Q4G1C9 (GRPL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GLIPR1-like protein 2

Gene names

Name:

GLIPR1L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow. Ref.6
Induction	Up-regulated by doxycycline. Ref.6
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain.
Sequence caution	The sequence AAH16749.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAC04085.1 differs from that shown. Reason: Erroneous termination at position 230. Translated as Gln. The sequence CAE45957.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4G1C9-1)

Also known as: delta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4G1C9-2)

Also known as: alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     225-344: NADRDQATYY...QKEKMEEEEK → KIKKINMKKMHNGLDKKNKRLNTSFLWSC

Isoform 3 (identifier: Q4G1C9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     79-106: TWDVALSRTARAWGKKCLFTHNIYLQDV → LWYCCDSDGSRFIIGFPNLSPRTPSAPL
     107-344: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q4G1C9-4)

Also known as: epsilon;

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: L → RNTDEKTL
     162-344: Missing.

Isoform 5 (identifier: Q4G1C9-5)

Also known as: gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Isoform 6 (identifier: Q4G1C9-6)

Also known as: beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-78: M → MLITMILHRARTK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	GLIPR1-like protein 2		PRO_0000324387
Regions
	Transmembrane	254 – 274	21	Helical; Potential
	Domain	58 – 192	135	SCP
	Compositional bias	292 – 343	52	Glu-rich
Natural variations
	Alternative sequence	1 – 107	107	Missing in isoform 5.		VSP_032239
	Alternative sequence	1 – 77	77	Missing in isoform 6.		VSP_032240
	Alternative sequence	78	1	M → MLITMILHRARTK in isoform 6.		VSP_032241
	Alternative sequence	79 – 106	28	TWDVA…YLQDV → LWYCCDSDGSRFIIGFPNLS PRTPSAPL in isoform 3.		VSP_032242
	Alternative sequence	107 – 344	238	Missing in isoform 3.		VSP_032243
	Alternative sequence	161	1	L → RNTDEKTL in isoform 4.		VSP_032244
	Alternative sequence	162 – 344	183	Missing in isoform 4.		VSP_032245
	Alternative sequence	225 – 344	120	NADRD…EEEEK → KIKKINMKKMHNGLDKKNKR LNTSFLWSC in isoform 2.		VSP_032246

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (delta) [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 8D19B8CB2CEC5786	FASTA	344	40,179
	10 20 30 40 50 60 MEAARPFARE WRAQSLPLAV GGVLKLRLCE LWLLLLGSSL NARFLPDEED VDFINEYVNL 70 80 90 100 110 120 HNELRGDVIP RGSNLRFMTW DVALSRTARA WGKKCLFTHN IYLQDVQMVH PKFYGIGENM 130 140 150 160 170 180 WVGPENEFTA SIAIRSWHAE KKMYNFENGS CSGDCSNYIQ LVWDHSYKVG CAVTPCSKIG 190 200 210 220 230 240 HIIHAAIFIC NYAPGGTLTR RPYEPGIFCT RCGRRDKCTD FLCSNADRDQ ATYYRFWYPK 250 260 270 280 290 300 WEMPRPVVCD PLCTFILLLR ILCFILCVIT VLIVQSQFPN ILLEQQMIFT PEESEAGNEE 310 320 330 340 EEKEEEKKEK EEMEMEIMEM EEEKEEREEE EEETQKEKME EEEK
	Isoform 2 (alpha) [UniParc]. Checksum: C5FD2B6C60D939A2	FASTA	253	29,005
	10 20 30 40 50 60 MEAARPFARE WRAQSLPLAV GGVLKLRLCE LWLLLLGSSL NARFLPDEED VDFINEYVNL 70 80 90 100 110 120 HNELRGDVIP RGSNLRFMTW DVALSRTARA WGKKCLFTHN IYLQDVQMVH PKFYGIGENM 130 140 150 160 170 180 WVGPENEFTA SIAIRSWHAE KKMYNFENGS CSGDCSNYIQ LVWDHSYKVG CAVTPCSKIG 190 200 210 220 230 240 HIIHAAIFIC NYAPGGTLTR RPYEPGIFCT RCGRRDKCTD FLCSKIKKIN MKKMHNGLDK 250 KNKRLNTSFL WSC
	Isoform 3 [UniParc]. Checksum: 7A73BDED667F5D5F	FASTA	106	12,049
	10 20 30 40 50 60 MEAARPFARE WRAQSLPLAV GGVLKLRLCE LWLLLLGSSL NARFLPDEED VDFINEYVNL 70 80 90 100 HNELRGDVIP RGSNLRFMLW YCCDSDGSRF IIGFPNLSPR TPSAPL
	Isoform 4 (epsilon) [UniParc]. Checksum: 47CE644DE34F45DA	FASTA	168	19,373
	10 20 30 40 50 60 MEAARPFARE WRAQSLPLAV GGVLKLRLCE LWLLLLGSSL NARFLPDEED VDFINEYVNL 70 80 90 100 110 120 HNELRGDVIP RGSNLRFMTW DVALSRTARA WGKKCLFTHN IYLQDVQMVH PKFYGIGENM 130 140 150 160 WVGPENEFTA SIAIRSWHAE KKMYNFENGS CSGDCSNYIQ RNTDEKTL
	Isoform 5 (gamma) [UniParc]. Checksum: 5F2A475172E31593	FASTA	237	27,840
	10 20 30 40 50 60 MVHPKFYGIG ENMWVGPENE FTASIAIRSW HAEKKMYNFE NGSCSGDCSN YIQLVWDHSY 70 80 90 100 110 120 KVGCAVTPCS KIGHIIHAAI FICNYAPGGT LTRRPYEPGI FCTRCGRRDK CTDFLCSNAD 130 140 150 160 170 180 RDQATYYRFW YPKWEMPRPV VCDPLCTFIL LLRILCFILC VITVLIVQSQ FPNILLEQQM 190 200 210 220 230 IFTPEESEAG NEEEEKEEEK KEKEEMEMEI MEMEEEKEER EEEEEETQKE KMEEEEK
	Isoform 6 (beta) [UniParc]. Checksum: 586B750F9B0D53B4	FASTA	279	32,810
	10 20 30 40 50 60 MLITMILHRA RTKTWDVALS RTARAWGKKC LFTHNIYLQD VQMVHPKFYG IGENMWVGPE 70 80 90 100 110 120 NEFTASIAIR SWHAEKKMYN FENGSCSGDC SNYIQLVWDH SYKVGCAVTP CSKIGHIIHA 130 140 150 160 170 180 AIFICNYAPG GTLTRRPYEP GIFCTRCGRR DKCTDFLCSN ADRDQATYYR FWYPKWEMPR 190 200 210 220 230 240 PVVCDPLCTF ILLLRILCFI LCVITVLIVQ SQFPNILLEQ QMIFTPEESE AGNEEEEKEE 250 260 270 EKKEKEEMEM EIMEMEEEKE EREEEEEETQ KEKMEEEEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Lymph node.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-308 (ISOFORM 1). Tissue: Brain and Testis.
[6]	"Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster." Ren C., Ren C.-H., Li L., Goltsov A.A., Thompson T.C. Genomics 88:163-172(2006) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 4; 5 AND 6), TISSUE SPECIFICITY, INDUCTION BY DOXYCYCLINE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093175 mRNA. Translation: BAC04085.1. Sequence problems. BX640916 mRNA. Translation: CAE45957.1. Different initiation. AC121761 Genomic DNA. No translation available. CH471054 Genomic DNA. Translation: EAW97305.1. BC016749 mRNA. Translation: AAH16749.1. Sequence problems. BC029557 mRNA. Translation: AAH29557.1.
IPI	IPI00167040. IPI00426028. IPI00644623. IPI00886902. IPI00887390. IPI00887563.
RefSeq	NP_001257325.1. NM_001270396.1. NP_689649.1. NM_152436.2.
UniGene	Hs.406728.
3D structure databases
HSSP	HSSP built from PDB template 1XTA based on UniProtKB Q7T1K6.
ProteinModelPortal	Q4G1C9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q4G1C9. 1 interaction.
STRING	9606.ENSP00000317385.
Polymorphism databases
DMDM	172046790.
Proteomic databases
PaxDb	Q4G1C9.
PRIDE	Q4G1C9.
Protocols and materials databases
DNASU	144321.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320460; ENSP00000317385; ENSG00000180481. ENST00000378689; ENSP00000367960; ENSG00000180481. ENST00000378692; ENSP00000367963; ENSG00000180481. ENST00000435775; ENSP00000398328; ENSG00000180481. ENST00000441218; ENSP00000405273; ENSG00000180481. ENST00000547164; ENSP00000447980; ENSG00000180481. ENST00000550916; ENSP00000448248; ENSG00000180481.
GeneID	144321.
KEGG	hsa:144321.
UCSC	uc001sxp.1. human. uc001sxq.1. human.
Organism-specific databases
CTD	144321.
GeneCards	GC12P075784.
H-InvDB	HIX0022476.
HGNC	HGNC:28592. GLIPR1L2.
HPA	HPA039795. HPA039866.
MIM	610394. gene.
neXtProt	NX_Q4G1C9.
PharmGKB	PA145008279.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327530.
HOGENOM	HOG000036879.
HOVERGEN	HBG072125.
InParanoid	Q4G1C9.
OMA	DTSYKIG.
OrthoDB	EOG4J3WHH.
Gene expression databases
Bgee	Q4G1C9.
CleanEx	HS_GLIPR1L2.
Genevestigator	Q4G1C9.
Family and domain databases
Gene3D	3.40.33.10. 1 hit.
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR014044. CAP_domain. [Graphical view]
PANTHER	PTHR10334. PTHR10334. 1 hit.
Pfam	PF00188. CAP. 1 hit. [Graphical view]
PRINTS	PR00837. V5TPXLIKE.
SMART	SM00198. SCP. 1 hit. [Graphical view]
SUPFAM	SSF55797. SCP-like_extracellular. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	144321.
NextBio	84878.
SOURCE	Search...

Entry information

Entry name

GRPL2_HUMAN

Accession

Primary (citable) accession number: Q4G1C9
Secondary accession number(s): Q6MZS1, Q8N6N0, Q8NA43

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.