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Q4H3L3

- Q4H3L3_CIOIN

UniProt

Q4H3L3 - Q4H3L3_CIOIN

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Protein

Mitogen-activated protein kinase

Gene

Ci-ERK5

Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Magnesium.UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotation (EC:2.7.11.24UniRule annotation)
Gene namesi
Name:Ci-ERK5Imported
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona

Interactioni

Protein-protein interaction databases

STRINGi7719.ENSCINP00000019973.

Structurei

3D structure databases

ProteinModelPortaliQ4H3L3.
SMRiQ4H3L3. Positions 31-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000113595.
HOVERGENiHBG108137.
KOiK04464.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4H3L3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAESEPQKVL IKSKLSRKLG VQHQASDGFV LFDVGPQYKI LETIGTGAYG
60 70 80 90 100
IVCSAIDNKT GKHVAIKKVV QAFEVVTTAK RTLRELKLLL HFKHDNIVGI
110 120 130 140 150
KSIIQSKKED FKHVYFVMDL MESDLHHIIR SDQPLTTEHI CYFMYQLLRG
160 170 180 190 200
LKYIHSANVI HRDLKPSNLL VNENCELRIG DFGMARAVSQ EPEDHKSFMT
210 220 230 240 250
EYVATRWYRA PELMLSFGRY SQAIDMWSVG CIFAEMIGRR QIFPGKHYVH
260 270 280 290 300
QLQLIISVLG SPPSGLVSTI RSDRVRNYVT GLPSKSATPF KQLYTKATQP
310 320 330 340 350
MVDLLTSLLR FNPEERPTSV QALTHPFLSG YHDKDDEPTC HAPFDFQFEA
360 370 380 390 400
TATREGVHEE VTAVIKKYHE KKNRFAKQLT PIRRSEKTDP PKNDLLIFKK
410 420 430 440 450
PAAPVSFPKE SAPDAASTMD LDAGEAEAEK RPMITVQVLQ DEPVKDTKGA
460 470 480 490 500
AKKKTISEDT KLKIRDIIFA SMFAKQKGLG KPLDKVKKSV TAADRQKERE
510 520 530 540 550
SKRKKRLDRA AEKERKRREE TKNLLSEADR SLLDRWTKMQ KSTTTENPAK
560 570 580 590 600
QTETEEPKVT LIRHQSLPPS SIRQARQRQL IEATNVRPNS VHIDDATWLV
610 620 630 640 650
PSLDARLAPE TPMLQPSTDH PTVAPNTSMV PNTSWGTNCT ENTQQKQVEV
660 670 680 690 700
KRPSSLSVQP SNQDLTNQTL TRSDTEGLTA ISPGTVDRVL TQQFHVNHDL
710 720 730 740 750
HNPPQELEGA KQKEAARTPE LAGRLNVSNH GEFPSLGAIG YGLGVDISDI
760 770 780 790 800
IPQSAGDVAP GTSQELMTSA ASEQCSSSLL AEWSDLHRMH PQDMEALQRE
810
LELGSPMIVQ YET
Length:813
Mass (Da):91,346
Last modified:August 30, 2005 - v1
Checksum:i8C901CE22F8D6EF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB210409 mRNA. Translation: BAE06414.1.
RefSeqiNP_001071698.1. NM_001078230.1.
UniGeneiCin.30537.

Genome annotation databases

GeneIDi778597.
KEGGicin:778597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB210409 mRNA. Translation: BAE06414.1 .
RefSeqi NP_001071698.1. NM_001078230.1.
UniGenei Cin.30537.

3D structure databases

ProteinModelPortali Q4H3L3.
SMRi Q4H3L3. Positions 31-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7719.ENSCINP00000019973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 778597.
KEGGi cin:778597.

Organism-specific databases

CTDi 778597.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000113595.
HOVERGENi HBG108137.
KOi K04464.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomewide surveys of developmentally relevant genes in Ciona intestinalis."
    Satou Y., Satoh N.
    Dev. Genes Evol. 213:211-212(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks."
    Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.
    Development 131:4047-4058(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Expressed genes in Ciona intestinalis."
    Satou Y.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ4H3L3_CIOIN
AccessioniPrimary (citable) accession number: Q4H3L3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)