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Protein

Cytochrome P450 27C1

Gene

CYP27C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi318Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Chemistry databases

SwissLipidsiSLP:000001617.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 27C1 (EC:1.14.-.-)
Gene namesi
Name:CYP27C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33480. CYP27C1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186684.
PharmGKBiPA162383091.

Polymorphism and mutation databases

BioMutaiCYP27C1.
DMDMi296434415.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002937321 – 372Cytochrome P450 27C1Add BLAST372

Proteomic databases

PaxDbiQ4G0S4.
PeptideAtlasiQ4G0S4.
PRIDEiQ4G0S4.

PTM databases

iPTMnetiQ4G0S4.
PhosphoSitePlusiQ4G0S4.

Expressioni

Gene expression databases

BgeeiENSG00000186684.
CleanExiHS_CYP27C1.
ExpressionAtlasiQ4G0S4. baseline and differential.
GenevisibleiQ4G0S4. HS.

Interactioni

Protein-protein interaction databases

BioGridi130927. 1 interactor.
IntActiQ4G0S4. 1 interactor.
STRINGi9606.ENSP00000334128.

Structurei

3D structure databases

ProteinModelPortaliQ4G0S4.
SMRiQ4G0S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000119243.
HOGENOMiHOG000253961.
HOVERGENiHBG106909.
InParanoidiQ4G0S4.
KOiK17951.
OMAiEMPGPNT.
OrthoDBiEOG091G0MI3.
PhylomeDBiQ4G0S4.
TreeFamiTF105094.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSVLRQRIL KPKDVAIYSG EVNQVIADLI KRIYLLRSQA EDGETVTNVN
60 70 80 90 100
DLFFKYSMEG VATILYESRL GCLENSIPQL TVEYIEALEL MFSMFKTSMY
110 120 130 140 150
AGAIPRWLRP FIPKPWREFC RSWDGLFKFS QIHVDNKLRD IQYQMDRGRR
160 170 180 190 200
VSGGLLTYLF LSQALTLQEI YANVTEMLLA GVDTTSFTLS WTVYLLARHP
210 220 230 240 250
EVQQTVYREI VKNLGERHVP TAADVPKVPL VRALLKETLR LFPVLPGNGR
260 270 280 290 300
VTQEDLVIGG YLIPKGTQLA LCHYATSYQD ENFPRAKEFR PERWLRKGDL
310 320 330 340 350
DRVDNFGSIP FGHGVRSCIG RRIAELEIHL VVIQLLQHFE IKTSSQTNAV
360 370
HAKTHGLLTP GGPIHVRFVN RK
Length:372
Mass (Da):42,632
Last modified:May 18, 2010 - v2
Checksum:iF6274FE61FCA3A8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195L → I in AAH39307 (PubMed:15815621).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033120359T → M.Corresponds to variant rs35075135dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131190 mRNA. Translation: BAD18388.1.
AC110926 Genomic DNA. No translation available.
BC039307 mRNA. Translation: AAH39307.1.
CCDSiCCDS33285.1.
RefSeqiNP_001001665.3. NM_001001665.3.
UniGeneiHs.407639.

Genome annotation databases

EnsembliENST00000335247; ENSP00000334128; ENSG00000186684.
ENST00000409327; ENSP00000387198; ENSG00000186684.
GeneIDi339761.
KEGGihsa:339761.
UCSCiuc002tod.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131190 mRNA. Translation: BAD18388.1.
AC110926 Genomic DNA. No translation available.
BC039307 mRNA. Translation: AAH39307.1.
CCDSiCCDS33285.1.
RefSeqiNP_001001665.3. NM_001001665.3.
UniGeneiHs.407639.

3D structure databases

ProteinModelPortaliQ4G0S4.
SMRiQ4G0S4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130927. 1 interactor.
IntActiQ4G0S4. 1 interactor.
STRINGi9606.ENSP00000334128.

Chemistry databases

SwissLipidsiSLP:000001617.

PTM databases

iPTMnetiQ4G0S4.
PhosphoSitePlusiQ4G0S4.

Polymorphism and mutation databases

BioMutaiCYP27C1.
DMDMi296434415.

Proteomic databases

PaxDbiQ4G0S4.
PeptideAtlasiQ4G0S4.
PRIDEiQ4G0S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335247; ENSP00000334128; ENSG00000186684.
ENST00000409327; ENSP00000387198; ENSG00000186684.
GeneIDi339761.
KEGGihsa:339761.
UCSCiuc002tod.3. human.

Organism-specific databases

CTDi339761.
GeneCardsiCYP27C1.
HGNCiHGNC:33480. CYP27C1.
neXtProtiNX_Q4G0S4.
OpenTargetsiENSG00000186684.
PharmGKBiPA162383091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000119243.
HOGENOMiHOG000253961.
HOVERGENiHBG106909.
InParanoidiQ4G0S4.
KOiK17951.
OMAiEMPGPNT.
OrthoDBiEOG091G0MI3.
PhylomeDBiQ4G0S4.
TreeFamiTF105094.

Miscellaneous databases

ChiTaRSiCYP27C1. human.
GeneWikiiCYP27C1.
GenomeRNAii339761.
PROiQ4G0S4.

Gene expression databases

BgeeiENSG00000186684.
CleanExiHS_CYP27C1.
ExpressionAtlasiQ4G0S4. baseline and differential.
GenevisibleiQ4G0S4. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC27C1_HUMAN
AccessioniPrimary (citable) accession number: Q4G0S4
Secondary accession number(s): Q6ZNI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.