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Protein

Trypsin inhibitor 1

Gene

sfti1

Organism
Helianthus annuus (Common sunflower)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei44 – 45Reactive bondBy similarity2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI12.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor 1
Alternative name(s):
SFTI-1
Gene namesi
Name:sfti1Imported
OrganismiHelianthus annuus (Common sunflower)
Taxonomic identifieri4232 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeHelianthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000004267226 – 39Sequence analysis1 PublicationAdd BLAST14
PeptideiPRO_000004267340 – 53Trypsin inhibitor 1Add BLAST14
PropeptideiPRO_000004267454 – 563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40 ↔ 53Cyclopeptide (Gly-Asp)
Disulfide bondi42 ↔ 502 Publications

Post-translational modificationi

This is a cyclic peptide.1 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Beta strandi41 – 47Combined sources7
Beta strandi49 – 52Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JBLNMR-A40-53[»]
1JBNNMR-A40-53[»]
1O8YNMR-A40-53[»]
1O8ZNMR-A40-53[»]
1SFIX-ray1.65I40-53[»]
1T9ENMR-A40-53[»]
2AB9NMR-A26-56[»]
3P8FX-ray2.00I40-53[»]
4ABIX-ray1.55B40-53[»]
4ABJX-ray1.45B40-53[»]
4HGCX-ray1.29I40-53[»]
4K1EX-ray1.30B40-53[»]
4K8YX-ray1.00B40-53[»]
4KELX-ray1.15B40-53[»]
4XOJX-ray0.91B40-52[»]
ProteinModelPortaliQ4GWU5.
SMRiQ4GWU5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4GWU5.

Family & Domainsi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4GWU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTMAKLIT LVVLAILAFV EVSVSGYKTS ISTITIEDNG RCTKSIPPIC

FPDGRP
Length:56
Mass (Da):5,971
Last modified:August 30, 2005 - v1
Checksum:iBF3BAF97C25F19A7
GO

Mass spectrometryi

Molecular mass is 1513 Da from positions 40 - 53. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM050587 Genomic DNA. Translation: CAJ19097.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM050587 Genomic DNA. Translation: CAJ19097.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JBLNMR-A40-53[»]
1JBNNMR-A40-53[»]
1O8YNMR-A40-53[»]
1O8ZNMR-A40-53[»]
1SFIX-ray1.65I40-53[»]
1T9ENMR-A40-53[»]
2AB9NMR-A26-56[»]
3P8FX-ray2.00I40-53[»]
4ABIX-ray1.55B40-53[»]
4ABJX-ray1.45B40-53[»]
4HGCX-ray1.29I40-53[»]
4K1EX-ray1.30B40-53[»]
4K8YX-ray1.00B40-53[»]
4KELX-ray1.15B40-53[»]
4XOJX-ray0.91B40-52[»]
ProteinModelPortaliQ4GWU5.
SMRiQ4GWU5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI12.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ4GWU5.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSFTI1_HELAN
AccessioniPrimary (citable) accession number: Q4GWU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.