ID   SET1_GIBZE              Reviewed;        1252 AA.
AC   Q4I5R3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 36.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-4 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=COMPASS component SET1;
DE   AltName: Full=SET domain-containing protein 1;
GN   Name=SET1; ORFNames=FG07445;
OS   Gibberella zeae (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Gibberella.
OX   NCBI_TaxID=5518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / NRRL 31084;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G.,
RA   Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G.,
RA   Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D.,
RA   Gale L.R., Gnerre S., Goswami R.S., Hammond-Kosack K., Harris L.J.,
RA   Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G.,
RA   Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G.,
RA   Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W.,
RA   Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
CC   -!- FUNCTION: Catalytic component of the COMPASS (Set1C) complex that
CC       specifically mono-, di- and trimethylates histone H3 to form
CC       H3K4me1/2/3, which subsequently plays a role in telomere length
CC       maintenance and transcription elongation regulation (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine =
CC       S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
CC   -!- SUBUNIT: Component of the COMPASS (Set1C) complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Contains 1 post-SET domain.
CC   -!- SIMILARITY: Contains 1 SET domain.
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DR   EMBL; AACM01000310; EAA77462.1; -; Genomic_DNA.
DR   RefSeq; XP_387621.1; -.
DR   GeneID; 2788586; -.
DR   KEGG; fgr:FG07445.1; -.
DR   BRENDA; 2.1.1.43; 74326.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   InterPro; IPR017111; Hist_H3-K4_MeTrfase_1_fun.
DR   InterPro; IPR015722; MLL.
DR   InterPro; IPR003616; Post-SET_Zn_bd.
DR   InterPro; IPR001214; SET.
DR   PANTHER; PTHR22884:SF10; MLL; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF037104; Histone_H3-K4_mtfrase_Set1_fun; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosomal protein; Methyltransferase; Nucleus;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1   1252       Histone-lysine N-methyltransferase, H3
FT                                lysine-4 specific.
FT                                /FTId=PRO_0000269774.
FT   DOMAIN     1120   1231       SET.
FT   DOMAIN     1236   1252       Post-SET.
SQ   SEQUENCE   1252 AA;  139577 MW;  A9676716CBFA6426 CRC64;
     MTRPPGASFA EFFPTAPKVK AQAQTRADQV RDRDRFKTAS TPATINGTID STTGTAVLEA
     DANVSLNGIV SASDTMPTQP DDTESPFTDI PNTVDSASSY SSAASSIFST STRHGAAATT
     ASSRLPTSSL TPSAFKESPN SAPAAAKPDM STYQTSDRAA RQSSRNSPAT GPNVSISNGL
     PSNERIPARD PLPSVKGLRC TYDPLLDRVH NKSVSKSAKP TYEEFGREDD APPPKDPRLA
     RSDGRLGYIN TDYYLPKSRL RTAPENIKPY PYDPKTSIGP GPPTQIVVTR YNPLIPFSKV
     TAIFASFGEI AESSNKMHPE TGSYLGFATI RYRDSKRPDR PPVSGIDAAR RAVRARGIKV
     DADIVRVEYD AEGRRSRRML EEHLKREKEK FEKIEQERLA LAAKAPPTGP KSGTAPAFTR
     PPPTAPKGPS AQRQSIPTGT PQIPLLGTQV QGLNLEPSNL AQKLADDPYI YVTGDSVPVL
     PSILPHMKKR LKSYGFEEIR VDKSGYFIVF RNSFTGSSEA ERCFRAVNHT EFFNYDMTMQ
     LCLPRPRRED GSGRRRSSAS SDRHTHAEPR YRDEKDRRRR EEEADLEEEK KQRAKNFDPV
     IEAVEVVRRE MMEHLIRHIR TKVAAPALSD FLDPANHAAK RRKLNIEHPD DLQEIPSIED
     GNDSSRVGTP NSRADPIERR TGRLEPKALP RIRKTKVKGQ AQKSAFVDPF ARKRPPVARN
     AFRSLHHRLR SLDSDAESDD DTDTRALLAR ETEEADSRPR SRMSTDDEAS KDDFVPWEQG
     EDDSMTEASF AIADTASTRK RKLVASLESV FKRQKKSDEE LFGVNLETLD SEFKGREDSV
     DIIPEPETGD DVESRVSRSE TPASAIGKPL KKRPGKRKKT KKASFEEPEA AKTQPETEQQ
     PGDEATEPSK VKQEKAEKTS MEELVPEKFD EKLFATEPLT PALELPEGAK PDLPIFQGLT
     VSAQDIPDLA KLARRFNTKD IGNAELWLWT RNRIRELNSA RRTLDSPVTI GGYYVPNPTG
     CARTEGVKKI LNSEKSKYLP HHIKVQKARQ EREARNKLGR DAAAEAADAA RIAAEKLVAK
     GNSRANRATN RRYVADLNDQ KKTLGQDSDV FKFNQLKKRK KPVKFARSAI HNWGLYAMEN
     IAKDDMIIEY VGEQVRQQIS EIRENRYLKS GIGSSYLFRI DDNTVIDATK KGGIARFINH
     SFEGSKRIVI YALRDIALNE ELTYDYKFER EIGSTDRIPC LCGTAACKGF LN
//