Reviewed, UniProtKB/Swiss-Prot Q4I2X5 (NNT1_GIBZE)

Names and origin

Protein names

Recommended name:
    Putative nicotinamide N-methyltransferase
    EC=2.1.1.1

Gene names

Name:	NNT1
ORF Names:	FG08433

Organism

Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum)

Taxonomic identifier

5518 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	594 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 594	594	Putative nicotinamide N-methyltransferase		PRO_0000096896

Sequences

	Sequence		Length	Mass (Da)
	Q4I2X5-1 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: B2241835739B26EB	FASTA	594	67,350
	10 20 30 40 50 60 MSGEVDYGFG DLMDDPEDYC PPTPPPTSQV FTMQSGKPIT LHLVGASPTE AHHLWNGAKM 70 80 90 100 110 120 IADFFEEDLS RVKGKTVLEL GAAAGLPSLV AAILGAHKVV VTDYPDPDII RIMQKNVDEC 130 140 150 160 170 180 DETVEPRGRI VDTVDAMGFV WGADSVPLLA RLNPTDDSHK ERFDILILAD LLFRHSEHGN 190 200 210 220 230 240 MVKTIKETLK ISRESVAYVF FTSYRPWKKE LDMGFFDIAR EQGFEVEQIA ERRLDKPLFE 250 260 270 280 290 300 NDPGDLDVQK TVKGFAQKVD TGVNLDTTEV SDYELIFLTA TLLEPPSQMQ RADDGRVQYH 310 320 330 340 350 360 IITMPTSQYL QDLDRDGFVV IKSIVDSDKL EALRGVSSKA TQLARDGQWP FVRTVPKQFP 370 380 390 400 410 420 PWDASQAREH GIWGVQHLMN PELPGHELFT ELYFSETILG IVKQLLQCQD EHLVMELFNM 430 440 450 460 470 480 LVRPEKDFEL RWHRDDIPAE ASQEEEMERL GKHAYHAQYN FALWEDESLI VVPGSHKRAR 490 500 510 520 530 540 TSTERDADPF AKSLPNQLIV KLEPGDIVFY NNNILHRGAY DNSKERMTLH GSVGHIQGNS 550 560 570 580 590 LRARNVLQHG VGSWVDKCDF QPLLEDDRRR AEEMRQRLIR LGSESGQVGY SLQG

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / FGSC 9075 / NRRL 31084.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACM01000338 Genomic DNA. Translation: EAA71910.1.
RefSeq	XP_388609.1.
3D structure databases
SMR	Q4I2X5. Positions 48-231.
ModBase	Search...
Genome annotation databases
GeneID	2790508.
KEGG	fgr:FG08433.1.
Phylogenomic databases
eggNOG	fuNOG07310.
PhylomeDB	Q4I2X5.
Enzyme and pathway databases
BRENDA	2.1.1.1. 74326.
Family and domain databases
InterPro	IPR019410. Methyltransferase-16_put. IPR008775. Phytyl_CoA_dOase. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. PF05721. PhyH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_GIBZE

Accession

Primary (citable) accession number: Q4I2X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 16, 2005
Last modified:	January 19, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)