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Protein

BTB/POZ domain-containing protein KCTD21

Gene

KCTD21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • cullin family protein binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD21
Alternative name(s):
KCASH2 protein1 Publication
Potassium channel tetramerization domain-containing protein 21
Gene namesi
Name:KCTD21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000188997.7.
HGNCiHGNC:27452. KCTD21.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85 – 87DFY → KKK: Abolishes interaction with CUL3. 1 Publication3

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi283219.
OpenTargetsiENSG00000188997.
PharmGKBiPA145148689.

Polymorphism and mutation databases

BioMutaiKCTD21.
DMDMi121943921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811511 – 260BTB/POZ domain-containing protein KCTD21Add BLAST260

Proteomic databases

EPDiQ4G0X4.
MaxQBiQ4G0X4.
PaxDbiQ4G0X4.
PeptideAtlasiQ4G0X4.
PRIDEiQ4G0X4.

PTM databases

iPTMnetiQ4G0X4.
PhosphoSitePlusiQ4G0X4.

Expressioni

Tissue specificityi

Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.1 Publication

Gene expression databases

BgeeiENSG00000188997.
CleanExiHS_KCTD21.
ExpressionAtlasiQ4G0X4. baseline and differential.
GenevisibleiQ4G0X4. HS.

Organism-specific databases

HPAiHPA041964.

Interactioni

Subunit structurei

Homopentamer (By similarity). Interacts with KCTD11; KCTD21 and KCTD11 may associate in pentameric assemblies. Interacts (via BTB domain) with CUL3; indicative for a participation in a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:21472142).By similarityCurated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPLO604374EBI-11976683,EBI-368321

GO - Molecular functioni

  • cullin family protein binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi129500. 13 interactors.
IntActiQ4G0X4. 9 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ4G0X4.
SMRiQ4G0X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 72BTBPROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili88 – 112Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 140Poly-Ser6

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000231837.
HOVERGENiHBG080457.
InParanoidiQ4G0X4.
KOiK21922.
OMAiYTRQNLK.
OrthoDBiEOG091G0DC8.
PhylomeDBiQ4G0X4.
TreeFamiTF315332.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4G0X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID
60 70 80 90 100
RDGKVFRYIL NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE
110 120 130 140 150
VELSKAEKNA MLNITLNQRV QTVHFTVREA PQIYSLSSSS MEVFNANIFS
160 170 180 190 200
TSCLFLKLLG SKLFYCSNGN LSSITSHLQD PNHLTLDWVA NVEGLPEEEY
210 220 230 240 250
TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS SHPHALDFMN
260
NKIIRLIRYR
Length:260
Mass (Da):29,643
Last modified:August 30, 2005 - v1
Checksum:iE94BAD422C106070
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152S → P in BAG62072 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300320 mRNA. Translation: BAG62072.1.
BC036058 mRNA. Translation: AAH36058.1.
CCDSiCCDS31645.1.
RefSeqiNP_001025030.1. NM_001029859.2.
XP_005273985.1. XM_005273928.1.
XP_006718580.1. XM_006718517.2.
XP_006718581.1. XM_006718518.3.
XP_011543257.1. XM_011544955.2.
UniGeneiHs.528439.

Genome annotation databases

EnsembliENST00000340067; ENSP00000339340; ENSG00000188997.
GeneIDi283219.
KEGGihsa:283219.
UCSCiuc001ozb.4. human.

Similar proteinsi

Entry informationi

Entry nameiKCD21_HUMAN
AccessioniPrimary (citable) accession number: Q4G0X4
Secondary accession number(s): B4DTR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 30, 2005
Last modified: November 22, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways