ID   NNT1_GIBZE              Reviewed;         594 AA.
AC   Q4I2X5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Putative nicotinamide N-methyltransferase;
DE            EC=2.1.1.1;
GN   Name=NNT1; ORFNames=FG08433;
OS   Gibberella zeae (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Gibberella.
OX   NCBI_TaxID=5518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / NRRL 31084;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G.,
RA   Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G.,
RA   Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D.,
RA   Gale L.R., Gnerre S., Goswami R.S., Hammond-Kosack K., Harris L.J.,
RA   Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G.,
RA   Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G.,
RA   Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W.,
RA   Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
CC   -!- FUNCTION: Putative nicotinamide N-methyltransferase involved in
CC       rDNA silencing and in lifespan determination (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + nicotinamide = S-
CC       adenosyl-L-homocysteine + 1-methylnicotinamide.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the NNT1 family.
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DR   EMBL; AACM01000338; EAA71910.1; -; Genomic_DNA.
DR   RefSeq; XP_388609.1; -.
DR   GeneID; 2790508; -.
DR   KEGG; fgr:FG08433.1; -.
DR   BRENDA; 2.1.1.1; 74326.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008112; F:nicotinamide N-methyltransferase activity; IEA:EC.
DR   InterPro; IPR019410; Methyltransferase-16_put.
DR   Pfam; PF10294; Methyltransf_16; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    594       Putative nicotinamide N-
FT                                methyltransferase.
FT                                /FTId=PRO_0000096896.
SQ   SEQUENCE   594 AA;  67350 MW;  B2241835739B26EB CRC64;
     MSGEVDYGFG DLMDDPEDYC PPTPPPTSQV FTMQSGKPIT LHLVGASPTE AHHLWNGAKM
     IADFFEEDLS RVKGKTVLEL GAAAGLPSLV AAILGAHKVV VTDYPDPDII RIMQKNVDEC
     DETVEPRGRI VDTVDAMGFV WGADSVPLLA RLNPTDDSHK ERFDILILAD LLFRHSEHGN
     MVKTIKETLK ISRESVAYVF FTSYRPWKKE LDMGFFDIAR EQGFEVEQIA ERRLDKPLFE
     NDPGDLDVQK TVKGFAQKVD TGVNLDTTEV SDYELIFLTA TLLEPPSQMQ RADDGRVQYH
     IITMPTSQYL QDLDRDGFVV IKSIVDSDKL EALRGVSSKA TQLARDGQWP FVRTVPKQFP
     PWDASQAREH GIWGVQHLMN PELPGHELFT ELYFSETILG IVKQLLQCQD EHLVMELFNM
     LVRPEKDFEL RWHRDDIPAE ASQEEEMERL GKHAYHAQYN FALWEDESLI VVPGSHKRAR
     TSTERDADPF AKSLPNQLIV KLEPGDIVFY NNNILHRGAY DNSKERMTLH GSVGHIQGNS
     LRARNVLQHG VGSWVDKCDF QPLLEDDRRR AEEMRQRLIR LGSESGQVGY SLQG
//