Q4G0W2 (DUS28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity phosphatase 28
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:

DUSP28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Dual specificity phosphatase 28		PRO_0000302840
Regions
	Domain	76 – 138	63	Tyrosine-protein phosphatase
Sites
	Active site	103	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4G0W2 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 3BB208F7373814B0	FASTA	176	18,324
	10 20 30 40 50 60 MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN VSRQQPGPRA 70 80 90 100 110 120 PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL VYCKNGRSRS AAVCTAYLMR 130 140 150 160 170 HRGLSLAKAF QMVKSARPVA EPNPGFWSQL QKYEEALQAQ SCLQGEPPAL GLGPEA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC036198 mRNA. Translation: AAH36198.1.
IPI	IPI00175103.
RefSeq	NP_001028747.1. NM_001033575.1.
UniGene	Hs.369297.
3D structure databases
HSSP	HSSP built from PDB template 2ESB based on UniProtKB Q8NEJ0.
ProteinModelPortal	Q4G0W2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000344235.
Polymorphism databases
DMDM	121943916.
Proteomic databases
PaxDb	Q4G0W2.
PRIDE	Q4G0W2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343217; ENSP00000344235; ENSG00000188542. ENST00000405954; ENSP00000385885; ENSG00000188542.
GeneID	285193.
KEGG	hsa:285193.
UCSC	uc002vzg.3. human.
Organism-specific databases
CTD	285193.
GeneCards	GC02P241499.
HGNC	HGNC:33237. DUSP28.
HPA	HPA047456.
neXtProt	NX_Q4G0W2.
PharmGKB	PA162384124.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313004.
HOGENOM	HOG000233766.
HOVERGEN	HBG051422.
InParanoid	Q4G0W2.
KO	K14165.
OMA	EPNLGFW.
OrthoDB	EOG447FVS.
Gene expression databases
Bgee	Q4G0W2.
CleanEx	HS_DUSP28.
Genevestigator	Q4G0W2.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	285193.
NextBio	95338.

Entry information

Entry name

DUS28_HUMAN

Accession

Primary (citable) accession number: Q4G0W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.