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Q4I5U9

- BUR1_GIBZE

UniProt

Q4I5U9 - BUR1_GIBZE

Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661ATPPROSITE-ProRule annotation
    Active sitei169 – 1691Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 519ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:BUR1
    ORF Names:FGSG_07409
    OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
    Taxonomic identifieri229533 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
    ProteomesiUP000009057: Chromosome 4

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Serine/threonine-protein kinase BUR1PRO_0000085683Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5518.FG07409.1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 339303Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi411 – 539129Arg-richAdd
    BLAST
    Compositional biasi432 – 49362Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4I5U9-1 [UniParc]FASTAAdd to Basket

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    MEKLSETTPN GTSPRTFALN HSRPRSSFKG CSRISDYELL GKLGEGTFGE    50
    VHRARLRKTG ALVALKKIIM HHEKDGFPIT ALREIKLLKL LSHKNILRLE 100
    DMAIEHPTRQ TDKRKKPIVY MATPYMDHDL SGLLDNPSVQ FKEPQIKCYM 150
    LQLLEGLRYL HDSRILHRDM KAANLLINNK GILQIADFGL ARHYDGRTPE 200
    SGVPMGEGKR DYTGLVVTRW YRPPELLLQL RQYTPAIDVW GVGCVFGEML 250
    YGKPILAGES DAAQLDIIWD LMGSPNEENM PRWKSLPGAD HLTPRPRTGN 300
    LETRFRQYGS GAVSLLKELL RLDWRTRINA VDALQHPWFK MQPLPLEPHE 350
    IPTYEESHEL DRRKFHDRKA ALPPAPKGGT VGVGPDANGA TAGFNSNEPY 400
    GNGRNGVNGG RYRNGPDDRR PAWQRERGAG LPPRPPPNND DADFRERGPP 450
    RARGPPGPRG PDVDTYIPAY NRDDPGRRRD DRPPPPRDDR PPPRDDRRRR 500
    NSREDRRFDR DRGTMSRSRS PRHDRSRDRD RPDHNGYRR 539
    Length:539
    Mass (Da):61,614
    Last modified:October 31, 2012 - v2
    Checksum:i1320870273F2BD61
    GO

    Sequence cautioni

    The sequence ESU13671.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231666 Genomic DNA. Translation: ESU13671.1. Sequence problems.

    Genome annotation databases

    EnsemblFungiiFGSG_07409T0; FGSG_07409P0; FGSG_07409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231666 Genomic DNA. Translation: ESU13671.1 . Sequence problems.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5518.FG07409.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii FGSG_07409T0 ; FGSG_07409P0 ; FGSG_07409 .

    Phylogenomic databases

    eggNOGi COG0515.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
    2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
      Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
      , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
      Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

    Entry informationi

    Entry nameiBUR1_GIBZE
    AccessioniPrimary (citable) accession number: Q4I5U9
    Secondary accession number(s): I1RTA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3