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Protein

Dual specificity phosphatase 28

Gene

DUSP28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei103 – 1031Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: GO_Central
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. JNK cascade Source: GO_Central
  2. protein dephosphorylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase 28 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUSP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33237. DUSP28.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Dual specificity phosphatase 28PRO_0000302840Add
BLAST

Proteomic databases

PaxDbiQ4G0W2.
PRIDEiQ4G0W2.

PTM databases

DEPODiQ4G0W2.

Expressioni

Gene expression databases

BgeeiQ4G0W2.
CleanExiHS_DUSP28.
GenevestigatoriQ4G0W2.

Organism-specific databases

HPAiCAB069448.
HPA047456.

Interactioni

Protein-protein interaction databases

BioGridi130042. 3 interactions.
STRINGi9606.ENSP00000344235.

Structurei

3D structure databases

ProteinModelPortaliQ4G0W2.
SMRiQ4G0W2. Positions 10-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 13863Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG313004.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ4G0W2.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG715Q5Z.
PhylomeDBiQ4G0W2.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN
60 70 80 90 100
VSRQQPGPRA PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL
110 120 130 140 150
VYCKNGRSRS AAVCTAYLMR HRGLSLAKAF QMVKSARPVA EPNPGFWSQL
160 170
QKYEEALQAQ SCLQGEPPAL GLGPEA
Length:176
Mass (Da):18,324
Last modified:August 30, 2005 - v1
Checksum:i3BB208F7373814B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036198 mRNA. Translation: AAH36198.1.
CCDSiCCDS33418.1.
RefSeqiNP_001028747.1. NM_001033575.1.
XP_006712518.1. XM_006712455.1.
XP_006712519.1. XM_006712456.1.
UniGeneiHs.369297.
Hs.672568.

Genome annotation databases

EnsembliENST00000343217; ENSP00000344235; ENSG00000188542.
ENST00000405954; ENSP00000385885; ENSG00000188542.
GeneIDi285193.
KEGGihsa:285193.
UCSCiuc002vzg.3. human.

Polymorphism databases

DMDMi121943916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036198 mRNA. Translation: AAH36198.1.
CCDSiCCDS33418.1.
RefSeqiNP_001028747.1. NM_001033575.1.
XP_006712518.1. XM_006712455.1.
XP_006712519.1. XM_006712456.1.
UniGeneiHs.369297.
Hs.672568.

3D structure databases

ProteinModelPortaliQ4G0W2.
SMRiQ4G0W2. Positions 10-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130042. 3 interactions.
STRINGi9606.ENSP00000344235.

PTM databases

DEPODiQ4G0W2.

Polymorphism databases

DMDMi121943916.

Proteomic databases

PaxDbiQ4G0W2.
PRIDEiQ4G0W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343217; ENSP00000344235; ENSG00000188542.
ENST00000405954; ENSP00000385885; ENSG00000188542.
GeneIDi285193.
KEGGihsa:285193.
UCSCiuc002vzg.3. human.

Organism-specific databases

CTDi285193.
GeneCardsiGC02P241499.
HGNCiHGNC:33237. DUSP28.
HPAiCAB069448.
HPA047456.
neXtProtiNX_Q4G0W2.
PharmGKBiPA162384124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG313004.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ4G0W2.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG715Q5Z.
PhylomeDBiQ4G0W2.
TreeFamiTF105128.

Miscellaneous databases

GenomeRNAii285193.
NextBioi95338.
PROiQ4G0W2.

Gene expression databases

BgeeiQ4G0W2.
CleanExiHS_DUSP28.
GenevestigatoriQ4G0W2.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDUS28_HUMAN
AccessioniPrimary (citable) accession number: Q4G0W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 30, 2005
Last modified: March 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.