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Q4G0W2

- DUS28_HUMAN

UniProt

Q4G0W2 - DUS28_HUMAN

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Protein

Dual specificity phosphatase 28

Gene
DUSP28
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei103 – 1031Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. JNK cascade Source: RefGenome
  2. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase 28 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUSP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:33237. DUSP28.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Dual specificity phosphatase 28PRO_0000302840Add
BLAST

Proteomic databases

PaxDbiQ4G0W2.
PRIDEiQ4G0W2.

Expressioni

Gene expression databases

BgeeiQ4G0W2.
CleanExiHS_DUSP28.
GenevestigatoriQ4G0W2.

Organism-specific databases

HPAiHPA047456.

Interactioni

Protein-protein interaction databases

BioGridi130042. 1 interaction.
STRINGi9606.ENSP00000344235.

Structurei

3D structure databases

ProteinModelPortaliQ4G0W2.
SMRiQ4G0W2. Positions 10-166.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 13863Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG313004.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ4G0W2.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG715Q5Z.
PhylomeDBiQ4G0W2.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0W2-1 [UniParc]FASTAAdd to Basket

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MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN    50
VSRQQPGPRA PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL 100
VYCKNGRSRS AAVCTAYLMR HRGLSLAKAF QMVKSARPVA EPNPGFWSQL 150
QKYEEALQAQ SCLQGEPPAL GLGPEA 176
Length:176
Mass (Da):18,324
Last modified:August 30, 2005 - v1
Checksum:i3BB208F7373814B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC036198 mRNA. Translation: AAH36198.1.
CCDSiCCDS33418.1.
RefSeqiNP_001028747.1. NM_001033575.1.
XP_006712518.1. XM_006712455.1.
XP_006712519.1. XM_006712456.1.
UniGeneiHs.369297.
Hs.672568.

Genome annotation databases

EnsembliENST00000343217; ENSP00000344235; ENSG00000188542.
ENST00000405954; ENSP00000385885; ENSG00000188542.
GeneIDi285193.
KEGGihsa:285193.
UCSCiuc002vzg.3. human.

Polymorphism databases

DMDMi121943916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC036198 mRNA. Translation: AAH36198.1 .
CCDSi CCDS33418.1.
RefSeqi NP_001028747.1. NM_001033575.1.
XP_006712518.1. XM_006712455.1.
XP_006712519.1. XM_006712456.1.
UniGenei Hs.369297.
Hs.672568.

3D structure databases

ProteinModelPortali Q4G0W2.
SMRi Q4G0W2. Positions 10-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130042. 1 interaction.
STRINGi 9606.ENSP00000344235.

Polymorphism databases

DMDMi 121943916.

Proteomic databases

PaxDbi Q4G0W2.
PRIDEi Q4G0W2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343217 ; ENSP00000344235 ; ENSG00000188542 .
ENST00000405954 ; ENSP00000385885 ; ENSG00000188542 .
GeneIDi 285193.
KEGGi hsa:285193.
UCSCi uc002vzg.3. human.

Organism-specific databases

CTDi 285193.
GeneCardsi GC02P241499.
HGNCi HGNC:33237. DUSP28.
HPAi HPA047456.
neXtProti NX_Q4G0W2.
PharmGKBi PA162384124.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313004.
HOGENOMi HOG000233766.
HOVERGENi HBG051422.
InParanoidi Q4G0W2.
KOi K14165.
OMAi AKAFQMV.
OrthoDBi EOG715Q5Z.
PhylomeDBi Q4G0W2.
TreeFami TF105128.

Miscellaneous databases

GenomeRNAii 285193.
NextBioi 95338.
PROi Q4G0W2.

Gene expression databases

Bgeei Q4G0W2.
CleanExi HS_DUSP28.
Genevestigatori Q4G0W2.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDUS28_HUMAN
AccessioniPrimary (citable) accession number: Q4G0W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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