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Q4GWZ2 (RSSA_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein SA
Alternative name(s):
37 kDa laminin receptor precursor
Short name=37LRP
37/67 kDa laminin receptor
Short name=LRP/LR
67 kDa laminin receptor
Short name=67LR
Laminin receptor 1
Short name=LamR
Laminin-binding protein precursor p40
Short name=LBP/p40
Gene names
Name:RPSA
Synonyms:LAMR1
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA By similarity. Ref.2

Subunit structure

Monomer (37LRP) and homodimer (67LR) By similarity. Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21 By similarity. Interacts with several laminins including at least LAMB1 By similarity. Interacts with MDK By similarity. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B By similarity. HAMAP-Rule MF_03016

Subcellular location

Cell membrane By similarity. Cytoplasm By similarity. Nucleus By similarity. Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane By similarity. HAMAP-Rule MF_03016

Post-translational modification

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association By similarity. HAMAP-Rule MF_03016

Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions By similarity. HAMAP-Rule MF_03016

Miscellaneous

This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

Sequence similarities

Belongs to the ribosomal protein S2P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 29529440S ribosomal protein SA HAMAP-Rule MF_03016
PRO_0000271751

Regions

Repeat230 – 2323[DE]-W-[ST] 1 HAMAP-Rule MF_03016
Repeat247 – 2493[DE]-W-[ST] 2 HAMAP-Rule MF_03016
Repeat266 – 2683[DE]-W-[ST] 3 HAMAP-Rule MF_03016
Repeat275 – 2773[DE]-W-[ST] 4 HAMAP-Rule MF_03016
Repeat293 – 2953[DE]-W-[ST] 5 HAMAP-Rule MF_03016
Region54 – 11360Interaction with PPP1R16B By similarity
Region161 – 18020Laminin-binding By similarity
Region205 – 22925Laminin-binding By similarity
Region242 – 29554Laminin-binding By similarity

Sites

Site115 – 1162Cleavage; by ST3; site 1 By similarity
Site133 – 1342Cleavage; by ST3; site 2 By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue891N6-acetyllysine By similarity
Modified residue1391Phosphotyrosine By similarity
Modified residue2411Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4GWZ2 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: C7C8DAA6B7459785

FASTA29532,928
        10         20         30         40         50         60 
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL 

        70         80         90        100        110        120 
AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR 

       130        140        150        160        170        180 
LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR 

       190        200        210        220        230        240 
EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA 

       250        260        270        280        290 
TQPEVADWSE GVQVPSVPIQ QFPTEDWSAQ PTTEDWSAAP TAQATEWVGT TTEWS 

« Hide

References

[1]"Characterization of the porcine multicopy ribosomal protein SA/37-kDa laminin receptor gene family."
Knorr C., Beuermann C., Beck J., Brenig B.
Gene 395:135-143(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Two dimensional VOPBA reveals laminin receptor (LAMR1) interaction with dengue virus serotypes 1, 2 and 3."
Tio P.H., Jong W.W., Cardosa M.J.
Virol. J. 2:25-25(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A VIRUS RECEPTOR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM050292 mRNA. Translation: CAJ18354.1.
RefSeqNP_001032223.1. NM_001037146.2.
UniGeneSsc.11095.

3D structure databases

ProteinModelPortalQ4GWZ2.
SMRQ4GWZ2. Positions 9-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000012012.

Proteomic databases

PaxDbQ4GWZ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID641351.
KEGGssc:641351.

Organism-specific databases

CTD3921.

Phylogenomic databases

eggNOGCOG0052.
HOGENOMHOG000232073.
HOVERGENHBG054466.
KOK02998.

Family and domain databases

HAMAPMF_03015. Ribosomal_S2_euk.
MF_03016. Ribosomal_S2_laminin_receptor.
InterProIPR027504. 40S_ribosomal_SA.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERPTHR11489. PTHR11489. 1 hit.
PfamPF00318. Ribosomal_S2. 1 hit.
[Graphical view]
PRINTSPR00395. RIBOSOMALS2.
SUPFAMSSF52313. SSF52313. 1 hit.
TIGRFAMsTIGR01012. Sa_S2_E_A. 1 hit.
PROSITEPS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRSSA_PIG
AccessionPrimary (citable) accession number: Q4GWZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries