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Protein

Genome polyprotein

Gene
N/A
Organism
Lily mottle virus
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.SAAS annotation

Catalytic activityi

Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei654For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei727For helper component proteinase activityPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, ProteaseSAAS annotation, RNA-directed RNA polymeraseSAAS annotation, Suppressor of RNA silencingSAAS annotation, Transferase
Biological processViral RNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiC04.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiLily mottle virusImported
Taxonomic identifieri32624 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePotyviridaePotyvirus

Subcellular locationi

  • Virion SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinSAAS annotationImported, Virion

Structurei

3D structure databases

ProteinModelPortaliQ4GXV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini646 – 768Peptidase C6InterPro annotationAdd BLAST123
Domaini1245 – 1397Helicase ATP-bindingInterPro annotationAdd BLAST153
Domaini1416 – 1575Helicase C-terminalInterPro annotationAdd BLAST160
Domaini2063 – 2281Peptidase C4InterPro annotationAdd BLAST219
Domaini2547 – 2670RdRp catalyticInterPro annotationAdd BLAST124

Sequence similaritiesi

Belongs to the potyviridae genome polyprotein family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR011492. DEAD_Flavivir.
IPR001456. HC-pro.
IPR031159. HC_PRO_CPD_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002540. Pept_S30_P1_potyvir.
IPR009003. Peptidase_S1_PA.
IPR001592. Poty_coat.
IPR001730. Potyv_NIa-pro_dom.
IPR013648. PP_Potyviridae.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
PfamiView protein in Pfam
PF07652. Flavi_DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00863. Peptidase_C4. 1 hit.
PF00851. Peptidase_C6. 1 hit.
PF01577. Peptidase_S30. 1 hit.
PF00767. Poty_coat. 1 hit.
PF08440. Poty_PP. 1 hit.
PF00680. RdRP_1. 1 hit.
PRINTSiPR00966. NIAPOTYPTASE.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS51744. HC_PRO_CPD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51436. POTYVIRUS_NIA_PRO. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4GXV0-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MASFTVGSIL VNTASVLKES FAQKVLTTPP VLVAQPVQRS FGAARMCARE
60 70 80 90 100
AIADDEEKVA KAFSALEARC AARVSRMGTI RVKVTRSGTL RAQPLPKREQ
110 120 130 140 150
ARLRKAERKA RLDREEFLKG SPTVIDHISI AGGAQPSQDM VEPMSTRKAP
160 170 180 190 200
WHSESKKARK AIPRSPTLNE TGLASLMRAI AKIGAKNSIR IEIVDERKVQ
210 220 230 240 250
ARYIKRDAGS YLQVRVAHHE GLRRRRDLKL SAFADQCLTQ LASTTHGTKY
260 270 280 290 300
HHVTQLKAGD SGIVLLARRL FGWHSGSCSQ IFVVRGNHEG KLYEARRKVT
310 320 330 340 350
LTMTHKMIHY SRPGDKFWAG FNSQFLRIKP KEIPHTCTSN FNVFECGQVA
360 370 380 390 400
ALMCQALYPC GRITCQQCAS EYLELTKVEL GEKLSDGLYR TSSQIRENHR
410 420 430 440 450
EFAHVAHILN VIADLLSLKN NNMEAFTEVH KLIGERTQSP FTHLNRLNSI
460 470 480 490 500
LIKGSDLSSN ELYECSDCIR ELARFQKNRT DNIKKLDVSV FRNKASSKSY
510 520 530 540 550
FNLDLMCDNQ LDKNGNFEWG QRGYHAKRFL SNYFEVVNTQ NAYREHTLRK
560 570 580 590 600
HPNGTRELAI GKFIVSTNFE VFRKSMEGKR IPQMPVTEAC LSQRGERFIY
610 620 630 640 650
QCCCVTNEDG TPLESTFKMP TKNTLVLGNT GDEKFVDMPT DTDEKMYIAR
660 670 680 690 700
EGYCYINIFF AMLINVRESQ AKAFTKMVRD RLVPELGTWP TMIDVATACH
710 720 730 740 750
TLTVFFPDTL SAELPRILVD HNTKTMHVID SYGSVSTGYH QLKANTVSQL
760 770 780 790 800
VLFASDTLKS EMKHYQVGGR KFTVEYEAVK LLIKAIYRPK LMRTLMEDEP
810 820 830 840 850
YLICLAMCSP GVLIALFNSG SLETAINYWI ARHKDTAQIF ALLTVLATKV
860 870 880 890 900
SVARTLTEQL AILSDHATDV LKIMDRTFAT QHSVSLVHTF LMQLEEKRHT
910 920 930 940 950
DVSLVGSGFA NLSATTHELM EKNYLAELDA SWQDLSLLEK CSQMRWSFRS
960 970 980 990 1000
PQQFSNELHP SASTDLNGRY NTSVRALSTR YMNNLRKSVC TKYHNMKIRT
1010 1020 1030 1040 1050
HQFIGRQVCN SIMGSSRFFP DLAQCVHILA IFSILLNIIR TINIYTSEYI
1060 1070 1080 1090 1100
RLKNCELSQI EEKRWNKLLH TFDMMEKIDG QKPTLIEFTK HLKQWDPELY
1110 1120 1130 1140 1150
SEFHSILQDE EEDTEEVQFQ AKPDGERNLE RIMAIIALTM MVFDADRSDC
1160 1170 1180 1190 1200
VYKVLNKLKG LLNTVHQEPV KFQSIDDIQD YLEEREMVID FEISADDHNI
1210 1220 1230 1240 1250
NKLAGATFEQ WWSNQMECNN VLPHYRTEGF FMEFTRANAA HVANEIAHGP
1260 1270 1280 1290 1300
HKDLLIRGAV GSGKSTGLPF YLSKRGRVLM LEPTRPLASN VHKQLAGDPF
1310 1320 1330 1340 1350
LVSATLKMRG ETTFGSAPIT VMTSGYAFHY YANNPNQLRD FEFIIFDECH
1360 1370 1380 1390 1400
VNDSSAMAFR SLLAEYTYDG RIIKVSATPP GREVEFATQH PVEIIPIERL
1410 1420 1430 1440 1450
TFQQFVAVQG TGAVGDVTTK GDNILVYVAS YSEVDNLSKG LVEKGHKVTK
1460 1470 1480 1490 1500
VDGRTMKVGG VEIITSGSQA KKHFVVATNI IENGVTLDID VVVDFGLKVV
1510 1520 1530 1540 1550
AEVDIDSRLT RYVKKSISYG ERIQRLGRVG RNKPGAAVRV GTTEKGLQAI
1560 1570 1580 1590 1600
PVTTATEAAF LCFAYGLPVM TNNVSTNILT NCTVLQARTM MLFEINPFYM
1610 1620 1630 1640 1650
CHFVRFDGTM HPEVHRILTP YKLRDSEIIL NKVAIPNKGL MQWPTAKEYA
1660 1670 1680 1690 1700
YQGFKMNIPD TVRLPFHSLD IPERLHERMW QIVETHKGDA GFGRITTASA
1710 1720 1730 1740 1750
CKIAYTLKTD AASIQRTIHI LDKLIENELK KQEYFRNITS ASCSSSSFSL
1760 1770 1780 1790 1800
TTITNAIRAR HIKDHTVENV SVLQAAKAQI LEFKNVTFDL DHVNRMTEYG
1810 1820 1830 1840 1850
ALECVQFQTL ESMTHHLQLK GHWNKSLLTH DVVICGAVLI GCVLMVGSYF
1860 1870 1880 1890 1900
KERCSGVVKR YNENVKFQAK NKRQRQRLRF REARDNKHAY EVHGDDADIQ
1910 1920 1930 1940 1950
TYFGSAYTKK GKTKGVTRGM GIKTRKFVNM YNFDPTEYSF ARYVDPLTGY
1960 1970 1980 1990 2000
TLDEQTLTDI ALVQDHFGRI RRKLMEDGEL EKESLAQNAR LEVYFVKNLA
2010 2020 2030 2040 2050
SQILKIDMTP HNPLRVCDRI ETVAGFPERD MGLRQSGKSV MVTAAELPKE
2060 2070 2080 2090 2100
NPYPGGEIVE FENKSTFHGL RDYNPIATCV CRLEHNSDGH TSSLYGIGYG
2110 2120 2130 2140 2150
SYIITNQHLF IRNNGTINIE SHHGTYHIRN STQLQLYPIE GRDIVIIQLP
2160 2170 2180 2190 2200
KDFPPFARRL KFRHPTTTDK VCLVGTNFQE KTTTSTVSEA SLITRKDDSH
2210 2220 2230 2240 2250
FFRHWISTKD GQCGLPAVST KDGCVLGLHS LTSLVNDSNF FIAFPDDFEK
2260 2270 2280 2290 2300
NYLERANELN WVKHWKLNVD KICWGALSLE KDKPSNMFKL SKDIQRLDME
2310 2320 2330 2340 2350
PVGLQSREDK WLFDRLNGNL KAMARTRNQL VTKHVVKGKC LLFETYLNVT
2360 2370 2380 2390 2400
PKAKEYFTPM MGAYQKSRLN KEAYIKDLFK YSSPIVVGDV DCAAFEAACD
2410 2420 2430 2440 2450
SVTQLFEGAG FGRCNYVTDE QEIFSALNMN AAVGAMYSGK KRDYFKDFTD
2460 2470 2480 2490 2500
LDKESILRDS CLRLYQGKMG VWNGSLKAEL RAKEKVDLNK TRTFTAAPVD
2510 2520 2530 2540 2550
TLLGEKTCVD DFNNRFYSLN IACPWSVGMT KFYKGWDEML RKLPEGWVYC
2560 2570 2580 2590 2600
DADGSQFDSS LSPYLINAVL NLRLHFMEEW DVGAQMLQNL YTEIIYTPIA
2610 2620 2630 2640 2650
TPDGTIIKKF KGNNSGQPST VVDNTIMVIL AIHYSYKYLK ITKPLDEFCK
2660 2670 2680 2690 2700
YFVNGDDILL AVAPEFEYLL DHFANTFQQL GLNYDFSSRT KNREELWFMS
2710 2720 2730 2740 2750
HRGIMTDGLY IPKLEPERIV SILEWDRAVE PVHRPEAICA SMIEAWGYPQ
2760 2770 2780 2790 2800
LLHEIRKFYY WVLEQAPYSE LAQLGKAPYL SEAALRALFT GEATSQDELE
2810 2820 2830 2840 2850
RYLAALDLEG ECGGAEIVAF QANETLNAGA SSSTQTSRPA RPETAAVDVA
2860 2870 2880 2890 2900
PQQSPEPRVR DRDVDAGTVG TFQIPRLKAL ATKISIPKIR GRTIVNLGHL
2910 2920 2930 2940 2950
ANYNPEQTDI SNTRSTQKQF ETWYNAVKDE YGLNDESMAL TMNGLMVWCI
2960 2970 2980 2990 3000
ENGTSPNING AWLMMDGDQQ VEFPLRPIIE HAKPTLRQIM AHFSHLAEAY
3010 3020 3030 3040 3050
IEKQNAEKPY MPRYGLQRNL TDFTLARFAF DFYEVTSRTP ARAKEAHFQM
3060 3070 3080 3090
KTAALRGKQS KLFGLDGKVT TQDEDTERHT ADDVNKNMHP LLGISM
Length:3,096
Mass (Da):351,365
Last modified:August 30, 2005 - v1
Checksum:i1EB701758A76B215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM048875 Genomic RNA. Translation: CAJ15516.1.

Similar proteinsi

Entry informationi

Entry nameiQ4GXV0_9POTV
AccessioniPrimary (citable) accession number: Q4GXV0
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 10, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)