Q4HWQ2 (CCPR2_GIBZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative heme-binding peroxidase
EC=1.11.1.-

Gene names

ORF Names:

FG10606

Organism

Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)

Taxonomic identifier

229533 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Putative heme-binding peroxidase		PRO_0000055588
Sites
	Active site	50	1	Proton acceptor By similarity
	Active site	190	1	Tryptophan radical intermediate By similarity
	Metal binding	174	1	Iron (heme axial ligand) By similarity
	Site	46	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4HWQ2 [UniParc]. Last modified August 16, 2005. Version 1. Checksum: 43F7BBBBD23A91F4	FASTA	331	36,252
	10 20 30 40 50 60 MGIVDQPQSK GQESTPGDFA AVQKSIIDLL NQPDYDDGSA GPVLVRLAWH SSGTYDKVTD 70 80 90 100 110 120 TGGSNGAGMR YEAEGGDPAN AGLQNARVFL EPVKRLHPWI TYSDLWTLAG VTAIHAMGGP 130 140 150 160 170 180 EIDWLPGRTD FVDDSKLPPR GRLPDAAQGA EHIRHIFYRM GFNDREIVAL SGAHNLGRCH 190 200 210 220 230 240 TANSGFEGKW VNNPTRFSNQ YFRLLLSETW TEKTIPESGL LQFSSVDQDT EEELMMLPTD 250 260 270 280 290 300 IALTTDSEFS KYVQLYAKDK DVFFQDFKKA FAKLLELGIA RNSEGKVINT DNQKGGYRSA 310 320 330 PKKSDSTPAT SGQPGASKTG GCPVMHHKAK L

References

[1]

"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization." Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S. , Goswami R.S., Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M., Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C. Science 317:1400-1402(2007) [PubMed: 17823352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACM01000444 Genomic DNA. Translation: EAA68615.1.
RefSeq	XP_390782.1. XM_390782.1.
3D structure databases
ProteinModelPortal	Q4HWQ2.
ModBase	Search...
Protein family/group databases
PeroxiBase	3391. GzCcP01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	FGSG_10606T0; FGSG_10606P0; FGSG_10606.
GeneID	2792149.
KEGG	fgr:FG10606.1.
Phylogenomic databases
eggNOG	fuNOG07575.
Family and domain databases
InterPro	IPR002207. Asc_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
KO	K00428.
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR2_GIBZE

Accession

Primary (citable) accession number: Q4HWQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	August 16, 2005
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program