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Q4H4C3

- CP1A2_MACFU

UniProt

Q4H4C3 - CP1A2_MACFU

Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Macaca fuscata fuscata (Japanese macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei226 – 2261SubstrateBy similarity
    Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Gene namesi
    Name:CYP1A2
    OrganismiMacaca fuscata fuscata (Japanese macaque)
    Taxonomic identifieri9543 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 516515Cytochrome P450 1A2PRO_0000232908Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ4H4C3.
    SMRiQ4H4C3. Positions 34-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4H4C3-1 [UniParc]FASTAAdd to Basket

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    MALSQFVPFS ATELLLASAI FCLVFWVLRG SRPRVPKGLK SPPEPWGWPL    50
    LGHVLTLGKN PHLALSRMSQ LYGDVLQIRI GSTPVLVLSG LDTIRQALVR 100
    QGDDFKGRPD LYSFTFITDG QSMSFSPDSG PVWAARRRLA QNALNTFSIA 150
    SDPASSSSCY LEEHVSKEAE ALISRLQELM AGPGHFDPYN QVVVSVANVI 200
    GAMCFGQHFP ESSDEMLSLV KNSHEFVESA SSGNPVDFFP ILRYLPNPAL 250
    QRFKAFNQRF RRFLQKTVQE HYQDFDKNSV QDITGALFKH SKKGPRASGN 300
    LIPQEKIVNL VNDIFGAEFD TIATAISWSL MYLVTKPEIQ RKIQKELDAV 350
    IGRGRRPRLS DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLNGFY 400
    IPRECCVFIN QWQVNHDPQL WGDPSEFRPE RFLTAEGTTI NKPLSEKIML 450
    FGLGKRRCIG EVLGKWEVFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK 500
    HARCEHFQAR LRFSFQ 516
    Length:516
    Mass (Da):58,337
    Last modified:January 23, 2007 - v3
    Checksum:iEFD7214ACBC6403E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB185338 mRNA. Translation: BAE16271.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB185338 mRNA. Translation: BAE16271.1 .

    3D structure databases

    ProteinModelPortali Q4H4C3.
    SMRi Q4H4C3. Positions 34-514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and function analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset CYP1A2."
      Narimatsu S., Oda M., Hichiya H., Asaoka K., Hanioka N., Yamamoto S.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP1A2_MACFU
    AccessioniPrimary (citable) accession number: Q4H4C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3