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Q4G112

- HSF5_HUMAN

UniProt

Q4G112 - HSF5_HUMAN

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Protein

Heat shock factor protein 5

Gene

HSF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a transcriptional factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi10 – 200191By similarityAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor protein 5
Short name:
HSF 5
Alternative name(s):
Heat shock transcription factor 5
Short name:
HSTF 5
Gene namesi
Name:HSF5
Synonyms:HSTF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26862. HSF5.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Heat shock factor protein 5PRO_0000333041Add
BLAST

Proteomic databases

PaxDbiQ4G112.
PRIDEiQ4G112.

PTM databases

PhosphoSiteiQ4G112.

Expressioni

Gene expression databases

BgeeiQ4G112.
CleanExiHS_HSF5.
GenevestigatoriQ4G112.

Organism-specific databases

HPAiHPA016440.

Interactioni

Protein-protein interaction databases

BioGridi125871. 2 interactions.
IntActiQ4G112. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ4G112.
SMRiQ4G112. Positions 11-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiCOG5169.
GeneTreeiENSGT00510000048674.
HOGENOMiHOG000059263.
HOVERGENiHBG096755.
InParanoidiQ4G112.
OMAiTNFTSFI.
OrthoDBiEOG7J70F6.
PhylomeDBiQ4G112.
TreeFamiTF330401.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR027736. HSF5.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF138. PTHR10015:SF138. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
SMARTiSM00415. HSF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q4G112-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL
60 70 80 90 100
LSPPGPGGGG GTAGAGAEPE LFKTTSFTSF IRQLNLYGFR KVVLGGPGGG
110 120 130 140 150
KPAGNGPLHH FHNPHFRRDQ PQLLVHLKRL TSANKAKLAA GLEVPCRPPN
160 170 180 190 200
RFQRLLITSA SAATAPLQHQ QPPPPAGPRP EPHGPVAVGQ FHRSFRRDSL
210 220 230 240 250
SPYSCVSTPS HDHSTYPLKG LDRTPVPHRI WQNSLGMHPG QVETSPTFSD
260 270 280 290 300
KGVPFPVLQR FPTEVTYTLQ PSTTSVHVQQ GPQTMVSSSQ KYSNYTPSAQ
310 320 330 340 350
YSQAYYPTAV LQCCSPTHMD ALSSCVTPNA SSYAHCNYFQ NPSMQSSYPV
360 370 380 390 400
EFLPSNWPCS TTDENTKTEV NLEAVFQIVD ELHSSPKLEM VKVEPVENQC
410 420 430 440 450
PTSPSYRGQH ILANSNNSNP CSASQASQLE PLTPVGSDIM SFVVGTEQAV
460 470 480 490 500
ACSLPQSPEY IYTIHTAQPV ENSTIQESAA IQQAHVKLKE HLNHNPSPSS
510 520 530 540 550
VVFVQEGPPF STHQVDANIK CQTSSRENIL PSEQMGFLIS EMGPASKPSE
560 570 580 590
DTGLATPARY REHRSNSQQG KSPDLHLLVD VACKQERFPK EEELKE
Length:596
Mass (Da):65,278
Last modified:May 18, 2010 - v2
Checksum:iB00CD96A9375896E
GO
Isoform 2 (identifier: Q4G112-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-173: Missing.

Show »
Length:475
Mass (Da):52,541
Checksum:iACA45B99DCD12BC9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti329 – 3291N → T.2 Publications
Corresponds to variant rs1017089 [ dbSNP | Ensembl ].
VAR_043115
Natural varianti473 – 4731S → N.
Corresponds to variant rs3803752 [ dbSNP | Ensembl ].
VAR_055935

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei53 – 173121Missing in isoform 2. 1 PublicationVSP_033454Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005666 Genomic DNA. No translation available.
AC023992 Genomic DNA. No translation available.
BC033017 mRNA. Translation: AAH33017.1.
BC033020 mRNA. Translation: AAH33020.1.
BC115385 mRNA. Translation: AAI15386.1.
AK097630 mRNA. Translation: BAC05124.1.
CCDSiCCDS32690.1. [Q4G112-1]
RefSeqiNP_001073908.2. NM_001080439.2.
UniGeneiHs.380061.

Genome annotation databases

EnsembliENST00000323777; ENSP00000313243; ENSG00000176160.
ENST00000617946; ENSP00000484295; ENSG00000176160.
GeneIDi124535.
KEGGihsa:124535.
UCSCiuc002iwi.1. human. [Q4G112-1]

Polymorphism databases

DMDMi296434535.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005666 Genomic DNA. No translation available.
AC023992 Genomic DNA. No translation available.
BC033017 mRNA. Translation: AAH33017.1 .
BC033020 mRNA. Translation: AAH33020.1 .
BC115385 mRNA. Translation: AAI15386.1 .
AK097630 mRNA. Translation: BAC05124.1 .
CCDSi CCDS32690.1. [Q4G112-1 ]
RefSeqi NP_001073908.2. NM_001080439.2.
UniGenei Hs.380061.

3D structure databases

ProteinModelPortali Q4G112.
SMRi Q4G112. Positions 11-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125871. 2 interactions.
IntActi Q4G112. 2 interactions.

PTM databases

PhosphoSitei Q4G112.

Polymorphism databases

DMDMi 296434535.

Proteomic databases

PaxDbi Q4G112.
PRIDEi Q4G112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323777 ; ENSP00000313243 ; ENSG00000176160 .
ENST00000617946 ; ENSP00000484295 ; ENSG00000176160 .
GeneIDi 124535.
KEGGi hsa:124535.
UCSCi uc002iwi.1. human. [Q4G112-1 ]

Organism-specific databases

CTDi 124535.
GeneCardsi GC17M056497.
HGNCi HGNC:26862. HSF5.
HPAi HPA016440.
neXtProti NX_Q4G112.
PharmGKBi PA145008204.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5169.
GeneTreei ENSGT00510000048674.
HOGENOMi HOG000059263.
HOVERGENi HBG096755.
InParanoidi Q4G112.
OMAi TNFTSFI.
OrthoDBi EOG7J70F6.
PhylomeDBi Q4G112.
TreeFami TF330401.

Miscellaneous databases

ChiTaRSi HSF5. human.
GenomeRNAii 124535.
NextBioi 81304.
PROi Q4G112.

Gene expression databases

Bgeei Q4G112.
CleanExi HS_HSF5.
Genevestigatori Q4G112.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR027736. HSF5.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10015. PTHR10015. 1 hit.
PTHR10015:SF138. PTHR10015:SF138. 1 hit.
Pfami PF00447. HSF_DNA-bind. 1 hit.
[Graphical view ]
SMARTi SM00415. HSF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-329.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-596 (ISOFORMS 1/2), VARIANT THR-329.
    Tissue: Testis.

Entry informationi

Entry nameiHSF5_HUMAN
AccessioniPrimary (citable) accession number: Q4G112
Secondary accession number(s): Q08EH7, Q8N7V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3