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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates Lys-12 of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
ORF Names:FGRRES_07254, FGSG_07254
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 4
  • UP000009057 Componenti: Unplaced

Organism-specific databases

EuPathDBiFungiDB:FGSG_07254.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277241 – 477Histone acetyltransferase type B catalytic subunitAdd BLAST477

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei189Interaction with histone H4 N-terminusBy similarity1

Protein-protein interaction databases

STRINGi229533.XP_387430.1.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 46Interaction with histone H4 N-terminusBy similarity3
Regioni215 – 217Interaction with histone H4 N-terminusBy similarity3
Regioni255 – 257Acetyl-CoA bindingBy similarity3
Regioni262 – 268Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiKOG2696. Eukaryota.
ENOG410XPH4. LUCA.
InParanoidiQ4I6A4.
KOiK11303.
OrthoDBiEOG092C3YYH.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 2 hits.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4I6A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDTTQWLSD ASTAIHISLV SPSESGLQHV ATFNPRHTYS IFGDDEKIFG
60 70 80 90 100
YQDLKVNLRY RANDMRPHLN ISYSKKSGTI NELEPTDVAA ILDEGNHLPK
110 120 130 140 150
IAFAKARDFE ESSKQLSDDW TPPGKLHTTF DSPEGQYEIW CGNLADPAVK
160 170 180 190 200
QLNSRLQIFV PLFIEGGTYI GQDPDEDSAE LDLSDADRWT FFSLYQKRKV
210 220 230 240 250
GDKTAYVFVG YSTIYRFYYF QPPTPPASPQ SDEWELPNGN MDLGELPCRT
260 270 280 290 300
RLSQFIILPP FQGKGNGARL YKTIFEHYHK IPQTYEFTVE DPNEAFDDLR
310 320 330 340 350
DICDLQFLRK MPEFNNLLVD TNIKIPKKGF LPKLIIGSSL LEEIRLRAKI
360 370 380 390 400
APRQFGRVLE MHLMSKLPVS VRPTMAIEDQ PAATKADQHE AKVWGLIVKQ
410 420 430 440 450
RLYRHNKEVL SQIEPAERVE KLDDTLHGVG LEYARILAAV DRSDKYEGQT
460 470
TASSKRKLDA DEITEDLSNK KARVEDA
Length:477
Mass (Da):54,380
Last modified:October 31, 2012 - v2
Checksum:iB353317F4741E1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231666 Genomic DNA. Translation: ESU13485.1.
HG970335 Genomic DNA. Translation: CEF84494.1.
RefSeqiXP_011326992.1. XM_011328690.1.

Genome annotation databases

GeneIDi23554341.
KEGGifgr:FGSG_07254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231666 Genomic DNA. Translation: ESU13485.1.
HG970335 Genomic DNA. Translation: CEF84494.1.
RefSeqiXP_011326992.1. XM_011328690.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi229533.XP_387430.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23554341.
KEGGifgr:FGSG_07254.

Organism-specific databases

EuPathDBiFungiDB:FGSG_07254.

Phylogenomic databases

eggNOGiKOG2696. Eukaryota.
ENOG410XPH4. LUCA.
InParanoidiQ4I6A4.
KOiK11303.
OrthoDBiEOG092C3YYH.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 2 hits.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHAT1_GIBZE
AccessioniPrimary (citable) accession number: Q4I6A4
Secondary accession number(s): A0A0E0SDI1, I1RSW8, V6RNJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 31, 2012
Last modified: November 30, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.