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Protein

Kelch domain-containing protein 2

Gene

Klhdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 2
Alternative name(s):
Endothelial differentiation inhibitory protein TNG
Gene namesi
Name:Klhdc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1916804. Klhdc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Kelch domain-containing protein 2PRO_0000228993Add
BLAST

Proteomic databases

MaxQBiQ4G5Y1.
PaxDbiQ4G5Y1.
PRIDEiQ4G5Y1.

PTM databases

iPTMnetiQ4G5Y1.
PhosphoSiteiQ4G5Y1.

Expressioni

Gene expression databases

BgeeiQ4G5Y1.
CleanExiMM_KLHDC2.
GenevisibleiQ4G5Y1. MM.

Interactioni

Subunit structurei

Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA.By similarity

Protein-protein interaction databases

IntActiQ4G5Y1. 1 interaction.
MINTiMINT-218864.
STRINGi10090.ENSMUSP00000021362.

Structurei

3D structure databases

ProteinModelPortaliQ4G5Y1.
SMRiQ4G5Y1. Positions 196-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 8947Kelch 1Add
BLAST
Repeati102 – 15554Kelch 2Add
BLAST
Repeati157 – 20246Kelch 3Add
BLAST
Repeati229 – 27850Kelch 4Add
BLAST
Repeati280 – 32950Kelch 5Add
BLAST
Repeati331 – 37747Kelch 6Add
BLAST

Sequence similaritiesi

Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000006587.
HOVERGENiHBG067471.
InParanoidiQ4G5Y1.
OMAiIWSQPIT.
OrthoDBiEOG75TMBP.
TreeFamiTF314081.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4G5Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGNEDARA EDLPGPAFEN YEAMELACPA ERSGHVAVSD GRHMFVWGGY
60 70 80 90 100
KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD
110 120 130 140 150
RVLYLFGGHH SRGNTNKFYM LDSRSADRGL QWERIDCQGI PPSSKDKLGV
160 170 180 190 200
WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT
210 220 230 240 250
ETFAWSQPIT TGKAPSPRAA HACATVGNKG FVFGGRYRDA RMNDLHYLNL
260 270 280 290 300
DTWEWNELIP QGVCPVGRSW HSLTPVSSDH LFLFGGFTTE KQPLSDAWTY
310 320 330 340 350
CISKNEWIQF NHPYVEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH
360 370 380 390 400
SNEVLIFSVQ PKSLVRLSLE AVICFKEMLA NSWSCLPKHL LHSVNQRFGS

NNTSGS
Length:406
Mass (Da):45,909
Last modified:July 27, 2011 - v3
Checksum:i9CD61E844607ACEF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221E → G in BAB26317 (PubMed:16141072).Curated
Sequence conflicti72 – 721N → Y in AAH05581 (PubMed:15489334).Curated
Sequence conflicti368 – 3681S → I in BAB26317 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513272 mRNA. Translation: AAS82954.1.
AK009481 mRNA. Translation: BAB26317.1.
AC099934 Genomic DNA. No translation available.
BC005581 mRNA. Translation: AAH05581.1.
CCDSiCCDS25950.1.
RefSeqiNP_081393.2. NM_027117.3.
UniGeneiMm.234368.

Genome annotation databases

EnsembliENSMUST00000021362; ENSMUSP00000021362; ENSMUSG00000020978.
GeneIDi69554.
KEGGimmu:69554.
UCSCiuc007nrz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513272 mRNA. Translation: AAS82954.1.
AK009481 mRNA. Translation: BAB26317.1.
AC099934 Genomic DNA. No translation available.
BC005581 mRNA. Translation: AAH05581.1.
CCDSiCCDS25950.1.
RefSeqiNP_081393.2. NM_027117.3.
UniGeneiMm.234368.

3D structure databases

ProteinModelPortaliQ4G5Y1.
SMRiQ4G5Y1. Positions 196-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4G5Y1. 1 interaction.
MINTiMINT-218864.
STRINGi10090.ENSMUSP00000021362.

PTM databases

iPTMnetiQ4G5Y1.
PhosphoSiteiQ4G5Y1.

Proteomic databases

MaxQBiQ4G5Y1.
PaxDbiQ4G5Y1.
PRIDEiQ4G5Y1.

Protocols and materials databases

DNASUi69554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021362; ENSMUSP00000021362; ENSMUSG00000020978.
GeneIDi69554.
KEGGimmu:69554.
UCSCiuc007nrz.2. mouse.

Organism-specific databases

CTDi23588.
MGIiMGI:1916804. Klhdc2.

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000006587.
HOVERGENiHBG067471.
InParanoidiQ4G5Y1.
OMAiIWSQPIT.
OrthoDBiEOG75TMBP.
TreeFamiTF314081.

Miscellaneous databases

NextBioi329768.
PROiQ4G5Y1.
SOURCEiSearch...

Gene expression databases

BgeeiQ4G5Y1.
CleanExiMM_KLHDC2.
GenevisibleiQ4G5Y1. MM.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differentially expressed genes in endothelial differentiation."
    Ishii H., Mimori K., Mori M., Vecchione A.
    DNA Cell Biol. 24:432-437(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiKLDC2_MOUSE
AccessioniPrimary (citable) accession number: Q4G5Y1
Secondary accession number(s): E9QKN6, Q99JY2, Q9D784
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 27, 2011
Last modified: February 17, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.