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Protein

BTB/POZ domain-containing protein KCTD21

Gene

KCTD21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD21
Gene namesi
Name:KCTD21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27452. KCTD21.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148689.

Polymorphism and mutation databases

BioMutaiKCTD21.
DMDMi121943921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260BTB/POZ domain-containing protein KCTD21PRO_0000281151Add
BLAST

Proteomic databases

EPDiQ4G0X4.
MaxQBiQ4G0X4.
PaxDbiQ4G0X4.
PeptideAtlasiQ4G0X4.
PRIDEiQ4G0X4.

PTM databases

iPTMnetiQ4G0X4.

Expressioni

Gene expression databases

BgeeiQ4G0X4.
CleanExiHS_KCTD21.
ExpressionAtlasiQ4G0X4. baseline and differential.
GenevisibleiQ4G0X4. HS.

Organism-specific databases

HPAiHPA041964.

Interactioni

Protein-protein interaction databases

BioGridi129500. 9 interactions.
STRINGi9606.ENSP00000339340.

Structurei

3D structure databases

ProteinModelPortaliQ4G0X4.
SMRiQ4G0X4. Positions 4-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 7270BTBPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili88 – 11225Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1406Poly-Ser

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000231837.
HOVERGENiHBG080457.
InParanoidiQ4G0X4.
OMAiYTRQNLK.
OrthoDBiEOG741Z4M.
PhylomeDBiQ4G0X4.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID
60 70 80 90 100
RDGKVFRYIL NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE
110 120 130 140 150
VELSKAEKNA MLNITLNQRV QTVHFTVREA PQIYSLSSSS MEVFNANIFS
160 170 180 190 200
TSCLFLKLLG SKLFYCSNGN LSSITSHLQD PNHLTLDWVA NVEGLPEEEY
210 220 230 240 250
TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS SHPHALDFMN
260
NKIIRLIRYR
Length:260
Mass (Da):29,643
Last modified:August 30, 2005 - v1
Checksum:iE94BAD422C106070
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521S → P in BAG62072 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300320 mRNA. Translation: BAG62072.1.
BC036058 mRNA. Translation: AAH36058.1.
CCDSiCCDS31645.1.
RefSeqiNP_001025030.1. NM_001029859.2.
XP_005273985.1. XM_005273928.1.
XP_005273986.1. XM_005273929.2.
XP_006718580.1. XM_006718517.2.
XP_006718581.1. XM_006718518.2.
XP_011543257.1. XM_011544955.1.
XP_011543258.1. XM_011544956.1.
UniGeneiHs.528439.

Genome annotation databases

EnsembliENST00000340067; ENSP00000339340; ENSG00000188997.
GeneIDi283219.
KEGGihsa:283219.
UCSCiuc001ozb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300320 mRNA. Translation: BAG62072.1.
BC036058 mRNA. Translation: AAH36058.1.
CCDSiCCDS31645.1.
RefSeqiNP_001025030.1. NM_001029859.2.
XP_005273985.1. XM_005273928.1.
XP_005273986.1. XM_005273929.2.
XP_006718580.1. XM_006718517.2.
XP_006718581.1. XM_006718518.2.
XP_011543257.1. XM_011544955.1.
XP_011543258.1. XM_011544956.1.
UniGeneiHs.528439.

3D structure databases

ProteinModelPortaliQ4G0X4.
SMRiQ4G0X4. Positions 4-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129500. 9 interactions.
STRINGi9606.ENSP00000339340.

PTM databases

iPTMnetiQ4G0X4.

Polymorphism and mutation databases

BioMutaiKCTD21.
DMDMi121943921.

Proteomic databases

EPDiQ4G0X4.
MaxQBiQ4G0X4.
PaxDbiQ4G0X4.
PeptideAtlasiQ4G0X4.
PRIDEiQ4G0X4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340067; ENSP00000339340; ENSG00000188997.
GeneIDi283219.
KEGGihsa:283219.
UCSCiuc001ozb.4. human.

Organism-specific databases

CTDi283219.
GeneCardsiKCTD21.
HGNCiHGNC:27452. KCTD21.
HPAiHPA041964.
neXtProtiNX_Q4G0X4.
PharmGKBiPA145148689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000231837.
HOVERGENiHBG080457.
InParanoidiQ4G0X4.
OMAiYTRQNLK.
OrthoDBiEOG741Z4M.
PhylomeDBiQ4G0X4.
TreeFamiTF315332.

Miscellaneous databases

ChiTaRSiKCTD21. human.
GenomeRNAii283219.
PROiQ4G0X4.

Gene expression databases

BgeeiQ4G0X4.
CleanExiHS_KCTD21.
ExpressionAtlasiQ4G0X4. baseline and differential.
GenevisibleiQ4G0X4. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKCD21_HUMAN
AccessioniPrimary (citable) accession number: Q4G0X4
Secondary accession number(s): B4DTR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 30, 2005
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.