Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock factor protein 5

Gene

HSF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcriptional factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi10 – 200By similarityAdd BLAST191

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor protein 5
Short name:
HSF 5
Alternative name(s):
Heat shock transcription factor 5
Short name:
HSTF 5
Gene namesi
Name:HSF5
Synonyms:HSTF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000176160.9
HGNCiHGNC:26862 HSF5
neXtProtiNX_Q4G112

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi124535
PharmGKBiPA145008204

Polymorphism and mutation databases

BioMutaiHSF5
DMDMi296434535

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330411 – 596Heat shock factor protein 5Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei572PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4G112
PeptideAtlasiQ4G112
PRIDEiQ4G112

PTM databases

iPTMnetiQ4G112
PhosphoSitePlusiQ4G112

Expressioni

Gene expression databases

BgeeiENSG00000176160
CleanExiHS_HSF5
GenevisibleiQ4G112 HS

Organism-specific databases

HPAiHPA063613

Interactioni

Protein-protein interaction databases

BioGridi125871, 2 interactors
IntActiQ4G112, 2 interactors
STRINGi9606.ENSP00000313243

Structurei

3D structure databases

ProteinModelPortaliQ4G112
SMRiQ4G112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiKOG1508 Eukaryota
ENOG410XQRX LUCA
HOGENOMiHOG000059263
HOVERGENiHBG096755
InParanoidiQ4G112
OrthoDBiEOG091G07YE
PhylomeDBiQ4G112
TreeFamiTF330401

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR027736 HSF5
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PTHR10015:SF215 PTHR10015:SF215, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4G112-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL
60 70 80 90 100
LSPPGPGGGG GTAGAGAEPE LFKTTSFTSF IRQLNLYGFR KVVLGGPGGG
110 120 130 140 150
KPAGNGPLHH FHNPHFRRDQ PQLLVHLKRL TSANKAKLAA GLEVPCRPPN
160 170 180 190 200
RFQRLLITSA SAATAPLQHQ QPPPPAGPRP EPHGPVAVGQ FHRSFRRDSL
210 220 230 240 250
SPYSCVSTPS HDHSTYPLKG LDRTPVPHRI WQNSLGMHPG QVETSPTFSD
260 270 280 290 300
KGVPFPVLQR FPTEVTYTLQ PSTTSVHVQQ GPQTMVSSSQ KYSNYTPSAQ
310 320 330 340 350
YSQAYYPTAV LQCCSPTHMD ALSSCVTPNA SSYAHCNYFQ NPSMQSSYPV
360 370 380 390 400
EFLPSNWPCS TTDENTKTEV NLEAVFQIVD ELHSSPKLEM VKVEPVENQC
410 420 430 440 450
PTSPSYRGQH ILANSNNSNP CSASQASQLE PLTPVGSDIM SFVVGTEQAV
460 470 480 490 500
ACSLPQSPEY IYTIHTAQPV ENSTIQESAA IQQAHVKLKE HLNHNPSPSS
510 520 530 540 550
VVFVQEGPPF STHQVDANIK CQTSSRENIL PSEQMGFLIS EMGPASKPSE
560 570 580 590
DTGLATPARY REHRSNSQQG KSPDLHLLVD VACKQERFPK EEELKE
Length:596
Mass (Da):65,278
Last modified:May 18, 2010 - v2
Checksum:iB00CD96A9375896E
GO
Isoform 2 (identifier: Q4G112-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-173: Missing.

Show »
Length:475
Mass (Da):52,541
Checksum:iACA45B99DCD12BC9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043115329N → T2 PublicationsCorresponds to variant dbSNP:rs1017089Ensembl.1
Natural variantiVAR_055935473S → N. Corresponds to variant dbSNP:rs3803752Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03345453 – 173Missing in isoform 2. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005666 Genomic DNA No translation available.
AC023992 Genomic DNA No translation available.
BC033017 mRNA Translation: AAH33017.1
BC033020 mRNA Translation: AAH33020.1
BC115385 mRNA Translation: AAI15386.1
AK097630 mRNA Translation: BAC05124.1
CCDSiCCDS32690.1 [Q4G112-1]
RefSeqiNP_001073908.2, NM_001080439.2
UniGeneiHs.380061

Genome annotation databases

EnsembliENST00000323777; ENSP00000313243; ENSG00000176160
ENST00000617946; ENSP00000484295; ENSG00000176160
GeneIDi124535
KEGGihsa:124535
UCSCiuc002iwi.2 human [Q4G112-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHSF5_HUMAN
AccessioniPrimary (citable) accession number: Q4G112
Secondary accession number(s): Q08EH7, Q8N7V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health