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Q4I5G1 (COX10_GIBZE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protoheme IX farnesyltransferase, mitochondrial
EC=2.5.1.-
Alternative name(s):
Heme O synthase
Gene names
Name:COX10
ORF Names:FGSG_07547
OrganismGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) [Reference proteome]
Taxonomic identifier229533 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella ›

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts protoheme IX and farnesyl diphosphate to heme O By similarity.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentMembrane
Mitochondrion
   DomainTransit peptide
Transmembrane
Transmembrane helix
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheme O biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotoheme IX farnesyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 507Protoheme IX farnesyltransferase, mitochondrialPRO_0000045416

Regions

Transmembrane166 – 18621Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane248 – 26821Helical; Potential
Transmembrane270 – 29021Helical; Potential
Transmembrane298 – 31821Helical; Potential
Transmembrane339 – 35921Helical; Potential
Transmembrane392 – 41221Helical; Potential
Transmembrane441 – 46121Helical; Potential
Compositional bias475 – 48410Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q4I5G1 [UniParc].

Last modified August 16, 2005. Version 1.
Checksum: FCACC851BE274587

FASTA50755,397
        10         20         30         40         50         60 
MRPPRCLFPA AEILLKAPPS RRCMSSAAAF QPPKIVAAIP WKGSSFFLSN RLFDRSTCLD 

        70         80         90        100        110        120 
FVVLRRANGI RSTSASASTT HDSTLSSSPT ANHSTSAHKD HKIAPHRKRQ AQRREKAAAE 

       130        140        150        160        170        180 
AAAAAARGEK PLPPDASSLL AAHAASQTSP LRRHLSACLS LAKPRLTMLV VLTAMATYAL 

       190        200        210        220        230        240 
YPVPEMLSPS TTETPSLSPL TLLFLTIGTT FCSASANALN MLYEPSTDAK MTRTRNRPLV 

       250        260        270        280        290        300 
RNLISKRAAV LFAILSGFVG TGALYFGVNP TVSGLGFANI VIYAGMYTPL KAVTAFNTWI 

       310        320        330        340        350        360 
GAVVGGIPPL MGWAAAAGET ATKDGSWREL LFASDGSSIG GWVMAGLLFA WQFPHFMALS 

       370        380        390        400        410        420 
WPIREEYKKA GLRMLAWTNP ARNGRVALRY SFVFIPLCLS LCAAGVTEWS FAVTSFPINA 

       430        440        450        460        470        480 
WLIRESVRFW RYEGNKGSAR GLFWASVWHL PGVMILALLH KKGMWTRVWR SVFGEDEGEW 

       490        500 
EEEELDEMMS VAVANTNSHM QNQKTVR

« Hide

References

« Hide 'large scale' references
[1]"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization."
Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. expand/collapse author list , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.
Science 317:1400-1402(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
[2]"Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E. expand/collapse author list , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

Cross-references

Sequence databases

RefSeqXP_387723.1. XM_387723.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING5518.FG07547.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiFGSG_07547T0; FGSG_07547P0; FGSG_07547.
GeneID2788677.
KEGGfgr:FG07547.1.

Phylogenomic databases

eggNOGCOG0109.
KOK02257.

Family and domain databases

InterProIPR006369. Protohaem_IX_farnesylTrfase.
IPR016315. Protohaem_IX_farnesylTrfase_mt.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFPIRSF001773. COX10. 1 hit.
TIGRFAMsTIGR01473. cyoE_ctaB. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX10_GIBZE
AccessionPrimary (citable) accession number: Q4I5G1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2005
Last modified: April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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