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Q4G0N8

- SL9C1_HUMAN

UniProt

Q4G0N8 - SL9C1_HUMAN

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Protein

Sodium/hydrogen exchanger 10

Gene

SLC9C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi870 – 1003134cNMPAdd
BLAST

GO - Molecular functioni

  1. solute:proton antiporter activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. ion transmembrane transport Source: Reactome
  3. multicellular organismal development Source: UniProtKB-KW
  4. sodium ion transport Source: UniProtKB-KW
  5. spermatogenesis Source: UniProtKB-KW
  6. sperm motility Source: Ensembl
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Antiport, Differentiation, Ion transport, Sodium transport, Spermatogenesis, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 10
Alternative name(s):
Na(+)/H(+) exchanger 10
Short name:
NHE-10
Solute carrier family 9 member 10
Solute carrier family 9 member C1
Sperm-specific Na(+)/H(+) exchanger
Short name:
sNHE
Gene namesi
Name:SLC9C1
Synonyms:SLC9A10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:31401. SLC9C1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. motile cilium Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11771177Sodium/hydrogen exchanger 10PRO_0000295704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4G0N8.
PRIDEiQ4G0N8.

PTM databases

PhosphoSiteiQ4G0N8.

Expressioni

Gene expression databases

BgeeiQ4G0N8.
CleanExiHS_SLC9A10.
ExpressionAtlasiQ4G0N8. baseline.
GenevestigatoriQ4G0N8.

Organism-specific databases

HPAiHPA044853.

Interactioni

Subunit structurei

Interacts with soluble adenylyl cyclase (sAC).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000306627.

Structurei

3D structure databases

ProteinModelPortaliQ4G0N8.
SMRiQ4G0N8. Positions 133-188, 797-866.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST
Transmembranei364 – 38421HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Transmembranei613 – 63321HelicalSequence AnalysisAdd
BLAST
Transmembranei646 – 66621HelicalSequence AnalysisAdd
BLAST
Transmembranei675 – 69521HelicalSequence AnalysisAdd
BLAST
Transmembranei707 – 72721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni598 – 67881Ion transport-likeAdd
BLAST

Domaini

The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown (By similarity).By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG126655.
GeneTreeiENSGT00530000063840.
HOGENOMiHOG000169764.
HOVERGENiHBG071202.
InParanoidiQ4G0N8.
KOiK14726.
OMAiASYQRQY.
OrthoDBiEOG7N37BW.
PhylomeDBiQ4G0N8.
TreeFamiTF328865.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR028483. N/H_exchanger_10.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PTHR10110:SF87. PTHR10110:SF87. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q4G0N8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIFKEFFF STEDLPEVIL TLSLISSIGA FLNRHLEDFP IPVPVILFLL
60 70 80 90 100
GCSFEVLSFT SSQVQRYANA IQWMSPDLFF RIFTPVVFFT TAFDMDTYML
110 120 130 140 150
QKLFWQILLI SIPGFLVNYI LVLWHLASVN QLLLKPTQWL LFSAILVSSD
160 170 180 190 200
PMLTAAAIRD LGLSRSLISL INGESLMTSV ISLITFTSIM DFDQRLQSKR
210 220 230 240 250
NHTLAEEIVG GICSYIIASF LFGILSSKLI QFWMSTVFGD DVNHISLIFS
260 270 280 290 300
ILYLIFYICE LVGMSGIFTL AIVGLLLNST SFKAAIEETL LLEFWTFLSR
310 320 330 340 350
IAFLMVFTFF GLLIPAHTYL YIEFVDIYYS LNIYLTLIVL RFLTLLLISP
360 370 380 390 400
VLSRVGHEFS WRWIFIMVCS EMKGMPNINM ALLLAYSDLY FGSDKEKSQI
410 420 430 440 450
LFHGVLVCLI TLVVNRFILP VAVTILGLRD ATSTKYKSVC CTFQHFQELT
460 470 480 490 500
KSAASALKFD KDLANADWNM IEKAITLENP YMLNEEETTE HQKVKCPHCN
510 520 530 540 550
KEIDEIFNTE AMELANRRLL SAQIASYQRQ YRNEILSQSA VQVLVGAAES
560 570 580 590 600
FGEKKGKCMS LDTIKNYSES QKTVTFARKL LLNWVYNTRK EKEGPSKYFF
610 620 630 640 650
FRICHTIVFT EEFEHVGYLV ILMNIFPFII SWISQLNVIY HSELKHTNYC
660 670 680 690 700
FLTLYILEAL LKIAAMRKDF FSHAWNIFEL AITLIGILHV ILIEIDTIKY
710 720 730 740 750
IFNETEVIVF IKVVQFFRIL RIFKLIAPKL LQIIDKRMSH QKTFWYGILK
760 770 780 790 800
GYVQGEADIM TIIDQITSSK QIKQMLLKQV IRNMEHAIKE LGYLEYDHPE
810 820 830 840 850
IAVTVKTKEE INVMLNMATE ILKAFGLKGI ISKTEGAGIN KLIMAKKKEV
860 870 880 890 900
LDSQSIIRPL TVEEVLYHIP WLDKNKDYIN FIQEKAKVVT FDCGNDIFEE
910 920 930 940 950
GDEPKGIYII ISGMVKLEKS KPGLGIDQMV ESKEKDFPII DTDYMLSGEI
960 970 980 990 1000
IGEINCLTNE PMKYSATCKT VVETCFIPKT HLYDAFEQCS PLIKQKMWLK
1010 1020 1030 1040 1050
LGLAITARKI REHLSYEDWN YNMQLKLSNI YVVDIPMSTK TDIYDENLIY
1060 1070 1080 1090 1100
VILIHGAVED CLLRKTYRAP FLIPITCHQI QSIEDFTKVV IIQTPINMKT
1110 1120 1130 1140 1150
FRRNIRKFVP KHKSYLTPGL IGSVGTLEEG IQEERNVKED GAHSAATARS
1160 1170
PQPCSLLGTK FNCKESPRIN LRKVRKE
Length:1,177
Mass (Da):135,206
Last modified:July 24, 2007 - v2
Checksum:iFD04B5B41D0EA2DC
GO
Isoform 2 (identifier: Q4G0N8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-341: Missing.

Note: No experimental confirmation available.

Show »
Length:1,129
Mass (Da):129,365
Checksum:i1C290AB522BBA8D6
GO

Sequence cautioni

The sequence DAA01462.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741M → I in BAC87265. (PubMed:14702039)Curated
Sequence conflicti785 – 7851E → D in BAC87265. (PubMed:14702039)Curated
Sequence conflicti788 – 7881I → T in BAC87265. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581I → V.1 Publication
Corresponds to variant rs9828502 [ dbSNP | Ensembl ].
VAR_033324
Natural varianti286 – 2861I → V.1 Publication
Corresponds to variant rs9872691 [ dbSNP | Ensembl ].
VAR_033325
Natural varianti348 – 3481I → M.1 Publication
Corresponds to variant rs9809404 [ dbSNP | Ensembl ].
VAR_033326
Natural varianti364 – 3641I → V.1 Publication
Corresponds to variant rs9809384 [ dbSNP | Ensembl ].
VAR_050233
Natural varianti424 – 4241T → A.1 Publication
Corresponds to variant rs6768523 [ dbSNP | Ensembl ].
VAR_033327
Natural varianti705 – 7051T → I.1 Publication
Corresponds to variant rs4434123 [ dbSNP | Ensembl ].
VAR_033328
Natural varianti732 – 7321Q → K.1 Publication
Corresponds to variant rs6781844 [ dbSNP | Ensembl ].
VAR_033329
Natural varianti768 – 7681S → I.1 Publication
Corresponds to variant rs9288938 [ dbSNP | Ensembl ].
VAR_033330
Natural varianti826 – 8261G → S.1 Publication
Corresponds to variant rs28516377 [ dbSNP | Ensembl ].
VAR_061369

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei294 – 34148Missing in isoform 2. 1 PublicationVSP_027010Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128084 mRNA. Translation: BAC87265.1.
BC044801 mRNA. Translation: AAH44801.1.
BK001328 mRNA. Translation: DAA01462.1. Sequence problems.
CCDSiCCDS33817.1. [Q4G0N8-1]
RefSeqiNP_898884.1. NM_183061.1. [Q4G0N8-1]
UniGeneiHs.680112.

Genome annotation databases

EnsembliENST00000305815; ENSP00000306627; ENSG00000172139. [Q4G0N8-1]
ENST00000487372; ENSP00000420688; ENSG00000172139. [Q4G0N8-2]
GeneIDi285335.
KEGGihsa:285335.
UCSCiuc003dyu.3. human. [Q4G0N8-1]
uc010hqc.3. human. [Q4G0N8-2]

Polymorphism databases

DMDMi158563886.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128084 mRNA. Translation: BAC87265.1 .
BC044801 mRNA. Translation: AAH44801.1 .
BK001328 mRNA. Translation: DAA01462.1 . Sequence problems.
CCDSi CCDS33817.1. [Q4G0N8-1 ]
RefSeqi NP_898884.1. NM_183061.1. [Q4G0N8-1 ]
UniGenei Hs.680112.

3D structure databases

ProteinModelPortali Q4G0N8.
SMRi Q4G0N8. Positions 133-188, 797-866.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000306627.

Protein family/group databases

TCDBi 2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

PhosphoSitei Q4G0N8.

Polymorphism databases

DMDMi 158563886.

Proteomic databases

PaxDbi Q4G0N8.
PRIDEi Q4G0N8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305815 ; ENSP00000306627 ; ENSG00000172139 . [Q4G0N8-1 ]
ENST00000487372 ; ENSP00000420688 ; ENSG00000172139 . [Q4G0N8-2 ]
GeneIDi 285335.
KEGGi hsa:285335.
UCSCi uc003dyu.3. human. [Q4G0N8-1 ]
uc010hqc.3. human. [Q4G0N8-2 ]

Organism-specific databases

CTDi 285335.
GeneCardsi GC03M111860.
H-InvDB HIX0200547.
HGNCi HGNC:31401. SLC9C1.
HPAi HPA044853.
MIMi 612738. gene.
neXtProti NX_Q4G0N8.
PharmGKBi PA134914619.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG126655.
GeneTreei ENSGT00530000063840.
HOGENOMi HOG000169764.
HOVERGENi HBG071202.
InParanoidi Q4G0N8.
KOi K14726.
OMAi ASYQRQY.
OrthoDBi EOG7N37BW.
PhylomeDBi Q4G0N8.
TreeFami TF328865.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi SLC9C1. human.
GeneWikii SLC9A10.
GenomeRNAii 285335.
NextBioi 95448.
PROi Q4G0N8.
SOURCEi Search...

Gene expression databases

Bgeei Q4G0N8.
CleanExi HS_SLC9A10.
ExpressionAtlasi Q4G0N8. baseline.
Genevestigatori Q4G0N8.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR028483. N/H_exchanger_10.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
PANTHERi PTHR10110. PTHR10110. 1 hit.
PTHR10110:SF87. PTHR10110:SF87. 1 hit.
Pfami PF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-158; VAL-286; MET-348; VAL-364; ALA-424; ILE-705; LYS-732; ILE-768 AND SER-826.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
    Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
    BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSL9C1_HUMAN
AccessioniPrimary (citable) accession number: Q4G0N8
Secondary accession number(s): Q6ZRP4, Q7RTP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3