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Q4G1L2

- Q4G1L2_EPTBU

UniProt

Q4G1L2 - Q4G1L2_EPTBU

Protein
Submitted name:

Variable lymphocyte receptor B

Gene

VLRB

Organism
Eptatretus burgeri (Inshore hagfish)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei156 – 1561SulfateImported
    Binding sitei185 – 1851SulfateImported

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Variable lymphocyte receptor BImported
    Gene namesi
    Name:VLRBImported
    OrganismiEptatretus burgeri (Inshore hagfish)Imported
    Taxonomic identifieri7764 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeEptatretinaeEptatretus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2O6RX-ray2.30A24-200[»]
    3A79X-ray2.90A133-200[»]
    3A7BX-ray2.53A133-200[»]
    3A7CX-ray2.40A133-200[»]
    3UL7X-ray2.37A126-199[»]
    3UL8X-ray2.50A126-199[»]
    3UL9X-ray2.45A126-199[»]
    3ULAX-ray3.60A/C126-199[»]
    3V44X-ray2.83A126-200[»]
    3V47X-ray2.47A/B126-200[»]
    4ARNX-ray2.41A/B/C/D133-201[»]
    4ARRX-ray3.00A/B133-201[»]
    4BV4X-ray2.35R133-201[»]
    4QDHX-ray2.40A/B126-200[»]
    A/B21-81[»]
    ProteinModelPortaliQ4G1L2.
    SMRiQ4G1L2. Positions 24-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ4G1L2.

    Family & Domainsi

    Keywords - Domaini

    Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG061418.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR024592. Variable_lymphocyte_rcpt_C.
    [Graphical view]
    PfamiPF11921. DUF3439. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4G1L2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFALRGTCV LLALLLCCRN GKACPSRCSC SGTEIRCNSK GLTSVPTGIP    50
    SSATRLELES NKLQSLPHGV FDKLTQLTKL SLSQNQIQSL PDGVFDKLTK 100
    LTILYLHENK LQSLPNGVFD KLTQLKELAL DTNQLKSVPD GIFDRLTSLQ 150
    KIWLHTNPWD CSCPRIDYLS RWLNKNSQKE QGSAKCSGSG KPVRSIICPT 200
    TTTTTTTTTM PTTTTLPTTT KMSMVKVPLV PPEAFGRVMN ACAYFPSYIF 250
    LHLVHGLAAV PLVYLICHAS QLL 273
    Length:273
    Mass (Da):30,001
    Last modified:August 30, 2005 - v1
    Checksum:i5B0BBBB883D12E2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY965531 mRNA. Translation: AAZ16361.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY965531 mRNA. Translation: AAZ16361.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2O6R X-ray 2.30 A 24-200 [» ]
    3A79 X-ray 2.90 A 133-200 [» ]
    3A7B X-ray 2.53 A 133-200 [» ]
    3A7C X-ray 2.40 A 133-200 [» ]
    3UL7 X-ray 2.37 A 126-199 [» ]
    3UL8 X-ray 2.50 A 126-199 [» ]
    3UL9 X-ray 2.45 A 126-199 [» ]
    3ULA X-ray 3.60 A/C 126-199 [» ]
    3V44 X-ray 2.83 A 126-200 [» ]
    3V47 X-ray 2.47 A/B 126-200 [» ]
    4ARN X-ray 2.41 A/B/C/D 133-201 [» ]
    4ARR X-ray 3.00 A/B 133-201 [» ]
    4BV4 X-ray 2.35 R 133-201 [» ]
    4QDH X-ray 2.40 A/B 126-200 [» ]
    A/B 21-81 [» ]
    ProteinModelPortali Q4G1L2.
    SMRi Q4G1L2. Positions 24-200.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG061418.

    Miscellaneous databases

    EvolutionaryTracei Q4G1L2.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR024592. Variable_lymphocyte_rcpt_C.
    [Graphical view ]
    Pfami PF11921. DUF3439. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 24-200.
    3. "Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer."
      Kang J.Y., Nan X., Jin M.S., Youn S.J., Ryu Y.H., Mah S., Han S.H., Lee H., Paik S.G., Lee J.O.
      Immunity 31:873-884(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 133-200.
    4. "Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein."
      Han J., Kim H.J., Lee S.C., Hong S., Park K., Jeon Y.H., Kim D., Cheong H.K., Kim H.S.
      PLoS ONE 7:E30929-E30929(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 126-199.
    5. "Structural basis of TLR5-flagellin recognition and signaling."
      Yoon S.I., Kurnasov O., Natarajan V., Hong M., Gudkov A.V., Osterman A.L., Wilson I.A.
      Science 335:859-864(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 126-200.
    6. "Liesegang-like patterns of Toll crystals grown in gel."
      Gangloff M., Moreno A., Gay N.J.
      J Appl Crystallogr 46:337-345(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 133-201.
    7. "Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation."
      Lewis M., Arnot C.J., Beeston H., McCoy A., Ashcroft A.E., Gay N.J., Gangloff M.
      Proc. Natl. Acad. Sci. U.S.A. 110:20461-20466(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 133-201.
    8. "Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor."
      Gangloff M., Arnot C.J., Lewis M., Gay N.J.
      Structure 21:143-153(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 133-201.
    9. "Crystal structure of the C-terminal domain of mouse TLR9."
      Collins B., Wilson I.A.
      Proteins 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 126-200 AND 21-81.

    Entry informationi

    Entry nameiQ4G1L2_EPTBU
    AccessioniPrimary (citable) accession number: Q4G1L2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3