Q4G0P3 (HYDIN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hydrocephalus-inducing protein homolog

Gene names

Name:	HYDIN
Synonyms:	HYDIN1, KIAA1864

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	5121 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Involvement in disease

Primary ciliary dyskinesia 5 (CILD5) [MIM:608647]: An autosomal recessive form of primary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. CILD5 is characterized by early onset of a progressive decline in lung function due to an inability to clear mucus and particles from the airways. Affected individuals have recurrent infections of the sinuses, ears, airways, and lungs. Sperm motility is also decreased. Individuals with CILD5 do not have situs inversus. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence caution

The sequence AAH28351.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB15527.1 differs from that shown. Reason: Frameshift at position 4804.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Ciliopathy Primary ciliary dyskinesia
Domain	Coiled coil
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4G0P3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4G0P3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-3823: Missing.
     3824-3824: E → M
     4887-5121: GTFSFEFQPL...WVYYLKGITL → RWGLTASSRLECSGMIIAPCSLKLLQSRPPPASAS

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q4G0P3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1015-1017: IVK → VRG
     1018-5121: Missing.

Isoform 5 (identifier: Q4G0P3-6)

The sequence of this isoform differs from the canonical sequence as follows:
     693-708: CVVPALHLVNTEVDFG → YCSPACSSPESPPSLQ
     709-5121: Missing.

Isoform 6 (identifier: Q4G0P3-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MESAGGFKLGMEPLSGGGVCEKKKLLKM
     923-923: S → R
     924-5121: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 5121

5121

Hydrocephalus-inducing protein homolog

PRO_0000284844

Regions

Coiled coil

1908 – 1933

26

Potential

Coiled coil

2267 – 2365

99

Potential

Coiled coil

2504 – 2549

46

Potential

Compositional bias

1975 – 1981

7

Poly-Glu

Natural variations

Alternative sequence

1 – 3823

3823

Missing in isoform 2.

VSP_024684

Alternative sequence

1

1

M → MESAGGFKLGMEPLSGGGVC EKKKLLKM in isoform 6.

VSP_042692

Alternative sequence

693 – 708

16

CVVPA…EVDFG → YCSPACSSPESPPSLQ in isoform 5.

VSP_024687

Alternative sequence

709 – 5121

4413

Missing in isoform 5.

VSP_024688

Alternative sequence

923

1

S → R in isoform 6.

VSP_042693

Alternative sequence

924 – 5121

4198

Missing in isoform 6.

VSP_042694

Alternative sequence

1015 – 1017

3

IVK → VRG in isoform 4.

VSP_024691

Alternative sequence

1018 – 5121

4104

Missing in isoform 4.

VSP_024692

Alternative sequence

3824

1

E → M in isoform 2.

VSP_024697

Alternative sequence

4887 – 5121

235

GTFSF…KGITL → RWGLTASSRLECSGMIIAPC SLKLLQSRPPPASAS in isoform 2.

VSP_024698

Natural variant

451

1

R → P.
Corresponds to variant rs7200485 [ dbSNP | Ensembl ].

VAR_031837

Natural variant

584

1

T → N.
Corresponds to variant rs7200126 [ dbSNP | Ensembl ].

VAR_031838

Natural variant

690

1

T → A.
Corresponds to variant rs10744982 [ dbSNP | Ensembl ].

VAR_031839

Natural variant

724

1

N → D.
Corresponds to variant rs3817211 [ dbSNP | Ensembl ].

VAR_031840

Natural variant

1077

1

I → V.
Corresponds to variant rs6416709 [ dbSNP | Ensembl ].

VAR_059667

Natural variant

1228

1

V → L.
Corresponds to variant rs1774513 [ dbSNP | Ensembl ].

VAR_059668

Natural variant

1534

1

I → V.
Corresponds to variant rs1774303 [ dbSNP | Ensembl ].

VAR_059669

Natural variant

1718

1

V → M.
Corresponds to variant rs783762 [ dbSNP | Ensembl ].

VAR_051036

Natural variant

1892

1

R → H.
Corresponds to variant rs783732 [ dbSNP | Ensembl ].

VAR_051037

Natural variant

1952

1

R → Q.
Corresponds to variant rs17321570 [ dbSNP | Ensembl ].

VAR_051038

Natural variant

2087

1

R → C.
Corresponds to variant rs1774541 [ dbSNP | Ensembl ].

VAR_059670

Natural variant

2099

1

V → M.
Corresponds to variant rs1798337 [ dbSNP | Ensembl ].

VAR_051039

Natural variant

2242

1

Q → R.
Corresponds to variant rs2258307 [ dbSNP | Ensembl ].

VAR_059671

Natural variant

2276

1

Q → R.
Corresponds to variant rs1815707 [ dbSNP | Ensembl ].

VAR_051040

Natural variant

2298

1

R → G.
Corresponds to variant rs1774360 [ dbSNP | Ensembl ].

VAR_059672

Natural variant

2306

1

E → G.
Corresponds to variant rs2502726 [ dbSNP | Ensembl ].

VAR_051041

Natural variant

2445

1

N → I.
Corresponds to variant rs1798532 [ dbSNP | Ensembl ].

VAR_051042

Natural variant

2455

1

P → Q.
Corresponds to variant rs1798531 [ dbSNP | Ensembl ].

VAR_061666

Natural variant

2502

1

L → S.
Corresponds to variant rs1798529 [ dbSNP | Ensembl ].

VAR_051043

Natural variant

2530

1

K → E.
Corresponds to variant rs1798528 [ dbSNP | Ensembl ].

VAR_059673

Natural variant

2558

1

G → E.
Corresponds to variant rs8044142 [ dbSNP | Ensembl ].

VAR_051044

Natural variant

2570

1

D → N.
Corresponds to variant rs8044001 [ dbSNP | Ensembl ].

VAR_059674

Natural variant

2589

1

K → R.
Corresponds to variant rs1774395 [ dbSNP | Ensembl ].

VAR_051045

Natural variant

2694

1

I → S.
Corresponds to variant rs1774449 [ dbSNP | Ensembl ].

VAR_059675

Natural variant

2932

1

P → L.
Corresponds to variant rs11075812 [ dbSNP | Ensembl ].

VAR_051046

Natural variant

2937

1

E → K.
Corresponds to variant rs8047935 [ dbSNP | Ensembl ].

VAR_051047

Natural variant

2939

1

R → K.
Corresponds to variant rs7188837 [ dbSNP | Ensembl ].

VAR_051048

Natural variant

2994

1

E → G.
Corresponds to variant rs12102425 [ dbSNP | Ensembl ].

VAR_051049

Natural variant

3116

1

T → R.
Corresponds to variant rs1774423 [ dbSNP | Ensembl ].

VAR_051050

Natural variant

3269

1

Y → D.
Corresponds to variant rs7197263 [ dbSNP | Ensembl ].

VAR_051051

Natural variant

3291

1

A → P.
Corresponds to variant rs1798440 [ dbSNP | Ensembl ].

VAR_059676

Natural variant

3316

1

L → P.
Corresponds to variant rs1774331 [ dbSNP | Ensembl ].

VAR_059677

Natural variant

3739

1

A → T.
Corresponds to variant rs1774504 [ dbSNP | Ensembl ].

VAR_059678

Natural variant

3742

1

V → I.
Corresponds to variant rs1798413 [ dbSNP | Ensembl ].

VAR_059679

Natural variant

3811

1

R → H.
Corresponds to variant rs13338821 [ dbSNP | Ensembl ].

VAR_051052

Natural variant

3840

1

V → L.
Corresponds to variant rs1798325 [ dbSNP | Ensembl ].

VAR_059680

Natural variant

3869

1

M → R.
Corresponds to variant rs7192347 [ dbSNP | Ensembl ].

VAR_059681

Natural variant

3899

1

V → M.
Corresponds to variant rs1626593 [ dbSNP | Ensembl ].

VAR_051053

Natural variant

4005

1

T → A.
Corresponds to variant rs1539302 [ dbSNP | Ensembl ].

VAR_059682

Natural variant

4026

1

A → T.
Corresponds to variant rs11075798 [ dbSNP | Ensembl ].

VAR_051054

Natural variant

4088

1

K → R.
Corresponds to variant rs1774416 [ dbSNP | Ensembl ].

VAR_051055

Natural variant

4160

1

E → Q.
Corresponds to variant rs1798314 [ dbSNP | Ensembl ].

VAR_059683

Natural variant

4270

1

H → Y.
Corresponds to variant rs1891343 [ dbSNP | Ensembl ].

VAR_051056

Natural variant

4363

1

S → C.
Corresponds to variant rs1770434 [ dbSNP | Ensembl ].

VAR_059684

Natural variant

4412

1

K → E.
Corresponds to variant rs1774480 [ dbSNP | Ensembl ].

VAR_059685

Natural variant

4520

1

G → S.
Corresponds to variant rs2292127 [ dbSNP | Ensembl ].

VAR_051057

Natural variant

4552

1

M → L.
Corresponds to variant rs1770442 [ dbSNP | Ensembl ].

VAR_059686

Natural variant

4606

1

N → K.
Corresponds to variant rs783898 [ dbSNP | Ensembl ].

VAR_051058

Natural variant

4869

1

R → Q.
Corresponds to variant rs2795652 [ dbSNP | Ensembl ].

VAR_059687

Experimental info

Sequence conflict

299

1

L → P in BAB14314. Ref.1

Sequence conflict

313

1

L → M in AAH28351. Ref.3

Sequence conflict

460

1

K → T in BAB14314. Ref.1

Sequence conflict

532

1

T → I in AAH28351. Ref.3

Sequence conflict

3945

1

S → N in AAH43273. Ref.3

Sequence conflict

4663

1

P → T in AAH43273. Ref.3

Sequence conflict

4667

1

G → V in BAB15527. Ref.1

Secondary structure

1

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5121

Helix Strand Turn

Details...

Beta strand

204 – 206

3

Beta strand

210 – 215

6

Beta strand

217 – 224

8

Beta strand

227 – 229

3

Beta strand

231 – 236

6

Beta strand

241 – 250

10

Beta strand

255 – 262

8

Beta strand

265 – 268

4

Beta strand

275 – 281

7

Beta strand

460 – 464

5

Beta strand

466 – 476

11

Beta strand

479 – 487

9

Beta strand

493 – 497

5

Helix

503 – 507

5

Beta strand

509 – 517

9

Beta strand

524 – 529

6

Beta strand

535 – 541

7

Beta strand

543 – 547

5

Beta strand

554 – 561

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 47FB2A11C7E50A4F	FASTA	5,121	575,892
	10 20 30 40 50 60 MTSRRLEESM GAVQMGLVNM FKGFQSKVLP PLSPKVVTEE EVNRMLTPSE FLKEMSLTTE 70 80 90 100 110 120 QRLAKTRLMC RPQIIELLDM GETTHQKFSG IDLDQALFQP FPSEIIFQNY TPCEVYEVPL 130 140 150 160 170 180 ILRNNDKIPR LVKVVEESSP YFKVISPKDI GHKVAPGVPS IFRILFTPEE NKDYAHTLTC 190 200 210 220 230 240 VTEREKFIVP IKARGARAIL DFPDKLNFST CPVKYSTQKI LLVRNIGNKN AVFHIKTCRP 250 260 270 280 290 300 FSIEPAIGTL NVGESMQLEV EFEPQSVGDH SGRLIVCYDT GEKVFVSLYG AAIDMNIRLD 310 320 330 340 350 360 KNSLTIEKTY ISLANQRTIT IHNRSNIIAH FLWKVFATQQ EEDREKYRAC DDLIKEEKDE 370 380 390 400 410 420 TDEFFEECIT DPLLREHLSV LSRTFANQRR LVQGDSKLFF NNVFTVEPLE GDVWPNSSAE 430 440 450 460 470 480 ITVYFNPLEA KLYQQTIYCD ILGREIRLPL RIKGEGMGPK IHFNFELLDI GKVFTGSAHC 490 500 510 520 530 540 YEAILYNKGS IDALFNMTPP TSALGACFVF SPKEGIIEPS GVQAIQISFS STILGNFEEE 550 560 570 580 590 600 FLVNVNGSPE PVKLTIRGCV IGPTFHFNVP ALHFGDVSFG FPHTLICSLN NTSLIPMTYK 610 620 630 640 650 660 LRIPGDGLGH KSISYCEQHV DYKRPSWTKE EISSMKPKEF TISPDCGTIR PQGFAAIRVT 670 680 690 700 710 720 LCSNTVQKYE LALVVDVEGI GEEVLALLIT ARCVVPALHL VNTEVDFGHC FLKYPYEKTL 730 740 750 760 770 780 QLANQDDLPG FYEVQPQVCE EVPTVLFSSP TPSGVISPSS TIHIPLVLET QVTGEHRSTV 790 800 810 820 830 840 YISIFGSQDP PLVCHLKSAG EGPVIYVHPN QVDFGNIYVL KDSSRILNLC NQSFIPAFFQ 850 860 870 880 890 900 AHMAHKKSLW TIEPNEGMVP PETDVQLALT ANLNDTLTFK DCVILDIENS STYRIPVQAS 910 920 930 940 950 960 GTGSTIVSDK PFAPELNLGA HFSLDTHYYH FKLINKGRRI QQLFWMNDSF RPQAKLSKKG 970 980 990 1000 1010 1020 RVKKGHAHVQ PQPSGSQEPR DPQSPVFHLH PASMELYPGQ AIDVILEGYS ATPRIVKEKL 1030 1040 1050 1060 1070 1080 VCHAIIGAQK GKSLVMAVNI TCEFVAPLIQ LSTKQLIYRL EKKPNSILKP DYQPLAIKNI 1090 1100 1110 1120 1130 1140 STLPVNLLLS TSGPFFICET DKSLLPATPE PIKLEIDEEK NLLIKFDPSY RNDLNNWVAE 1150 1160 1170 1180 1190 1200 EILAIKYVEH PQIDSLDLRG EVHYPNLSFE TKELDFGCIL NDTELIRYVT ITNCSPLVVK 1210 1220 1230 1240 1250 1260 FRWFFLVNDE ENQIRFVTLP KKPYSAPVSQ MESIPATSEA ASPPAILVTV ESPEMDLNDF 1270 1280 1290 1300 1310 1320 VKTVLVDEDA RPEEKELRKT KASSVISDEI KISSTEIERI YSSQSQVEDQ ESLQTCEQNE 1330 1340 1350 1360 1370 1380 MLSIGIEEVF DILPLFGVLQ PHSSHQISFT FYGHANIIAQ AKALCEVEEG PTYEITLKGE 1390 1400 1410 1420 1430 1440 ASLVNYSFDT KDIHYGLQLF DHVTEREITL TNMGKVGFEF KVLTDHQSSP DNLLPGVPLI 1450 1460 1470 1480 1490 1500 LPVSGFISSH QEQVLKVYYL PGVPEVFKRS FQIQIAHLDP ENITLSGEGI FPQICLDLPR 1510 1520 1530 1540 1550 1560 NLTANEKYEM FLNQARKNTD KEYNKCEMLD HFDIITEEVP EDEPAEVSAH LQMEVERLIV 1570 1580 1590 1600 1610 1620 QSYVLEHQKT TTPDPMDDPC FSHRSRRKLA KIQLPEYILD FGYIILGEVR THIIKIINTS 1630 1640 1650 1660 1670 1680 HFPVSFHADK RVLHETGFST ELDRVKNLPH CETEIFEVRF DPQGANLPVG SKEVILPIKV 1690 1700 1710 1720 1730 1740 VGGPTVHICL QAKVTIPTMT LSRGKVDFAT IQCGQCLVET IQLSNHLQVP CEWFVQSQKP 1750 1760 1770 1780 1790 1800 VDKLEKHMPK YLRQKLRAEL KPKTRIFEIQ PISGVLDPGE KSNVQVKFMP KEEKFYSQTL 1810 1820 1830 1840 1850 1860 VFQIAQSAQK LTLLARGQGL EPRLEFSPSV LDLGPLLLCA PGDEAEVIVK NPCNFPIEFY 1870 1880 1890 1900 1910 1920 SLEFDQQYLI EEKILRKLKG YDSYNTLLLP PRNPGEKLPP ELYEYFKEIK KSKEEQMRAK 1930 1940 1950 1960 1970 1980 YLENLAQENE EEDITSSDQG TSNSTKRTSL SRGISVTSNL EEWHALLVES KTYLEEEEDE 1990 2000 2010 2020 2030 2040 ESLEKIIFQT DKLQSIDSHS MEEVGEVENN PVSKAIARHL GIDISAEGRL AKNRKGIAII 2050 2060 2070 2080 2090 2100 IHGTPLSGKS ANAVSVAKYY NAACLSIDSI VLEAVANSNN IPGIRARELC IRAAIEQSVK 2110 2120 2130 2140 2150 2160 EGEEAAQEAA VGQNVIGQGR LSTDTLGKLA SEMTLVAPEI KPGKSVRGSV VITKSKADSH 2170 2180 2190 2200 2210 2220 GSGSQKQHHS HQSETPQISS SPLPPGPIHR WLSVSPSVGG ETGLMSCVLP DELLVQILAE 2230 2240 2250 2260 2270 2280 RIQLSDCYRG VVFDGLDTLF AQNAAAALLC LLKAIGSREH IYILNMAQDY AAMKAQEKAK 2290 2300 2310 2320 2330 2340 KEQEERKHKG ALEKEKERLQ NMDEEEYDAL TEEEKLTFDR GIQQALRERK KREQERLAKE 2350 2360 2370 2380 2390 2400 MQEKKLQQEL ERQKEEDELK RRVKKGKQGP IKEEPPMKKS QAANKQVPPL TKVDVKMETI 2410 2420 2430 2440 2450 2460 ERKISVREQT MSEKEELNKK KRNMGDVSMH GLPLVQDQED SEGDNSKDPD KQLAPKFKTY 2470 2480 2490 2500 2510 2520 ELTLKDVQNI LMYWDRKQGV QLPPAGMEEA PHEPDDQRQV PLGGRRGRKD RERERLEKER 2530 2540 2550 2560 2570 2580 TEKERLEREK AERERLEKLR ALEERSDWEG EGEEDHEGKK EKDLGVPFLD IQTPDFEGLS 2590 2600 2610 2620 2630 2640 WKQALESDKL PKGEQILDIL GLGASGPPIP PPALFSIVSY PVKRPPLTMT DDLEHFVFVI 2650 2660 2670 2680 2690 2700 PPSEDISLDE KKEMEIESDF LATTNTTKAQ EEQTSSSKGG KQKMKEKIDQ VFEIQKDKRH 2710 2720 2730 2740 2750 2760 MALNRKVLSG EPAGTISQLS DTDLDNFNGQ HSQEKFTRLN HFRWIVPANG EVTLQVHFSS 2770 2780 2790 2800 2810 2820 DEFGNFDQTF NFEILGTCCQ YQLYCRGICT YPYICQDPKV VFPQRKMDMK TNEVIFKKYV 2830 2840 2850 2860 2870 2880 MSTETYYFGP LLCGKSRDKY KSSLFPGNME TLTILNTSLM VVEASFYFQN DVKANTYFLE 2890 2900 2910 2920 2930 2940 PNTMVLKPNE KQILNVWAYP TSVGVFEDSI VCCINDNPEP AIFQLSCQGI RPELELEPRQ 2950 2960 2970 2980 2990 3000 LHFDRLLLHR QESRVVLLRN VTLLPVAWRI TSLEHLGDDF TVSLMQGTIP PEAEYGLHLY 3010 3020 3030 3040 3050 3060 FQPTKPVNIK KAIRLEVLDA ENLLGVVQIE NIMVFAEAYD IALDITFPKG AEGGLDFGIV 3070 3080 3090 3100 3110 3120 RVTEEAKQPL QLKNRGKYEI AFSFSVDSVG ISTPNINSMI SVQPKKGSLT PTEKPTNVQV 3130 3140 3150 3160 3170 3180 FFHAKKEVKI EHQPVLRCQI IEPNISEGGE IIASIPIKFS ANAVYSKYNI TPSSVINFGA 3190 3200 3210 3220 3230 3240 LICGTRKSTT FTIENQGVTD FKFALYKLTG ESPIHQKKAA SHVRHARSRE SESFYKTGSS 3250 3260 3270 3280 3290 3300 RAAKFSDTIQ KEVTTTGQAR FAHGMFTVYP GFGSIPSGGQ QVINVDCVAD AMGKCEEFIA 3310 3320 3330 3340 3350 3360 IDISGRDPAV HPAGILYTLL AEACLPAFVT ENNALIFEEH QICTSANLHH ILQTIESGGL 3370 3380 3390 3400 3410 3420 FVEDENKFIF CNVLVGRQAK ARFKISNVGK ITCDVNIVVR PISNKPFARI VDIFEVEPSK 3430 3440 3450 3460 3470 3480 MCIASHSHAF ATVSFTPQIM QNYQCIFEAT LDGLPSTLAK SRGLVFDIAG EGNLPRVTVV 3490 3500 3510 3520 3530 3540 RPVLHNQYGN PLLLFKRLLL GHSEKLPLIL KNNGVLPAQL HVDLQDELGV FSLKGRPTTA 3550 3560 3570 3580 3590 3600 YIYITEENKP HVKAKKAHTA SLVVSPGDTA EFDVVFHSQK VGRMRGIIHL SVINNQYEET 3610 3620 3630 3640 3650 3660 SIHMVGEGYE DDITLDNIHG LVAPTSQEDI SISEFTEIIE DNDMEDLVAA ALVDHIQFGD 3670 3680 3690 3700 3710 3720 CHIGHSYNAS FTVTNHSQVN LIRFEWPVSA TIAFSPQMGH LHPGCAKDIV VTMKSDVPIN 3730 3740 3750 3760 3770 3780 LKNMRIRCKL SRIMFQLPAD QVPDWDDRMH TVKWVDVPRN MPGTFTTKRK VIETDPEPAH 3790 3800 3810 3820 3830 3840 SVLEENYQEL QLQISANVDF ASYHCQARDV RFKETLVYQT RVFEFDVINS GRVQLEFSWV 3850 3860 3870 3880 3890 3900 SEDTSKAVSF AKPDHQGSAQ KDQLSQGTMH TGSTLDSTMD HWAEGSPQPF SVEPSSGIVP 3910 3920 3930 3940 3950 3960 VGKIQKFKVK FSPLDIGDFE SNLFCQIPNL PPGEQGPVLV AKGRSTLPIC HFDLKDSDYI 3970 3980 3990 4000 4010 4020 SGHQRNPELR GSSGGALDPN TRVIEFTTVG IGGKNLRTFT ILNPTNSTYS FCWISEEIES 4030 4040 4050 4060 4070 4080 LQNPAAFTCL TEKGFIHPEK KAEIVFQFTP FHLGITESSW TFLIPEHNIT VPFLLVGKTT 4090 4100 4110 4120 4130 4140 EPLISLNKSH LNFSSLLIGR EARETVQIIN KEEQGFDFSF QDNSRYSEGF SNSLLVCPME 4150 4160 4170 4180 4190 4200 GWIPPLSRFP IDIFFTPKQE GDVNFNLICN VEKKVHPVTL NVKAEGYTMN VEIKCKDRTG 4210 4220 4230 4240 4250 4260 SITLLTPNQT NIINFYEVEL NECVQCEFNF INTGKFTFSF QAQLCGSKTL LQYLEFSPID 4270 4280 4290 4300 4310 4320 STVDVGQSVH ATLSFQPLKK CVLTDLELII KISHGPTFMC NISGCAVSPA IHFSFTSYNF 4330 4340 4350 4360 4370 4380 GTCFIYQAGM PPYKQTLVIT NKEETPMSID CLYTNTTHLE VNSRVDVVKP GNTLEIPITF 4390 4400 4410 4420 4430 4440 YPRESINYQE LIPFEINGLS QQTVEIKGKG TKMKILVLDP ANRIVKLGAV LPGQVVKRTV 4450 4460 4470 4480 4490 4500 SIMNNSLAQL TFNQSILFTI PELQEPKVLT LAPFHNITLK PKEVCKLEVI FAPKKRVPPF 4510 4520 4530 4540 4550 4560 SEEVFMECMG LLRPLFLLSG CCQALEISLD QEHIPFGPVV YQTQATRRIL MMNTGDVGAR 4570 4580 4590 4600 4610 4620 FKWDIKKFEP HFSISPEEGY ITSGMEVSFE VTYHPTEVGK ESLCKNILCY IQGGSPLSLT 4630 4640 4650 4660 4670 4680 LSGVCVGPPA VKEVVNFTCQ VRSKHTQTIL LSNRTNQTWN LHPIFEGEHW EGPEFITLEA 4690 4700 4710 4720 4730 4740 HQQNKPYEIT YRPRTMNLEN RKHQGTLFFP LPDGTGWLYA LHGTSELPKA VANIYREVPC 4750 4760 4770 4780 4790 4800 KTPYTELLPI TNWLNKPQRF RVIVEILKPE KPDLSITMKG LDYIDVLSGS KKDYKLNFFS 4810 4820 4830 4840 4850 4860 HKEGTYAAKV IFRNEVTNEF LYYNVSFRVI PSGIIKTIEM VTPVRQVASA SIKLENPLPY 4870 4880 4890 4900 4910 4920 SVTFSTECRM PDIALPSQFV VPANSEGTFS FEFQPLKAGE TFGRLTLHNT DLGYYQYELY 4930 4940 4950 4960 4970 4980 LKATPALPEK PVHFQTVLGS SQIILVKFIN YTRQRTEYYC RTDCTDFHAE KLINAAPGGQ 4990 5000 5010 5020 5030 5040 GGTEASVEVL FEPSHLGETK GILILSSLAG GEYIIPLFGM ALPPKPQGPF SIRAGYSIII 5050 5060 5070 5080 5090 5100 PFKNVFYHMV TFSIIVDNPA FTIRAGESVR PKKINNITVS FEGNPSGSKT PITTKLTVSC 5110 5120 PPGEGSETGV KWVYYLKGIT L
	Isoform 2 [UniParc]. Checksum: 253E0EF252881F8B	FASTA	1,098	123,076
	10 20 30 40 50 60 MFDVINSGRV QLEFSWVSED TSKAVSFAKP DHQGSAQKDQ LSQGTMHTGS TLDSTMDHWA 70 80 90 100 110 120 EGSPQPFSVE PSSGIVPVGK IQKFKVKFSP LDIGDFESNL FCQIPNLPPG EQGPVLVAKG 130 140 150 160 170 180 RSTLPICHFD LKDSDYISGH QRNPELRGSS GGALDPNTRV IEFTTVGIGG KNLRTFTILN 190 200 210 220 230 240 PTNSTYSFCW ISEEIESLQN PAAFTCLTEK GFIHPEKKAE IVFQFTPFHL GITESSWTFL 250 260 270 280 290 300 IPEHNITVPF LLVGKTTEPL ISLNKSHLNF SSLLIGREAR ETVQIINKEE QGFDFSFQDN 310 320 330 340 350 360 SRYSEGFSNS LLVCPMEGWI PPLSRFPIDI FFTPKQEGDV NFNLICNVEK KVHPVTLNVK 370 380 390 400 410 420 AEGYTMNVEI KCKDRTGSIT LLTPNQTNII NFYEVELNEC VQCEFNFINT GKFTFSFQAQ 430 440 450 460 470 480 LCGSKTLLQY LEFSPIDSTV DVGQSVHATL SFQPLKKCVL TDLELIIKIS HGPTFMCNIS 490 500 510 520 530 540 GCAVSPAIHF SFTSYNFGTC FIYQAGMPPY KQTLVITNKE ETPMSIDCLY TNTTHLEVNS 550 560 570 580 590 600 RVDVVKPGNT LEIPITFYPR ESINYQELIP FEINGLSQQT VEIKGKGTKM KILVLDPANR 610 620 630 640 650 660 IVKLGAVLPG QVVKRTVSIM NNSLAQLTFN QSILFTIPEL QEPKVLTLAP FHNITLKPKE 670 680 690 700 710 720 VCKLEVIFAP KKRVPPFSEE VFMECMGLLR PLFLLSGCCQ ALEISLDQEH IPFGPVVYQT 730 740 750 760 770 780 QATRRILMMN TGDVGARFKW DIKKFEPHFS ISPEEGYITS GMEVSFEVTY HPTEVGKESL 790 800 810 820 830 840 CKNILCYIQG GSPLSLTLSG VCVGPPAVKE VVNFTCQVRS KHTQTILLSN RTNQTWNLHP 850 860 870 880 890 900 IFEGEHWEGP EFITLEAHQQ NKPYEITYRP RTMNLENRKH QGTLFFPLPD GTGWLYALHG 910 920 930 940 950 960 TSELPKAVAN IYREVPCKTP YTELLPITNW LNKPQRFRVI VEILKPEKPD LSITMKGLDY 970 980 990 1000 1010 1020 IDVLSGSKKD YKLNFFSHKE GTYAAKVIFR NEVTNEFLYY NVSFRVIPSG IIKTIEMVTP 1030 1040 1050 1060 1070 1080 VRQVASASIK LENPLPYSVT FSTECRMPDI ALPSQFVVPA NSERWGLTAS SRLECSGMII 1090 APCSLKLLQS RPPPASAS
	Isoform 4 [UniParc]. Checksum: B4AB03CA5302D5BB	FASTA	1,017	114,208
	10 20 30 40 50 60 MTSRRLEESM GAVQMGLVNM FKGFQSKVLP PLSPKVVTEE EVNRMLTPSE FLKEMSLTTE 70 80 90 100 110 120 QRLAKTRLMC RPQIIELLDM GETTHQKFSG IDLDQALFQP FPSEIIFQNY TPCEVYEVPL 130 140 150 160 170 180 ILRNNDKIPR LVKVVEESSP YFKVISPKDI GHKVAPGVPS IFRILFTPEE NKDYAHTLTC 190 200 210 220 230 240 VTEREKFIVP IKARGARAIL DFPDKLNFST CPVKYSTQKI LLVRNIGNKN AVFHIKTCRP 250 260 270 280 290 300 FSIEPAIGTL NVGESMQLEV EFEPQSVGDH SGRLIVCYDT GEKVFVSLYG AAIDMNIRLD 310 320 330 340 350 360 KNSLTIEKTY ISLANQRTIT IHNRSNIIAH FLWKVFATQQ EEDREKYRAC DDLIKEEKDE 370 380 390 400 410 420 TDEFFEECIT DPLLREHLSV LSRTFANQRR LVQGDSKLFF NNVFTVEPLE GDVWPNSSAE 430 440 450 460 470 480 ITVYFNPLEA KLYQQTIYCD ILGREIRLPL RIKGEGMGPK IHFNFELLDI GKVFTGSAHC 490 500 510 520 530 540 YEAILYNKGS IDALFNMTPP TSALGACFVF SPKEGIIEPS GVQAIQISFS STILGNFEEE 550 560 570 580 590 600 FLVNVNGSPE PVKLTIRGCV IGPTFHFNVP ALHFGDVSFG FPHTLICSLN NTSLIPMTYK 610 620 630 640 650 660 LRIPGDGLGH KSISYCEQHV DYKRPSWTKE EISSMKPKEF TISPDCGTIR PQGFAAIRVT 670 680 690 700 710 720 LCSNTVQKYE LALVVDVEGI GEEVLALLIT ARCVVPALHL VNTEVDFGHC FLKYPYEKTL 730 740 750 760 770 780 QLANQDDLPG FYEVQPQVCE EVPTVLFSSP TPSGVISPSS TIHIPLVLET QVTGEHRSTV 790 800 810 820 830 840 YISIFGSQDP PLVCHLKSAG EGPVIYVHPN QVDFGNIYVL KDSSRILNLC NQSFIPAFFQ 850 860 870 880 890 900 AHMAHKKSLW TIEPNEGMVP PETDVQLALT ANLNDTLTFK DCVILDIENS STYRIPVQAS 910 920 930 940 950 960 GTGSTIVSDK PFAPELNLGA HFSLDTHYYH FKLINKGRRI QQLFWMNDSF RPQAKLSKKG 970 980 990 1000 1010 RVKKGHAHVQ PQPSGSQEPR DPQSPVFHLH PASMELYPGQ AIDVILEGYS ATPRVRG
	Isoform 5 [UniParc]. Checksum: 06C5B2713F7D7470	FASTA	708	79,722
	10 20 30 40 50 60 MTSRRLEESM GAVQMGLVNM FKGFQSKVLP PLSPKVVTEE EVNRMLTPSE FLKEMSLTTE 70 80 90 100 110 120 QRLAKTRLMC RPQIIELLDM GETTHQKFSG IDLDQALFQP FPSEIIFQNY TPCEVYEVPL 130 140 150 160 170 180 ILRNNDKIPR LVKVVEESSP YFKVISPKDI GHKVAPGVPS IFRILFTPEE NKDYAHTLTC 190 200 210 220 230 240 VTEREKFIVP IKARGARAIL DFPDKLNFST CPVKYSTQKI LLVRNIGNKN AVFHIKTCRP 250 260 270 280 290 300 FSIEPAIGTL NVGESMQLEV EFEPQSVGDH SGRLIVCYDT GEKVFVSLYG AAIDMNIRLD 310 320 330 340 350 360 KNSLTIEKTY ISLANQRTIT IHNRSNIIAH FLWKVFATQQ EEDREKYRAC DDLIKEEKDE 370 380 390 400 410 420 TDEFFEECIT DPLLREHLSV LSRTFANQRR LVQGDSKLFF NNVFTVEPLE GDVWPNSSAE 430 440 450 460 470 480 ITVYFNPLEA KLYQQTIYCD ILGREIRLPL RIKGEGMGPK IHFNFELLDI GKVFTGSAHC 490 500 510 520 530 540 YEAILYNKGS IDALFNMTPP TSALGACFVF SPKEGIIEPS GVQAIQISFS STILGNFEEE 550 560 570 580 590 600 FLVNVNGSPE PVKLTIRGCV IGPTFHFNVP ALHFGDVSFG FPHTLICSLN NTSLIPMTYK 610 620 630 640 650 660 LRIPGDGLGH KSISYCEQHV DYKRPSWTKE EISSMKPKEF TISPDCGTIR PQGFAAIRVT 670 680 690 700 LCSNTVQKYE LALVVDVEGI GEEVLALLIT ARYCSPACSS PESPPSLQ
	Isoform 6 [UniParc]. Checksum: 7236F8324AD317AF	FASTA	950	106,269
	10 20 30 40 50 60 MESAGGFKLG MEPLSGGGVC EKKKLLKMTS RRLEESMGAV QMGLVNMFKG FQSKVLPPLS 70 80 90 100 110 120 PKVVTEEEVN RMLTPSEFLK EMSLTTEQRL AKTRLMCRPQ IIELLDMGET THQKFSGIDL 130 140 150 160 170 180 DQALFQPFPS EIIFQNYTPC EVYEVPLILR NNDKIPRLVK VVEESSPYFK VISPKDIGHK 190 200 210 220 230 240 VAPGVPSIFR ILFTPEENKD YAHTLTCVTE REKFIVPIKA RGARAILDFP DKLNFSTCPV 250 260 270 280 290 300 KYSTQKILLV RNIGNKNAVF HIKTCRPFSI EPAIGTLNVG ESMQLEVEFE PQSVGDHSGR 310 320 330 340 350 360 LIVCYDTGEK VFVSLYGAAI DMNIRLDKNS LTIEKTYISL ANQRTITIHN RSNIIAHFLW 370 380 390 400 410 420 KVFATQQEED REKYRACDDL IKEEKDETDE FFEECITDPL LREHLSVLSR TFANQRRLVQ 430 440 450 460 470 480 GDSKLFFNNV FTVEPLEGDV WPNSSAEITV YFNPLEAKLY QQTIYCDILG REIRLPLRIK 490 500 510 520 530 540 GEGMGPKIHF NFELLDIGKV FTGSAHCYEA ILYNKGSIDA LFNMTPPTSA LGACFVFSPK 550 560 570 580 590 600 EGIIEPSGVQ AIQISFSSTI LGNFEEEFLV NVNGSPEPVK LTIRGCVIGP TFHFNVPALH 610 620 630 640 650 660 FGDVSFGFPH TLICSLNNTS LIPMTYKLRI PGDGLGHKSI SYCEQHVDYK RPSWTKEEIS 670 680 690 700 710 720 SMKPKEFTIS PDCGTIRPQG FAAIRVTLCS NTVQKYELAL VVDVEGIGEE VLALLITARC 730 740 750 760 770 780 VVPALHLVNT EVDFGHCFLK YPYEKTLQLA NQDDLPGFYE VQPQVCEEVP TVLFSSPTPS 790 800 810 820 830 840 GVISPSSTIH IPLVLETQVT GEHRSTVYIS IFGSQDPPLV CHLKSAGEGP VIYVHPNQVD 850 860 870 880 890 900 FGNIYVLKDS SRILNLCNQS FIPAFFQAHM AHKKSLWTIE PNEGMVPPET DVQLALTANL 910 920 930 940 950 NDTLTFKDCV ILDIENSSTY RIPVQASGTG STIVSDKPFA PELNLGAHFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4575-5121 (ISOFORM 1). Tissue: Lung and Teratocarcinoma.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5). Tissue: Testis.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 715-5121 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4141-5121 (ISOFORM 1). Tissue: Amygdala and Testis.
[5]	"A 360-kb interchromosomal duplication of the human HYDIN locus." Doggett N.A., Xie G., Meincke L.J., Sutherland R.D., Mundt M.O., Berbari N.S., Davy B.E., Robinson M.L., Rudd M.K., Weber J.L., Stallings R.L., Han C. Genomics 88:762-771(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	"Recessive HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right body asymmetry." Olbrich H., Schmidts M., Werner C., Onoufriadis A., Loges N.T., Raidt J., Banki N.F., Shoemark A., Burgoyne T., Al Turki S., Hurles M.E., Kohler G., Schroeder J., Nurnberg G., Nurnberg P., Chung E.M., Reinhardt R., Marthin J.K. , Nielsen K.G., Mitchison H.M., Omran H. Am. J. Hum. Genet. 91:672-684(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CILD5.
[7]	"Solution structure of the C-terminal PAPD-like domain from human HYDIN protein." RIKEN structural genomics initiative (RSGI) Submitted (JUL-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 458-563.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK022933 mRNA. Translation: BAB14314.1.
AK026688 mRNA. Translation: BAB15527.1. Frameshift.
AK299348 mRNA. Translation: BAG61346.1.
AC027281 Genomic DNA. No translation available.
AC099495 Genomic DNA. No translation available.
AC138625 Genomic DNA. No translation available.
BC028351 mRNA. Translation: AAH28351.2. Different initiation.
BC043273 mRNA. Translation: AAH43273.1.
AL122038 mRNA. Translation: CAB59178.1.
AL133042 mRNA. Translation: CAB61370.1.
AL137259 mRNA. Translation: CAB70660.1.

IPI

IPI00014215.
IPI00296510.
IPI00640533.
IPI00641530.
IPI00647188.
IPI00843807.

PIR

T42699.
T46330.

RefSeq

NP_001185471.1. NM_001198542.1.
NP_001185472.1. NM_001198543.1.
NP_001257903.1. NM_001270974.1.
NP_060028.2. NM_017558.4.

UniGene

Hs.461229.
Hs.743479.
Hs.744828.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E6J	NMR	-	A	458-563	[»]
2YS4	NMR	-	A	182-296	[»]

ProteinModelPortal

Q4G0P3.

SMR

Q4G0P3. Positions 182-296, 458-563.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q4G0P3. 1 interaction.

PTM databases

PhosphoSite

Q4G0P3.

Polymorphism databases

DMDM

145558935.

Proteomic databases

PaxDb

Q4G0P3.

PRIDE

Q4G0P3.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000321489; ENSP00000314736; ENSG00000157423.
ENST00000393567; ENSP00000377197; ENSG00000157423.
ENST00000448691; ENSP00000394826; ENSG00000157423.
ENST00000538248; ENSP00000444970; ENSG00000157423.

GeneID

54768.

KEGG

hsa:54768.

UCSC

uc010cfz.2. human.
uc010vmd.2. human.

Organism-specific databases

CTD

54768.

GeneCards

GC16M070842.

H-InvDB

HIX0021241.
HIX0161592.

HGNC

HGNC:19368. HYDIN.

HPA

HPA046282.

MIM

608647. phenotype.
610812. gene.

neXtProt

NX_Q4G0P3.

Orphanet

244. Primary ciliary dyskinesia.

PharmGKB

PA134866950.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG44977.

HOGENOM

HOG000171495.

HOVERGEN

HBG099337.

InParanoid

Q4G0P3.

OMA

PEYILDF.

Gene expression databases

ArrayExpress

Q4G0P3.

Bgee

Q4G0P3.

CleanEx

HS_HYDIN.

Genevestigator

Q4G0P3.

Family and domain databases

Gene3D

2.60.40.360. 2 hits.

InterPro

IPR027417. P-loop_NTPase.
IPR008962. PapD-like.
[Graphical view]

SUPFAM

SSF52540. SSF52540. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q4G0P3.

GenomeRNAi

54768.

NextBio

57417.

SOURCE

Search...

Entry information

Entry name

HYDIN_HUMAN

Accession

Primary (citable) accession number: Q4G0P3
Secondary accession number(s): A6NC70 , A6NLZ0, B4DRN4, Q8N3H8, Q8N3P6, Q8TC08, Q96JG3, Q96SS4, Q9H5U3, Q9H9B8, Q9NTI0, Q9UBE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 5, 2011
Last modified:	May 29, 2013
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.