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Protein

Dihydrofolate reductase

Gene

dfrG

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (dhfrXII), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA), Dihydrofolate reductase type 1 from Tn4003 (dfrA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (folA), Dihydrofolate reductase (BSZ10_04505), Dihydrofolate reductase (B9Y41_06955), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA_1), Dihydrofolate reductase (dfrK), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (C7J96_04650), Dihydrofolate reductase (dfrG)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00158

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
Name:dfrGImported
ORF Names:BTN44_10825Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000236484 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 160DHFRInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

KOiK18591

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4H3Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSLIAAMD KNRVIGKEND IPWRIPKDWE YVKNTTKGHP IILGRKNLES
60 70 80 90 100
IGRALPDRRN IILTRDKGFT FNGCEIVHSI EDVFELCKNE EEIFIFGGEQ
110 120 130 140 150
IYNLFFPYVE KMYITKIHHE FEGDTFFPEV NYEEWNEVFA QKGIKNDKNP
160
YNYYFHVYER KNLLS
Length:165
Mass (Da):19,691
Last modified:August 30, 2005 - v1
Checksum:iFED9F29AF099A430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP018629 Genomic DNA Translation: AUS75691.1
AB205645 Genomic DNA Translation: BAE15963.1
RefSeqiWP_000868795.1, NZ_PGXA01000083.1

Genome annotation databases

EnsemblBacteriaiCXE67848; CXE67848; ERS074020_01602
CXM64868; CXM64868; ERS072738_02931
CZQ26768; CZQ26768; ERS1058648_00624
GeneIDi29754808
KEGGiag:BAE15963
PATRICifig|1280.3356.peg.461

Similar proteinsi

Entry informationi

Entry nameiQ4H3Y3_STAAU
AccessioniPrimary (citable) accession number: Q4H3Y3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: June 20, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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