDTT MRLWDLKTLK ADSRILNPSR TYRHHTQIVN DVQYHPISKN
     FIGSVSDDQT LQIVDIRHSE TNKAAVVAKR GHLDAINALA FNPNSEVLVA TASADKTIGI
     WDLRNVKEKV HTLEGHNDAV TSLAWHPTEA GILGSASYDR RIIFWDLSRV GEEQLPDDQD
     DGPPELLFMH GGHTNHLADF SWNPNEPWLV ASAAEDNLLQ IWKVAESIVG KDDGDLPIDE
     LDR
//