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Q4HZ35

- DOHH_GIBZE

UniProt

Q4HZ35 - DOHH_GIBZE

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Protein

Deoxyhypusine hydroxylase

Gene

LIA1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.UniRule annotation

Catalytic activityi

[eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Iron 1UniRule annotation
Metal bindingi76 – 761Iron 1UniRule annotation
Metal bindingi108 – 1081Iron 1UniRule annotation
Metal bindingi109 – 1091Iron 1UniRule annotation
Metal bindingi242 – 2421Iron 2UniRule annotation
Metal bindingi243 – 2431Iron 2UniRule annotation
Metal bindingi275 – 2751Iron 2UniRule annotation
Metal bindingi276 – 2761Iron 2UniRule annotation

GO - Molecular functioni

  1. deoxyhypusine monooxygenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. microtubule cytoskeleton organization Source: EnsemblFungi
  2. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyhypusine hydroxylaseUniRule annotation (EC:1.14.99.29UniRule annotation)
Short name:
DOHHUniRule annotation
Alternative name(s):
Deoxyhypusine dioxygenaseUniRule annotation
Deoxyhypusine monooxygenaseUniRule annotation
Gene namesi
Name:LIA1UniRule annotation
ORF Names:FGSG_09773
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
ProteomesiUP000009057: Chromosome 4

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Deoxyhypusine hydroxylasePRO_0000283666Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4HZ35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati73 – 9927HEAT-like PBS-type 1Add
BLAST
Repeati106 – 13227HEAT-like PBS-type 2Add
BLAST
Repeati202 – 23534HEAT-like PBS-type 3Add
BLAST
Repeati240 – 26627HEAT-like PBS-type 4Add
BLAST
Repeati273 – 30028HEAT-like PBS-type 5Add
BLAST

Sequence similaritiesi

Belongs to the deoxyhypusine hydroxylase family.UniRule annotation
Contains 5 HEAT-like PBS-type repeats.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ4HZ35.
KOiK06072.
OrthoDBiEOG7QC85Z.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
HAMAPiMF_03101. Deoxyhypusine_hydroxylase.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR021133. HEAT_type_2.
IPR004155. PBS_lyase_HEAT.
[Graphical view]
SMARTiSM00567. EZ_HEAT. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4HZ35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPSADTPEI SNSADSTVLS LKKSLCSEDS PLPIRFRALF SLKHVATTAD
60 70 80 90 100
DDATRVAAIE AIAAGFASPS ALLKHELAYC LGQTGNTAAV KPLRQVLSDL
110 120 130 140 150
KEDPMCRHEA AEALGALGWA DNLDILREYR DRKEEDISIV ETCEIAIERI
160 170 180 190 200
EWENSAERQK EKLRPSDFAS IDPAPPMPES DKEAEVEDLG RKLMDTNADL
210 220 230 240 250
FSRYRAMFAL RDLASPPDLP TATPAVLALA KGLSDSSALF RHEIAFVFGQ
260 270 280 290 300
LSHPASIPAL TEALSNTNEA SMVRHEAAEA LGSLGEKDGV EDTLRKFLHD
310 320 330
KEKVVRESCI VALDIAEYEK GEDAEYALIP ESAGAAA
Length:337
Mass (Da):36,535
Last modified:August 16, 2005 - v1
Checksum:i4806FBD8DB5E74F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231668 Genomic DNA. Translation: ESU16395.1.
RefSeqiXP_389949.1. XM_389949.1.

Genome annotation databases

EnsemblFungiiFGSG_09773T0; FGSG_09773P0; FGSG_09773.
GeneIDi2791492.
KEGGifgr:FG09773.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231668 Genomic DNA. Translation: ESU16395.1 .
RefSeqi XP_389949.1. XM_389949.1.

3D structure databases

ProteinModelPortali Q4HZ35.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii FGSG_09773T0 ; FGSG_09773P0 ; FGSG_09773 .
GeneIDi 2791492.
KEGGi fgr:FG09773.1.

Phylogenomic databases

InParanoidi Q4HZ35.
KOi K06072.
OrthoDBi EOG7QC85Z.

Enzyme and pathway databases

UniPathwayi UPA00354 .

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
HAMAPi MF_03101. Deoxyhypusine_hydroxylase.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR021133. HEAT_type_2.
IPR004155. PBS_lyase_HEAT.
[Graphical view ]
SMARTi SM00567. EZ_HEAT. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50077. HEAT_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
  2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
    Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
    , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
    Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

Entry informationi

Entry nameiDOHH_GIBZE
AccessioniPrimary (citable) accession number: Q4HZ35
Secondary accession number(s): V6RWN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: August 16, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3