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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates Lys-12 of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
ORF Names:FGRRES_07254, FGSG_07254
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:FGRAMPH1_01G24355

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277241 – 477Histone acetyltransferase type B catalytic subunitAdd BLAST477

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei189Interaction with histone H4 N-terminusBy similarity1

Protein-protein interaction databases

STRINGi229533.XP_387430.1

Structurei

3D structure databases

SMRiQ4I6A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 46Interaction with histone H4 N-terminusBy similarity3
Regioni215 – 217Interaction with histone H4 N-terminusBy similarity3
Regioni255 – 257Acetyl-CoA bindingBy similarity3
Regioni262 – 268Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiKOG2696 Eukaryota
ENOG410XPH4 LUCA
InParanoidiQ4I6A4
KOiK11303
OrthoDBiEOG092C3YYH

Family and domain databases

Gene3Di3.90.360.10, 2 hits
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR019467 Hat1_N
IPR037113 Hat1_N_sf
IPR017380 Hist_AcTrfase_B-typ_cat-su
PANTHERiPTHR12046 PTHR12046, 1 hit
PfamiView protein in Pfam
PF10394 Hat1_N, 1 hit
PIRSFiPIRSF038084 HAT-B_cat, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Q4I6A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDTTQWLSD ASTAIHISLV SPSESGLQHV ATFNPRHTYS IFGDDEKIFG
60 70 80 90 100
YQDLKVNLRY RANDMRPHLN ISYSKKSGTI NELEPTDVAA ILDEGNHLPK
110 120 130 140 150
IAFAKARDFE ESSKQLSDDW TPPGKLHTTF DSPEGQYEIW CGNLADPAVK
160 170 180 190 200
QLNSRLQIFV PLFIEGGTYI GQDPDEDSAE LDLSDADRWT FFSLYQKRKV
210 220 230 240 250
GDKTAYVFVG YSTIYRFYYF QPPTPPASPQ SDEWELPNGN MDLGELPCRT
260 270 280 290 300
RLSQFIILPP FQGKGNGARL YKTIFEHYHK IPQTYEFTVE DPNEAFDDLR
310 320 330 340 350
DICDLQFLRK MPEFNNLLVD TNIKIPKKGF LPKLIIGSSL LEEIRLRAKI
360 370 380 390 400
APRQFGRVLE MHLMSKLPVS VRPTMAIEDQ PAATKADQHE AKVWGLIVKQ
410 420 430 440 450
RLYRHNKEVL SQIEPAERVE KLDDTLHGVG LEYARILAAV DRSDKYEGQT
460 470
TASSKRKLDA DEITEDLSNK KARVEDA
Length:477
Mass (Da):54,380
Last modified:October 31, 2012 - v2
Checksum:iB353317F4741E1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231666 Genomic DNA Translation: ESU13485.1
HG970335 Genomic DNA Translation: CEF84494.1
RefSeqiXP_011326992.1, XM_011328690.1

Genome annotation databases

GeneIDi23554341
KEGGifgr:FGSG_07254

Similar proteinsi

Entry informationi

Entry nameiHAT1_GIBZE
AccessioniPrimary (citable) accession number: Q4I6A4
Secondary accession number(s): A0A0E0SDI1, I1RSW8, V6RNJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 31, 2012
Last modified: March 28, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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