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Q4HZ35

- DOHH_GIBZE

UniProt

Q4HZ35 - DOHH_GIBZE

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Protein
Deoxyhypusine hydroxylase
Gene
LIA1, FGSG_09773
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor By similarity.UniRule annotation

Catalytic activityi

[eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Iron 1 By similarity
Metal bindingi76 – 761Iron 1 By similarity
Metal bindingi108 – 1081Iron 1 By similarity
Metal bindingi109 – 1091Iron 1 By similarity
Metal bindingi242 – 2421Iron 2 By similarity
Metal bindingi243 – 2431Iron 2 By similarity
Metal bindingi275 – 2751Iron 2 By similarity
Metal bindingi276 – 2761Iron 2 By similarity

GO - Molecular functioni

  1. deoxyhypusine monooxygenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. microtubule cytoskeleton organization Source: EnsemblFungi
  2. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyhypusine hydroxylase (EC:1.14.99.29)
Short name:
DOHH
Alternative name(s):
Deoxyhypusine dioxygenase
Deoxyhypusine monooxygenase
Gene namesi
Name:LIA1
ORF Names:FGSG_09773
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
ProteomesiUP000009057: Chromosome 4

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Deoxyhypusine hydroxylaseUniRule annotation
PRO_0000283666Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4HZ35.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati73 – 9927HEAT-like PBS-type 1UniRule annotation
Add
BLAST
Repeati106 – 13227HEAT-like PBS-type 2UniRule annotation
Add
BLAST
Repeati202 – 23534HEAT-like PBS-type 3UniRule annotation
Add
BLAST
Repeati240 – 26627HEAT-like PBS-type 4UniRule annotation
Add
BLAST
Repeati273 – 30028HEAT-like PBS-type 5UniRule annotation
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK06072.
OrthoDBiEOG7QC85Z.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
HAMAPiMF_03101. Deoxyhypusine_hydroxylase.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR021133. HEAT_type_2.
IPR004155. PBS_lyase_HEAT.
[Graphical view]
SMARTiSM00567. EZ_HEAT. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4HZ35-1 [UniParc]FASTAAdd to Basket

« Hide

MSPSADTPEI SNSADSTVLS LKKSLCSEDS PLPIRFRALF SLKHVATTAD    50
DDATRVAAIE AIAAGFASPS ALLKHELAYC LGQTGNTAAV KPLRQVLSDL 100
KEDPMCRHEA AEALGALGWA DNLDILREYR DRKEEDISIV ETCEIAIERI 150
EWENSAERQK EKLRPSDFAS IDPAPPMPES DKEAEVEDLG RKLMDTNADL 200
FSRYRAMFAL RDLASPPDLP TATPAVLALA KGLSDSSALF RHEIAFVFGQ 250
LSHPASIPAL TEALSNTNEA SMVRHEAAEA LGSLGEKDGV EDTLRKFLHD 300
KEKVVRESCI VALDIAEYEK GEDAEYALIP ESAGAAA 337
Length:337
Mass (Da):36,535
Last modified:August 16, 2005 - v1
Checksum:i4806FBD8DB5E74F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231668 Genomic DNA. Translation: ESU16395.1.
RefSeqiXP_389949.1. XM_389949.1.

Genome annotation databases

EnsemblFungiiFGSG_09773T0; FGSG_09773P0; FGSG_09773.
GeneIDi2791492.
KEGGifgr:FG09773.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231668 Genomic DNA. Translation: ESU16395.1 .
RefSeqi XP_389949.1. XM_389949.1.

3D structure databases

ProteinModelPortali Q4HZ35.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii FGSG_09773T0 ; FGSG_09773P0 ; FGSG_09773 .
GeneIDi 2791492.
KEGGi fgr:FG09773.1.

Phylogenomic databases

KOi K06072.
OrthoDBi EOG7QC85Z.

Enzyme and pathway databases

UniPathwayi UPA00354 .

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
HAMAPi MF_03101. Deoxyhypusine_hydroxylase.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR021133. HEAT_type_2.
IPR004155. PBS_lyase_HEAT.
[Graphical view ]
SMARTi SM00567. EZ_HEAT. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50077. HEAT_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
  2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
    Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
    , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
    Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

Entry informationi

Entry nameiDOHH_GIBZE
AccessioniPrimary (citable) accession number: Q4HZ35
Secondary accession number(s): V6RWN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: August 16, 2005
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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