Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4G0W2

- DUS28_HUMAN

UniProt

Q4G0W2 - DUS28_HUMAN

Protein

Dual specificity phosphatase 28

Gene

DUSP28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei103 – 1031Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. JNK cascade Source: RefGenome
    2. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity phosphatase 28 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:DUSP28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:33237. DUSP28.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162384124.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 176176Dual specificity phosphatase 28PRO_0000302840Add
    BLAST

    Proteomic databases

    PaxDbiQ4G0W2.
    PRIDEiQ4G0W2.

    Expressioni

    Gene expression databases

    BgeeiQ4G0W2.
    CleanExiHS_DUSP28.
    GenevestigatoriQ4G0W2.

    Organism-specific databases

    HPAiHPA047456.

    Interactioni

    Protein-protein interaction databases

    BioGridi130042. 1 interaction.
    STRINGi9606.ENSP00000344235.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G0W2.
    SMRiQ4G0W2. Positions 10-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini76 – 13863Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG313004.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiQ4G0W2.
    KOiK14165.
    OMAiAKAFQMV.
    OrthoDBiEOG715Q5Z.
    PhylomeDBiQ4G0W2.
    TreeFamiTF105128.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4G0W2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN    50
    VSRQQPGPRA PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL 100
    VYCKNGRSRS AAVCTAYLMR HRGLSLAKAF QMVKSARPVA EPNPGFWSQL 150
    QKYEEALQAQ SCLQGEPPAL GLGPEA 176
    Length:176
    Mass (Da):18,324
    Last modified:August 30, 2005 - v1
    Checksum:i3BB208F7373814B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC036198 mRNA. Translation: AAH36198.1.
    CCDSiCCDS33418.1.
    RefSeqiNP_001028747.1. NM_001033575.1.
    XP_006712518.1. XM_006712455.1.
    XP_006712519.1. XM_006712456.1.
    UniGeneiHs.369297.
    Hs.672568.

    Genome annotation databases

    EnsembliENST00000343217; ENSP00000344235; ENSG00000188542.
    ENST00000405954; ENSP00000385885; ENSG00000188542.
    GeneIDi285193.
    KEGGihsa:285193.
    UCSCiuc002vzg.3. human.

    Polymorphism databases

    DMDMi121943916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC036198 mRNA. Translation: AAH36198.1 .
    CCDSi CCDS33418.1.
    RefSeqi NP_001028747.1. NM_001033575.1.
    XP_006712518.1. XM_006712455.1.
    XP_006712519.1. XM_006712456.1.
    UniGenei Hs.369297.
    Hs.672568.

    3D structure databases

    ProteinModelPortali Q4G0W2.
    SMRi Q4G0W2. Positions 10-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130042. 1 interaction.
    STRINGi 9606.ENSP00000344235.

    Polymorphism databases

    DMDMi 121943916.

    Proteomic databases

    PaxDbi Q4G0W2.
    PRIDEi Q4G0W2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343217 ; ENSP00000344235 ; ENSG00000188542 .
    ENST00000405954 ; ENSP00000385885 ; ENSG00000188542 .
    GeneIDi 285193.
    KEGGi hsa:285193.
    UCSCi uc002vzg.3. human.

    Organism-specific databases

    CTDi 285193.
    GeneCardsi GC02P241499.
    HGNCi HGNC:33237. DUSP28.
    HPAi HPA047456.
    neXtProti NX_Q4G0W2.
    PharmGKBi PA162384124.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313004.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi Q4G0W2.
    KOi K14165.
    OMAi AKAFQMV.
    OrthoDBi EOG715Q5Z.
    PhylomeDBi Q4G0W2.
    TreeFami TF105128.

    Miscellaneous databases

    GenomeRNAii 285193.
    NextBioi 95338.
    PROi Q4G0W2.

    Gene expression databases

    Bgeei Q4G0W2.
    CleanExi HS_DUSP28.
    Genevestigatori Q4G0W2.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiDUS28_HUMAN
    AccessioniPrimary (citable) accession number: Q4G0W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3