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Q4G0W2 (DUS28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity phosphatase 28

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:DUSP28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Dual specificity phosphatase 28
PRO_0000302840

Regions

Domain76 – 13863Tyrosine-protein phosphatase

Sites

Active site1031Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4G0W2 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 3BB208F7373814B0

FASTA17618,324
        10         20         30         40         50         60 
MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN VSRQQPGPRA 

        70         80         90        100        110        120 
PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL VYCKNGRSRS AAVCTAYLMR 

       130        140        150        160        170 
HRGLSLAKAF QMVKSARPVA EPNPGFWSQL QKYEEALQAQ SCLQGEPPAL GLGPEA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC036198 mRNA. Translation: AAH36198.1.
RefSeqNP_001028747.1. NM_001033575.1.
UniGeneHs.369297.
Hs.672568.

3D structure databases

ProteinModelPortalQ4G0W2.
SMRQ4G0W2. Positions 10-166.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130042. 1 interaction.
STRING9606.ENSP00000344235.

Polymorphism databases

DMDM121943916.

Proteomic databases

PaxDbQ4G0W2.
PRIDEQ4G0W2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343217; ENSP00000344235; ENSG00000188542.
ENST00000405954; ENSP00000385885; ENSG00000188542.
GeneID285193.
KEGGhsa:285193.
UCSCuc002vzg.3. human.

Organism-specific databases

CTD285193.
GeneCardsGC02P241499.
HGNCHGNC:33237. DUSP28.
HPAHPA047456.
neXtProtNX_Q4G0W2.
PharmGKBPA162384124.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313004.
HOGENOMHOG000233766.
HOVERGENHBG051422.
InParanoidQ4G0W2.
KOK14165.
OMAAKAFQMV.
OrthoDBEOG715Q5Z.
PhylomeDBQ4G0W2.
TreeFamTF105128.

Gene expression databases

BgeeQ4G0W2.
CleanExHS_DUSP28.
GenevestigatorQ4G0W2.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi285193.
NextBio95338.
PROQ4G0W2.

Entry information

Entry nameDUS28_HUMAN
AccessionPrimary (citable) accession number: Q4G0W2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 30, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM