Q4G1L2 (Q4G1L2_EPTBU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Variable lymphocyte receptor B EMBL AAZ16361.1

Gene names

Name:

VLRB EMBL AAZ16361.1

Organism

Eptatretus burgeri (Inshore hagfish) EMBL AAZ16361.1

Taxonomic identifier

7764 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Hyperotreti › Myxiniformes › Myxinidae › Eptatretinae › Eptatretus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Leucine-rich repeat SAAS SAAS000483 Repeat SAAS SAAS000483
Molecular function	Receptor EMBL AAZ16361.1
Technical term	3D-structure PDB 4ARN PDB 4ARR PDB 3A79 PDB 3A7C PDB 3A7B PDB 2O6R PDB 3UL7 PDB 3UL8 PDB 3UL9 PDB 3ULA PDB 3V44 PDB 3V47
Gene Ontology (GO)
None. [Check GOA]

Sequences

	Sequence		Length	Mass (Da)
	Q4G1L2 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 5B0BBBB883D12E2B	FASTA	273	30,001
	10 20 30 40 50 60 MKFALRGTCV LLALLLCCRN GKACPSRCSC SGTEIRCNSK GLTSVPTGIP SSATRLELES 70 80 90 100 110 120 NKLQSLPHGV FDKLTQLTKL SLSQNQIQSL PDGVFDKLTK LTILYLHENK LQSLPNGVFD 130 140 150 160 170 180 KLTQLKELAL DTNQLKSVPD GIFDRLTSLQ KIWLHTNPWD CSCPRIDYLS RWLNKNSQKE 190 200 210 220 230 240 QGSAKCSGSG KPVRSIICPT TTTTTTTTTM PTTTTLPTTT KMSMVKVPLV PPEAFGRVMN 250 260 270 ACAYFPSYIF LHLVHGLAAV PLVYLICHAS QLL

References

[1]	"Variable lymphocyte receptors in hagfish." Pancer Z., Saha N.R., Kasamatsu J., Suzuki T., Amemiya C.T., Kasahara M., Cooper M.D. Proc. Natl. Acad. Sci. U.S.A. 102:9224-9229(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structural diversity of the hagfish variable lymphocyte receptors." Kim H.M., Oh S.C., Lim K.J., Kasamatsu J., Heo J.Y., Park B.S., Lee H., Yoo O.J., Kasahara M., Lee J.O. J. Biol. Chem. 282:6726-6732(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 24-200.
[3]	"Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer." Kang J.Y., Nan X., Jin M.S., Youn S.J., Ryu Y.H., Mah S., Han S.H., Lee H., Paik S.G., Lee J.O. Immunity 31:873-884(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 133-200.
[4]	"Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein." Han J., Kim H.J., Lee S.C., Hong S., Park K., Jeon Y.H., Kim D., Cheong H.K., Kim H.S. PLoS ONE 7:e30929-e30929(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 126-200.
[5]	"Structural basis of TLR5-flagellin recognition and signaling." Yoon S.I., Kurnasov O., Natarajan V., Hong M., Gudkov A.V., Osterman A.L., Wilson I.A. Science 335:859-864(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 126-200.
[6]	"Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor." Gangloff M., Arnot C.J., Lewis M., Gay N.J. Structure 21:143-153(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 133-201.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY965531 mRNA. Translation: AAZ16361.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2O6R	X-ray	2.30	A	24-200	[»]
3A79	X-ray	2.90	A	133-200	[»]
3A7B	X-ray	2.53	A	133-200	[»]
3A7C	X-ray	2.40	A	133-200	[»]
3UL7	X-ray	2.37	A	126-200	[»]
3UL8	X-ray	2.50	A	126-200	[»]
3UL9	X-ray	2.45	A	126-200	[»]
3ULA	X-ray	3.60	A/C	126-200	[»]
3V44	X-ray	2.83	A	126-200	[»]
3V47	X-ray	2.47	A/B	126-200	[»]
4ARN	X-ray	2.41	A/B/C/D	133-201	[»]
4ARR	X-ray	3.00	A/B	136-201	[»]

ProteinModelPortal

Q4G1L2.

SMR

Q4G1L2. Positions 24-200.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG061418.

Family and domain databases

InterPro

IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR024592. Variable_lymphocyte_rcpt_C.
[Graphical view]

Pfam

PF11921. DUF3439. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]

SMART

SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]

PROSITE

PS51450. LRR. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q4G1L2.

Entry information

Entry name

Q4G1L2_EPTBU

Accession

Primary (citable) accession number: Q4G1L2

Entry history

Integrated into UniProtKB/TrEMBL:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)