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Protein

Scavenger receptor cysteine-rich domain-containing protein SCART1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • T cell mediated immunity Source: UniProtKB

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor cysteine-rich domain-containing protein SCART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 906ExtracellularSequence analysisAdd BLAST887
Transmembranei907 – 927HelicalSequence analysisAdd BLAST21
Topological domaini928 – 1027CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214279.

Polymorphism and mutation databases

DMDMi308153504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039939220 – 1027Scavenger receptor cysteine-rich domain-containing protein SCART1Add BLAST1008

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 117PROSITE-ProRule annotation
Disulfide bondi66 ↔ 127PROSITE-ProRule annotation
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 107PROSITE-ProRule annotation
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 216PROSITE-ProRule annotation
Disulfide bondi171 ↔ 226PROSITE-ProRule annotation
Disulfide bondi196 ↔ 206PROSITE-ProRule annotation
Disulfide bondi253 ↔ 315PROSITE-ProRule annotation
Disulfide bondi266 ↔ 325PROSITE-ProRule annotation
Disulfide bondi297 ↔ 307PROSITE-ProRule annotation
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi353 ↔ 417PROSITE-ProRule annotation
Disulfide bondi366 ↔ 427PROSITE-ProRule annotation
Disulfide bondi397 ↔ 407PROSITE-ProRule annotation
Disulfide bondi472 ↔ 533PROSITE-ProRule annotation
Disulfide bondi503 ↔ 513PROSITE-ProRule annotation
Disulfide bondi594 ↔ 655PROSITE-ProRule annotation
Disulfide bondi625 ↔ 635PROSITE-ProRule annotation
Disulfide bondi824 ↔ 885PROSITE-ProRule annotation
Disulfide bondi855 ↔ 865PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4G0T1.
PeptideAtlasiQ4G0T1.
PRIDEiQ4G0T1.

Expressioni

Tissue specificityi

Mainly expressed by CD4+ and CD8+ T lymphocytes. Also highly expressed in small intestine and colon. Expressed (at protein level) in small intestine, stomach, gall bladder, and placental villi.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329303.

Structurei

3D structure databases

ProteinModelPortaliQ4G0T1.
SMRiQ4G0T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 128SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini135 – 227SRCR 2PROSITE-ProRule annotationAdd BLAST93
Domaini232 – 326SRCR 3PROSITE-ProRule annotationAdd BLAST95
Domaini328 – 428SRCR 4PROSITE-ProRule annotationAdd BLAST101
Domaini434 – 534SRCR 5PROSITE-ProRule annotationAdd BLAST101
Domaini555 – 656SRCR 6PROSITE-ProRule annotationAdd BLAST102
Domaini661 – 761SRCR 7PROSITE-ProRule annotationAdd BLAST101
Domaini786 – 886SRCR 8PROSITE-ProRule annotationAdd BLAST101

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00900000140803.
HOGENOMiHOG000290652.
PhylomeDBiQ4G0T1.

Family and domain databases

Gene3Di3.10.250.10. 3 hits.
InterProiView protein in InterPro
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR036772. SRCR-like_dom_sf.
PfamiView protein in Pfam
PF00530. SRCR. 8 hits.
PRINTSiPR00258. SPERACTRCPTR.
SMARTiView protein in SMART
SM00202. SR. 7 hits.
SUPFAMiSSF56487. SSF56487. 8 hits.
PROSITEiView protein in PROSITE
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 8 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4G0T1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAALWTLGL GPLLLNLWAV PIGGPGALRL AYRHSTCDGV VLVRHHGAWG
60 70 80 90 100
YVCNQEWTLA EASVVCRQLG CGPAVGAPKY VPLPGEMAQP WLHNVSCRGN
110 120 130 140 150
ESSLWECSLG SWCQSPCPHA WVVVALCSNG TFRELRLVKG RSPCAGLPEI
160 170 180 190 200
RNVNGVDRLC VLHVEEAMVF CRELGCGPVL QAPRRDVGVV RKYLACRGTE
210 220 230 240 250
PTIRSCRLDN NFRSGCDLRL DAEVVCSGHT EARLVGGEHP CAGRLEVTWG
260 270 280 290 300
TVCDAALDLA TAHVVCRELQ CGAVVSTPEG ARFGRGSGPV WTEAFRCAGN
310 320 330 340 350
ESLLFHCPRG RGSQCGHGHD AGLRCSEFRM VNGSSSCEGR VEFQVQGSWA
360 370 380 390 400
PLCATHWDIA DATVLCHQLN CGNAVAAPGG GHFGDGDAAI WPDAFHCEGT
410 420 430 440 450
ESYLWNCPVS TLGAPACAPG NTASAVCSGL AHALRLREGQ SRCDGRVEVS
460 470 480 490 500
LDGVWGRVLD DAWDLRGAGV VCRQLGCRGA QQAYDAPAPS RGSVQVALSR
510 520 530 540 550
VRCLGTETRL TQCNVSATLQ EPAGTSRDAG VVCSGEVGTA SPMARRHGIP
560 570 580 590 600
GALTLSLHRE PQGAAGRGAG ALHGGAWGTV CDDAWDLRDA HVVCRQLGCG
610 620 630 640 650
RALSALGAAH FGAGAGRIWL DELGCQGHES ALWQCPSAGW GRHDWRHKED
660 670 680 690 700
AGVFCSESVA LRLRGGTCCC AGWLDVFYNG TWGAMCSNAL KDLSLSIICK
710 720 730 740 750
QLGCGVWGVG LAGEQALPLC GHRDRLGGQH RVPQAAQLHS VAMPFPPMAP
760 770 780 790 800
ALLRPSRAGL SEDRPQAAGE PLNCSSWLGC PEEGALRVRG GEDRCSGRVE
810 820 830 840 850
LWHAGSWGTV CDDGWDLADA EVVCRQLGCG RAVAALGAAA FGPGSGPVWL
860 870 880 890 900
DEVGCRGSEA SLWGCPAERW GRGDRAHEED AGVRCWEPGP GPPLPAAPFR
910 920 930 940 950
TFWVVSVVLG SLLGLLLLGL MAFLILPRVT QAMQRGLGRS EVSPGEAIYD
960 970 980 990 1000
VIGEMPPAGL YEEIMEAEAV LQDEEDGSVV KVDTEAAVSG EVSNLLEGQS
1010 1020
IRAEGGHSRP VSQGYDEAAF PLEEMTL
Note: Gene prediction based on EST data.
Length:1,027
Mass (Da):108,611
Last modified:October 5, 2010 - v2
Checksum:i6E956AC67ECDA48D
GO
Isoform Gamma (identifier: Q4G0T1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-232: HTEA → EAAT
     233-1027: Missing.

Show »
Length:232
Mass (Da):25,190
Checksum:i64AD58CC652C3A88
GO
Isoform Alpha (identifier: Q4G0T1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-324: Missing.
     657-935: Missing.

Show »
Length:649
Mass (Da):68,842
Checksum:i91DB49F1C4E9017A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89Q → K in BC038300 (PubMed:15489334).Curated1
Sequence conflicti136R → G in BC038300 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053841226 – 324Missing in isoform Alpha. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_039839229 – 232HTEA → EAAT in isoform Gamma. 1 Publication4
Alternative sequenceiVSP_039840233 – 1027Missing in isoform Gamma. 1 PublicationAdd BLAST795
Alternative sequenceiVSP_053842657 – 935Missing in isoform Alpha. 1 PublicationAdd BLAST279

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161645 Genomic DNA. No translation available.
BC038300 mRNA. No translation available.
UniGeneiHs.659384.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRCRM_HUMAN
AccessioniPrimary (citable) accession number: Q4G0T1
Secondary accession number(s): C9K0L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 5, 2010
Last modified: October 25, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM