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Q4G0N8

- SL9C1_HUMAN

UniProt

Q4G0N8 - SL9C1_HUMAN

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Protein

Sodium/hydrogen exchanger 10

Gene
SLC9C1, SLC9A10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi870 – 1003134cNMPAdd
BLAST

GO - Molecular functioni

  1. solute:proton antiporter activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. ion transmembrane transport Source: Reactome
  3. multicellular organismal development Source: UniProtKB-KW
  4. sodium ion transport Source: UniProtKB-KW
  5. spermatogenesis Source: UniProtKB-KW
  6. sperm motility Source: Ensembl
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Antiport, Differentiation, Ion transport, Sodium transport, Spermatogenesis, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 10
Alternative name(s):
Na(+)/H(+) exchanger 10
Short name:
NHE-10
Solute carrier family 9 member 10
Solute carrier family 9 member C1
Sperm-specific Na(+)/H(+) exchanger
Short name:
sNHE
Gene namesi
Name:SLC9C1
Synonyms:SLC9A10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:31401. SLC9C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Transmembranei73 – 9321Helical; Reviewed predictionAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Reviewed predictionAdd
BLAST
Transmembranei167 – 18721Helical; Reviewed predictionAdd
BLAST
Transmembranei204 – 22421Helical; Reviewed predictionAdd
BLAST
Transmembranei248 – 26821Helical; Reviewed predictionAdd
BLAST
Transmembranei301 – 32121Helical; Reviewed predictionAdd
BLAST
Transmembranei333 – 35321Helical; Reviewed predictionAdd
BLAST
Transmembranei364 – 38421Helical; Reviewed predictionAdd
BLAST
Transmembranei405 – 42521Helical; Reviewed predictionAdd
BLAST
Transmembranei613 – 63321Helical; Reviewed predictionAdd
BLAST
Transmembranei646 – 66621Helical; Reviewed predictionAdd
BLAST
Transmembranei675 – 69521Helical; Reviewed predictionAdd
BLAST
Transmembranei707 – 72721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. motile cilium Source: Ensembl
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11771177Sodium/hydrogen exchanger 10PRO_0000295704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4G0N8.
PRIDEiQ4G0N8.

PTM databases

PhosphoSiteiQ4G0N8.

Expressioni

Gene expression databases

BgeeiQ4G0N8.
CleanExiHS_SLC9A10.
GenevestigatoriQ4G0N8.

Organism-specific databases

HPAiHPA044853.

Interactioni

Subunit structurei

Interacts with soluble adenylyl cyclase (sAC) By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000306627.

Structurei

3D structure databases

ProteinModelPortaliQ4G0N8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni598 – 67881Ion transport-likeAdd
BLAST

Domaini

The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG126655.
HOGENOMiHOG000169764.
HOVERGENiHBG071202.
InParanoidiQ4G0N8.
KOiK14726.
OMAiASYQRQY.
OrthoDBiEOG7N37BW.
PhylomeDBiQ4G0N8.
TreeFamiTF328865.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR028483. N/H_exchanger_10.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PTHR10110:SF87. PTHR10110:SF87. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q4G0N8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGIFKEFFF STEDLPEVIL TLSLISSIGA FLNRHLEDFP IPVPVILFLL     50
GCSFEVLSFT SSQVQRYANA IQWMSPDLFF RIFTPVVFFT TAFDMDTYML 100
QKLFWQILLI SIPGFLVNYI LVLWHLASVN QLLLKPTQWL LFSAILVSSD 150
PMLTAAAIRD LGLSRSLISL INGESLMTSV ISLITFTSIM DFDQRLQSKR 200
NHTLAEEIVG GICSYIIASF LFGILSSKLI QFWMSTVFGD DVNHISLIFS 250
ILYLIFYICE LVGMSGIFTL AIVGLLLNST SFKAAIEETL LLEFWTFLSR 300
IAFLMVFTFF GLLIPAHTYL YIEFVDIYYS LNIYLTLIVL RFLTLLLISP 350
VLSRVGHEFS WRWIFIMVCS EMKGMPNINM ALLLAYSDLY FGSDKEKSQI 400
LFHGVLVCLI TLVVNRFILP VAVTILGLRD ATSTKYKSVC CTFQHFQELT 450
KSAASALKFD KDLANADWNM IEKAITLENP YMLNEEETTE HQKVKCPHCN 500
KEIDEIFNTE AMELANRRLL SAQIASYQRQ YRNEILSQSA VQVLVGAAES 550
FGEKKGKCMS LDTIKNYSES QKTVTFARKL LLNWVYNTRK EKEGPSKYFF 600
FRICHTIVFT EEFEHVGYLV ILMNIFPFII SWISQLNVIY HSELKHTNYC 650
FLTLYILEAL LKIAAMRKDF FSHAWNIFEL AITLIGILHV ILIEIDTIKY 700
IFNETEVIVF IKVVQFFRIL RIFKLIAPKL LQIIDKRMSH QKTFWYGILK 750
GYVQGEADIM TIIDQITSSK QIKQMLLKQV IRNMEHAIKE LGYLEYDHPE 800
IAVTVKTKEE INVMLNMATE ILKAFGLKGI ISKTEGAGIN KLIMAKKKEV 850
LDSQSIIRPL TVEEVLYHIP WLDKNKDYIN FIQEKAKVVT FDCGNDIFEE 900
GDEPKGIYII ISGMVKLEKS KPGLGIDQMV ESKEKDFPII DTDYMLSGEI 950
IGEINCLTNE PMKYSATCKT VVETCFIPKT HLYDAFEQCS PLIKQKMWLK 1000
LGLAITARKI REHLSYEDWN YNMQLKLSNI YVVDIPMSTK TDIYDENLIY 1050
VILIHGAVED CLLRKTYRAP FLIPITCHQI QSIEDFTKVV IIQTPINMKT 1100
FRRNIRKFVP KHKSYLTPGL IGSVGTLEEG IQEERNVKED GAHSAATARS 1150
PQPCSLLGTK FNCKESPRIN LRKVRKE 1177
Length:1,177
Mass (Da):135,206
Last modified:July 24, 2007 - v2
Checksum:iFD04B5B41D0EA2DC
GO
Isoform 2 (identifier: Q4G0N8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-341: Missing.

Note: No experimental confirmation available.

Show »
Length:1,129
Mass (Da):129,365
Checksum:i1C290AB522BBA8D6
GO

Sequence cautioni

The sequence DAA01462.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581I → V.1 Publication
Corresponds to variant rs9828502 [ dbSNP | Ensembl ].
VAR_033324
Natural varianti286 – 2861I → V.1 Publication
Corresponds to variant rs9872691 [ dbSNP | Ensembl ].
VAR_033325
Natural varianti348 – 3481I → M.1 Publication
Corresponds to variant rs9809404 [ dbSNP | Ensembl ].
VAR_033326
Natural varianti364 – 3641I → V.1 Publication
Corresponds to variant rs9809384 [ dbSNP | Ensembl ].
VAR_050233
Natural varianti424 – 4241T → A.1 Publication
Corresponds to variant rs6768523 [ dbSNP | Ensembl ].
VAR_033327
Natural varianti705 – 7051T → I.1 Publication
Corresponds to variant rs4434123 [ dbSNP | Ensembl ].
VAR_033328
Natural varianti732 – 7321Q → K.1 Publication
Corresponds to variant rs6781844 [ dbSNP | Ensembl ].
VAR_033329
Natural varianti768 – 7681S → I.1 Publication
Corresponds to variant rs9288938 [ dbSNP | Ensembl ].
VAR_033330
Natural varianti826 – 8261G → S.1 Publication
Corresponds to variant rs28516377 [ dbSNP | Ensembl ].
VAR_061369

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei294 – 34148Missing in isoform 2. VSP_027010Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741M → I in BAC87265. 1 Publication
Sequence conflicti785 – 7851E → D in BAC87265. 1 Publication
Sequence conflicti788 – 7881I → T in BAC87265. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128084 mRNA. Translation: BAC87265.1.
BC044801 mRNA. Translation: AAH44801.1.
BK001328 mRNA. Translation: DAA01462.1. Sequence problems.
CCDSiCCDS33817.1. [Q4G0N8-1]
RefSeqiNP_898884.1. NM_183061.1. [Q4G0N8-1]
UniGeneiHs.680112.

Genome annotation databases

EnsembliENST00000305815; ENSP00000306627; ENSG00000172139. [Q4G0N8-1]
ENST00000487372; ENSP00000420688; ENSG00000172139. [Q4G0N8-2]
GeneIDi285335.
KEGGihsa:285335.
UCSCiuc003dyu.3. human. [Q4G0N8-1]
uc010hqc.3. human. [Q4G0N8-2]

Polymorphism databases

DMDMi158563886.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128084 mRNA. Translation: BAC87265.1 .
BC044801 mRNA. Translation: AAH44801.1 .
BK001328 mRNA. Translation: DAA01462.1 . Sequence problems.
CCDSi CCDS33817.1. [Q4G0N8-1 ]
RefSeqi NP_898884.1. NM_183061.1. [Q4G0N8-1 ]
UniGenei Hs.680112.

3D structure databases

ProteinModelPortali Q4G0N8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000306627.

Protein family/group databases

TCDBi 2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

PhosphoSitei Q4G0N8.

Polymorphism databases

DMDMi 158563886.

Proteomic databases

PaxDbi Q4G0N8.
PRIDEi Q4G0N8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305815 ; ENSP00000306627 ; ENSG00000172139 . [Q4G0N8-1 ]
ENST00000487372 ; ENSP00000420688 ; ENSG00000172139 . [Q4G0N8-2 ]
GeneIDi 285335.
KEGGi hsa:285335.
UCSCi uc003dyu.3. human. [Q4G0N8-1 ]
uc010hqc.3. human. [Q4G0N8-2 ]

Organism-specific databases

CTDi 285335.
GeneCardsi GC03M111860.
H-InvDB HIX0200547.
HGNCi HGNC:31401. SLC9C1.
HPAi HPA044853.
MIMi 612738. gene.
neXtProti NX_Q4G0N8.
PharmGKBi PA134914619.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG126655.
HOGENOMi HOG000169764.
HOVERGENi HBG071202.
InParanoidi Q4G0N8.
KOi K14726.
OMAi ASYQRQY.
OrthoDBi EOG7N37BW.
PhylomeDBi Q4G0N8.
TreeFami TF328865.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi SLC9C1. human.
GeneWikii SLC9A10.
GenomeRNAii 285335.
NextBioi 95448.
PROi Q4G0N8.
SOURCEi Search...

Gene expression databases

Bgeei Q4G0N8.
CleanExi HS_SLC9A10.
Genevestigatori Q4G0N8.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR028483. N/H_exchanger_10.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
PANTHERi PTHR10110. PTHR10110. 1 hit.
PTHR10110:SF87. PTHR10110:SF87. 1 hit.
Pfami PF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-158; VAL-286; MET-348; VAL-364; ALA-424; ILE-705; LYS-732; ILE-768 AND SER-826.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
    Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
    BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSL9C1_HUMAN
AccessioniPrimary (citable) accession number: Q4G0N8
Secondary accession number(s): Q6ZRP4, Q7RTP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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