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Protein

GLIPR1-like protein 2

Gene

GLIPR1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GLIPR1-like protein 2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28592. GLIPR1L2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180481.
PharmGKBiPA145008279.

Polymorphism and mutation databases

BioMutaiGLIPR1L2.
DMDMi172046790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003243871 – 344GLIPR1-like protein 2Add BLAST344

Proteomic databases

EPDiQ4G1C9.
PaxDbiQ4G1C9.
PeptideAtlasiQ4G1C9.
PRIDEiQ4G1C9.
TopDownProteomicsiQ4G1C9-6. [Q4G1C9-6]

PTM databases

PhosphoSitePlusiQ4G1C9.

Expressioni

Tissue specificityi

Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow.1 Publication

Inductioni

Up-regulated by doxycycline.1 Publication

Gene expression databases

BgeeiENSG00000180481.
CleanExiHS_GLIPR1L2.

Organism-specific databases

HPAiHPA039795.
HPA039866.

Interactioni

Protein-protein interaction databases

BioGridi126842. 11 interactors.
IntActiQ4G1C9. 1 interactor.
STRINGi9606.ENSP00000317385.

Structurei

3D structure databases

ProteinModelPortaliQ4G1C9.
SMRiQ4G1C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 192SCPAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi292 – 343Glu-richAdd BLAST52

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiQ4G1C9.
OMAiENIWIAS.
OrthoDBiEOG091G048D.
PhylomeDBiQ4G1C9.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4G1C9-1) [UniParc]FASTAAdd to basket
Also known as: delta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAARPFARE WRAQSLPLAV GGVLKLRLCE LWLLLLGSSL NARFLPDEED
60 70 80 90 100
VDFINEYVNL HNELRGDVIP RGSNLRFMTW DVALSRTARA WGKKCLFTHN
110 120 130 140 150
IYLQDVQMVH PKFYGIGENM WVGPENEFTA SIAIRSWHAE KKMYNFENGS
160 170 180 190 200
CSGDCSNYIQ LVWDHSYKVG CAVTPCSKIG HIIHAAIFIC NYAPGGTLTR
210 220 230 240 250
RPYEPGIFCT RCGRRDKCTD FLCSNADRDQ ATYYRFWYPK WEMPRPVVCD
260 270 280 290 300
PLCTFILLLR ILCFILCVIT VLIVQSQFPN ILLEQQMIFT PEESEAGNEE
310 320 330 340
EEKEEEKKEK EEMEMEIMEM EEEKEEREEE EEETQKEKME EEEK
Length:344
Mass (Da):40,179
Last modified:March 18, 2008 - v2
Checksum:i8D19B8CB2CEC5786
GO
Isoform 2 (identifier: Q4G1C9-2) [UniParc]FASTAAdd to basket
Also known as: alpha

The sequence of this isoform differs from the canonical sequence as follows:
     225-344: NADRDQATYY...QKEKMEEEEK → KIKKINMKKMHNGLDKKNKRLNTSFLWSC

Show »
Length:253
Mass (Da):29,005
Checksum:iC5FD2B6C60D939A2
GO
Isoform 3 (identifier: Q4G1C9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-106: TWDVALSRTARAWGKKCLFTHNIYLQDV → LWYCCDSDGSRFIIGFPNLSPRTPSAPL
     107-344: Missing.

Note: No experimental confirmation available.
Show »
Length:106
Mass (Da):12,049
Checksum:i7A73BDED667F5D5F
GO
Isoform 4 (identifier: Q4G1C9-4) [UniParc]FASTAAdd to basket
Also known as: epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: L → RNTDEKTL
     162-344: Missing.

Show »
Length:168
Mass (Da):19,373
Checksum:i47CE644DE34F45DA
GO
Isoform 5 (identifier: Q4G1C9-5) [UniParc]FASTAAdd to basket
Also known as: gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Show »
Length:237
Mass (Da):27,840
Checksum:i5F2A475172E31593
GO
Isoform 6 (identifier: Q4G1C9-6) [UniParc]FASTAAdd to basket
Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-78: M → MLITMILHRARTK

Show »
Length:279
Mass (Da):32,810
Checksum:i586B750F9B0D53B4
GO

Sequence cautioni

The sequence AAH16749 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC04085 differs from that shown. Reason: Erroneous termination at position 230. Translated as Gln.Curated
The sequence CAE45957 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0322391 – 107Missing in isoform 5. CuratedAdd BLAST107
Alternative sequenceiVSP_0322401 – 77Missing in isoform 6. CuratedAdd BLAST77
Alternative sequenceiVSP_03224178M → MLITMILHRARTK in isoform 6. Curated1
Alternative sequenceiVSP_03224279 – 106TWDVA…YLQDV → LWYCCDSDGSRFIIGFPNLS PRTPSAPL in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_032243107 – 344Missing in isoform 3. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_032244161L → RNTDEKTL in isoform 4. Curated1
Alternative sequenceiVSP_032245162 – 344Missing in isoform 4. CuratedAdd BLAST183
Alternative sequenceiVSP_032246225 – 344NADRD…EEEEK → KIKKINMKKMHNGLDKKNKR LNTSFLWSC in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093175 mRNA. Translation: BAC04085.1. Sequence problems.
BX640916 mRNA. Translation: CAE45957.1. Different initiation.
AC121761 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97305.1.
BC016749 mRNA. Translation: AAH16749.1. Sequence problems.
BC029557 mRNA. Translation: AAH29557.1.
CCDSiCCDS58258.1. [Q4G1C9-1]
CCDS9010.1. [Q4G1C9-2]
RefSeqiNP_001257325.1. NM_001270396.1. [Q4G1C9-1]
NP_689649.1. NM_152436.2. [Q4G1C9-2]
XP_011536251.1. XM_011537949.2. [Q4G1C9-5]
XP_011536252.1. XM_011537950.2. [Q4G1C9-5]
XP_016874338.1. XM_017018849.1. [Q4G1C9-5]
UniGeneiHs.406728.

Genome annotation databases

EnsembliENST00000320460; ENSP00000317385; ENSG00000180481. [Q4G1C9-2]
ENST00000378692; ENSP00000367963; ENSG00000180481. [Q4G1C9-5]
ENST00000547164; ENSP00000447980; ENSG00000180481. [Q4G1C9-4]
ENST00000550916; ENSP00000448248; ENSG00000180481. [Q4G1C9-1]
GeneIDi144321.
KEGGihsa:144321.
UCSCiuc001sxp.3. human. [Q4G1C9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093175 mRNA. Translation: BAC04085.1. Sequence problems.
BX640916 mRNA. Translation: CAE45957.1. Different initiation.
AC121761 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97305.1.
BC016749 mRNA. Translation: AAH16749.1. Sequence problems.
BC029557 mRNA. Translation: AAH29557.1.
CCDSiCCDS58258.1. [Q4G1C9-1]
CCDS9010.1. [Q4G1C9-2]
RefSeqiNP_001257325.1. NM_001270396.1. [Q4G1C9-1]
NP_689649.1. NM_152436.2. [Q4G1C9-2]
XP_011536251.1. XM_011537949.2. [Q4G1C9-5]
XP_011536252.1. XM_011537950.2. [Q4G1C9-5]
XP_016874338.1. XM_017018849.1. [Q4G1C9-5]
UniGeneiHs.406728.

3D structure databases

ProteinModelPortaliQ4G1C9.
SMRiQ4G1C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126842. 11 interactors.
IntActiQ4G1C9. 1 interactor.
STRINGi9606.ENSP00000317385.

PTM databases

PhosphoSitePlusiQ4G1C9.

Polymorphism and mutation databases

BioMutaiGLIPR1L2.
DMDMi172046790.

Proteomic databases

EPDiQ4G1C9.
PaxDbiQ4G1C9.
PeptideAtlasiQ4G1C9.
PRIDEiQ4G1C9.
TopDownProteomicsiQ4G1C9-6. [Q4G1C9-6]

Protocols and materials databases

DNASUi144321.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320460; ENSP00000317385; ENSG00000180481. [Q4G1C9-2]
ENST00000378692; ENSP00000367963; ENSG00000180481. [Q4G1C9-5]
ENST00000547164; ENSP00000447980; ENSG00000180481. [Q4G1C9-4]
ENST00000550916; ENSP00000448248; ENSG00000180481. [Q4G1C9-1]
GeneIDi144321.
KEGGihsa:144321.
UCSCiuc001sxp.3. human. [Q4G1C9-1]

Organism-specific databases

CTDi144321.
GeneCardsiGLIPR1L2.
H-InvDBHIX0022476.
HGNCiHGNC:28592. GLIPR1L2.
HPAiHPA039795.
HPA039866.
MIMi610394. gene.
neXtProtiNX_Q4G1C9.
OpenTargetsiENSG00000180481.
PharmGKBiPA145008279.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiQ4G1C9.
OMAiENIWIAS.
OrthoDBiEOG091G048D.
PhylomeDBiQ4G1C9.
TreeFamiTF316148.

Miscellaneous databases

GenomeRNAii144321.
PROiQ4G1C9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180481.
CleanExiHS_GLIPR1L2.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRPL2_HUMAN
AccessioniPrimary (citable) accession number: Q4G1C9
Secondary accession number(s): Q6MZS1, Q8N6N0, Q8NA43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.