ID   HYDIN_HUMAN             Reviewed;        5121 AA.
AC   Q4G0P3; A6NC70; A6NLZ0; B4DQY4; B4DRN4; F5H6V3; Q8N3H8; Q8N3P6; Q8TC08;
AC   Q96JG3; Q96SS4; Q9H5U3; Q9H9B8; Q9NTI0; Q9UBE5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 3.
DT   24-JAN-2024, entry version 156.
DE   RecName: Full=Hydrocephalus-inducing protein homolog;
GN   Name=HYDIN; Synonyms=HYDIN1, KIAA1864;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 6 AND 7), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4575-5121 (ISOFORM 1).
RC   TISSUE=Lung, and Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 715-5121 (ISOFORM 4), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4141-5121 (ISOFORM 1).
RC   TISSUE=Amygdala, and Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=16938426; DOI=10.1016/j.ygeno.2006.07.012;
RA   Doggett N.A., Xie G., Meincke L.J., Sutherland R.D., Mundt M.O.,
RA   Berbari N.S., Davy B.E., Robinson M.L., Rudd M.K., Weber J.L.,
RA   Stallings R.L., Han C.;
RT   "A 360-kb interchromosomal duplication of the human HYDIN locus.";
RL   Genomics 88:762-771(2006).
RN   [6]
RP   REVIEW.
RX   PubMed=17296793; DOI=10.1083/jcb.200701113;
RA   Smith E.F.;
RT   "Hydin seek: finding a function in ciliary motility.";
RL   J. Cell Biol. 176:403-404(2007).
RN   [7]
RP   INVOLVEMENT IN CILD5.
RX   PubMed=23022101; DOI=10.1016/j.ajhg.2012.08.016;
RA   Olbrich H., Schmidts M., Werner C., Onoufriadis A., Loges N.T., Raidt J.,
RA   Banki N.F., Shoemark A., Burgoyne T., Al Turki S., Hurles M.E., Kohler G.,
RA   Schroeder J., Nurnberg G., Nurnberg P., Chung E.M., Reinhardt R.,
RA   Marthin J.K., Nielsen K.G., Mitchison H.M., Omran H.;
RT   "Recessive HYDIN mutations cause primary ciliary dyskinesia without
RT   randomization of left-right body asymmetry.";
RL   Am. J. Hum. Genet. 91:672-684(2012).
RN   [8]
RP   INVOLVEMENT IN CILD5.
RX   PubMed=25186273; DOI=10.1183/09031936.00052014;
RA   Raidt J., Wallmeier J., Hjeij R., Onnebrink J.G., Pennekamp P., Loges N.T.,
RA   Olbrich H., Haeffner K., Dougherty G.W., Omran H., Werner C.;
RT   "Ciliary beat pattern and frequency in genetic variants of primary ciliary
RT   dyskinesia.";
RL   Eur. Respir. J. 44:1579-1588(2014).
RN   [9]
RP   STRUCTURE BY NMR OF 458-563.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of the C-terminal PAPD-like domain from human HYDIN
RT   protein.";
RL   Submitted (JUL-2007) to the PDB data bank.
CC   -!- FUNCTION: Required for ciliary motility. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KIF9. {ECO:0000250|UniProtKB:Q80W93}.
CC   -!- INTERACTION:
CC       Q4G0P3-6; Q9UBV8: PEF1; NbExp=3; IntAct=EBI-14748124, EBI-724639;
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}. Cytoplasm,
CC       cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q80W93}.
CC       Note=Localizes in the cilium axoneme in a SPEF1-dependent manner.
CC       {ECO:0000250|UniProtKB:Q80W93}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=1;
CC         IsoId=Q4G0P3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4G0P3-2; Sequence=VSP_024684, VSP_024697, VSP_024698;
CC       Name=4;
CC         IsoId=Q4G0P3-5; Sequence=VSP_024691, VSP_024692;
CC       Name=5;
CC         IsoId=Q4G0P3-6; Sequence=VSP_024687, VSP_024688;
CC       Name=6;
CC         IsoId=Q4G0P3-8; Sequence=VSP_042692, VSP_042693, VSP_042694;
CC       Name=7;
CC         IsoId=Q4G0P3-10; Sequence=VSP_046818, VSP_042693, VSP_042694;
CC   -!- DISEASE: Ciliary dyskinesia, primary, 5 (CILD5) [MIM:608647]: An
CC       autosomal recessive form of primary dyskinesia, a disorder
CC       characterized by abnormalities of motile cilia. Respiratory infections
CC       leading to chronic inflammation and bronchiectasis are recurrent, due
CC       to defects in the respiratory cilia; reduced fertility is often
CC       observed in male patients due to abnormalities of sperm tails. Half of
CC       the patients exhibit randomization of left-right body asymmetry and
CC       situs inversus, due to dysfunction of monocilia at the embryonic node.
CC       Primary ciliary dyskinesia associated with situs inversus is referred
CC       to as Kartagener syndrome. CILD5 is characterized by early onset of a
CC       progressive decline in lung function due to an inability to clear mucus
CC       and particles from the airways. Affected individuals have recurrent
CC       infections of the sinuses, ears, airways, and lungs. Sperm motility is
CC       also decreased. Individuals with CILD5 do not have situs inversus.
CC       {ECO:0000269|PubMed:23022101, ECO:0000269|PubMed:25186273}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC       premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC       decay. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH28351.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB15527.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK022933; BAB14314.1; -; mRNA.
DR   EMBL; AK026688; BAB15527.1; ALT_FRAME; mRNA.
DR   EMBL; AK299016; BAG61096.1; -; mRNA.
DR   EMBL; AK299348; BAG61346.1; -; mRNA.
DR   EMBL; AC027281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC099495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC138625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC028351; AAH28351.2; ALT_INIT; mRNA.
DR   EMBL; BC043273; AAH43273.1; -; mRNA.
DR   EMBL; AL122038; CAB59178.1; -; mRNA.
DR   EMBL; AL133042; CAB61370.1; -; mRNA.
DR   EMBL; AL137259; CAB70660.1; -; mRNA.
DR   CCDS; CCDS10897.1; -. [Q4G0P3-5]
DR   CCDS; CCDS56004.1; -. [Q4G0P3-8]
DR   CCDS; CCDS56005.1; -. [Q4G0P3-10]
DR   CCDS; CCDS59269.1; -. [Q4G0P3-1]
DR   PIR; T42699; T42699.
DR   PIR; T46330; T46330.
DR   RefSeq; NP_001185471.1; NM_001198542.1. [Q4G0P3-8]
DR   RefSeq; NP_001185472.1; NM_001198543.1. [Q4G0P3-10]
DR   RefSeq; NP_001257903.1; NM_001270974.2. [Q4G0P3-1]
DR   RefSeq; NP_060028.2; NM_017558.4. [Q4G0P3-5]
DR   PDB; 2E6J; NMR; -; A=459-563.
DR   PDB; 2YS4; NMR; -; A=182-296.
DR   PDBsum; 2E6J; -.
DR   PDBsum; 2YS4; -.
DR   BMRB; Q4G0P3; -.
DR   SMR; Q4G0P3; -.
DR   BioGRID; 120142; 12.
DR   IntAct; Q4G0P3; 3.
DR   STRING; 9606.ENSP00000377197; -.
DR   GlyGen; Q4G0P3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q4G0P3; -.
DR   PhosphoSitePlus; Q4G0P3; -.
DR   BioMuta; HYDIN; -.
DR   DMDM; 327478578; -.
DR   EPD; Q4G0P3; -.
DR   MassIVE; Q4G0P3; -.
DR   MaxQB; Q4G0P3; -.
DR   PaxDb; 9606-ENSP00000377197; -.
DR   PeptideAtlas; Q4G0P3; -.
DR   ProteomicsDB; 27301; -.
DR   ProteomicsDB; 62119; -. [Q4G0P3-1]
DR   ProteomicsDB; 62120; -. [Q4G0P3-2]
DR   ProteomicsDB; 62121; -. [Q4G0P3-5]
DR   ProteomicsDB; 62122; -. [Q4G0P3-6]
DR   ProteomicsDB; 62123; -. [Q4G0P3-8]
DR   Antibodypedia; 66504; 59 antibodies from 12 providers.
DR   DNASU; 54768; -.
DR   Ensembl; ENST00000321489.9; ENSP00000314736.5; ENSG00000157423.18. [Q4G0P3-5]
DR   Ensembl; ENST00000393567.7; ENSP00000377197.2; ENSG00000157423.18. [Q4G0P3-1]
DR   Ensembl; ENST00000538248.5; ENSP00000444970.1; ENSG00000157423.18. [Q4G0P3-8]
DR   Ensembl; ENST00000541601.5; ENSP00000437341.1; ENSG00000157423.18. [Q4G0P3-10]
DR   GeneID; 54768; -.
DR   KEGG; hsa:54768; -.
DR   MANE-Select; ENST00000393567.7; ENSP00000377197.2; NM_001270974.2; NP_001257903.1.
DR   UCSC; uc010vmc.3; human. [Q4G0P3-1]
DR   AGR; HGNC:19368; -.
DR   CTD; 54768; -.
DR   DisGeNET; 54768; -.
DR   GeneCards; HYDIN; -.
DR   GeneReviews; HYDIN; -.
DR   HGNC; HGNC:19368; HYDIN.
DR   HPA; ENSG00000157423; Tissue enhanced (retina).
DR   MalaCards; HYDIN; -.
DR   MIM; 608647; phenotype.
DR   MIM; 610812; gene.
DR   neXtProt; NX_Q4G0P3; -.
DR   OpenTargets; ENSG00000157423; -.
DR   Orphanet; 244; Primary ciliary dyskinesia.
DR   PharmGKB; PA134866950; -.
DR   VEuPathDB; HostDB:ENSG00000157423; -.
DR   eggNOG; ENOG502QQ4F; Eukaryota.
DR   GeneTree; ENSGT00610000086095; -.
DR   HOGENOM; CLU_000116_1_0_1; -.
DR   InParanoid; Q4G0P3; -.
DR   OMA; FTVTNHS; -.
DR   OrthoDB; 49424at2759; -.
DR   PhylomeDB; Q4G0P3; -.
DR   TreeFam; TF340616; -.
DR   PathwayCommons; Q4G0P3; -.
DR   SignaLink; Q4G0P3; -.
DR   SIGNOR; Q4G0P3; -.
DR   BioGRID-ORCS; 54768; 47 hits in 1134 CRISPR screens.
DR   ChiTaRS; HYDIN; human.
DR   EvolutionaryTrace; Q4G0P3; -.
DR   GenomeRNAi; 54768; -.
DR   Pharos; Q4G0P3; Tbio.
DR   PRO; PR:Q4G0P3; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q4G0P3; Protein.
DR   Bgee; ENSG00000157423; Expressed in right uterine tube and 102 other cell types or tissues.
DR   ExpressionAtlas; Q4G0P3; baseline and differential.
DR   GO; GO:1990716; C:axonemal central apparatus; ISS:UniProtKB.
DR   GO; GO:1990718; C:axonemal central pair projection; IEA:Ensembl.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:1904158; P:axonemal central apparatus assembly; IBA:GO_Central.
DR   GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR   GO; GO:0002064; P:epithelial cell development; IEA:Ensembl.
DR   GO; GO:0060438; P:trachea development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 22.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR031549; ASH.
DR   InterPro; IPR033305; Hydin-like.
DR   InterPro; IPR033768; Hydin_ADK.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23053; DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1; 1.
DR   PANTHER; PTHR23053:SF0; HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG; 1.
DR   Pfam; PF15780; ASH; 1.
DR   Pfam; PF17213; Hydin_ADK; 1.
DR   Genevisible; Q4G0P3; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cell projection; Ciliopathy;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Kartagener syndrome;
KW   Primary ciliary dyskinesia; Reference proteome.
FT   CHAIN           1..5121
FT                   /note="Hydrocephalus-inducing protein homolog"
FT                   /id="PRO_0000284844"
FT   REGION          363..754
FT                   /note="Interaction with KIF9"
FT                   /evidence="ECO:0000250|UniProtKB:Q80W93"
FT   REGION          956..987
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1925..1951
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2155..2186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2333..2459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2482..2534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2664..2684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3852..3874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1908..1933
FT                   /evidence="ECO:0000255"
FT   COILED          2267..2365
FT                   /evidence="ECO:0000255"
FT   COILED          2504..2549
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1936..1951
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2333..2374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2395..2426
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2440..2455
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2489..2534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3856..3874
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..3823
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024684"
FT   VAR_SEQ         1
FT                   /note="M -> MESAGGFKLGMEPLSGGGVCEKKKLLKM (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_042692"
FT   VAR_SEQ         1
FT                   /note="M -> MESAGGFKLGEKKKLLKM (in isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_046818"
FT   VAR_SEQ         693..708
FT                   /note="CVVPALHLVNTEVDFG -> YCSPACSSPESPPSLQ (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024687"
FT   VAR_SEQ         709..5121
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024688"
FT   VAR_SEQ         923
FT                   /note="S -> R (in isoform 6 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_042693"
FT   VAR_SEQ         924..5121
FT                   /note="Missing (in isoform 6 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_042694"
FT   VAR_SEQ         1015..1017
FT                   /note="IVK -> VRG (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_024691"
FT   VAR_SEQ         1018..5121
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_024692"
FT   VAR_SEQ         3824
FT                   /note="E -> M (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024697"
FT   VAR_SEQ         4887..5121
FT                   /note="GTFSFEFQPLKAGETFGRLTLHNTDLGYYQYELYLKATPALPEKPVHFQTVL
FT                   GSSQIILVKFINYTRQRTEYYCRTDCTDFHAEKLINAAPGGQGGTEASVEVLFEPSHLG
FT                   ETKGILILSSLAGGEYIIPLFGMALPPKPQGPFSIRAGYSIIIPFKNVFYHMVTFSIIV
FT                   DNPAFTIRAGESVRPKKINNITVSFEGNPSGSKTPITTKLTVSCPPGEGSETGVKWVYY
FT                   LKGITL -> RWGLTASSRLECSGMIIAPCSLKLLQSRPPPASAS (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024698"
FT   VARIANT         451
FT                   /note="R -> P (in dbSNP:rs7200485)"
FT                   /id="VAR_031837"
FT   VARIANT         584
FT                   /note="T -> N (in dbSNP:rs7200126)"
FT                   /id="VAR_031838"
FT   VARIANT         690
FT                   /note="T -> A (in dbSNP:rs10744982)"
FT                   /id="VAR_031839"
FT   VARIANT         724
FT                   /note="N -> D (in dbSNP:rs3817211)"
FT                   /id="VAR_031840"
FT   VARIANT         1077
FT                   /note="I -> V (in dbSNP:rs6416709)"
FT                   /id="VAR_059667"
FT   VARIANT         1228
FT                   /note="V -> L (in dbSNP:rs1774513)"
FT                   /id="VAR_059668"
FT   VARIANT         1534
FT                   /note="I -> V (in dbSNP:rs1774303)"
FT                   /id="VAR_059669"
FT   VARIANT         1718
FT                   /note="V -> M (in dbSNP:rs783762)"
FT                   /id="VAR_051036"
FT   VARIANT         1892
FT                   /note="R -> H (in dbSNP:rs783732)"
FT                   /id="VAR_051037"
FT   VARIANT         1952
FT                   /note="R -> Q (in dbSNP:rs17321570)"
FT                   /id="VAR_051038"
FT   VARIANT         2087
FT                   /note="R -> C (in dbSNP:rs1774541)"
FT                   /id="VAR_059670"
FT   VARIANT         2099
FT                   /note="V -> M (in dbSNP:rs1798337)"
FT                   /id="VAR_051039"
FT   VARIANT         2242
FT                   /note="Q -> R (in dbSNP:rs2258307)"
FT                   /id="VAR_059671"
FT   VARIANT         2276
FT                   /note="Q -> R (in dbSNP:rs1815707)"
FT                   /id="VAR_051040"
FT   VARIANT         2298
FT                   /note="R -> G (in dbSNP:rs1774360)"
FT                   /id="VAR_059672"
FT   VARIANT         2306
FT                   /note="E -> G (in dbSNP:rs2502726)"
FT                   /id="VAR_051041"
FT   VARIANT         2445
FT                   /note="N -> I (in dbSNP:rs1798532)"
FT                   /id="VAR_051042"
FT   VARIANT         2455
FT                   /note="P -> Q (in dbSNP:rs1798531)"
FT                   /id="VAR_061666"
FT   VARIANT         2502
FT                   /note="L -> S (in dbSNP:rs1798529)"
FT                   /id="VAR_051043"
FT   VARIANT         2530
FT                   /note="K -> E (in dbSNP:rs1798528)"
FT                   /id="VAR_059673"
FT   VARIANT         2558
FT                   /note="G -> E (in dbSNP:rs8044142)"
FT                   /id="VAR_051044"
FT   VARIANT         2570
FT                   /note="D -> N (in dbSNP:rs8044001)"
FT                   /id="VAR_059674"
FT   VARIANT         2589
FT                   /note="K -> R (in dbSNP:rs1774395)"
FT                   /id="VAR_051045"
FT   VARIANT         2694
FT                   /note="I -> S (in dbSNP:rs1774449)"
FT                   /id="VAR_059675"
FT   VARIANT         2932
FT                   /note="P -> L (in dbSNP:rs11075812)"
FT                   /id="VAR_051046"
FT   VARIANT         2937
FT                   /note="E -> K (in dbSNP:rs8047935)"
FT                   /id="VAR_051047"
FT   VARIANT         2939
FT                   /note="R -> K (in dbSNP:rs7188837)"
FT                   /id="VAR_051048"
FT   VARIANT         2994
FT                   /note="E -> G (in dbSNP:rs12102425)"
FT                   /id="VAR_051049"
FT   VARIANT         3116
FT                   /note="T -> R (in dbSNP:rs1774423)"
FT                   /id="VAR_051050"
FT   VARIANT         3269
FT                   /note="Y -> D (in dbSNP:rs7197263)"
FT                   /id="VAR_051051"
FT   VARIANT         3291
FT                   /note="A -> P (in dbSNP:rs1798440)"
FT                   /id="VAR_059676"
FT   VARIANT         3316
FT                   /note="L -> P (in dbSNP:rs1774331)"
FT                   /id="VAR_059677"
FT   VARIANT         3739
FT                   /note="A -> T (in dbSNP:rs1774504)"
FT                   /id="VAR_059678"
FT   VARIANT         3742
FT                   /note="V -> I (in dbSNP:rs1798413)"
FT                   /id="VAR_059679"
FT   VARIANT         3811
FT                   /note="R -> H (in dbSNP:rs13338821)"
FT                   /id="VAR_051052"
FT   VARIANT         3840
FT                   /note="V -> L (in dbSNP:rs1798325)"
FT                   /id="VAR_059680"
FT   VARIANT         3869
FT                   /note="M -> R (in dbSNP:rs7192347)"
FT                   /id="VAR_059681"
FT   VARIANT         3899
FT                   /note="V -> M (in dbSNP:rs1626593)"
FT                   /id="VAR_051053"
FT   VARIANT         4005
FT                   /note="T -> A (in dbSNP:rs1539302)"
FT                   /id="VAR_059682"
FT   VARIANT         4026
FT                   /note="A -> T (in dbSNP:rs11075798)"
FT                   /id="VAR_051054"
FT   VARIANT         4088
FT                   /note="K -> R (in dbSNP:rs1774416)"
FT                   /id="VAR_051055"
FT   VARIANT         4160
FT                   /note="E -> Q (in dbSNP:rs1798314)"
FT                   /id="VAR_059683"
FT   VARIANT         4270
FT                   /note="H -> Y (in dbSNP:rs1891343)"
FT                   /id="VAR_051056"
FT   VARIANT         4363
FT                   /note="S -> C (in dbSNP:rs1770434)"
FT                   /id="VAR_059684"
FT   VARIANT         4412
FT                   /note="K -> E (in dbSNP:rs1774480)"
FT                   /id="VAR_059685"
FT   VARIANT         4552
FT                   /note="M -> L (in dbSNP:rs1770442)"
FT                   /id="VAR_059686"
FT   VARIANT         4606
FT                   /note="N -> K (in dbSNP:rs783898)"
FT                   /id="VAR_051058"
FT   VARIANT         4869
FT                   /note="R -> Q (in dbSNP:rs2795652)"
FT                   /id="VAR_059687"
FT   CONFLICT        299
FT                   /note="L -> P (in Ref. 1; BAB14314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        313
FT                   /note="L -> M (in Ref. 3; AAH28351)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        460
FT                   /note="K -> T (in Ref. 1; BAB14314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        532
FT                   /note="T -> I (in Ref. 3; AAH28351)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        584
FT                   /note="T -> I (in Ref. 1; BAG61096)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        881
FT                   /note="D -> N (in Ref. 1; BAG61096)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3945
FT                   /note="S -> N (in Ref. 3; AAH43273)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        4663
FT                   /note="P -> T (in Ref. 3; AAH43273)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        4667
FT                   /note="G -> V (in Ref. 1; BAB15527)"
FT                   /evidence="ECO:0000305"
FT   STRAND          204..206
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          210..215
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          217..224
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          227..229
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          231..236
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          241..250
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          255..262
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          265..268
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          275..281
FT                   /evidence="ECO:0007829|PDB:2YS4"
FT   STRAND          460..464
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          466..476
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          479..487
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          493..497
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   HELIX           503..507
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          509..517
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          524..529
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          535..541
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          543..547
FT                   /evidence="ECO:0007829|PDB:2E6J"
FT   STRAND          554..561
FT                   /evidence="ECO:0007829|PDB:2E6J"
SQ   SEQUENCE   5121 AA;  575892 MW;  47FB2A11C7E50A4F CRC64;
     MTSRRLEESM GAVQMGLVNM FKGFQSKVLP PLSPKVVTEE EVNRMLTPSE FLKEMSLTTE
     QRLAKTRLMC RPQIIELLDM GETTHQKFSG IDLDQALFQP FPSEIIFQNY TPCEVYEVPL
     ILRNNDKIPR LVKVVEESSP YFKVISPKDI GHKVAPGVPS IFRILFTPEE NKDYAHTLTC
     VTEREKFIVP IKARGARAIL DFPDKLNFST CPVKYSTQKI LLVRNIGNKN AVFHIKTCRP
     FSIEPAIGTL NVGESMQLEV EFEPQSVGDH SGRLIVCYDT GEKVFVSLYG AAIDMNIRLD
     KNSLTIEKTY ISLANQRTIT IHNRSNIIAH FLWKVFATQQ EEDREKYRAC DDLIKEEKDE
     TDEFFEECIT DPLLREHLSV LSRTFANQRR LVQGDSKLFF NNVFTVEPLE GDVWPNSSAE
     ITVYFNPLEA KLYQQTIYCD ILGREIRLPL RIKGEGMGPK IHFNFELLDI GKVFTGSAHC
     YEAILYNKGS IDALFNMTPP TSALGACFVF SPKEGIIEPS GVQAIQISFS STILGNFEEE
     FLVNVNGSPE PVKLTIRGCV IGPTFHFNVP ALHFGDVSFG FPHTLICSLN NTSLIPMTYK
     LRIPGDGLGH KSISYCEQHV DYKRPSWTKE EISSMKPKEF TISPDCGTIR PQGFAAIRVT
     LCSNTVQKYE LALVVDVEGI GEEVLALLIT ARCVVPALHL VNTEVDFGHC FLKYPYEKTL
     QLANQDDLPG FYEVQPQVCE EVPTVLFSSP TPSGVISPSS TIHIPLVLET QVTGEHRSTV
     YISIFGSQDP PLVCHLKSAG EGPVIYVHPN QVDFGNIYVL KDSSRILNLC NQSFIPAFFQ
     AHMAHKKSLW TIEPNEGMVP PETDVQLALT ANLNDTLTFK DCVILDIENS STYRIPVQAS
     GTGSTIVSDK PFAPELNLGA HFSLDTHYYH FKLINKGRRI QQLFWMNDSF RPQAKLSKKG
     RVKKGHAHVQ PQPSGSQEPR DPQSPVFHLH PASMELYPGQ AIDVILEGYS ATPRIVKEKL
     VCHAIIGAQK GKSLVMAVNI TCEFVAPLIQ LSTKQLIYRL EKKPNSILKP DYQPLAIKNI
     STLPVNLLLS TSGPFFICET DKSLLPATPE PIKLEIDEEK NLLIKFDPSY RNDLNNWVAE
     EILAIKYVEH PQIDSLDLRG EVHYPNLSFE TKELDFGCIL NDTELIRYVT ITNCSPLVVK
     FRWFFLVNDE ENQIRFVTLP KKPYSAPVSQ MESIPATSEA ASPPAILVTV ESPEMDLNDF
     VKTVLVDEDA RPEEKELRKT KASSVISDEI KISSTEIERI YSSQSQVEDQ ESLQTCEQNE
     MLSIGIEEVF DILPLFGVLQ PHSSHQISFT FYGHANIIAQ AKALCEVEEG PTYEITLKGE
     ASLVNYSFDT KDIHYGLQLF DHVTEREITL TNMGKVGFEF KVLTDHQSSP DNLLPGVPLI
     LPVSGFISSH QEQVLKVYYL PGVPEVFKRS FQIQIAHLDP ENITLSGEGI FPQICLDLPR
     NLTANEKYEM FLNQARKNTD KEYNKCEMLD HFDIITEEVP EDEPAEVSAH LQMEVERLIV
     QSYVLEHQKT TTPDPMDDPC FSHRSRRKLA KIQLPEYILD FGYIILGEVR THIIKIINTS
     HFPVSFHADK RVLHETGFST ELDRVKNLPH CETEIFEVRF DPQGANLPVG SKEVILPIKV
     VGGPTVHICL QAKVTIPTMT LSRGKVDFAT IQCGQCLVET IQLSNHLQVP CEWFVQSQKP
     VDKLEKHMPK YLRQKLRAEL KPKTRIFEIQ PISGVLDPGE KSNVQVKFMP KEEKFYSQTL
     VFQIAQSAQK LTLLARGQGL EPRLEFSPSV LDLGPLLLCA PGDEAEVIVK NPCNFPIEFY
     SLEFDQQYLI EEKILRKLKG YDSYNTLLLP PRNPGEKLPP ELYEYFKEIK KSKEEQMRAK
     YLENLAQENE EEDITSSDQG TSNSTKRTSL SRGISVTSNL EEWHALLVES KTYLEEEEDE
     ESLEKIIFQT DKLQSIDSHS MEEVGEVENN PVSKAIARHL GIDISAEGRL AKNRKGIAII
     IHGTPLSGKS ANAVSVAKYY NAACLSIDSI VLEAVANSNN IPGIRARELC IRAAIEQSVK
     EGEEAAQEAA VGQNVIGQGR LSTDTLGKLA SEMTLVAPEI KPGKSVRGSV VITKSKADSH
     GSGSQKQHHS HQSETPQISS SPLPPGPIHR WLSVSPSVGG ETGLMSCVLP DELLVQILAE
     RIQLSDCYRG VVFDGLDTLF AQNAAAALLC LLKAIGSREH IYILNMAQDY AAMKAQEKAK
     KEQEERKHKG ALEKEKERLQ NMDEEEYDAL TEEEKLTFDR GIQQALRERK KREQERLAKE
     MQEKKLQQEL ERQKEEDELK RRVKKGKQGP IKEEPPMKKS QAANKQVPPL TKVDVKMETI
     ERKISVREQT MSEKEELNKK KRNMGDVSMH GLPLVQDQED SEGDNSKDPD KQLAPKFKTY
     ELTLKDVQNI LMYWDRKQGV QLPPAGMEEA PHEPDDQRQV PLGGRRGRKD RERERLEKER
     TEKERLEREK AERERLEKLR ALEERSDWEG EGEEDHEGKK EKDLGVPFLD IQTPDFEGLS
     WKQALESDKL PKGEQILDIL GLGASGPPIP PPALFSIVSY PVKRPPLTMT DDLEHFVFVI
     PPSEDISLDE KKEMEIESDF LATTNTTKAQ EEQTSSSKGG KQKMKEKIDQ VFEIQKDKRH
     MALNRKVLSG EPAGTISQLS DTDLDNFNGQ HSQEKFTRLN HFRWIVPANG EVTLQVHFSS
     DEFGNFDQTF NFEILGTCCQ YQLYCRGICT YPYICQDPKV VFPQRKMDMK TNEVIFKKYV
     MSTETYYFGP LLCGKSRDKY KSSLFPGNME TLTILNTSLM VVEASFYFQN DVKANTYFLE
     PNTMVLKPNE KQILNVWAYP TSVGVFEDSI VCCINDNPEP AIFQLSCQGI RPELELEPRQ
     LHFDRLLLHR QESRVVLLRN VTLLPVAWRI TSLEHLGDDF TVSLMQGTIP PEAEYGLHLY
     FQPTKPVNIK KAIRLEVLDA ENLLGVVQIE NIMVFAEAYD IALDITFPKG AEGGLDFGIV
     RVTEEAKQPL QLKNRGKYEI AFSFSVDSVG ISTPNINSMI SVQPKKGSLT PTEKPTNVQV
     FFHAKKEVKI EHQPVLRCQI IEPNISEGGE IIASIPIKFS ANAVYSKYNI TPSSVINFGA
     LICGTRKSTT FTIENQGVTD FKFALYKLTG ESPIHQKKAA SHVRHARSRE SESFYKTGSS
     RAAKFSDTIQ KEVTTTGQAR FAHGMFTVYP GFGSIPSGGQ QVINVDCVAD AMGKCEEFIA
     IDISGRDPAV HPAGILYTLL AEACLPAFVT ENNALIFEEH QICTSANLHH ILQTIESGGL
     FVEDENKFIF CNVLVGRQAK ARFKISNVGK ITCDVNIVVR PISNKPFARI VDIFEVEPSK
     MCIASHSHAF ATVSFTPQIM QNYQCIFEAT LDGLPSTLAK SRGLVFDIAG EGNLPRVTVV
     RPVLHNQYGN PLLLFKRLLL GHSEKLPLIL KNNGVLPAQL HVDLQDELGV FSLKGRPTTA
     YIYITEENKP HVKAKKAHTA SLVVSPGDTA EFDVVFHSQK VGRMRGIIHL SVINNQYEET
     SIHMVGEGYE DDITLDNIHG LVAPTSQEDI SISEFTEIIE DNDMEDLVAA ALVDHIQFGD
     CHIGHSYNAS FTVTNHSQVN LIRFEWPVSA TIAFSPQMGH LHPGCAKDIV VTMKSDVPIN
     LKNMRIRCKL SRIMFQLPAD QVPDWDDRMH TVKWVDVPRN MPGTFTTKRK VIETDPEPAH
     SVLEENYQEL QLQISANVDF ASYHCQARDV RFKETLVYQT RVFEFDVINS GRVQLEFSWV
     SEDTSKAVSF AKPDHQGSAQ KDQLSQGTMH TGSTLDSTMD HWAEGSPQPF SVEPSSGIVP
     VGKIQKFKVK FSPLDIGDFE SNLFCQIPNL PPGEQGPVLV AKGRSTLPIC HFDLKDSDYI
     SGHQRNPELR GSSGGALDPN TRVIEFTTVG IGGKNLRTFT ILNPTNSTYS FCWISEEIES
     LQNPAAFTCL TEKGFIHPEK KAEIVFQFTP FHLGITESSW TFLIPEHNIT VPFLLVGKTT
     EPLISLNKSH LNFSSLLIGR EARETVQIIN KEEQGFDFSF QDNSRYSEGF SNSLLVCPME
     GWIPPLSRFP IDIFFTPKQE GDVNFNLICN VEKKVHPVTL NVKAEGYTMN VEIKCKDRTG
     SITLLTPNQT NIINFYEVEL NECVQCEFNF INTGKFTFSF QAQLCGSKTL LQYLEFSPID
     STVDVGQSVH ATLSFQPLKK CVLTDLELII KISHGPTFMC NISGCAVSPA IHFSFTSYNF
     GTCFIYQAGM PPYKQTLVIT NKEETPMSID CLYTNTTHLE VNSRVDVVKP GNTLEIPITF
     YPRESINYQE LIPFEINGLS QQTVEIKGKG TKMKILVLDP ANRIVKLGAV LPGQVVKRTV
     SIMNNSLAQL TFNQSILFTI PELQEPKVLT LAPFHNITLK PKEVCKLEVI FAPKKRVPPF
     SEEVFMECMG LLRPLFLLSG CCQALEISLD QEHIPFGPVV YQTQATRRIL MMNTGDVGAR
     FKWDIKKFEP HFSISPEEGY ITSGMEVSFE VTYHPTEVGK ESLCKNILCY IQGGSPLSLT
     LSGVCVGPPA VKEVVNFTCQ VRSKHTQTIL LSNRTNQTWN LHPIFEGEHW EGPEFITLEA
     HQQNKPYEIT YRPRTMNLEN RKHQGTLFFP LPDGTGWLYA LHGTSELPKA VANIYREVPC
     KTPYTELLPI TNWLNKPQRF RVIVEILKPE KPDLSITMKG LDYIDVLSGS KKDYKLNFFS
     HKEGTYAAKV IFRNEVTNEF LYYNVSFRVI PSGIIKTIEM VTPVRQVASA SIKLENPLPY
     SVTFSTECRM PDIALPSQFV VPANSEGTFS FEFQPLKAGE TFGRLTLHNT DLGYYQYELY
     LKATPALPEK PVHFQTVLGS SQIILVKFIN YTRQRTEYYC RTDCTDFHAE KLINAAPGGQ
     GGTEASVEVL FEPSHLGETK GILILSSLAG GEYIIPLFGM ALPPKPQGPF SIRAGYSIII
     PFKNVFYHMV TFSIIVDNPA FTIRAGESVR PKKINNITVS FEGNPSGSKT PITTKLTVSC
     PPGEGSETGV KWVYYLKGIT L
//