Reviewed, UniProtKB/Swiss-Prot Q4I1Y5 (MPG1_GIBZE)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase
    GDP-mannose pyrophosphorylase

Gene names

Name:	MPG1
ORF Names:	FG08773

Organism

Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum)

Taxonomic identifier

5518 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Mannose-1-phosphate guanyltransferase		PRO_0000238489

Sequences

	Sequence		Length	Mass (Da)
	Q4I1Y5-1 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: 398D527067FC0497	FASTA	364	40,059
	10 20 30 40 50 60 MKGLILVGGY GTRLRPLTLS VPKPLVEFAN KPMIVHQIEA LVAAGVTDIV LAVNYRPEVM 70 80 90 100 110 120 EKFLAEYEEK FGINIEFSVE TEPLDTAGPL KLAERILAKD DSPFFVLNSD VICDFPFEDL 130 140 150 160 170 180 LAFHKSHGNE GTIVVTKVEE PSKYGVVVHQ PGHRSLIDRF VEKPVEFVGN RINAGLYIFN 190 200 210 220 230 240 TSILDRIELR PTSIEKETFP AMVKDNQLHS FDLEGFWMDV GQPKDFLSGT CLYLSSLTKK 250 260 270 280 290 300 GSKELTSPSE PFVHGGNVLI DPSAKIGKNC RIGPNVTIGP NVVIGDGVRL QRCVLLKGSK 310 320 330 340 350 360 VKDHAWVKST IVGWNSTIGR WARLENVTVL GDDVTVGDEI YVNGGSVLPH KSIKANVDIP AIIM

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / NRRL 31084.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACM01000354 Genomic DNA. Translation: EAA71086.1.
RefSeq	XP_388949.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4I1Y5.
Genome annotation databases
GeneID	2790633.
KEGG	fgr:FG08773.1.
Enzyme and pathway databases
BRENDA	2.7.7.13. 74326.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPG1_GIBZE

Accession

Primary (citable) accession number: Q4I1Y5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	August 16, 2005
Last modified:	September 22, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)