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Protein

CTP synthase

Gene

TB927.1.1240

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase (TB927.1.1240)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
Alternative name(s):
UTP--ammonia ligaseUniRule annotation
Gene namesi
ORF Names:TB927.1.1240Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
Proteomesi
  • UP000008524 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.1.1240.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W7TX-ray2.10A319-589[»]
ProteinModelPortaliQ4GZ95.
SMRiQ4GZ95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4GZ95.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 576Glutamine amidotransferase type-1InterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the CTP synthase family.UniRule annotation
Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotation

Phylogenomic databases

HOGENOMiHOG000077514.
InParanoidiQ4GZ95.
KOiK01937.
OMAiNIWHIPR.

Family and domain databases

CDDicd01746. GATase1_CTP_Synthase. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR033828. GATase1_CTP_Synthase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4GZ95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSATAKAY MLPSPELRPV SGTGACKYIV VTGGVCSSLG KGVTTSATGA
60 70 80 90 100
LLRAEGYQVC SIKIDPYINM DAGLMSPYEH GEVYVLDDGG EVDLDLGNYE
110 120 130 140 150
RWMSVQLRRE HNITTGKVYQ KLINKERQGG FLGKTVQLVP HFTNDVVESI
160 170 180 190 200
FRVSQSPVDE SGAQPEICMI ELGGTVGDME SQPFVEALRR LRCLVGPDEF
210 220 230 240 250
CLMHTTYLPV FGGSQKTKPT QHSTRTLLSM GLQPDILICR SENRLTPDAK
260 270 280 290 300
EKLSNLCGVR SGDIVSAPNV SCLYEVPVVF TKDGLVDRLV EKLRLVKRTP
310 320 330 340 350
ATDVPRIDTY KTYVKILRNM SNPTVRIAFV GKYLQDAGDT YFSVLQCFEH
360 370 380 390 400
CQIALQVRLD ILYVDSEELE GPNADEARKA LLGCDGIFVP GGFGNRGVDG
410 420 430 440 450
KCAAAQVARM NNIPYFGVCL GMQVAVIELS RNVVGWSDAN SEEFNKESTH
460 470 480 490 500
QVVRIMDCDR NKMGANMHLG ACDVHIVEKS SIMAKIYSKS NIVVERHRHR
510 520 530 540 550
YEVNTAYFED LRKAGLCISA VTDPTFSSRC RVEAVENPSL RFFLAVQFHP
560 570 580
EFISTPMDPA PTYLSFMAAA AKKDYVWPQK CSQRRLKQA
Length:589
Mass (Da):65,213
Last modified:August 30, 2005 - v1
Checksum:iC3005DABAE3C386E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929603 Genomic DNA. Translation: CAJ16071.1.
RefSeqiXP_001218826.1. XM_001218825.1.

Genome annotation databases

EnsemblProtistsiCAJ16071; CAJ16071; Tb927.1.1240.
GeneDBiTb927.1.1240:pep.
GeneIDi4357199.
KEGGitbr:Tb927.1.1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929603 Genomic DNA. Translation: CAJ16071.1.
RefSeqiXP_001218826.1. XM_001218825.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W7TX-ray2.10A319-589[»]
ProteinModelPortaliQ4GZ95.
SMRiQ4GZ95.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAJ16071; CAJ16071; Tb927.1.1240.
GeneDBiTb927.1.1240:pep.
GeneIDi4357199.
KEGGitbr:Tb927.1.1240.

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.1.1240.

Phylogenomic databases

HOGENOMiHOG000077514.
InParanoidiQ4GZ95.
KOiK01937.
OMAiNIWHIPR.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Miscellaneous databases

EvolutionaryTraceiQ4GZ95.

Family and domain databases

CDDicd01746. GATase1_CTP_Synthase. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR033828. GATase1_CTP_Synthase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4GZ95_TRYB2
AccessioniPrimary (citable) accession number: Q4GZ95
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.