ID   HAT1_GIBZE              Reviewed;         478 AA.
AC   Q4I6A4;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Histone acetyltransferase type B catalytic subunit;
DE            EC=2.3.1.48;
GN   Name=HAT1; ORFNames=FG07254;
OS   Gibberella zeae (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Gibberella.
OX   NCBI_TaxID=5518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / NRRL 31084;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G.,
RA   Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G.,
RA   Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D.,
RA   Gale L.R., Gnerre S., Goswami R.S., Hammond-Kosack K., Harris L.J.,
RA   Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G.,
RA   Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G.,
RA   Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W.,
RA   Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
CC   -!- FUNCTION: Catalytic component of the histone acetylase B (HAT-B)
CC       complex. Acetylates Lys-12 of histone H4 which is required for
CC       telomeric silencing. Has intrinsic substrate specificity that
CC       modifies lysine in recognition sequence GXGKXG. Involved in DNA
CC       double-strand break repair (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + histone = CoA + acetylhistone.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1
CC       and HAT2. The HAT-B complex binds to histone H4 tail (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the HAT1 family.
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DR   EMBL; AACM01000303; EAA77852.1; -; Genomic_DNA.
DR   RefSeq; XP_387430.1; -.
DR   GeneID; 2788834; -.
DR   KEGG; fgr:FG07254.1; -.
DR   BRENDA; 2.3.1.48; 74326.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:EC.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0006348; P:chromatin silencing at telomere; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR019467; Hat1_N.
DR   InterPro; IPR017380; Hist_AcTrfase_B-typ_cat-su.
DR   Gene3D; G3DSA:3.40.630.30; Acyl_CoA_acyltransferase; 1.
DR   Pfam; PF10394; Hat1_N; 1.
DR   PIRSF; PIRSF038084; HAT-B_cat; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Chromatin regulator; Cytoplasm; DNA damage;
KW   DNA repair; Nucleus; Transferase.
FT   CHAIN         1    478       Histone acetyltransferase type B
FT                                catalytic subunit.
FT                                /FTId=PRO_0000227724.
SQ   SEQUENCE   478 AA;  54501 MW;  F84A44346A28CF0D CRC64;
     MEDTTQLLTF FKGLSDASTA IHISLVSPSE SGLQHVATFN PRHTYSIFGD DEKIFGYQDL
     KVNLRYRAND MRPHLNISYS KKSGTINELE PTDVAAILDE GNHLPKTRDF EESSKQLSDD
     WTPPGKLHTT FDSPEGQYEI WCGNLADPAV KQLNSRLQIF VPLFIEGGTY IGQDPDEDSA
     ELDLSDADRW TFFSLYQKRK VGDKTAYVFV GYSTIYRFYY FQPPTPPASP QSDEWELPNG
     NMDLGELPCR TRLSQFIILP PFQGKGNGAR LYKTIFEHYH KIPQTYEFTV EDPNEAFDDL
     RDICDLQFLR KMPEFNNLLV DTNIKIPKKG FLPKLIIGSS LLEEIRLRAK IAPRQFGRVL
     EMHLMSKLPV SVRPTMAIED QPAATKADQH EAKVWGLIVK QRLYRHNKEV LSQIEPAERV
     EKLDDTLHGV GLEYARILAA VDRSDKYEGQ TTASSKRKLD ADEITEDLSN KKARVEDA
//