Reviewed, UniProtKB/Swiss-Prot Q4I6A4 (HAT1_GIBZE)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase type B catalytic subunit
    EC=2.3.1.48

Gene names

Name:	HAT1
ORF Names:	FG07254

Organism

Gibberella zeae (Fusarium graminearum)

Taxonomic identifier

5518 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates Lys-12 of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Subunit structure	Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the HAT1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Chromatin regulator Transferase
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin silencing at telomere Inferred from electronic annotation. Source: InterPro histone acetylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Histone acetyltransferase type B catalytic subunit		PRO_0000227724

Sequences

	Sequence		Length	Mass (Da)
	Q4I6A4-1 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: F84A44346A28CF0D	FASTA	478	54,501
	10 20 30 40 50 60 MEDTTQLLTF FKGLSDASTA IHISLVSPSE SGLQHVATFN PRHTYSIFGD DEKIFGYQDL 70 80 90 100 110 120 KVNLRYRAND MRPHLNISYS KKSGTINELE PTDVAAILDE GNHLPKTRDF EESSKQLSDD 130 140 150 160 170 180 WTPPGKLHTT FDSPEGQYEI WCGNLADPAV KQLNSRLQIF VPLFIEGGTY IGQDPDEDSA 190 200 210 220 230 240 ELDLSDADRW TFFSLYQKRK VGDKTAYVFV GYSTIYRFYY FQPPTPPASP QSDEWELPNG 250 260 270 280 290 300 NMDLGELPCR TRLSQFIILP PFQGKGNGAR LYKTIFEHYH KIPQTYEFTV EDPNEAFDDL 310 320 330 340 350 360 RDICDLQFLR KMPEFNNLLV DTNIKIPKKG FLPKLIIGSS LLEEIRLRAK IAPRQFGRVL 370 380 390 400 410 420 EMHLMSKLPV SVRPTMAIED QPAATKADQH EAKVWGLIVK QRLYRHNKEV LSQIEPAERV 430 440 450 460 470 EKLDDTLHGV GLEYARILAA VDRSDKYEGQ TTASSKRKLD ADEITEDLSN KKARVEDA

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / NRRL 31084.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACM01000303 Genomic DNA. Translation: EAA77852.1.
RefSeq	XP_387430.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2788834.
KEGG	fgr:FG07254.1.
Enzyme and pathway databases
BRENDA	2.3.1.48. 74326.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF10394. Hat1_N. 1 hit. [Graphical view]
PIRSF	PIRSF038084. HAT-B_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HAT1_GIBZE

Accession

Primary (citable) accession number: Q4I6A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	August 16, 2005
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)