ID   MPG1_GIBZE              Reviewed;         364 AA.
AC   Q4I1Y5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase;
DE            EC=2.7.7.13;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase;
DE   AltName: Full=GDP-mannose pyrophosphorylase;
GN   Name=MPG1; ORFNames=FG08773;
OS   Gibberella zeae (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Gibberella.
OX   NCBI_TaxID=5518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / NRRL 31084;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G.,
RA   Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G.,
RA   Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D.,
RA   Gale L.R., Gnerre S., Goswami R.S., Hammond-Kosack K., Harris L.J.,
RA   Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G.,
RA   Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G.,
RA   Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W.,
RA   Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
CC   -!- FUNCTION: Involved in cell wall synthesis where it is required for
CC       glycosylation. Involved in cell cycle progression through cell-
CC       size checkpoint (By similarity).
CC   -!- CATALYTIC ACTIVITY: GTP + alpha-D-mannose 1-phosphate =
CC       diphosphate + GDP-mannose.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACM01000354; EAA71086.1; -; Genomic_DNA.
DR   RefSeq; XP_388949.1; -.
DR   GeneID; 2790633; -.
DR   KEGG; fgr:FG08773.1; -.
DR   BRENDA; 2.7.7.13; 74326.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase act...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR001451; Hexapep_transf.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00132; Hexapep; 4.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; GTP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN         1    364       Mannose-1-phosphate guanyltransferase.
FT                                /FTId=PRO_0000238489.
SQ   SEQUENCE   364 AA;  40059 MW;  398D527067FC0497 CRC64;
     MKGLILVGGY GTRLRPLTLS VPKPLVEFAN KPMIVHQIEA LVAAGVTDIV LAVNYRPEVM
     EKFLAEYEEK FGINIEFSVE TEPLDTAGPL KLAERILAKD DSPFFVLNSD VICDFPFEDL
     LAFHKSHGNE GTIVVTKVEE PSKYGVVVHQ PGHRSLIDRF VEKPVEFVGN RINAGLYIFN
     TSILDRIELR PTSIEKETFP AMVKDNQLHS FDLEGFWMDV GQPKDFLSGT CLYLSSLTKK
     GSKELTSPSE PFVHGGNVLI DPSAKIGKNC RIGPNVTIGP NVVIGDGVRL QRCVLLKGSK
     VKDHAWVKST IVGWNSTIGR WARLENVTVL GDDVTVGDEI YVNGGSVLPH KSIKANVDIP
     AIIM
//