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Q4HYR2

- ACEA_GIBZE

UniProt

Q4HYR2 - ACEA_GIBZE

Protein

Isocitrate lyase

Gene

ICL1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei215 – 2151PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:ICL1
    ORF Names:FGSG_09896
    OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
    Taxonomic identifieri229533 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
    ProteomesiUP000009057: Chromosome 1

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 546546Isocitrate lyasePRO_0000286157Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi5518.FG09896.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4HYR2.
    SMRiQ4HYR2. Positions 16-529.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2224.
    KOiK01637.
    OrthoDBiEOG73Z331.

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4HYR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQNMTNPS INPDIEDELF QKEVEAVKTW WSDSRWRQTK RPFTAEQIVS    50
    KRGYLPIDYA SNTQAKKLWK ILEHRFENRD ASYTYGCLEP TMVTQMAKYL 100
    DTVYVSGWQS SSTASASDEP GPDLADYPYT TVPNKVGHLF MAQLFHDRKQ 150
    RQERLSVPKE QRANLLNIDY LRPIVADADT GHGGLTAVMK LTKLFIEKGA 200
    AGIHIEDQAP GTKKCGHMAG KVLVPIQEHI NRLVAIRAQA DIMGSDLLAI 250
    ARTDAEAATL LSTNIDPRDH AFILGSTNST LKPLNDLMIA AEATGKSGAE 300
    LQRIEDEWLA KANLSSFDDA VAAAIDAGSF SDKAGIKQEY TSRAKGKSNF 350
    EARAVARQLL GRDIFFDWDA PRTREGYFRL KGGCDCAVNR AIAYAPYCDA 400
    IWMESKLPDF AQAEQFAQGV HAVWPEKKLA YNLSPSFNWK TAMPRDEQET 450
    YIRRLAKLGY CWQFITLAGL HTTALISDQF AKAYSTVGMR AYGELVQEPE 500
    MDQKVDVVKH QKWSGATYVD ELQKMVTGGI SSTAAMGAGV TEDQFK 546
    Length:546
    Mass (Da):60,826
    Last modified:August 16, 2005 - v1
    Checksum:iC90BD9BFBAB4BE9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231669 Genomic DNA. Translation: ESU16540.1.
    RefSeqiXP_390072.1. XM_390072.1.

    Genome annotation databases

    EnsemblFungiiFGSG_09896T0; FGSG_09896P0; FGSG_09896.
    GeneIDi2791934.
    KEGGifgr:FG09896.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231669 Genomic DNA. Translation: ESU16540.1 .
    RefSeqi XP_390072.1. XM_390072.1.

    3D structure databases

    ProteinModelPortali Q4HYR2.
    SMRi Q4HYR2. Positions 16-529.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5518.FG09896.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii FGSG_09896T0 ; FGSG_09896P0 ; FGSG_09896 .
    GeneIDi 2791934.
    KEGGi fgr:FG09896.1.

    Phylogenomic databases

    eggNOGi COG2224.
    KOi K01637.
    OrthoDBi EOG73Z331.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.
    2. "Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium."
      Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R., Antoniw J., Baker S.E.
      , Bluhm B.H., Breakspear A., Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C., Rep M.
      Nature 464:367-373(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

    Entry informationi

    Entry nameiACEA_GIBZE
    AccessioniPrimary (citable) accession number: Q4HYR2
    Secondary accession number(s): V6RX12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3