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Protein
Submitted name:

Variable lymphocyte receptor B

Gene

VLRB

Organism
Eptatretus burgeri (Inshore hagfish)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Variable lymphocyte receptor BImported
Gene namesi
Name:VLRBImported
OrganismiEptatretus burgeri (Inshore hagfish)Imported
Taxonomic identifieri7764 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeEptatretinaeEptatretus

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 30Combined sources
Disulfide bondi28 ↔ 37Combined sources
Disulfide bondi161 ↔ 186Combined sources
Disulfide bondi163 ↔ 198Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O6RX-ray2.30A24-200[»]
3A79X-ray2.90A133-200[»]
3A7BX-ray2.53A133-200[»]
3A7CX-ray2.40A133-200[»]
3UL7X-ray2.37A126-199[»]
3UL8X-ray2.50A126-199[»]
3UL9X-ray2.45A126-199[»]
3ULAX-ray3.60A/C126-199[»]
3V44X-ray2.83A126-200[»]
3V47X-ray2.47A/B126-200[»]
4ARNX-ray2.41A/B/C/D133-201[»]
4ARRX-ray3.00A/B133-201[»]
4BV4X-ray2.35R133-201[»]
4QDHX-ray2.40A/B21-81[»]
A/B126-200[»]
4QXEX-ray2.20A131-200[»]
4QXFX-ray2.25A/B128-200[»]
ProteinModelPortaliQ4G1L2.
SMRiQ4G1L2. Positions 24-200.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4G1L2.

Family & Domainsi

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

HOVERGENiHBG061418.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR024592. Variable_lymphocyte_rcpt_C.
[Graphical view]
PfamiPF11921. DUF3439. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G1L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFALRGTCV LLALLLCCRN GKACPSRCSC SGTEIRCNSK GLTSVPTGIP
60 70 80 90 100
SSATRLELES NKLQSLPHGV FDKLTQLTKL SLSQNQIQSL PDGVFDKLTK
110 120 130 140 150
LTILYLHENK LQSLPNGVFD KLTQLKELAL DTNQLKSVPD GIFDRLTSLQ
160 170 180 190 200
KIWLHTNPWD CSCPRIDYLS RWLNKNSQKE QGSAKCSGSG KPVRSIICPT
210 220 230 240 250
TTTTTTTTTM PTTTTLPTTT KMSMVKVPLV PPEAFGRVMN ACAYFPSYIF
260 270
LHLVHGLAAV PLVYLICHAS QLL
Length:273
Mass (Da):30,001
Last modified:August 30, 2005 - v1
Checksum:i5B0BBBB883D12E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY965531 mRNA. Translation: AAZ16361.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY965531 mRNA. Translation: AAZ16361.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O6RX-ray2.30A24-200[»]
3A79X-ray2.90A133-200[»]
3A7BX-ray2.53A133-200[»]
3A7CX-ray2.40A133-200[»]
3UL7X-ray2.37A126-199[»]
3UL8X-ray2.50A126-199[»]
3UL9X-ray2.45A126-199[»]
3ULAX-ray3.60A/C126-199[»]
3V44X-ray2.83A126-200[»]
3V47X-ray2.47A/B126-200[»]
4ARNX-ray2.41A/B/C/D133-201[»]
4ARRX-ray3.00A/B133-201[»]
4BV4X-ray2.35R133-201[»]
4QDHX-ray2.40A/B21-81[»]
A/B126-200[»]
4QXEX-ray2.20A131-200[»]
4QXFX-ray2.25A/B128-200[»]
ProteinModelPortaliQ4G1L2.
SMRiQ4G1L2. Positions 24-200.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG061418.

Miscellaneous databases

EvolutionaryTraceiQ4G1L2.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR024592. Variable_lymphocyte_rcpt_C.
[Graphical view]
PfamiPF11921. DUF3439. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 24-200, ACTIVE SITE.
  3. "Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer."
    Kang J.Y., Nan X., Jin M.S., Youn S.J., Ryu Y.H., Mah S., Han S.H., Lee H., Paik S.G., Lee J.O.
    Immunity 31:873-884(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 133-200, ACTIVE SITE.
  4. "Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein."
    Han J., Kim H.J., Lee S.C., Hong S., Park K., Jeon Y.H., Kim D., Cheong H.K., Kim H.S.
    PLoS ONE 7:E30929-E30929(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 126-199, ACTIVE SITE.
  5. "Structural basis of TLR5-flagellin recognition and signaling."
    Yoon S.I., Kurnasov O., Natarajan V., Hong M., Gudkov A.V., Osterman A.L., Wilson I.A.
    Science 335:859-864(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 126-200, ACTIVE SITE.
  6. "Liesegang-like patterns of Toll crystals grown in gel."
    Gangloff M., Moreno A., Gay N.J.
    J. Appl. Crystallogr. 46:337-345(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 133-201, ACTIVE SITE.
  7. "Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation."
    Lewis M., Arnot C.J., Beeston H., McCoy A., Ashcroft A.E., Gay N.J., Gangloff M.
    Proc. Natl. Acad. Sci. U.S.A. 110:20461-20466(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 133-201, ACTIVE SITE.
  8. "Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor."
    Gangloff M., Arnot C.J., Lewis M., Gay N.J.
    Structure 21:143-153(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 133-201, ACTIVE SITE.
  9. "Crystal structure of the C-terminal domain of mouse TLR9."
    Collins B., Wilson I.A.
    Proteins 82:2874-2878(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 21-81 AND 126-200, ACTIVE SITE.
  10. "crystal structure of human LGR4 and Rspo1."
    Xu J.G., Huang C., Zhou Y., Zhu Y.
    Submitted (JUL-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 128-200, ACTIVE SITE.
  11. "Crystal structure of LGR4 fused with hagfish VLR."
    Xu J.G., Huang C., Zhou Y., Zhu Y.
    Submitted (JUL-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 131-200, ACTIVE SITE.

Entry informationi

Entry nameiQ4G1L2_EPTBU
AccessioniPrimary (citable) accession number: Q4G1L2
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.