Q4I298 (MRS2_GIBZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial inner membrane magnesium transporter mrs2

Alternative name(s):
RNA-splicing protein MRS2

Gene names

Name:	MRS2
ORF Names:	FG08660

Organism

Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)

Taxonomic identifier

229533 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Involved in the splicing of mitochondrial mRNA group II introns By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport mRNA processing mRNA splicing
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Magnesium
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial magnesium ion transport Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	magnesium ion transmembrane transporter activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 58	58	Mitochondrion Potential
	Chain	59 – 498	440	Mitochondrial inner membrane magnesium transporter mrs2		PRO_0000043245
Regions
	Transmembrane	386 – 406	21	Helical; Potential
	Transmembrane	417 – 437	21	Helical; Potential
	Motif	403 – 406	4	YGMN

Sequences

	Sequence		Length	Mass (Da)
	Q4I298 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: 29972D61E0944CB3	FASTA	498	56,680
	10 20 30 40 50 60 MQSTLCLPVP SRSLLRFLRS LTTACERRVT TVEPSLFDKD PVTRKLPDRN QPLTSQNHFS 70 80 90 100 110 120 TSRNAQGFWS GRKSSSSYMP TWNSFLKFAG KKNEKALKPD DLPNHDEFGD NSSIFNNRRT 130 140 150 160 170 180 LAAKAASEPR LRCTEVDEHG NVILVDGEFK KTELIAKFGL LPRDLRKIDS SNLPHILIRP 190 200 210 220 230 240 SAILLNLLHL KVLIKHDRVL LFDIYGSKTS YPQSAFMYDL QGKLQQKTAP GNASLPYEFR 250 260 270 280 290 300 ALEAVLTSVT SELEADFEAV REPVMHILSE LEDDIDRHKL RMLLILSKRV STFEQKAKLV 310 320 330 340 350 360 RDAIEDLLEA DDDLADMYLT EKTHDLYRGE DDHTEVEMLL ESYHKLTDEI VQEAGNLVSG 370 380 390 400 410 420 IRNTEEIVRA ILDANRNALM LLDLKFSVGT LGLAMGTFLA GLYGMNLENF IEETNWGFAG 430 440 450 460 470 480 VTGVSVVFSL IVCWYGLTKL RRVQRIKMMD AERPAIARGQ SYFPDDRSAL GLLDNRNREM 490 LRRINMQKAV SQQKKKWL

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACM01000349 Genomic DNA. Translation: EAA72250.1.
RefSeq	XP_388836.1. XM_388836.1.
3D structure databases
ProteinModelPortal	Q4I298.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	FGSG_08660T0; FGSG_08660P0; FGSG_08660.
GeneID	2790196.
KEGG	fgr:FG08660.1.
Phylogenomic databases
eggNOG	fuNOG05683.
Family and domain databases
InterPro	IPR002523. MgTranspt_CorA/ZnTranspt_ZntB. [Graphical view]
Pfam	PF01544. CorA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MRS2_GIBZE

Accession

Primary (citable) accession number: Q4I298

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	August 16, 2005
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program