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Q4GWZ2

- RSSA_PIG

UniProt

Q4GWZ2 - RSSA_PIG

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Protein

40S ribosomal protein SA

Gene
RPSA, LAMR1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei115 – 1162Cleavage; by ST3; site 1 By similarity
Sitei133 – 1342Cleavage; by ST3; site 2 By similarity

GO - Molecular functioni

  1. laminin receptor activity Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: UniProtKB-HAMAP
  3. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-HAMAP
  2. ribosomal small subunit assembly Source: UniProtKB-HAMAP
  3. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor, Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SA
Alternative name(s):
37 kDa laminin receptor precursor
Short name:
37LRP
37/67 kDa laminin receptor
Short name:
LRP/LR
67 kDa laminin receptor
Short name:
67LR
Laminin receptor 1
Short name:
LamR
Laminin-binding protein precursor p40
Short name:
LBP/p40
Gene namesi
Name:RPSA
Synonyms:LAMR1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Cell membrane By similarity. Cytoplasm By similarity. Nucleus By similarity
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane By similarity.UniRule annotation

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: UniProtKB-HAMAP
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 29529440S ribosomal protein SAUniRule annotationPRO_0000271751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei89 – 891N6-acetyllysine By similarity
Modified residuei139 – 1391Phosphotyrosine By similarity
Modified residuei241 – 2411Phosphothreonine By similarity

Post-translational modificationi

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association By similarity.UniRule annotation
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4GWZ2.

Interactioni

Subunit structurei

Monomer (37LRP) and homodimer (67LR) By similarity. Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21 By similarity. Interacts with several laminins including at least LAMB1 By similarity. Interacts with MDK By similarity. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012012.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VX2electron microscopy3.90A1-295[»]
1VX5electron microscopy3.50A1-295[»]
ProteinModelPortaliQ4GWZ2.
SMRiQ4GWZ2. Positions 9-205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati230 – 2323[DE]-W-[ST] 1UniRule annotation
Repeati247 – 2493[DE]-W-[ST] 2UniRule annotation
Repeati266 – 2683[DE]-W-[ST] 3UniRule annotation
Repeati275 – 2773[DE]-W-[ST] 4UniRule annotation
Repeati293 – 2953[DE]-W-[ST] 5UniRule annotation

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 11360Interaction with PPP1R16B By similarityAdd
BLAST
Regioni161 – 18020Laminin-binding By similarityAdd
BLAST
Regioni205 – 22925Laminin-binding By similarityAdd
BLAST
Regioni242 – 29554Laminin-binding By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0052.
HOGENOMiHOG000232073.
HOVERGENiHBG054466.
KOiK02998.

Family and domain databases

HAMAPiMF_03015. Ribosomal_S2_euk.
MF_03016. Ribosomal_S2_laminin_receptor.
InterProiIPR027504. 40S_ribosomal_SA.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiPF00318. Ribosomal_S2. 1 hit.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. Sa_S2_E_A. 1 hit.
PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4GWZ2-1 [UniParc]FASTAAdd to Basket

« Hide

MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN    50
LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA 100
GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT 150
DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD 200
LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA TQPEVADWSE 250
GVQVPSVPIQ QFPTEDWSAQ PTTEDWSAAP TAQATEWVGT TTEWS 295
Length:295
Mass (Da):32,928
Last modified:January 23, 2007 - v3
Checksum:iC7C8DAA6B7459785
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM050292 mRNA. Translation: CAJ18354.1.
RefSeqiNP_001032223.1. NM_001037146.2.
UniGeneiSsc.11095.

Genome annotation databases

GeneIDi641351.
KEGGissc:641351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM050292 mRNA. Translation: CAJ18354.1 .
RefSeqi NP_001032223.1. NM_001037146.2.
UniGenei Ssc.11095.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VX2 electron microscopy 3.90 A 1-295 [» ]
1VX5 electron microscopy 3.50 A 1-295 [» ]
ProteinModelPortali Q4GWZ2.
SMRi Q4GWZ2. Positions 9-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000012012.

Proteomic databases

PaxDbi Q4GWZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 641351.
KEGGi ssc:641351.

Organism-specific databases

CTDi 3921.

Phylogenomic databases

eggNOGi COG0052.
HOGENOMi HOG000232073.
HOVERGENi HBG054466.
KOi K02998.

Family and domain databases

HAMAPi MF_03015. Ribosomal_S2_euk.
MF_03016. Ribosomal_S2_laminin_receptor.
InterProi IPR027504. 40S_ribosomal_SA.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view ]
PANTHERi PTHR11489. PTHR11489. 1 hit.
Pfami PF00318. Ribosomal_S2. 1 hit.
[Graphical view ]
PRINTSi PR00395. RIBOSOMALS2.
SUPFAMi SSF52313. SSF52313. 1 hit.
TIGRFAMsi TIGR01012. Sa_S2_E_A. 1 hit.
PROSITEi PS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the porcine multicopy ribosomal protein SA/37-kDa laminin receptor gene family."
    Knorr C., Beuermann C., Beck J., Brenig B.
    Gene 395:135-143(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Two dimensional VOPBA reveals laminin receptor (LAMR1) interaction with dengue virus serotypes 1, 2 and 3."
    Tio P.H., Jong W.W., Cardosa M.J.
    Virol. J. 2:25-25(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A VIRUS RECEPTOR.

Entry informationi

Entry nameiRSSA_PIG
AccessioniPrimary (citable) accession number: Q4GWZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi