Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kelch domain-containing protein 2

Gene

Klhdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 2
Alternative name(s):
Endothelial differentiation inhibitory protein TNG
Gene namesi
Name:Klhdc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1916804 Klhdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289931 – 406Kelch domain-containing protein 2Add BLAST406

Proteomic databases

MaxQBiQ4G5Y1
PaxDbiQ4G5Y1
PeptideAtlasiQ4G5Y1
PRIDEiQ4G5Y1

PTM databases

iPTMnetiQ4G5Y1
PhosphoSitePlusiQ4G5Y1

Expressioni

Gene expression databases

BgeeiENSMUSG00000020978
CleanExiMM_KLHDC2
GenevisibleiQ4G5Y1 MM

Interactioni

Subunit structurei

Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA.By similarity

Protein-protein interaction databases

BioGridi213528, 1 interactor
IntActiQ4G5Y1, 1 interactor
MINTiQ4G5Y1
STRINGi10090.ENSMUSP00000021362

Structurei

3D structure databases

ProteinModelPortaliQ4G5Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 89Kelch 1Add BLAST47
Repeati102 – 155Kelch 2Add BLAST54
Repeati157 – 202Kelch 3Add BLAST46
Repeati229 – 278Kelch 4Add BLAST50
Repeati280 – 329Kelch 5Add BLAST50
Repeati331 – 377Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOGENOMiHOG000006587
HOVERGENiHBG067471
InParanoidiQ4G5Y1
OMAiCATVGNK
OrthoDBiEOG091G06BF
TreeFamiTF314081

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011043 Gal_Oxase/kelch_b-propeller
IPR015915 Kelch-typ_b-propeller
SUPFAMiSSF117281 SSF117281, 1 hit
SSF50965 SSF50965, 1 hit

Sequencei

Sequence statusi: Complete.

Q4G5Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGNEDARA EDLPGPAFEN YEAMELACPA ERSGHVAVSD GRHMFVWGGY
60 70 80 90 100
KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD
110 120 130 140 150
RVLYLFGGHH SRGNTNKFYM LDSRSADRGL QWERIDCQGI PPSSKDKLGV
160 170 180 190 200
WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT
210 220 230 240 250
ETFAWSQPIT TGKAPSPRAA HACATVGNKG FVFGGRYRDA RMNDLHYLNL
260 270 280 290 300
DTWEWNELIP QGVCPVGRSW HSLTPVSSDH LFLFGGFTTE KQPLSDAWTY
310 320 330 340 350
CISKNEWIQF NHPYVEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH
360 370 380 390 400
SNEVLIFSVQ PKSLVRLSLE AVICFKEMLA NSWSCLPKHL LHSVNQRFGS

NNTSGS
Length:406
Mass (Da):45,909
Last modified:July 27, 2011 - v3
Checksum:i9CD61E844607ACEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22E → G in BAB26317 (PubMed:16141072).Curated1
Sequence conflicti72N → Y in AAH05581 (PubMed:15489334).Curated1
Sequence conflicti368S → I in BAB26317 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513272 mRNA Translation: AAS82954.1
AK009481 mRNA Translation: BAB26317.1
AC099934 Genomic DNA No translation available.
BC005581 mRNA Translation: AAH05581.1
CCDSiCCDS25950.1
RefSeqiNP_081393.2, NM_027117.3
UniGeneiMm.234368

Genome annotation databases

EnsembliENSMUST00000021362; ENSMUSP00000021362; ENSMUSG00000020978
GeneIDi69554
KEGGimmu:69554
UCSCiuc007nrz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLDC2_MOUSE
AccessioniPrimary (citable) accession number: Q4G5Y1
Secondary accession number(s): E9QKN6, Q99JY2, Q9D784
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 97 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health