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Protein

F-box only protein 43

Gene

FBXO43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).Curated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri622 – 681IBR-typeAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processMeiosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 43
Alternative name(s):
Endogenous meiotic inhibitor 2
Gene namesi
Name:FBXO43
Synonyms:EMI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000156509.13
HGNCiHGNC:28521 FBXO43
MIMi609110 gene
neXtProtiNX_Q4G163

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi75 – 76DS → AA: Impairs ubiquitination and degradation in response to calcium. 1 Publication2
Mutagenesisi333 – 334DS → AA: Impairs ubiquitination and degradation in response to calcium. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000156509
PharmGKBiPA134913061

Polymorphism and mutation databases

BioMutaiFBXO43
DMDMi152031603

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472331 – 708F-box only protein 43Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76Phosphoserine1 Publication1
Modified residuei234Phosphothreonine1 Publication1
Modified residuei334Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation.2 Publications
Ubiquitinated in response to calcium, which promotes proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ4G163
PaxDbiQ4G163
PeptideAtlasiQ4G163
PRIDEiQ4G163

PTM databases

iPTMnetiQ4G163
PhosphoSitePlusiQ4G163

Expressioni

Gene expression databases

BgeeiENSG00000156509
CleanExiHS_FBXO43
ExpressionAtlasiQ4G163 baseline and differential
GenevisibleiQ4G163 HS

Organism-specific databases

HPAiHPA024292
HPA024295
HPA024824

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. May interact with CDC20 (By similarity).By similarity

Protein-protein interaction databases

BioGridi130316, 2 interactors
ELMiQ4G163
IntActiQ4G163, 2 interactors
STRINGi9606.ENSP00000403293

Structurei

3D structure databases

ProteinModelPortaliQ4G163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini490 – 547F-boxAdd BLAST58

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri622 – 681IBR-typeAdd BLAST60

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHWX Eukaryota
ENOG410XUB4 LUCA
GeneTreeiENSGT00530000063692
HOGENOMiHOG000112548
HOVERGENiHBG081522
InParanoidiQ4G163
KOiK10318
OMAiFEVECIS
OrthoDBiEOG091G08DI
PhylomeDBiQ4G163
TreeFamiTF101170

Family and domain databases

InterProiView protein in InterPro
IPR002867 IBR_dom
SMARTiView protein in SMART
SM00647 IBR, 1 hit

Sequencei

Sequence statusi: Complete.

Q4G163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKDKDERI SCLEAYVTLT SKSSRFTDET EILKMSQRHS GQAGTEAGNG
60 70 80 90 100
ADSPPIVNSK YSTFRDFCST SSFQDSGYNE LKSCSFDNID KEYLGKKEKG
110 120 130 140 150
PTLLYEHPET SGLGLTHPLE SPTQKKKCIL PRKEKDKTPE LCETPKISGK
160 170 180 190 200
KCLPRRRLNV SFALLKGDFE SQNSSLESSI SQVINLEKNI PSSASGFSRA
210 220 230 240 250
NNFSPLVTST LKTEEVTSCS QKLRLNFSQQ KTSTIDDSKD DCSLFEVECI
260 270 280 290 300
SPIQGNNFKD SITHDFSDSS LCINDENACP ELLGSSVSGT TCGTDEDIFV
310 320 330 340 350
TPISNLVANI RFNASQILSP SPEVRGSIST PEDSGFNSLS LEKSEDSLSD
360 370 380 390 400
QEGSFQELLQ KHKGTPKVGD TIRKTRHLGR SRRLSTLREQ SSQSETEEEK
410 420 430 440 450
QIVHPDSEKR AAAASAISEG QLSSDESGDL TFSLKNLSKT PALQLVHELF
460 470 480 490 500
MKSKRKRLQE NSGHEFLEQG DGEKIAVLQC ILAGLIGKKM GIEKLDILTE
510 520 530 540 550
LKYRNLKHIL AMVLESLTAE SLCSVWKVSR NWREIVVQDK NANRRRKFYI
560 570 580 590 600
TQLKTDSEGA VLNVEDAATR LQLLNRSALR SVQAQARIPG SQREQGSTLS
610 620 630 640 650
PWGEVLTPLA SSSVTHLSSK QEEYVKVAKT LFTDEALKPC PRCQSPAKYQ
660 670 680 690 700
PYKKRGLCSR TACGFDFCVL CLCAYHGSEE CSRGAAKPRN RKDALPGSAQ

SKRNLKRL
Length:708
Mass (Da):78,402
Last modified:July 10, 2007 - v3
Checksum:iE42A358AE7BD29D1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061168139P → L. Corresponds to variant dbSNP:rs2279102Ensembl.1
Natural variantiVAR_061169139P → R. Corresponds to variant dbSNP:rs2279102Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021590 Genomic DNA No translation available.
CCDSiCCDS47904.1
RefSeqiNP_001025031.2, NM_001029860.3
UniGeneiHs.339577

Genome annotation databases

EnsembliENST00000428847; ENSP00000403293; ENSG00000156509
GeneIDi286151
KEGGihsa:286151
UCSCiuc003yjd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFBX43_HUMAN
AccessioniPrimary (citable) accession number: Q4G163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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