Reviewed, UniProtKB/Swiss-Prot Q4I5R3 (SET1_GIBZE)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specific
    EC=2.1.1.43
Alternative name(s):
    COMPASS component SET1
    SET domain-containing protein 1

Gene names

Name:	SET1
ORF Names:	FG07445

Organism

Gibberella zeae (Fusarium graminearum)

Taxonomic identifier

5518 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	1252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subunit structure	Component of the COMPASS (Set1C) complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 post-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Set1C/COMPASS complex Inferred from electronic annotation. Source: InterPro chromosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1252	1252	Histone-lysine N-methyltransferase, H3 lysine-4 specific		PRO_0000269774
Regions
	Domain	1120 – 1231	112	SET
	Domain	1236 – 1252	17	Post-SET

Sequences

	Sequence		Length	Mass (Da)
	Q4I5R3-1 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: A9676716CBFA6426	FASTA	1,252	139,577
	10 20 30 40 50 60 MTRPPGASFA EFFPTAPKVK AQAQTRADQV RDRDRFKTAS TPATINGTID STTGTAVLEA 70 80 90 100 110 120 DANVSLNGIV SASDTMPTQP DDTESPFTDI PNTVDSASSY SSAASSIFST STRHGAAATT 130 140 150 160 170 180 ASSRLPTSSL TPSAFKESPN SAPAAAKPDM STYQTSDRAA RQSSRNSPAT GPNVSISNGL 190 200 210 220 230 240 PSNERIPARD PLPSVKGLRC TYDPLLDRVH NKSVSKSAKP TYEEFGREDD APPPKDPRLA 250 260 270 280 290 300 RSDGRLGYIN TDYYLPKSRL RTAPENIKPY PYDPKTSIGP GPPTQIVVTR YNPLIPFSKV 310 320 330 340 350 360 TAIFASFGEI AESSNKMHPE TGSYLGFATI RYRDSKRPDR PPVSGIDAAR RAVRARGIKV 370 380 390 400 410 420 DADIVRVEYD AEGRRSRRML EEHLKREKEK FEKIEQERLA LAAKAPPTGP KSGTAPAFTR 430 440 450 460 470 480 PPPTAPKGPS AQRQSIPTGT PQIPLLGTQV QGLNLEPSNL AQKLADDPYI YVTGDSVPVL 490 500 510 520 530 540 PSILPHMKKR LKSYGFEEIR VDKSGYFIVF RNSFTGSSEA ERCFRAVNHT EFFNYDMTMQ 550 560 570 580 590 600 LCLPRPRRED GSGRRRSSAS SDRHTHAEPR YRDEKDRRRR EEEADLEEEK KQRAKNFDPV 610 620 630 640 650 660 IEAVEVVRRE MMEHLIRHIR TKVAAPALSD FLDPANHAAK RRKLNIEHPD DLQEIPSIED 670 680 690 700 710 720 GNDSSRVGTP NSRADPIERR TGRLEPKALP RIRKTKVKGQ AQKSAFVDPF ARKRPPVARN 730 740 750 760 770 780 AFRSLHHRLR SLDSDAESDD DTDTRALLAR ETEEADSRPR SRMSTDDEAS KDDFVPWEQG 790 800 810 820 830 840 EDDSMTEASF AIADTASTRK RKLVASLESV FKRQKKSDEE LFGVNLETLD SEFKGREDSV 850 860 870 880 890 900 DIIPEPETGD DVESRVSRSE TPASAIGKPL KKRPGKRKKT KKASFEEPEA AKTQPETEQQ 910 920 930 940 950 960 PGDEATEPSK VKQEKAEKTS MEELVPEKFD EKLFATEPLT PALELPEGAK PDLPIFQGLT 970 980 990 1000 1010 1020 VSAQDIPDLA KLARRFNTKD IGNAELWLWT RNRIRELNSA RRTLDSPVTI GGYYVPNPTG 1030 1040 1050 1060 1070 1080 CARTEGVKKI LNSEKSKYLP HHIKVQKARQ EREARNKLGR DAAAEAADAA RIAAEKLVAK 1090 1100 1110 1120 1130 1140 GNSRANRATN RRYVADLNDQ KKTLGQDSDV FKFNQLKKRK KPVKFARSAI HNWGLYAMEN 1150 1160 1170 1180 1190 1200 IAKDDMIIEY VGEQVRQQIS EIRENRYLKS GIGSSYLFRI DDNTVIDATK KGGIARFINH 1210 1220 1230 1240 1250 SFEGSKRIVI YALRDIALNE ELTYDYKFER EIGSTDRIPC LCGTAACKGF LN

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / NRRL 31084.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACM01000310 Genomic DNA. Translation: EAA77462.1.
RefSeq	XP_387621.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2788586.
KEGG	fgr:FG07445.1.
Enzyme and pathway databases
BRENDA	2.1.1.43. 74326.
Family and domain databases
InterPro	IPR017111. Hist_H3-K4_MeTrfase_1_fun. IPR015722. MLL. IPR003616. Post-SET_Zn_bd. IPR001214. SET. [Graphical view]
PANTHER	PTHR22884:SF10. MLL. 1 hit.
Pfam	PF00856. SET. 1 hit. [Graphical view]
PIRSF	PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMART	SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET1_GIBZE

Accession

Primary (citable) accession number: Q4I5R3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	August 16, 2005
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)