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Protein

Sodium/hydrogen exchanger 10

Gene

SLC9C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi870 – 1003cNMPAdd BLAST134

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Antiport, Differentiation, Ion transport, Sodium transport, Spermatogenesis, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Protein family/group databases

TCDBi2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 10
Alternative name(s):
Na(+)/H(+) exchanger 10
Short name:
NHE-10
Solute carrier family 9 member 10
Solute carrier family 9 member C1
Sperm-specific Na(+)/H(+) exchanger
Short name:
sNHE
Gene namesi
Name:SLC9C1
Synonyms:SLC9A10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31401. SLC9C1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Transmembranei613 – 633HelicalSequence analysisAdd BLAST21
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Transmembranei707 – 727HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi285335.
OpenTargetsiENSG00000172139.
PharmGKBiPA134914619.

Polymorphism and mutation databases

BioMutaiSLC9C1.
DMDMi158563886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957041 – 1177Sodium/hydrogen exchanger 10Add BLAST1177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4G0N8.
PeptideAtlasiQ4G0N8.
PRIDEiQ4G0N8.

PTM databases

iPTMnetiQ4G0N8.
PhosphoSitePlusiQ4G0N8.

Expressioni

Gene expression databases

BgeeiENSG00000172139.
CleanExiHS_SLC9A10.
ExpressionAtlasiQ4G0N8. baseline and differential.

Interactioni

Subunit structurei

Interacts with soluble adenylyl cyclase (sAC).By similarity

Protein-protein interaction databases

IntActiQ4G0N8. 1 interactor.
STRINGi9606.ENSP00000306627.

Structurei

3D structure databases

ProteinModelPortaliQ4G0N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni598 – 678Ion transport-likeAdd BLAST81

Domaini

The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown (By similarity).By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00530000063840.
HOGENOMiHOG000169764.
HOVERGENiHBG071202.
InParanoidiQ4G0N8.
KOiK14726.
OMAiKMQLKLC.
OrthoDBiEOG091G031U.
PhylomeDBiQ4G0N8.
TreeFamiTF328865.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR028483. N/H_exchanger_10.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 2 hits.
PTHR10110:SF87. PTHR10110:SF87. 2 hits.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4G0N8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIFKEFFF STEDLPEVIL TLSLISSIGA FLNRHLEDFP IPVPVILFLL
60 70 80 90 100
GCSFEVLSFT SSQVQRYANA IQWMSPDLFF RIFTPVVFFT TAFDMDTYML
110 120 130 140 150
QKLFWQILLI SIPGFLVNYI LVLWHLASVN QLLLKPTQWL LFSAILVSSD
160 170 180 190 200
PMLTAAAIRD LGLSRSLISL INGESLMTSV ISLITFTSIM DFDQRLQSKR
210 220 230 240 250
NHTLAEEIVG GICSYIIASF LFGILSSKLI QFWMSTVFGD DVNHISLIFS
260 270 280 290 300
ILYLIFYICE LVGMSGIFTL AIVGLLLNST SFKAAIEETL LLEFWTFLSR
310 320 330 340 350
IAFLMVFTFF GLLIPAHTYL YIEFVDIYYS LNIYLTLIVL RFLTLLLISP
360 370 380 390 400
VLSRVGHEFS WRWIFIMVCS EMKGMPNINM ALLLAYSDLY FGSDKEKSQI
410 420 430 440 450
LFHGVLVCLI TLVVNRFILP VAVTILGLRD ATSTKYKSVC CTFQHFQELT
460 470 480 490 500
KSAASALKFD KDLANADWNM IEKAITLENP YMLNEEETTE HQKVKCPHCN
510 520 530 540 550
KEIDEIFNTE AMELANRRLL SAQIASYQRQ YRNEILSQSA VQVLVGAAES
560 570 580 590 600
FGEKKGKCMS LDTIKNYSES QKTVTFARKL LLNWVYNTRK EKEGPSKYFF
610 620 630 640 650
FRICHTIVFT EEFEHVGYLV ILMNIFPFII SWISQLNVIY HSELKHTNYC
660 670 680 690 700
FLTLYILEAL LKIAAMRKDF FSHAWNIFEL AITLIGILHV ILIEIDTIKY
710 720 730 740 750
IFNETEVIVF IKVVQFFRIL RIFKLIAPKL LQIIDKRMSH QKTFWYGILK
760 770 780 790 800
GYVQGEADIM TIIDQITSSK QIKQMLLKQV IRNMEHAIKE LGYLEYDHPE
810 820 830 840 850
IAVTVKTKEE INVMLNMATE ILKAFGLKGI ISKTEGAGIN KLIMAKKKEV
860 870 880 890 900
LDSQSIIRPL TVEEVLYHIP WLDKNKDYIN FIQEKAKVVT FDCGNDIFEE
910 920 930 940 950
GDEPKGIYII ISGMVKLEKS KPGLGIDQMV ESKEKDFPII DTDYMLSGEI
960 970 980 990 1000
IGEINCLTNE PMKYSATCKT VVETCFIPKT HLYDAFEQCS PLIKQKMWLK
1010 1020 1030 1040 1050
LGLAITARKI REHLSYEDWN YNMQLKLSNI YVVDIPMSTK TDIYDENLIY
1060 1070 1080 1090 1100
VILIHGAVED CLLRKTYRAP FLIPITCHQI QSIEDFTKVV IIQTPINMKT
1110 1120 1130 1140 1150
FRRNIRKFVP KHKSYLTPGL IGSVGTLEEG IQEERNVKED GAHSAATARS
1160 1170
PQPCSLLGTK FNCKESPRIN LRKVRKE
Length:1,177
Mass (Da):135,206
Last modified:July 24, 2007 - v2
Checksum:iFD04B5B41D0EA2DC
GO
Isoform 2 (identifier: Q4G0N8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-341: Missing.

Note: No experimental confirmation available.
Show »
Length:1,129
Mass (Da):129,365
Checksum:i1C290AB522BBA8D6
GO

Sequence cautioni

The sequence DAA01462 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74M → I in BAC87265 (PubMed:14702039).Curated1
Sequence conflicti785E → D in BAC87265 (PubMed:14702039).Curated1
Sequence conflicti788I → T in BAC87265 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033324158I → V.1 PublicationCorresponds to variant rs9828502dbSNPEnsembl.1
Natural variantiVAR_033325286I → V.1 PublicationCorresponds to variant rs9872691dbSNPEnsembl.1
Natural variantiVAR_033326348I → M.1 PublicationCorresponds to variant rs9809404dbSNPEnsembl.1
Natural variantiVAR_050233364I → V.1 PublicationCorresponds to variant rs9809384dbSNPEnsembl.1
Natural variantiVAR_033327424T → A.1 PublicationCorresponds to variant rs6768523dbSNPEnsembl.1
Natural variantiVAR_033328705T → I.1 PublicationCorresponds to variant rs4434123dbSNPEnsembl.1
Natural variantiVAR_033329732Q → K.1 PublicationCorresponds to variant rs6781844dbSNPEnsembl.1
Natural variantiVAR_033330768S → I.1 PublicationCorresponds to variant rs9288938dbSNPEnsembl.1
Natural variantiVAR_061369826G → S.1 PublicationCorresponds to variant rs28516377dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027010294 – 341Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128084 mRNA. Translation: BAC87265.1.
BC044801 mRNA. Translation: AAH44801.1.
BK001328 mRNA. Translation: DAA01462.1. Sequence problems.
CCDSiCCDS33817.1. [Q4G0N8-1]
CCDS82818.1. [Q4G0N8-2]
RefSeqiNP_001307460.1. NM_001320531.1. [Q4G0N8-2]
NP_898884.1. NM_183061.2. [Q4G0N8-1]
UniGeneiHs.680112.

Genome annotation databases

EnsembliENST00000305815; ENSP00000306627; ENSG00000172139. [Q4G0N8-1]
ENST00000487372; ENSP00000420688; ENSG00000172139. [Q4G0N8-2]
GeneIDi285335.
KEGGihsa:285335.
UCSCiuc003dyu.4. human. [Q4G0N8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128084 mRNA. Translation: BAC87265.1.
BC044801 mRNA. Translation: AAH44801.1.
BK001328 mRNA. Translation: DAA01462.1. Sequence problems.
CCDSiCCDS33817.1. [Q4G0N8-1]
CCDS82818.1. [Q4G0N8-2]
RefSeqiNP_001307460.1. NM_001320531.1. [Q4G0N8-2]
NP_898884.1. NM_183061.2. [Q4G0N8-1]
UniGeneiHs.680112.

3D structure databases

ProteinModelPortaliQ4G0N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4G0N8. 1 interactor.
STRINGi9606.ENSP00000306627.

Protein family/group databases

TCDBi2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

iPTMnetiQ4G0N8.
PhosphoSitePlusiQ4G0N8.

Polymorphism and mutation databases

BioMutaiSLC9C1.
DMDMi158563886.

Proteomic databases

PaxDbiQ4G0N8.
PeptideAtlasiQ4G0N8.
PRIDEiQ4G0N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305815; ENSP00000306627; ENSG00000172139. [Q4G0N8-1]
ENST00000487372; ENSP00000420688; ENSG00000172139. [Q4G0N8-2]
GeneIDi285335.
KEGGihsa:285335.
UCSCiuc003dyu.4. human. [Q4G0N8-1]

Organism-specific databases

CTDi285335.
DisGeNETi285335.
GeneCardsiSLC9C1.
H-InvDBHIX0200547.
HGNCiHGNC:31401. SLC9C1.
MIMi612738. gene.
neXtProtiNX_Q4G0N8.
OpenTargetsiENSG00000172139.
PharmGKBiPA134914619.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00530000063840.
HOGENOMiHOG000169764.
HOVERGENiHBG071202.
InParanoidiQ4G0N8.
KOiK14726.
OMAiKMQLKLC.
OrthoDBiEOG091G031U.
PhylomeDBiQ4G0N8.
TreeFamiTF328865.

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Miscellaneous databases

GeneWikiiSLC9A10.
GenomeRNAii285335.
PROiQ4G0N8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172139.
CleanExiHS_SLC9A10.
ExpressionAtlasiQ4G0N8. baseline and differential.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR028483. N/H_exchanger_10.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 2 hits.
PTHR10110:SF87. PTHR10110:SF87. 2 hits.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSL9C1_HUMAN
AccessioniPrimary (citable) accession number: Q4G0N8
Secondary accession number(s): Q6ZRP4, Q7RTP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.