Q4G112 (HSF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock factor protein 5
Short name=HSF 5

Alternative name(s):
Heat shock transcription factor 5
Short name=HSTF 5

Gene names

Name:	HSF5
Synonyms:	HSTF5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a transcriptional factor By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the HSF family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4G112-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4G112-2)

The sequence of this isoform differs from the canonical sequence as follows:
     53-173: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Heat shock factor protein 5		PRO_0000333041
Regions
	DNA binding	10 – 200	191	By similarity
Natural variations
	Alternative sequence	53 – 173	121	Missing in isoform 2.		VSP_033454
	Natural variant	329	1	N → T. Ref.2 Ref.3 Corresponds to variant rs1017089 [ dbSNP | Ensembl ].		VAR_043115
	Natural variant	473	1	S → N. Corresponds to variant rs3803752 [ dbSNP | Ensembl ].		VAR_055935

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: B00CD96A9375896E	FASTA	596	65,278
	10 20 30 40 50 60 MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL LSPPGPGGGG 70 80 90 100 110 120 GTAGAGAEPE LFKTTSFTSF IRQLNLYGFR KVVLGGPGGG KPAGNGPLHH FHNPHFRRDQ 130 140 150 160 170 180 PQLLVHLKRL TSANKAKLAA GLEVPCRPPN RFQRLLITSA SAATAPLQHQ QPPPPAGPRP 190 200 210 220 230 240 EPHGPVAVGQ FHRSFRRDSL SPYSCVSTPS HDHSTYPLKG LDRTPVPHRI WQNSLGMHPG 250 260 270 280 290 300 QVETSPTFSD KGVPFPVLQR FPTEVTYTLQ PSTTSVHVQQ GPQTMVSSSQ KYSNYTPSAQ 310 320 330 340 350 360 YSQAYYPTAV LQCCSPTHMD ALSSCVTPNA SSYAHCNYFQ NPSMQSSYPV EFLPSNWPCS 370 380 390 400 410 420 TTDENTKTEV NLEAVFQIVD ELHSSPKLEM VKVEPVENQC PTSPSYRGQH ILANSNNSNP 430 440 450 460 470 480 CSASQASQLE PLTPVGSDIM SFVVGTEQAV ACSLPQSPEY IYTIHTAQPV ENSTIQESAA 490 500 510 520 530 540 IQQAHVKLKE HLNHNPSPSS VVFVQEGPPF STHQVDANIK CQTSSRENIL PSEQMGFLIS 550 560 570 580 590 EMGPASKPSE DTGLATPARY REHRSNSQQG KSPDLHLLVD VACKQERFPK EEELKE
	Isoform 2 [UniParc]. Checksum: ACA45B99DCD12BC9	FASTA	475	52,541
	10 20 30 40 50 60 MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL LSPPAGPRPE 70 80 90 100 110 120 PHGPVAVGQF HRSFRRDSLS PYSCVSTPSH DHSTYPLKGL DRTPVPHRIW QNSLGMHPGQ 130 140 150 160 170 180 VETSPTFSDK GVPFPVLQRF PTEVTYTLQP STTSVHVQQG PQTMVSSSQK YSNYTPSAQY 190 200 210 220 230 240 SQAYYPTAVL QCCSPTHMDA LSSCVTPNAS SYAHCNYFQN PSMQSSYPVE FLPSNWPCST 250 260 270 280 290 300 TDENTKTEVN LEAVFQIVDE LHSSPKLEMV KVEPVENQCP TSPSYRGQHI LANSNNSNPC 310 320 330 340 350 360 SASQASQLEP LTPVGSDIMS FVVGTEQAVA CSLPQSPEYI YTIHTAQPVE NSTIQESAAI 370 380 390 400 410 420 QQAHVKLKEH LNHNPSPSSV VFVQEGPPFS THQVDANIKC QTSSRENILP SEQMGFLISE 430 440 450 460 470 MGPASKPSED TGLATPARYR EHRSNSQQGK SPDLHLLVDV ACKQERFPKE EELKE

References

[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-329. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-596 (ISOFORMS 1/2), VARIANT THR-329. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005666 Genomic DNA. No translation available. AC023992 Genomic DNA. No translation available. BC033017 mRNA. Translation: AAH33017.1. BC033020 mRNA. Translation: AAH33020.1. BC115385 mRNA. Translation: AAI15386.1. AK097630 mRNA. Translation: BAC05124.1.
IPI	IPI00297953. IPI00983044.
RefSeq	NP_001073908.1. NM_001080439.1.
UniGene	Hs.380061.
3D structure databases
ProteinModelPortal	Q4G112.
SMR	Q4G112. Positions 11-129.
ModBase	Search...
PTM databases
PhosphoSite	Q4G112.
Polymorphism databases
DMDM	296434535.
Proteomic databases
PaxDb	Q4G112.
PRIDE	Q4G112.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323777; ENSP00000313243; ENSG00000176160.
GeneID	124535.
KEGG	hsa:124535.
UCSC	uc002iwi.1. human.
Organism-specific databases
CTD	124535.
GeneCards	GC17M056497.
HGNC	HGNC:26862. HSF5.
HPA	HPA016440.
neXtProt	NX_Q4G112.
PharmGKB	PA145008204.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5169.
HOGENOM	HOG000059263.
HOVERGEN	HBG096755.
InParanoid	Q4G112.
OMA	TNFTSFI.
OrthoDB	EOG42NJ04.
Gene expression databases
Bgee	Q4G112.
CleanEx	HS_HSF5.
Genevestigator	Q4G112.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR000232. HSF_DNA-bd. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00447. HSF_DNA-bind. 1 hit. [Graphical view]
SMART	SM00415. HSF. 1 hit. [Graphical view]
PROSITE	PS00434. HSF_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HSF5. human.
GenomeRNAi	124535.
NextBio	81304.

Entry information

Entry name

HSF5_HUMAN

Accession

Primary (citable) accession number: Q4G112
Secondary accession number(s): Q08EH7, Q8N7V2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.