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Q4G1L2

- Q4G1L2_EPTBU

UniProt

Q4G1L2 - Q4G1L2_EPTBU

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Protein
Submitted name:

Variable lymphocyte receptor B

Gene

VLRB

Organism
Eptatretus burgeri (Inshore hagfish)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei156 – 1561SulfateImported
Binding sitei185 – 1851SulfateImported

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Variable lymphocyte receptor BImported
Gene namesi
Name:VLRBImported
OrganismiEptatretus burgeri (Inshore hagfish)Imported
Taxonomic identifieri7764 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeEptatretinaeEptatretus

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O6RX-ray2.30A24-200[»]
3A79X-ray2.90A133-200[»]
3A7BX-ray2.53A133-200[»]
3A7CX-ray2.40A133-200[»]
3UL7X-ray2.37A126-199[»]
3UL8X-ray2.50A126-199[»]
3UL9X-ray2.45A126-199[»]
3ULAX-ray3.60A/C126-199[»]
3V44X-ray2.83A126-200[»]
3V47X-ray2.47A/B126-200[»]
4ARNX-ray2.41A/B/C/D133-201[»]
4ARRX-ray3.00A/B133-201[»]
4BV4X-ray2.35R133-201[»]
4QDHX-ray2.40A/B21-81[»]
A/B126-200[»]
ProteinModelPortaliQ4G1L2.
SMRiQ4G1L2. Positions 24-200.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4G1L2.

Family & Domainsi

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

HOVERGENiHBG061418.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR024592. Variable_lymphocyte_rcpt_C.
[Graphical view]
PfamiPF11921. DUF3439. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G1L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFALRGTCV LLALLLCCRN GKACPSRCSC SGTEIRCNSK GLTSVPTGIP
60 70 80 90 100
SSATRLELES NKLQSLPHGV FDKLTQLTKL SLSQNQIQSL PDGVFDKLTK
110 120 130 140 150
LTILYLHENK LQSLPNGVFD KLTQLKELAL DTNQLKSVPD GIFDRLTSLQ
160 170 180 190 200
KIWLHTNPWD CSCPRIDYLS RWLNKNSQKE QGSAKCSGSG KPVRSIICPT
210 220 230 240 250
TTTTTTTTTM PTTTTLPTTT KMSMVKVPLV PPEAFGRVMN ACAYFPSYIF
260 270
LHLVHGLAAV PLVYLICHAS QLL
Length:273
Mass (Da):30,001
Last modified:August 30, 2005 - v1
Checksum:i5B0BBBB883D12E2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY965531 mRNA. Translation: AAZ16361.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY965531 mRNA. Translation: AAZ16361.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2O6R X-ray 2.30 A 24-200 [» ]
3A79 X-ray 2.90 A 133-200 [» ]
3A7B X-ray 2.53 A 133-200 [» ]
3A7C X-ray 2.40 A 133-200 [» ]
3UL7 X-ray 2.37 A 126-199 [» ]
3UL8 X-ray 2.50 A 126-199 [» ]
3UL9 X-ray 2.45 A 126-199 [» ]
3ULA X-ray 3.60 A/C 126-199 [» ]
3V44 X-ray 2.83 A 126-200 [» ]
3V47 X-ray 2.47 A/B 126-200 [» ]
4ARN X-ray 2.41 A/B/C/D 133-201 [» ]
4ARR X-ray 3.00 A/B 133-201 [» ]
4BV4 X-ray 2.35 R 133-201 [» ]
4QDH X-ray 2.40 A/B 21-81 [» ]
A/B 126-200 [» ]
ProteinModelPortali Q4G1L2.
SMRi Q4G1L2. Positions 24-200.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG061418.

Miscellaneous databases

EvolutionaryTracei Q4G1L2.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR024592. Variable_lymphocyte_rcpt_C.
[Graphical view ]
Pfami PF11921. DUF3439. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 24-200.
  3. "Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer."
    Kang J.Y., Nan X., Jin M.S., Youn S.J., Ryu Y.H., Mah S., Han S.H., Lee H., Paik S.G., Lee J.O.
    Immunity 31:873-884(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 133-200.
  4. "Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein."
    Han J., Kim H.J., Lee S.C., Hong S., Park K., Jeon Y.H., Kim D., Cheong H.K., Kim H.S.
    PLoS ONE 7:E30929-E30929(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 126-199.
  5. "Structural basis of TLR5-flagellin recognition and signaling."
    Yoon S.I., Kurnasov O., Natarajan V., Hong M., Gudkov A.V., Osterman A.L., Wilson I.A.
    Science 335:859-864(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 126-200.
  6. "Liesegang-like patterns of Toll crystals grown in gel."
    Gangloff M., Moreno A., Gay N.J.
    J Appl Crystallogr 46:337-345(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 133-201.
  7. "Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation."
    Lewis M., Arnot C.J., Beeston H., McCoy A., Ashcroft A.E., Gay N.J., Gangloff M.
    Proc. Natl. Acad. Sci. U.S.A. 110:20461-20466(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 133-201.
  8. "Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor."
    Gangloff M., Arnot C.J., Lewis M., Gay N.J.
    Structure 21:143-153(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 133-201.
  9. "Crystal structure of the C-terminal domain of mouse TLR9."
    Collins B., Wilson I.A.
    Proteins 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 21-81 AND 126-200.

Entry informationi

Entry nameiQ4G1L2_EPTBU
AccessioniPrimary (citable) accession number: Q4G1L2
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3