Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4HZ35

- DOHH_GIBZE

UniProt

Q4HZ35 - DOHH_GIBZE

Protein

Deoxyhypusine hydroxylase

Gene

LIA1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (16 Aug 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.UniRule annotation

    Catalytic activityi

    [eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O.UniRule annotation

    Cofactori

    Binds 2 Fe2+ ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751Iron 1UniRule annotation
    Metal bindingi76 – 761Iron 1UniRule annotation
    Metal bindingi108 – 1081Iron 1UniRule annotation
    Metal bindingi109 – 1091Iron 1UniRule annotation
    Metal bindingi242 – 2421Iron 2UniRule annotation
    Metal bindingi243 – 2431Iron 2UniRule annotation
    Metal bindingi275 – 2751Iron 2UniRule annotation
    Metal bindingi276 – 2761Iron 2UniRule annotation

    GO - Molecular functioni

    1. deoxyhypusine monooxygenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. microtubule cytoskeleton organization Source: EnsemblFungi
    2. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Hypusine biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00354.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyhypusine hydroxylaseUniRule annotation (EC:1.14.99.29UniRule annotation)
    Short name:
    DOHHUniRule annotation
    Alternative name(s):
    Deoxyhypusine dioxygenaseUniRule annotation
    Deoxyhypusine monooxygenaseUniRule annotation
    Gene namesi
    Name:LIA1UniRule annotation
    ORF Names:FGSG_09773
    OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
    Taxonomic identifieri229533 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
    ProteomesiUP000009057: Chromosome 4

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Deoxyhypusine hydroxylasePRO_0000283666Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ4HZ35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati73 – 9927HEAT-like PBS-type 1Add
    BLAST
    Repeati106 – 13227HEAT-like PBS-type 2Add
    BLAST
    Repeati202 – 23534HEAT-like PBS-type 3Add
    BLAST
    Repeati240 – 26627HEAT-like PBS-type 4Add
    BLAST
    Repeati273 – 30028HEAT-like PBS-type 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the deoxyhypusine hydroxylase family.UniRule annotation
    Contains 5 HEAT-like PBS-type repeats.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    KOiK06072.
    OrthoDBiEOG7QC85Z.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    HAMAPiMF_03101. Deoxyhypusine_hydroxylase.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR027517. Deoxyhypusine_hydroxylase.
    IPR021133. HEAT_type_2.
    IPR004155. PBS_lyase_HEAT.
    [Graphical view]
    SMARTiSM00567. EZ_HEAT. 6 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50077. HEAT_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4HZ35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPSADTPEI SNSADSTVLS LKKSLCSEDS PLPIRFRALF SLKHVATTAD    50
    DDATRVAAIE AIAAGFASPS ALLKHELAYC LGQTGNTAAV KPLRQVLSDL 100
    KEDPMCRHEA AEALGALGWA DNLDILREYR DRKEEDISIV ETCEIAIERI 150
    EWENSAERQK EKLRPSDFAS IDPAPPMPES DKEAEVEDLG RKLMDTNADL 200
    FSRYRAMFAL RDLASPPDLP TATPAVLALA KGLSDSSALF RHEIAFVFGQ 250
    LSHPASIPAL TEALSNTNEA SMVRHEAAEA LGSLGEKDGV EDTLRKFLHD 300
    KEKVVRESCI VALDIAEYEK GEDAEYALIP ESAGAAA 337
    Length:337
    Mass (Da):36,535
    Last modified:August 16, 2005 - v1
    Checksum:i4806FBD8DB5E74F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231668 Genomic DNA. Translation: ESU16395.1.
    RefSeqiXP_389949.1. XM_389949.1.

    Genome annotation databases

    EnsemblFungiiFGSG_09773T0; FGSG_09773P0; FGSG_09773.
    GeneIDi2791492.
    KEGGifgr:FG09773.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231668 Genomic DNA. Translation: ESU16395.1 .
    RefSeqi XP_389949.1. XM_389949.1.

    3D structure databases

    ProteinModelPortali Q4HZ35.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii FGSG_09773T0 ; FGSG_09773P0 ; FGSG_09773 .
    GeneIDi 2791492.
    KEGGi fgr:FG09773.1.

    Phylogenomic databases

    KOi K06072.
    OrthoDBi EOG7QC85Z.

    Enzyme and pathway databases

    UniPathwayi UPA00354 .

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    HAMAPi MF_03101. Deoxyhypusine_hydroxylase.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR027517. Deoxyhypusine_hydroxylase.
    IPR021133. HEAT_type_2.
    IPR004155. PBS_lyase_HEAT.
    [Graphical view ]
    SMARTi SM00567. EZ_HEAT. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50077. HEAT_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
    2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
      Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
      , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
      Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

    Entry informationi

    Entry nameiDOHH_GIBZE
    AccessioniPrimary (citable) accession number: Q4HZ35
    Secondary accession number(s): V6RWN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3