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Protein

Mitogen-activated protein kinase

Gene

Ci-ERK5

Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Name:Ci-ERK5Imported
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona

Interactioni

Protein-protein interaction databases

STRINGi7719.ENSCINP00000019973.

Structurei

3D structure databases

ProteinModelPortaliQ4H3L3.
SMRiQ4H3L3. Positions 31-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000113595.
HOVERGENiHBG108137.
KOiK04464.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4H3L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESEPQKVL IKSKLSRKLG VQHQASDGFV LFDVGPQYKI LETIGTGAYG
60 70 80 90 100
IVCSAIDNKT GKHVAIKKVV QAFEVVTTAK RTLRELKLLL HFKHDNIVGI
110 120 130 140 150
KSIIQSKKED FKHVYFVMDL MESDLHHIIR SDQPLTTEHI CYFMYQLLRG
160 170 180 190 200
LKYIHSANVI HRDLKPSNLL VNENCELRIG DFGMARAVSQ EPEDHKSFMT
210 220 230 240 250
EYVATRWYRA PELMLSFGRY SQAIDMWSVG CIFAEMIGRR QIFPGKHYVH
260 270 280 290 300
QLQLIISVLG SPPSGLVSTI RSDRVRNYVT GLPSKSATPF KQLYTKATQP
310 320 330 340 350
MVDLLTSLLR FNPEERPTSV QALTHPFLSG YHDKDDEPTC HAPFDFQFEA
360 370 380 390 400
TATREGVHEE VTAVIKKYHE KKNRFAKQLT PIRRSEKTDP PKNDLLIFKK
410 420 430 440 450
PAAPVSFPKE SAPDAASTMD LDAGEAEAEK RPMITVQVLQ DEPVKDTKGA
460 470 480 490 500
AKKKTISEDT KLKIRDIIFA SMFAKQKGLG KPLDKVKKSV TAADRQKERE
510 520 530 540 550
SKRKKRLDRA AEKERKRREE TKNLLSEADR SLLDRWTKMQ KSTTTENPAK
560 570 580 590 600
QTETEEPKVT LIRHQSLPPS SIRQARQRQL IEATNVRPNS VHIDDATWLV
610 620 630 640 650
PSLDARLAPE TPMLQPSTDH PTVAPNTSMV PNTSWGTNCT ENTQQKQVEV
660 670 680 690 700
KRPSSLSVQP SNQDLTNQTL TRSDTEGLTA ISPGTVDRVL TQQFHVNHDL
710 720 730 740 750
HNPPQELEGA KQKEAARTPE LAGRLNVSNH GEFPSLGAIG YGLGVDISDI
760 770 780 790 800
IPQSAGDVAP GTSQELMTSA ASEQCSSSLL AEWSDLHRMH PQDMEALQRE
810
LELGSPMIVQ YET
Length:813
Mass (Da):91,346
Last modified:August 30, 2005 - v1
Checksum:i8C901CE22F8D6EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210409 mRNA. Translation: BAE06414.1.
RefSeqiNP_001071698.1. NM_001078230.1.
UniGeneiCin.30537.

Genome annotation databases

GeneIDi778597.
KEGGicin:778597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210409 mRNA. Translation: BAE06414.1.
RefSeqiNP_001071698.1. NM_001078230.1.
UniGeneiCin.30537.

3D structure databases

ProteinModelPortaliQ4H3L3.
SMRiQ4H3L3. Positions 31-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7719.ENSCINP00000019973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi778597.
KEGGicin:778597.

Organism-specific databases

CTDi778597.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000113595.
HOVERGENiHBG108137.
KOiK04464.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomewide surveys of developmentally relevant genes in Ciona intestinalis."
    Satou Y., Satoh N.
    Dev. Genes Evol. 213:211-212(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks."
    Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.
    Development 131:4047-4058(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Expressed genes in Ciona intestinalis."
    Satou Y.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ4H3L3_CIOIN
AccessioniPrimary (citable) accession number: Q4H3L3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: February 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.