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Protein

GLIPR1-like protein 2

Gene

GLIPR1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GLIPR1-like protein 2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28592. GLIPR1L2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei254 – 27421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008279.

Polymorphism and mutation databases

BioMutaiGLIPR1L2.
DMDMi172046790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344GLIPR1-like protein 2PRO_0000324387Add
BLAST

Proteomic databases

EPDiQ4G1C9.
PaxDbiQ4G1C9.
PRIDEiQ4G1C9.
TopDownProteomicsiQ4G1C9-6. [Q4G1C9-6]

Expressioni

Tissue specificityi

Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow.1 Publication

Inductioni

Up-regulated by doxycycline.1 Publication

Gene expression databases

BgeeiQ4G1C9.
CleanExiHS_GLIPR1L2.

Organism-specific databases

HPAiHPA039795.
HPA039866.

Interactioni

Protein-protein interaction databases

BioGridi126842. 11 interactions.
IntActiQ4G1C9. 1 interaction.
STRINGi9606.ENSP00000317385.

Structurei

3D structure databases

ProteinModelPortaliQ4G1C9.
SMRiQ4G1C9. Positions 42-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 192135SCPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 34352Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiQ4G1C9.
OMAiENIWIAS.
OrthoDBiEOG7F7WB4.
PhylomeDBiQ4G1C9.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4G1C9-1) [UniParc]FASTAAdd to basket

Also known as: delta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAARPFARE WRAQSLPLAV GGVLKLRLCE LWLLLLGSSL NARFLPDEED
60 70 80 90 100
VDFINEYVNL HNELRGDVIP RGSNLRFMTW DVALSRTARA WGKKCLFTHN
110 120 130 140 150
IYLQDVQMVH PKFYGIGENM WVGPENEFTA SIAIRSWHAE KKMYNFENGS
160 170 180 190 200
CSGDCSNYIQ LVWDHSYKVG CAVTPCSKIG HIIHAAIFIC NYAPGGTLTR
210 220 230 240 250
RPYEPGIFCT RCGRRDKCTD FLCSNADRDQ ATYYRFWYPK WEMPRPVVCD
260 270 280 290 300
PLCTFILLLR ILCFILCVIT VLIVQSQFPN ILLEQQMIFT PEESEAGNEE
310 320 330 340
EEKEEEKKEK EEMEMEIMEM EEEKEEREEE EEETQKEKME EEEK
Length:344
Mass (Da):40,179
Last modified:March 18, 2008 - v2
Checksum:i8D19B8CB2CEC5786
GO
Isoform 2 (identifier: Q4G1C9-2) [UniParc]FASTAAdd to basket

Also known as: alpha

The sequence of this isoform differs from the canonical sequence as follows:
     225-344: NADRDQATYY...QKEKMEEEEK → KIKKINMKKMHNGLDKKNKRLNTSFLWSC

Show »
Length:253
Mass (Da):29,005
Checksum:iC5FD2B6C60D939A2
GO
Isoform 3 (identifier: Q4G1C9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-106: TWDVALSRTARAWGKKCLFTHNIYLQDV → LWYCCDSDGSRFIIGFPNLSPRTPSAPL
     107-344: Missing.

Note: No experimental confirmation available.
Show »
Length:106
Mass (Da):12,049
Checksum:i7A73BDED667F5D5F
GO
Isoform 4 (identifier: Q4G1C9-4) [UniParc]FASTAAdd to basket

Also known as: epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: L → RNTDEKTL
     162-344: Missing.

Show »
Length:168
Mass (Da):19,373
Checksum:i47CE644DE34F45DA
GO
Isoform 5 (identifier: Q4G1C9-5) [UniParc]FASTAAdd to basket

Also known as: gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Show »
Length:237
Mass (Da):27,840
Checksum:i5F2A475172E31593
GO
Isoform 6 (identifier: Q4G1C9-6) [UniParc]FASTAAdd to basket

Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-78: M → MLITMILHRARTK

Show »
Length:279
Mass (Da):32,810
Checksum:i586B750F9B0D53B4
GO

Sequence cautioni

The sequence AAH16749.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC04085.1 differs from that shown. Reason: Erroneous termination at position 230. Translated as Gln.Curated
The sequence CAE45957.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 5. CuratedVSP_032239Add
BLAST
Alternative sequencei1 – 7777Missing in isoform 6. CuratedVSP_032240Add
BLAST
Alternative sequencei78 – 781M → MLITMILHRARTK in isoform 6. CuratedVSP_032241
Alternative sequencei79 – 10628TWDVA…YLQDV → LWYCCDSDGSRFIIGFPNLS PRTPSAPL in isoform 3. 1 PublicationVSP_032242Add
BLAST
Alternative sequencei107 – 344238Missing in isoform 3. 1 PublicationVSP_032243Add
BLAST
Alternative sequencei161 – 1611L → RNTDEKTL in isoform 4. CuratedVSP_032244
Alternative sequencei162 – 344183Missing in isoform 4. CuratedVSP_032245Add
BLAST
Alternative sequencei225 – 344120NADRD…EEEEK → KIKKINMKKMHNGLDKKNKR LNTSFLWSC in isoform 2. 1 PublicationVSP_032246Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093175 mRNA. Translation: BAC04085.1. Sequence problems.
BX640916 mRNA. Translation: CAE45957.1. Different initiation.
AC121761 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97305.1.
BC016749 mRNA. Translation: AAH16749.1. Sequence problems.
BC029557 mRNA. Translation: AAH29557.1.
CCDSiCCDS58258.1. [Q4G1C9-1]
CCDS9010.1. [Q4G1C9-2]
RefSeqiNP_001257325.1. NM_001270396.1. [Q4G1C9-1]
NP_689649.1. NM_152436.2. [Q4G1C9-2]
XP_011536251.1. XM_011537949.1. [Q4G1C9-5]
XP_011536252.1. XM_011537950.1. [Q4G1C9-5]
UniGeneiHs.406728.

Genome annotation databases

EnsembliENST00000320460; ENSP00000317385; ENSG00000180481. [Q4G1C9-2]
ENST00000378692; ENSP00000367963; ENSG00000180481. [Q4G1C9-5]
ENST00000547164; ENSP00000447980; ENSG00000180481. [Q4G1C9-4]
ENST00000550916; ENSP00000448248; ENSG00000180481. [Q4G1C9-1]
GeneIDi144321.
KEGGihsa:144321.
UCSCiuc001sxp.3. human. [Q4G1C9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093175 mRNA. Translation: BAC04085.1. Sequence problems.
BX640916 mRNA. Translation: CAE45957.1. Different initiation.
AC121761 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97305.1.
BC016749 mRNA. Translation: AAH16749.1. Sequence problems.
BC029557 mRNA. Translation: AAH29557.1.
CCDSiCCDS58258.1. [Q4G1C9-1]
CCDS9010.1. [Q4G1C9-2]
RefSeqiNP_001257325.1. NM_001270396.1. [Q4G1C9-1]
NP_689649.1. NM_152436.2. [Q4G1C9-2]
XP_011536251.1. XM_011537949.1. [Q4G1C9-5]
XP_011536252.1. XM_011537950.1. [Q4G1C9-5]
UniGeneiHs.406728.

3D structure databases

ProteinModelPortaliQ4G1C9.
SMRiQ4G1C9. Positions 42-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126842. 11 interactions.
IntActiQ4G1C9. 1 interaction.
STRINGi9606.ENSP00000317385.

Polymorphism and mutation databases

BioMutaiGLIPR1L2.
DMDMi172046790.

Proteomic databases

EPDiQ4G1C9.
PaxDbiQ4G1C9.
PRIDEiQ4G1C9.
TopDownProteomicsiQ4G1C9-6. [Q4G1C9-6]

Protocols and materials databases

DNASUi144321.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320460; ENSP00000317385; ENSG00000180481. [Q4G1C9-2]
ENST00000378692; ENSP00000367963; ENSG00000180481. [Q4G1C9-5]
ENST00000547164; ENSP00000447980; ENSG00000180481. [Q4G1C9-4]
ENST00000550916; ENSP00000448248; ENSG00000180481. [Q4G1C9-1]
GeneIDi144321.
KEGGihsa:144321.
UCSCiuc001sxp.3. human. [Q4G1C9-1]

Organism-specific databases

CTDi144321.
GeneCardsiGLIPR1L2.
H-InvDBHIX0022476.
HGNCiHGNC:28592. GLIPR1L2.
HPAiHPA039795.
HPA039866.
MIMi610394. gene.
neXtProtiNX_Q4G1C9.
PharmGKBiPA145008279.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiQ4G1C9.
OMAiENIWIAS.
OrthoDBiEOG7F7WB4.
PhylomeDBiQ4G1C9.
TreeFamiTF316148.

Miscellaneous databases

GenomeRNAii144321.
NextBioi84878.
PROiQ4G1C9.
SOURCEiSearch...

Gene expression databases

BgeeiQ4G1C9.
CleanExiHS_GLIPR1L2.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lymph node.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-308 (ISOFORM 1).
    Tissue: Brain and Testis.
  6. "Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster."
    Ren C., Ren C.-H., Li L., Goltsov A.A., Thompson T.C.
    Genomics 88:163-172(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 4; 5 AND 6), TISSUE SPECIFICITY, INDUCTION BY DOXYCYCLINE.

Entry informationi

Entry nameiGRPL2_HUMAN
AccessioniPrimary (citable) accession number: Q4G1C9
Secondary accession number(s): Q6MZS1, Q8N6N0, Q8NA43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 16, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.