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Q4G0N8 (SL9C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/hydrogen exchanger 10
Alternative name(s):
Na(+)/H(+) exchanger 10
Short name=NHE-10
Solute carrier family 9 member 10
Solute carrier family 9 member C1
Sperm-specific Na(+)/H(+) exchanger
Short name=sNHE
Gene names
Name:SLC9C1
Synonyms:SLC9A10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1177 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) By similarity.

Subunit structure

Interacts with soluble adenylyl cyclase (sAC) By similarity.

Subcellular location

Cell projectionciliumflagellum membrane; Multi-pass membrane protein By similarity.

Domain

The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown By similarity.

Sequence similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Sequence caution

The sequence DAA01462.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4G0N8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4G0N8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     294-341: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11771177Sodium/hydrogen exchanger 10
PRO_0000295704

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane248 – 26821Helical; Potential
Transmembrane301 – 32121Helical; Potential
Transmembrane333 – 35321Helical; Potential
Transmembrane364 – 38421Helical; Potential
Transmembrane405 – 42521Helical; Potential
Transmembrane613 – 63321Helical; Potential
Transmembrane646 – 66621Helical; Potential
Transmembrane675 – 69521Helical; Potential
Transmembrane707 – 72721Helical; Potential
Nucleotide binding870 – 1003134cNMP
Region598 – 67881Ion transport-like

Amino acid modifications

Glycosylation2781N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence294 – 34148Missing in isoform 2.
VSP_027010
Natural variant1581I → V. Ref.1
Corresponds to variant rs9828502 [ dbSNP | Ensembl ].
VAR_033324
Natural variant2861I → V. Ref.1
Corresponds to variant rs9872691 [ dbSNP | Ensembl ].
VAR_033325
Natural variant3481I → M. Ref.1
Corresponds to variant rs9809404 [ dbSNP | Ensembl ].
VAR_033326
Natural variant3641I → V. Ref.1
Corresponds to variant rs9809384 [ dbSNP | Ensembl ].
VAR_050233
Natural variant4241T → A. Ref.1
Corresponds to variant rs6768523 [ dbSNP | Ensembl ].
VAR_033327
Natural variant7051T → I. Ref.1
Corresponds to variant rs4434123 [ dbSNP | Ensembl ].
VAR_033328
Natural variant7321Q → K. Ref.1
Corresponds to variant rs6781844 [ dbSNP | Ensembl ].
VAR_033329
Natural variant7681S → I. Ref.1
Corresponds to variant rs9288938 [ dbSNP | Ensembl ].
VAR_033330
Natural variant8261G → S. Ref.1
Corresponds to variant rs28516377 [ dbSNP | Ensembl ].
VAR_061369

Experimental info

Sequence conflict741M → I in BAC87265. Ref.1
Sequence conflict7851E → D in BAC87265. Ref.1
Sequence conflict7881I → T in BAC87265. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: FD04B5B41D0EA2DC

FASTA1,177135,206
        10         20         30         40         50         60 
MAGIFKEFFF STEDLPEVIL TLSLISSIGA FLNRHLEDFP IPVPVILFLL GCSFEVLSFT 

        70         80         90        100        110        120 
SSQVQRYANA IQWMSPDLFF RIFTPVVFFT TAFDMDTYML QKLFWQILLI SIPGFLVNYI 

       130        140        150        160        170        180 
LVLWHLASVN QLLLKPTQWL LFSAILVSSD PMLTAAAIRD LGLSRSLISL INGESLMTSV 

       190        200        210        220        230        240 
ISLITFTSIM DFDQRLQSKR NHTLAEEIVG GICSYIIASF LFGILSSKLI QFWMSTVFGD 

       250        260        270        280        290        300 
DVNHISLIFS ILYLIFYICE LVGMSGIFTL AIVGLLLNST SFKAAIEETL LLEFWTFLSR 

       310        320        330        340        350        360 
IAFLMVFTFF GLLIPAHTYL YIEFVDIYYS LNIYLTLIVL RFLTLLLISP VLSRVGHEFS 

       370        380        390        400        410        420 
WRWIFIMVCS EMKGMPNINM ALLLAYSDLY FGSDKEKSQI LFHGVLVCLI TLVVNRFILP 

       430        440        450        460        470        480 
VAVTILGLRD ATSTKYKSVC CTFQHFQELT KSAASALKFD KDLANADWNM IEKAITLENP 

       490        500        510        520        530        540 
YMLNEEETTE HQKVKCPHCN KEIDEIFNTE AMELANRRLL SAQIASYQRQ YRNEILSQSA 

       550        560        570        580        590        600 
VQVLVGAAES FGEKKGKCMS LDTIKNYSES QKTVTFARKL LLNWVYNTRK EKEGPSKYFF 

       610        620        630        640        650        660 
FRICHTIVFT EEFEHVGYLV ILMNIFPFII SWISQLNVIY HSELKHTNYC FLTLYILEAL 

       670        680        690        700        710        720 
LKIAAMRKDF FSHAWNIFEL AITLIGILHV ILIEIDTIKY IFNETEVIVF IKVVQFFRIL 

       730        740        750        760        770        780 
RIFKLIAPKL LQIIDKRMSH QKTFWYGILK GYVQGEADIM TIIDQITSSK QIKQMLLKQV 

       790        800        810        820        830        840 
IRNMEHAIKE LGYLEYDHPE IAVTVKTKEE INVMLNMATE ILKAFGLKGI ISKTEGAGIN 

       850        860        870        880        890        900 
KLIMAKKKEV LDSQSIIRPL TVEEVLYHIP WLDKNKDYIN FIQEKAKVVT FDCGNDIFEE 

       910        920        930        940        950        960 
GDEPKGIYII ISGMVKLEKS KPGLGIDQMV ESKEKDFPII DTDYMLSGEI IGEINCLTNE 

       970        980        990       1000       1010       1020 
PMKYSATCKT VVETCFIPKT HLYDAFEQCS PLIKQKMWLK LGLAITARKI REHLSYEDWN 

      1030       1040       1050       1060       1070       1080 
YNMQLKLSNI YVVDIPMSTK TDIYDENLIY VILIHGAVED CLLRKTYRAP FLIPITCHQI 

      1090       1100       1110       1120       1130       1140 
QSIEDFTKVV IIQTPINMKT FRRNIRKFVP KHKSYLTPGL IGSVGTLEEG IQEERNVKED 

      1150       1160       1170 
GAHSAATARS PQPCSLLGTK FNCKESPRIN LRKVRKE 

« Hide

Isoform 2 [UniParc].

Checksum: 1C290AB522BBA8D6
Show »

FASTA1,129129,365

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-158; VAL-286; MET-348; VAL-364; ALA-424; ILE-705; LYS-732; ILE-768 AND SER-826.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[3]"Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK128084 mRNA. Translation: BAC87265.1.
BC044801 mRNA. Translation: AAH44801.1.
BK001328 mRNA. Translation: DAA01462.1. Sequence problems.
RefSeqNP_898884.1. NM_183061.1.
UniGeneHs.680112.

3D structure databases

ProteinModelPortalQ4G0N8.
SMRQ4G0N8. Positions 613-690, 862-1008.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000306627.

Protein family/group databases

TCDB2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

PhosphoSiteQ4G0N8.

Polymorphism databases

DMDM158563886.

Proteomic databases

PaxDbQ4G0N8.
PRIDEQ4G0N8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305815; ENSP00000306627; ENSG00000172139. [Q4G0N8-1]
ENST00000487372; ENSP00000420688; ENSG00000172139. [Q4G0N8-2]
GeneID285335.
KEGGhsa:285335.
UCSCuc003dyu.3. human. [Q4G0N8-1]
uc010hqc.3. human. [Q4G0N8-2]

Organism-specific databases

CTD285335.
GeneCardsGC03M111860.
H-InvDBHIX0200547.
HGNCHGNC:31401. SLC9C1.
HPAHPA044853.
MIM612738. gene.
neXtProtNX_Q4G0N8.
PharmGKBPA134914619.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG126655.
HOGENOMHOG000169764.
HOVERGENHBG071202.
InParanoidQ4G0N8.
KOK14726.
OMAASYQRQY.
OrthoDBEOG7N37BW.
PhylomeDBQ4G0N8.
TreeFamTF328865.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ4G0N8.
CleanExHS_SLC9A10.
GenevestigatorQ4G0N8.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR028483. N/H_exchanger_10.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERPTHR10110. PTHR10110. 1 hit.
PTHR10110:SF84. PTHR10110:SF84. 1 hit.
PfamPF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC9C1. human.
GeneWikiSLC9A10.
GenomeRNAi285335.
NextBio95448.
PROQ4G0N8.
SOURCESearch...

Entry information

Entry nameSL9C1_HUMAN
AccessionPrimary (citable) accession number: Q4G0N8
Secondary accession number(s): Q6ZRP4, Q7RTP2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM