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Q4H4C3

- CP1A2_MACFU

UniProt

Q4H4C3 - CP1A2_MACFU

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Protein
Cytochrome P450 1A2
Gene
CYP1A2
Organism
Macaca fuscata fuscata (Japanese macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261Substrate By similarity
Metal bindingi458 – 4581Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiMacaca fuscata fuscata (Japanese macaque)
Taxonomic identifieri9543 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 516515Cytochrome P450 1A2
PRO_0000232908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691O-linked (GlcNAc) By similarity

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4H4C3.
SMRiQ4H4C3. Positions 34-514.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4H4C3-1 [UniParc]FASTAAdd to Basket

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MALSQFVPFS ATELLLASAI FCLVFWVLRG SRPRVPKGLK SPPEPWGWPL    50
LGHVLTLGKN PHLALSRMSQ LYGDVLQIRI GSTPVLVLSG LDTIRQALVR 100
QGDDFKGRPD LYSFTFITDG QSMSFSPDSG PVWAARRRLA QNALNTFSIA 150
SDPASSSSCY LEEHVSKEAE ALISRLQELM AGPGHFDPYN QVVVSVANVI 200
GAMCFGQHFP ESSDEMLSLV KNSHEFVESA SSGNPVDFFP ILRYLPNPAL 250
QRFKAFNQRF RRFLQKTVQE HYQDFDKNSV QDITGALFKH SKKGPRASGN 300
LIPQEKIVNL VNDIFGAEFD TIATAISWSL MYLVTKPEIQ RKIQKELDAV 350
IGRGRRPRLS DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLNGFY 400
IPRECCVFIN QWQVNHDPQL WGDPSEFRPE RFLTAEGTTI NKPLSEKIML 450
FGLGKRRCIG EVLGKWEVFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK 500
HARCEHFQAR LRFSFQ 516
Length:516
Mass (Da):58,337
Last modified:January 23, 2007 - v3
Checksum:iEFD7214ACBC6403E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB185338 mRNA. Translation: BAE16271.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB185338 mRNA. Translation: BAE16271.1 .

3D structure databases

ProteinModelPortali Q4H4C3.
SMRi Q4H4C3. Positions 34-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and function analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset CYP1A2."
    Narimatsu S., Oda M., Hichiya H., Asaoka K., Hanioka N., Yamamoto S.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP1A2_MACFU
AccessioniPrimary (citable) accession number: Q4H4C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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