40S ribosomal protein SA - Sus scrofa (Pig)

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Q4GWZ2 (RSSA_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 52. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
40S ribosomal protein SA

Alternative name(s):
37 kDa laminin receptor precursor
Short name=37LRP
37/67 kDa laminin receptor
Short name=LRP/LR
67 kDa laminin receptor
Short name=67LR
Laminin receptor 1
Short name=LamR
Laminin-binding protein precursor p40
Short name=LBP/p40

Gene names

Name:	RPSA
Synonyms:	LAMR1

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA By similarity. Ref.2
Subunit structure	Monomer (37LRP) and homodimer (67LR) By similarity. Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21 By similarity. Interacts with several laminins including at least LAMB1 By similarity. Interacts with MDK By similarity. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B By similarity. HAMAP-Rule MF_03016
Subcellular location	Cell membrane By similarity. Cytoplasm By similarity. Nucleus By similarity. Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane By similarity. HAMAP-Rule MF_03016
Post-translational modification	Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association By similarity. HAMAP-Rule MF_03016 Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions By similarity. HAMAP-Rule MF_03016
Miscellaneous	This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. HAMAP-Rule MF_03016 It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity. HAMAP-Rule MF_03016
Sequence similarities	Belongs to the ribosomal protein S2P family.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane Nucleus
Domain	Repeat
Molecular function	Host cell receptor for virus entry Receptor Ribonucleoprotein Ribosomal protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	laminin receptor activity Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 295

294

40S ribosomal protein SA HAMAP-Rule MF_03016

PRO_0000271751

Regions

Repeat

230 – 232

[DE]-W-[ST] 1 HAMAP-Rule MF_03016

Repeat

247 – 249

[DE]-W-[ST] 2 HAMAP-Rule MF_03016

Repeat

266 – 268

[DE]-W-[ST] 3 HAMAP-Rule MF_03016

Repeat

275 – 277

[DE]-W-[ST] 4 HAMAP-Rule MF_03016

Repeat

293 – 295

[DE]-W-[ST] 5 HAMAP-Rule MF_03016

Region

54 – 113

Interaction with PPP1R16B By similarity

Region

161 – 180

Laminin-binding By similarity

Region

205 – 229

Laminin-binding By similarity

Region

242 – 295

Laminin-binding By similarity

Sites

Site

115 – 116

Cleavage; by ST3; site 1 By similarity

Site

133 – 134

Cleavage; by ST3; site 2 By similarity

Amino acid modifications

Modified residue

N-acetylserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

139

Phosphotyrosine By similarity

Modified residue

241

Phosphothreonine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q4GWZ2 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: C7C8DAA6B7459785
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FASTA

295

32,928

        10         20         30         40         50         60 
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL 

        70         80         90        100        110        120 
AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR 

       130        140        150        160        170        180 
LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR 

       190        200        210        220        230        240 
EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA 

       250        260        270        280        290 
TQPEVADWSE GVQVPSVPIQ QFPTEDWSAQ PTTEDWSAAP TAQATEWVGT TTEWS

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References

[1]	"Characterization of the porcine multicopy ribosomal protein SA/37-kDa laminin receptor gene family." Knorr C., Beuermann C., Beck J., Brenig B. Gene 395:135-143(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Two dimensional VOPBA reveals laminin receptor (LAMR1) interaction with dengue virus serotypes 1, 2 and 3." Tio P.H., Jong W.W., Cardosa M.J. Virol. J. 2:25-25(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS A VIRUS RECEPTOR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM050292 mRNA. Translation: CAJ18354.1.
RefSeq	NP_001032223.1. NM_001037146.2.
UniGene	Ssc.11095.
3D structure databases
ProteinModelPortal	Q4GWZ2.
SMR	Q4GWZ2. Positions 9-205.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000012012.
Proteomic databases
PaxDb	Q4GWZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	641351.
KEGG	ssc:641351.
Organism-specific databases
CTD	3921.
Phylogenomic databases
eggNOG	COG0052.
HOGENOM	HOG000232073.
HOVERGEN	HBG054466.
KO	K02998.
OrthoDB	EOG40ZQZ6.
Family and domain databases
HAMAP	MF_03015. Ribosomal_S2_euk. MF_03016. Ribosomal_S2-laminin_receptor.
InterPro	IPR027504. 40S_ribosomal_SA. IPR001865. Ribosomal_S2. IPR018130. Ribosomal_S2_CS. IPR027498. Ribosomal_S2_euk. IPR005707. Ribosomal_S2_euk/arc. IPR023591. Ribosomal_S2_flav_dom. [Graphical view]
PANTHER	PTHR11489. PTHR11489. 1 hit.
Pfam	PF00318. Ribosomal_S2. 1 hit. [Graphical view]
PRINTS	PR00395. RIBOSOMALS2.
SUPFAM	SSF52313. Ribosomal_S2. 1 hit.
TIGRFAMs	TIGR01012. Sa_S2_E_A. 1 hit.
PROSITE	PS00962. RIBOSOMAL_S2_1. 1 hit. PS00963. RIBOSOMAL_S2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSSA_PIG

Accession

Primary (citable) accession number: Q4GWZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 52 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Ribosomal proteins

Ribosomal proteins families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents