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Q4G112 (HSF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock factor protein 5

Short name=HSF 5
Alternative name(s):
Heat shock transcription factor 5
Short name=HSTF 5
Gene names
Name:HSF5
Synonyms:HSTF5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a transcriptional factor By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the HSF family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4G112-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4G112-2)

The sequence of this isoform differs from the canonical sequence as follows:
     53-173: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Heat shock factor protein 5
PRO_0000333041

Regions

DNA binding10 – 200191 By similarity

Natural variations

Alternative sequence53 – 173121Missing in isoform 2.
VSP_033454
Natural variant3291N → T. Ref.2 Ref.3
Corresponds to variant rs1017089 [ dbSNP | Ensembl ].
VAR_043115
Natural variant4731S → N.
Corresponds to variant rs3803752 [ dbSNP | Ensembl ].
VAR_055935

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: B00CD96A9375896E

FASTA59665,278
        10         20         30         40         50         60 
MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL LSPPGPGGGG 

        70         80         90        100        110        120 
GTAGAGAEPE LFKTTSFTSF IRQLNLYGFR KVVLGGPGGG KPAGNGPLHH FHNPHFRRDQ 

       130        140        150        160        170        180 
PQLLVHLKRL TSANKAKLAA GLEVPCRPPN RFQRLLITSA SAATAPLQHQ QPPPPAGPRP 

       190        200        210        220        230        240 
EPHGPVAVGQ FHRSFRRDSL SPYSCVSTPS HDHSTYPLKG LDRTPVPHRI WQNSLGMHPG 

       250        260        270        280        290        300 
QVETSPTFSD KGVPFPVLQR FPTEVTYTLQ PSTTSVHVQQ GPQTMVSSSQ KYSNYTPSAQ 

       310        320        330        340        350        360 
YSQAYYPTAV LQCCSPTHMD ALSSCVTPNA SSYAHCNYFQ NPSMQSSYPV EFLPSNWPCS 

       370        380        390        400        410        420 
TTDENTKTEV NLEAVFQIVD ELHSSPKLEM VKVEPVENQC PTSPSYRGQH ILANSNNSNP 

       430        440        450        460        470        480 
CSASQASQLE PLTPVGSDIM SFVVGTEQAV ACSLPQSPEY IYTIHTAQPV ENSTIQESAA 

       490        500        510        520        530        540 
IQQAHVKLKE HLNHNPSPSS VVFVQEGPPF STHQVDANIK CQTSSRENIL PSEQMGFLIS 

       550        560        570        580        590 
EMGPASKPSE DTGLATPARY REHRSNSQQG KSPDLHLLVD VACKQERFPK EEELKE 

« Hide

Isoform 2 [UniParc].

Checksum: ACA45B99DCD12BC9
Show »

FASTA47552,541

References

[1]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-329.
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-596 (ISOFORMS 1/2), VARIANT THR-329.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005666 Genomic DNA. No translation available.
AC023992 Genomic DNA. No translation available.
BC033017 mRNA. Translation: AAH33017.1.
BC033020 mRNA. Translation: AAH33020.1.
BC115385 mRNA. Translation: AAI15386.1.
AK097630 mRNA. Translation: BAC05124.1.
RefSeqNP_001073908.2. NM_001080439.2. [Q4G112-1]
UniGeneHs.380061.

3D structure databases

ProteinModelPortalQ4G112.
SMRQ4G112. Positions 11-129.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ4G112.

Polymorphism databases

DMDM296434535.

Proteomic databases

PaxDbQ4G112.
PRIDEQ4G112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323777; ENSP00000313243; ENSG00000176160. [Q4G112-1]
GeneID124535.
KEGGhsa:124535.
UCSCuc002iwi.1. human. [Q4G112-1]

Organism-specific databases

CTD124535.
GeneCardsGC17M056497.
HGNCHGNC:26862. HSF5.
HPAHPA016440.
neXtProtNX_Q4G112.
PharmGKBPA145008204.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5169.
HOGENOMHOG000059263.
HOVERGENHBG096755.
InParanoidQ4G112.
OMATNFTSFI.
OrthoDBEOG7J70F6.
PhylomeDBQ4G112.
TreeFamTF330401.

Gene expression databases

BgeeQ4G112.
CleanExHS_HSF5.
GenevestigatorQ4G112.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR027736. HSF5.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF138. PTHR10015:SF138. 1 hit.
PfamPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
SMARTSM00415. HSF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHSF5. human.
GenomeRNAi124535.
NextBio81304.
PROQ4G112.

Entry information

Entry nameHSF5_HUMAN
AccessionPrimary (citable) accession number: Q4G112
Secondary accession number(s): Q08EH7, Q8N7V2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM