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Protein

Iron-sulfur clusters transporter ATM1, mitochondrial

Gene

ATM1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei396Glutathione; via amide nitrogenBy similarity1
Binding sitei448ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi472 – 483ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial
Gene namesi
Name:ATM1
ORF Names:FGRAMPH1_01T20779, FGRRES_10911_M, FGSG_10911
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:FGRAMPH1_01G20779.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 113Mitochondrial matrixBy similarityAdd BLAST90
Transmembranei114 – 135HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini136 – 158Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei159 – 182HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini183 – 231Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei232 – 255HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini256Mitochondrial intermembraneBy similarity1
Transmembranei257 – 277HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini278 – 343Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei344 – 362HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini363 – 377Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei378 – 399HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini400 – 698Mitochondrial matrixBy similarityAdd BLAST299

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionSequence analysisAdd BLAST23
ChainiPRO_000025544624 – 698Iron-sulfur clusters transporter ATM1, mitochondrialAdd BLAST675

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi229533.XP_391087.1.

Structurei

3D structure databases

ProteinModelPortaliQ4HVU7.
SMRiQ4HVU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 404ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini439 – 675ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni283 – 287Glutathione bindingBy similarity5
Regioni346 – 349Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
InParanoidiQ4HVU7.
KOiK05663.
OrthoDBiEOG092C3H79.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4HVU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPQLLQRSS RACPRYNPAL YRLSTTSQQR PGLTQTFWTS APRREQPRTP
60 70 80 90 100
TDSKPTTTKP SAVFPANKKA TKQNDPLVTV EKSAPEQRKA DWAIMKEMTR
110 120 130 140 150
YLWPKDDWGT KLRVSLAVSL LIGAKVLNVQ VPFYFKSIVD SMNIDVAAVG
160 170 180 190 200
GTATTVAGAM ILAYGASRIG ATVFQELRNA VFASVAQNAI RKVACNVFDH
210 220 230 240 250
LLRLDLTFHL SKQTGGLTRA LDRGTKGISF ILSSMVFHVL PTALEISMVC
260 270 280 290 300
GILTYNYGAK FAALTVLTMV SYTAFTIWTT AWRTKFRRQA NAADNKASTV
310 320 330 340 350
AVDSLINYEA VKYFNNEKFE VARYDKALGQ YEKNSIKVAT SLALLNSGQN
360 370 380 390 400
IIFSSALTGM MYLAANGVAE GTLTVGDLVM VNQLVFQLSV PLNFLGSVYR
410 420 430 440 450
ELRQSLLDME TLFNLQKVNA NIKEKAGAKP LVLSKGGEIK FENVNFAYHP
460 470 480 490 500
NRPILRDLSL TIPAGKKVAV VGPSGCGKST LLRLLFRSYD VQGGRVLIDD
510 520 530 540 550
QDIRDVDLES LRRSIGVVPQ DTPLFNDTVE HNIRYGSINA THEEVVAVAK
560 570 580 590 600
RAHVHNTIQS FPDGYETKVG ERGLMISGGE KQRLAVSRIL LKDPPLLFFD
610 620 630 640 650
EATSALDTHT EQALMMNINS ILRERGRTSV FVAHRLRTIF DSDLIIVLKE
660 670 680 690
GHVAEMGTHR ELIDRDGVYA ELWSAQETMF GEDGKEKSEE ENDEQKKN
Length:698
Mass (Da):77,443
Last modified:August 16, 2005 - v1
Checksum:iED5E64D85A12EDC5
GO

Sequence cautioni

The sequence SCB64970 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231670 Genomic DNA. Translation: ESU17847.1.
HG970334 Genomic DNA. Translation: SCB64970.1. Different initiation.
RefSeqiXP_011325469.1. XM_011327167.1.

Genome annotation databases

GeneIDi23557791.
KEGGifgr:FGSG_10911.

Similar proteinsi

Entry informationi

Entry nameiATM1_GIBZE
AccessioniPrimary (citable) accession number: Q4HVU7
Secondary accession number(s): A0A098DZA1
, A0A0E0SJU1, A0A1C3YKA1, A0A1I9FV75, V6RV02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2005
Last modified: May 10, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families