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Protein

Dual specificity phosphatase 28

Gene

DUSP28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei103Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • dephosphorylation Source: UniProtKB
  • peptidyl-tyrosine dephosphorylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:G66-33658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase 28 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUSP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33237. DUSP28.

Pathology & Biotechi

Organism-specific databases

DisGeNETi285193.
OpenTargetsiENSG00000188542.
PharmGKBiPA162384124.

Polymorphism and mutation databases

BioMutaiDUSP28.
DMDMi121943916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028401 – 176Dual specificity phosphatase 28Add BLAST176

Proteomic databases

EPDiQ4G0W2.
PaxDbiQ4G0W2.
PeptideAtlasiQ4G0W2.
PRIDEiQ4G0W2.

PTM databases

DEPODiQ4G0W2.
iPTMnetiQ4G0W2.
PhosphoSitePlusiQ4G0W2.

Expressioni

Gene expression databases

BgeeiENSG00000188542.
CleanExiHS_DUSP28.
ExpressionAtlasiQ4G0W2. baseline and differential.
GenevisibleiQ4G0W2. HS.

Organism-specific databases

HPAiCAB069448.
HPA047456.

Interactioni

Protein-protein interaction databases

BioGridi130042. 3 interactors.
STRINGi9606.ENSP00000344235.

Structurei

3D structure databases

ProteinModelPortaliQ4G0W2.
SMRiQ4G0W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 138Tyrosine-protein phosphataseAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1718. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ4G0W2.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG091G0RMR.
PhylomeDBiQ4G0W2.
TreeFamiTF105128.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN
60 70 80 90 100
VSRQQPGPRA PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL
110 120 130 140 150
VYCKNGRSRS AAVCTAYLMR HRGLSLAKAF QMVKSARPVA EPNPGFWSQL
160 170
QKYEEALQAQ SCLQGEPPAL GLGPEA
Length:176
Mass (Da):18,324
Last modified:August 30, 2005 - v1
Checksum:i3BB208F7373814B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036198 mRNA. Translation: AAH36198.1.
CCDSiCCDS33418.1.
RefSeqiNP_001028747.1. NM_001033575.1.
UniGeneiHs.369297.
Hs.672568.

Genome annotation databases

EnsembliENST00000343217; ENSP00000344235; ENSG00000188542.
ENST00000405954; ENSP00000385885; ENSG00000188542.
GeneIDi285193.
KEGGihsa:285193.
UCSCiuc002vzg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036198 mRNA. Translation: AAH36198.1.
CCDSiCCDS33418.1.
RefSeqiNP_001028747.1. NM_001033575.1.
UniGeneiHs.369297.
Hs.672568.

3D structure databases

ProteinModelPortaliQ4G0W2.
SMRiQ4G0W2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130042. 3 interactors.
STRINGi9606.ENSP00000344235.

PTM databases

DEPODiQ4G0W2.
iPTMnetiQ4G0W2.
PhosphoSitePlusiQ4G0W2.

Polymorphism and mutation databases

BioMutaiDUSP28.
DMDMi121943916.

Proteomic databases

EPDiQ4G0W2.
PaxDbiQ4G0W2.
PeptideAtlasiQ4G0W2.
PRIDEiQ4G0W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343217; ENSP00000344235; ENSG00000188542.
ENST00000405954; ENSP00000385885; ENSG00000188542.
GeneIDi285193.
KEGGihsa:285193.
UCSCiuc002vzg.3. human.

Organism-specific databases

CTDi285193.
DisGeNETi285193.
GeneCardsiDUSP28.
HGNCiHGNC:33237. DUSP28.
HPAiCAB069448.
HPA047456.
neXtProtiNX_Q4G0W2.
OpenTargetsiENSG00000188542.
PharmGKBiPA162384124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1718. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ4G0W2.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG091G0RMR.
PhylomeDBiQ4G0W2.
TreeFamiTF105128.

Enzyme and pathway databases

BioCyciZFISH:G66-33658-MONOMER.

Miscellaneous databases

GenomeRNAii285193.
PROiQ4G0W2.

Gene expression databases

BgeeiENSG00000188542.
CleanExiHS_DUSP28.
ExpressionAtlasiQ4G0W2. baseline and differential.
GenevisibleiQ4G0W2. HS.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS28_HUMAN
AccessioniPrimary (citable) accession number: Q4G0W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.