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Protein

RPA-interacting protein

Gene

Rpain

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri137 – 212RIP-typeAdd BLAST76

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RPA-interacting protein
Gene namesi
Name:Rpain
Synonyms:Rip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1308492 Rpain

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763011 – 219RPA-interacting proteinAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated; required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4G2Y1

PTM databases

iPTMnetiQ4G2Y1
PhosphoSitePlusiQ4G2Y1

Expressioni

Gene expression databases

BgeeiENSRNOG00000006913

Interactioni

Subunit structurei

Interacts with the RPA1 subunit of RPA complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009082

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 180Mediates nuclear exportBy similarityAdd BLAST17

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri137 – 212RIP-typeAdd BLAST76

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IX54 Eukaryota
ENOG4111K6G LUCA
GeneTreeiENSGT00390000006416
HOGENOMiHOG000251596
HOVERGENiHBG082800
InParanoidiQ4G2Y1
OMAiEEWNALQ
OrthoDBiEOG091G0IK2
PhylomeDBiQ4G2Y1
TreeFamiTF326215

Family and domain databases

InterProiView protein in InterPro
IPR028156 RIP
IPR028159 RPA_interact_C_dom
IPR028155 RPA_interact_central
IPR028158 RPA_interact_N_dom
PANTHERiPTHR31742 PTHR31742, 1 hit
PfamiView protein in Pfam
PF14768 RPA_interact_C, 1 hit
PF14767 RPA_interact_M, 1 hit
PF14766 RPA_interact_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4G2Y1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESSGSPHR LLYKQVGSPP WKETFRQGCL ERMRNSRHKL LNRYRQAAGS
60 70 80 90 100
TLGTASDRLL VQEVMEEEWN SLQSVENCPE ALLQLELPLN LAVLQDIEQE
110 120 130 140 150
LWNEEKSIIS EYEKGLQFDE SCLNSMLAEW EANPLICPVC IKYNLRIMNS
160 170 180 190 200
VVTCPCGLHI PSHSTDLTEQ KLRACLEGNV NEHSAHCPHI PEFSVTGGTE
210
EKPSLLMSCL ACDTWAVIL
Length:219
Mass (Da):24,710
Last modified:December 6, 2005 - v2
Checksum:iE24EAF7CABEA2A8D
GO
Isoform 2 (identifier: Q4G2Y1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-219: CDTWAVIL → YKLHC

Show »
Length:216
Mass (Da):24,453
Checksum:iEFD96CA308051679
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43R → T in CF978727 (PubMed:15277470).Curated1
Sequence conflicti58R → G in CF978727 (PubMed:15277470).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016411212 – 219CDTWAVIL → YKLHC in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY775322 mRNA Translation: AAX14376.1
AABR03073214 Genomic DNA No translation available.
CF978727 mRNA No translation available.
RefSeqiNP_001028232.1, NM_001033060.1 [Q4G2Y1-2]
XP_006246730.1, XM_006246668.3 [Q4G2Y1-1]
UniGeneiRn.43464

Genome annotation databases

EnsembliENSRNOT00000009082; ENSRNOP00000009082; ENSRNOG00000006913 [Q4G2Y1-1]
ENSRNOT00000044363; ENSRNOP00000040269; ENSRNOG00000006913 [Q4G2Y1-2]
GeneIDi287463
KEGGirno:287463
UCSCiRGD:1308492 rat [Q4G2Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRIP_RAT
AccessioniPrimary (citable) accession number: Q4G2Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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