Reviewed, UniProtKB/Swiss-Prot Q4I7L0 (HAT2_GIBZE)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase type B subunit 2
    EC=2.3.1.48

Gene names

Name:	HAT2
ORF Names:	FG06798

Organism

Gibberella zeae (Fusarium graminearum)

Taxonomic identifier

5518 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Subunit structure	Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Molecular function	Acyltransferase Chromatin regulator Transferase
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Histone acetyltransferase type B subunit 2		PRO_0000227740
Regions
	Repeat	121 – 161	41	WD 1
	Repeat	174 – 214	41	WD 2
	Repeat	224 – 264	41	WD 3
	Repeat	271 – 311	41	WD 4
	Repeat	315 – 355	41	WD 5
	Repeat	372 – 412	41	WD 6

Sequences

	Sequence		Length	Mass (Da)
	Q4I7L0-1 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: 948167F15C9BCFE4	FASTA	423	47,397
	10 20 30 40 50 60 MDVDMIHDEE DDQGERLINE EYKTWKKNSP FLTALTWPTL TVQWFPDVKE PEGKNYKIHR 70 80 90 100 110 120 LLLGTHTSDE SPNYLQIADV QIPKVVAPNP DDYDEERGEI GGYGKSGDVA AIKCDIVQRI 130 140 150 160 170 180 EHPGEVNKAR YQPQNPDILA TLCVDGKILI FDRTKHPLDP TSTGKVNAQI ELVGHEAEGF 190 200 210 220 230 240 GLNWNPHEEG CLASGSEDTT MRLWDLKTLK ADSRILNPSR TYRHHTQIVN DVQYHPISKN 250 260 270 280 290 300 FIGSVSDDQT LQIVDIRHSE TNKAAVVAKR GHLDAINALA FNPNSEVLVA TASADKTIGI 310 320 330 340 350 360 WDLRNVKEKV HTLEGHNDAV TSLAWHPTEA GILGSASYDR RIIFWDLSRV GEEQLPDDQD 370 380 390 400 410 420 DGPPELLFMH GGHTNHLADF SWNPNEPWLV ASAAEDNLLQ IWKVAESIVG KDDGDLPIDE LDR

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / NRRL 31084.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACM01000276 Genomic DNA. Translation: EAA76730.1.
RefSeq	XP_386974.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2788868.
KEGG	fgr:FG06798.1.
Enzyme and pathway databases
BRENDA	2.3.1.48. 74326.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_region. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 5 hits. [Graphical view]
ProDom	PD000018. WD40. 3 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00320. WD40. 6 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT2_GIBZE

Accession

Primary (citable) accession number: Q4I7L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	August 16, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)