Q4GZL2 (ICP2_ENTHI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amoebiasin-2

Alternative name(s):
Cysteine protease inhibitor 2
EhICP2
Short name=ICP-2

Gene names

Name:

ICP2

Organism

Entamoeba histolytica

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits soluble trophozoite extract. Ref.1
Subcellular location	Cytoplasmic vesicle Ref.1.
Tissue specificity	Expressed in trophozoites (at protein level). Ref.1
Sequence similarities	Belongs to the protease inhibitor I42 family. [View classification]

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle
Domain	Signal
Molecular function	Protease inhibitor Thiol protease inhibitor
Gene Ontology (GO)
Cellular_component	cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 123	107	Amoebiasin-2		PRO_5000074670

Sequences

	Sequence		Length	Mass (Da)
	Q4GZL2 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 7B7A469353F73B68	FASTA	123	14,000
	10 20 30 40 50 60 MKQFIFFALL CTSTYAAIHI LTEKEDHATL HISFNDLIKI QLRTNPSTGY AWNIEYPTDT 70 80 90 100 110 120 FSLSQDTIKA EPHPSGMVGF PSIREIQLKP LKVGTTTIKL GYSRPWEKGK EPLRSLTYSV VIR

References

[1]

"The second cysteine protease inhibitor, EhICP2, has a different localization in trophozoites of Entamoeba histolytica than EhICP1." Saric M., Vahrmann A., Bruchhaus I., Bakker-Grunwald T., Scholze H. Parasitol. Res. 100:171-174(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Strain: ATCC 30459 / HM-1:IMSS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ890473 Genomic DNA. Translation: CAI77274.1.
3D structure databases
ProteinModelPortal	Q4GZL2.
ModBase	Search...
Protein family/group databases
MEROPS	I42.003.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG145589.
Family and domain databases
InterPro	IPR018990. Prot_inh_I42_chagasin. [Graphical view]
Pfam	PF09394. Inhibitor_I42. 1 hit. [Graphical view]
SUPFAM	SSF141066. SSF141066. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ICP2_ENTHI

Accession

Primary (citable) accession number: Q4GZL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 30, 2005
Last modified:	February 22, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)