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Q4G112

- HSF5_HUMAN

UniProt

Q4G112 - HSF5_HUMAN

Protein

Heat shock factor protein 5

Gene

HSF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May act as a transcriptional factor.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi10 – 200191By similarityAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock factor protein 5
    Short name:
    HSF 5
    Alternative name(s):
    Heat shock transcription factor 5
    Short name:
    HSTF 5
    Gene namesi
    Name:HSF5
    Synonyms:HSTF5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26862. HSF5.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145008204.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 596596Heat shock factor protein 5PRO_0000333041Add
    BLAST

    Proteomic databases

    PaxDbiQ4G112.
    PRIDEiQ4G112.

    PTM databases

    PhosphoSiteiQ4G112.

    Expressioni

    Gene expression databases

    BgeeiQ4G112.
    CleanExiHS_HSF5.
    GenevestigatoriQ4G112.

    Organism-specific databases

    HPAiHPA016440.

    Interactioni

    Protein-protein interaction databases

    IntActiQ4G112. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G112.
    SMRiQ4G112. Positions 11-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HSF family.Curated

    Phylogenomic databases

    eggNOGiCOG5169.
    HOGENOMiHOG000059263.
    HOVERGENiHBG096755.
    InParanoidiQ4G112.
    OMAiTNFTSFI.
    OrthoDBiEOG7J70F6.
    PhylomeDBiQ4G112.
    TreeFamiTF330401.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR027736. HSF5.
    IPR000232. HSF_DNA-bd.
    IPR027725. HSF_fam.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10015. PTHR10015. 1 hit.
    PTHR10015:SF138. PTHR10015:SF138. 1 hit.
    PfamiPF00447. HSF_DNA-bind. 1 hit.
    [Graphical view]
    SMARTiSM00415. HSF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4G112-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL    50
    LSPPGPGGGG GTAGAGAEPE LFKTTSFTSF IRQLNLYGFR KVVLGGPGGG 100
    KPAGNGPLHH FHNPHFRRDQ PQLLVHLKRL TSANKAKLAA GLEVPCRPPN 150
    RFQRLLITSA SAATAPLQHQ QPPPPAGPRP EPHGPVAVGQ FHRSFRRDSL 200
    SPYSCVSTPS HDHSTYPLKG LDRTPVPHRI WQNSLGMHPG QVETSPTFSD 250
    KGVPFPVLQR FPTEVTYTLQ PSTTSVHVQQ GPQTMVSSSQ KYSNYTPSAQ 300
    YSQAYYPTAV LQCCSPTHMD ALSSCVTPNA SSYAHCNYFQ NPSMQSSYPV 350
    EFLPSNWPCS TTDENTKTEV NLEAVFQIVD ELHSSPKLEM VKVEPVENQC 400
    PTSPSYRGQH ILANSNNSNP CSASQASQLE PLTPVGSDIM SFVVGTEQAV 450
    ACSLPQSPEY IYTIHTAQPV ENSTIQESAA IQQAHVKLKE HLNHNPSPSS 500
    VVFVQEGPPF STHQVDANIK CQTSSRENIL PSEQMGFLIS EMGPASKPSE 550
    DTGLATPARY REHRSNSQQG KSPDLHLLVD VACKQERFPK EEELKE 596
    Length:596
    Mass (Da):65,278
    Last modified:May 18, 2010 - v2
    Checksum:iB00CD96A9375896E
    GO
    Isoform 2 (identifier: Q4G112-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         53-173: Missing.

    Show »
    Length:475
    Mass (Da):52,541
    Checksum:iACA45B99DCD12BC9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti329 – 3291N → T.2 Publications
    Corresponds to variant rs1017089 [ dbSNP | Ensembl ].
    VAR_043115
    Natural varianti473 – 4731S → N.
    Corresponds to variant rs3803752 [ dbSNP | Ensembl ].
    VAR_055935

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei53 – 173121Missing in isoform 2. 1 PublicationVSP_033454Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005666 Genomic DNA. No translation available.
    AC023992 Genomic DNA. No translation available.
    BC033017 mRNA. Translation: AAH33017.1.
    BC033020 mRNA. Translation: AAH33020.1.
    BC115385 mRNA. Translation: AAI15386.1.
    AK097630 mRNA. Translation: BAC05124.1.
    CCDSiCCDS32690.1. [Q4G112-1]
    RefSeqiNP_001073908.2. NM_001080439.2.
    UniGeneiHs.380061.

    Genome annotation databases

    EnsembliENST00000323777; ENSP00000313243; ENSG00000176160. [Q4G112-1]
    GeneIDi124535.
    KEGGihsa:124535.
    UCSCiuc002iwi.1. human. [Q4G112-1]

    Polymorphism databases

    DMDMi296434535.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005666 Genomic DNA. No translation available.
    AC023992 Genomic DNA. No translation available.
    BC033017 mRNA. Translation: AAH33017.1 .
    BC033020 mRNA. Translation: AAH33020.1 .
    BC115385 mRNA. Translation: AAI15386.1 .
    AK097630 mRNA. Translation: BAC05124.1 .
    CCDSi CCDS32690.1. [Q4G112-1 ]
    RefSeqi NP_001073908.2. NM_001080439.2.
    UniGenei Hs.380061.

    3D structure databases

    ProteinModelPortali Q4G112.
    SMRi Q4G112. Positions 11-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q4G112. 2 interactions.

    PTM databases

    PhosphoSitei Q4G112.

    Polymorphism databases

    DMDMi 296434535.

    Proteomic databases

    PaxDbi Q4G112.
    PRIDEi Q4G112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323777 ; ENSP00000313243 ; ENSG00000176160 . [Q4G112-1 ]
    GeneIDi 124535.
    KEGGi hsa:124535.
    UCSCi uc002iwi.1. human. [Q4G112-1 ]

    Organism-specific databases

    CTDi 124535.
    GeneCardsi GC17M056497.
    HGNCi HGNC:26862. HSF5.
    HPAi HPA016440.
    neXtProti NX_Q4G112.
    PharmGKBi PA145008204.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5169.
    HOGENOMi HOG000059263.
    HOVERGENi HBG096755.
    InParanoidi Q4G112.
    OMAi TNFTSFI.
    OrthoDBi EOG7J70F6.
    PhylomeDBi Q4G112.
    TreeFami TF330401.

    Miscellaneous databases

    ChiTaRSi HSF5. human.
    GenomeRNAii 124535.
    NextBioi 81304.
    PROi Q4G112.

    Gene expression databases

    Bgeei Q4G112.
    CleanExi HS_HSF5.
    Genevestigatori Q4G112.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR027736. HSF5.
    IPR000232. HSF_DNA-bd.
    IPR027725. HSF_fam.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10015. PTHR10015. 1 hit.
    PTHR10015:SF138. PTHR10015:SF138. 1 hit.
    Pfami PF00447. HSF_DNA-bind. 1 hit.
    [Graphical view ]
    SMARTi SM00415. HSF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-329.
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-596 (ISOFORMS 1/2), VARIANT THR-329.
      Tissue: Testis.

    Entry informationi

    Entry nameiHSF5_HUMAN
    AccessioniPrimary (citable) accession number: Q4G112
    Secondary accession number(s): Q08EH7, Q8N7V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3