Reviewed,
UniProtKB/Swiss-Prot Q4I6A4 (HAT1_GIBZE)
Last modified
June 16, 2009.
Version 22.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase type B catalytic subunit EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Gibberella zeae (Fusarium graminearum) | ||||
| Taxonomic identifier | 5518 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella |
Protein attributes
| Sequence length | 478 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates Lys-12 of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity. |
| Catalytic activity | Acetyl-CoA + histone = CoA + acetylhistone. |
| Subunit structure | Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the HAT1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair |
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Acyltransferase Chromatin regulator Transferase |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin silencing at telomereInferred from electronic annotation. Source: InterPro histone acetylationInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | histone acetyltransferase activity Inferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 478 | 478 | Histone acetyltransferase type B catalytic subunit | PRO_0000227724 | |||
Sequences
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References
| [1] | "The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. Kistler H.C.Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / NRRL 31084. |
Cross-references
Sequence databases | |
|---|---|
| AACM01000303 Genomic DNA. Translation: EAA77852.1. | |
| RefSeq | XP_387430.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2788834. |
| KEGG | fgr:FG07254.1. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.48. 74326. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. |
| Pfam | PF10394. Hat1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF038084. HAT-B_cat. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HAT1_GIBZE | ||||||||
| Accession | Primary (citable) accession number: Q4I6A4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

Clusters with


