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Q4H3L3

- Q4H3L3_CIOIN

UniProt

Q4H3L3 - Q4H3L3_CIOIN

Protein

Mitogen-activated protein kinase

Gene

Ci-ERK5

Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinaseUniRule annotation (EC:2.7.11.24UniRule annotation)
    Gene namesi
    Name:Ci-ERK5Imported
    OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
    Taxonomic identifieri7719 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona

    Interactioni

    Protein-protein interaction databases

    STRINGi7719.ENSCINP00000019973.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4H3L3.
    SMRiQ4H3L3. Positions 31-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
    Contains 1 protein kinase domain.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000113595.
    HOVERGENiHBG108137.
    InParanoidiQ4H3L3.
    KOiK04464.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4H3L3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAESEPQKVL IKSKLSRKLG VQHQASDGFV LFDVGPQYKI LETIGTGAYG    50
    IVCSAIDNKT GKHVAIKKVV QAFEVVTTAK RTLRELKLLL HFKHDNIVGI 100
    KSIIQSKKED FKHVYFVMDL MESDLHHIIR SDQPLTTEHI CYFMYQLLRG 150
    LKYIHSANVI HRDLKPSNLL VNENCELRIG DFGMARAVSQ EPEDHKSFMT 200
    EYVATRWYRA PELMLSFGRY SQAIDMWSVG CIFAEMIGRR QIFPGKHYVH 250
    QLQLIISVLG SPPSGLVSTI RSDRVRNYVT GLPSKSATPF KQLYTKATQP 300
    MVDLLTSLLR FNPEERPTSV QALTHPFLSG YHDKDDEPTC HAPFDFQFEA 350
    TATREGVHEE VTAVIKKYHE KKNRFAKQLT PIRRSEKTDP PKNDLLIFKK 400
    PAAPVSFPKE SAPDAASTMD LDAGEAEAEK RPMITVQVLQ DEPVKDTKGA 450
    AKKKTISEDT KLKIRDIIFA SMFAKQKGLG KPLDKVKKSV TAADRQKERE 500
    SKRKKRLDRA AEKERKRREE TKNLLSEADR SLLDRWTKMQ KSTTTENPAK 550
    QTETEEPKVT LIRHQSLPPS SIRQARQRQL IEATNVRPNS VHIDDATWLV 600
    PSLDARLAPE TPMLQPSTDH PTVAPNTSMV PNTSWGTNCT ENTQQKQVEV 650
    KRPSSLSVQP SNQDLTNQTL TRSDTEGLTA ISPGTVDRVL TQQFHVNHDL 700
    HNPPQELEGA KQKEAARTPE LAGRLNVSNH GEFPSLGAIG YGLGVDISDI 750
    IPQSAGDVAP GTSQELMTSA ASEQCSSSLL AEWSDLHRMH PQDMEALQRE 800
    LELGSPMIVQ YET 813
    Length:813
    Mass (Da):91,346
    Last modified:August 30, 2005 - v1
    Checksum:i8C901CE22F8D6EF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB210409 mRNA. Translation: BAE06414.1.
    RefSeqiNP_001071698.1. NM_001078230.1.
    UniGeneiCin.30537.

    Genome annotation databases

    GeneIDi778597.
    KEGGicin:778597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB210409 mRNA. Translation: BAE06414.1 .
    RefSeqi NP_001071698.1. NM_001078230.1.
    UniGenei Cin.30537.

    3D structure databases

    ProteinModelPortali Q4H3L3.
    SMRi Q4H3L3. Positions 31-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7719.ENSCINP00000019973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 778597.
    KEGGi cin:778597.

    Organism-specific databases

    CTDi 778597.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000113595.
    HOVERGENi HBG108137.
    InParanoidi Q4H3L3.
    KOi K04464.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomewide surveys of developmentally relevant genes in Ciona intestinalis."
      Satou Y., Satoh N.
      Dev. Genes Evol. 213:211-212(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks."
      Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.
      Development 131:4047-4058(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Expressed genes in Ciona intestinalis."
      Satou Y.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ4H3L3_CIOIN
    AccessioniPrimary (citable) accession number: Q4H3L3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)