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Q4G0N8

- SL9C1_HUMAN

UniProt

Q4G0N8 - SL9C1_HUMAN

Protein

Sodium/hydrogen exchanger 10

Gene

SLC9C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi870 – 1003134cNMPAdd
    BLAST

    GO - Molecular functioni

    1. solute:proton antiporter activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. ion transmembrane transport Source: Reactome
    3. multicellular organismal development Source: UniProtKB-KW
    4. sodium ion transport Source: UniProtKB-KW
    5. spermatogenesis Source: UniProtKB-KW
    6. sperm motility Source: Ensembl
    7. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Antiport, Differentiation, Ion transport, Sodium transport, Spermatogenesis, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Protein family/group databases

    TCDBi2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchanger 10
    Alternative name(s):
    Na(+)/H(+) exchanger 10
    Short name:
    NHE-10
    Solute carrier family 9 member 10
    Solute carrier family 9 member C1
    Sperm-specific Na(+)/H(+) exchanger
    Short name:
    sNHE
    Gene namesi
    Name:SLC9C1
    Synonyms:SLC9A10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:31401. SLC9C1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. motile cilium Source: Ensembl
    3. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Flagellum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914619.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11771177Sodium/hydrogen exchanger 10PRO_0000295704Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ4G0N8.
    PRIDEiQ4G0N8.

    PTM databases

    PhosphoSiteiQ4G0N8.

    Expressioni

    Gene expression databases

    BgeeiQ4G0N8.
    CleanExiHS_SLC9A10.
    GenevestigatoriQ4G0N8.

    Organism-specific databases

    HPAiHPA044853.

    Interactioni

    Subunit structurei

    Interacts with soluble adenylyl cyclase (sAC).By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000306627.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G0N8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei364 – 38421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei613 – 63321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei646 – 66621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei675 – 69521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei707 – 72721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni598 – 67881Ion transport-likeAdd
    BLAST

    Domaini

    The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown By similarity.By similarity

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG126655.
    HOGENOMiHOG000169764.
    HOVERGENiHBG071202.
    InParanoidiQ4G0N8.
    KOiK14726.
    OMAiASYQRQY.
    OrthoDBiEOG7N37BW.
    PhylomeDBiQ4G0N8.
    TreeFamiTF328865.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR028483. N/H_exchanger_10.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PTHR10110:SF87. PTHR10110:SF87. 1 hit.
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4G0N8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGIFKEFFF STEDLPEVIL TLSLISSIGA FLNRHLEDFP IPVPVILFLL     50
    GCSFEVLSFT SSQVQRYANA IQWMSPDLFF RIFTPVVFFT TAFDMDTYML 100
    QKLFWQILLI SIPGFLVNYI LVLWHLASVN QLLLKPTQWL LFSAILVSSD 150
    PMLTAAAIRD LGLSRSLISL INGESLMTSV ISLITFTSIM DFDQRLQSKR 200
    NHTLAEEIVG GICSYIIASF LFGILSSKLI QFWMSTVFGD DVNHISLIFS 250
    ILYLIFYICE LVGMSGIFTL AIVGLLLNST SFKAAIEETL LLEFWTFLSR 300
    IAFLMVFTFF GLLIPAHTYL YIEFVDIYYS LNIYLTLIVL RFLTLLLISP 350
    VLSRVGHEFS WRWIFIMVCS EMKGMPNINM ALLLAYSDLY FGSDKEKSQI 400
    LFHGVLVCLI TLVVNRFILP VAVTILGLRD ATSTKYKSVC CTFQHFQELT 450
    KSAASALKFD KDLANADWNM IEKAITLENP YMLNEEETTE HQKVKCPHCN 500
    KEIDEIFNTE AMELANRRLL SAQIASYQRQ YRNEILSQSA VQVLVGAAES 550
    FGEKKGKCMS LDTIKNYSES QKTVTFARKL LLNWVYNTRK EKEGPSKYFF 600
    FRICHTIVFT EEFEHVGYLV ILMNIFPFII SWISQLNVIY HSELKHTNYC 650
    FLTLYILEAL LKIAAMRKDF FSHAWNIFEL AITLIGILHV ILIEIDTIKY 700
    IFNETEVIVF IKVVQFFRIL RIFKLIAPKL LQIIDKRMSH QKTFWYGILK 750
    GYVQGEADIM TIIDQITSSK QIKQMLLKQV IRNMEHAIKE LGYLEYDHPE 800
    IAVTVKTKEE INVMLNMATE ILKAFGLKGI ISKTEGAGIN KLIMAKKKEV 850
    LDSQSIIRPL TVEEVLYHIP WLDKNKDYIN FIQEKAKVVT FDCGNDIFEE 900
    GDEPKGIYII ISGMVKLEKS KPGLGIDQMV ESKEKDFPII DTDYMLSGEI 950
    IGEINCLTNE PMKYSATCKT VVETCFIPKT HLYDAFEQCS PLIKQKMWLK 1000
    LGLAITARKI REHLSYEDWN YNMQLKLSNI YVVDIPMSTK TDIYDENLIY 1050
    VILIHGAVED CLLRKTYRAP FLIPITCHQI QSIEDFTKVV IIQTPINMKT 1100
    FRRNIRKFVP KHKSYLTPGL IGSVGTLEEG IQEERNVKED GAHSAATARS 1150
    PQPCSLLGTK FNCKESPRIN LRKVRKE 1177
    Length:1,177
    Mass (Da):135,206
    Last modified:July 24, 2007 - v2
    Checksum:iFD04B5B41D0EA2DC
    GO
    Isoform 2 (identifier: Q4G0N8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         294-341: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,129
    Mass (Da):129,365
    Checksum:i1C290AB522BBA8D6
    GO

    Sequence cautioni

    The sequence DAA01462.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 741M → I in BAC87265. (PubMed:14702039)Curated
    Sequence conflicti785 – 7851E → D in BAC87265. (PubMed:14702039)Curated
    Sequence conflicti788 – 7881I → T in BAC87265. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1581I → V.1 Publication
    Corresponds to variant rs9828502 [ dbSNP | Ensembl ].
    VAR_033324
    Natural varianti286 – 2861I → V.1 Publication
    Corresponds to variant rs9872691 [ dbSNP | Ensembl ].
    VAR_033325
    Natural varianti348 – 3481I → M.1 Publication
    Corresponds to variant rs9809404 [ dbSNP | Ensembl ].
    VAR_033326
    Natural varianti364 – 3641I → V.1 Publication
    Corresponds to variant rs9809384 [ dbSNP | Ensembl ].
    VAR_050233
    Natural varianti424 – 4241T → A.1 Publication
    Corresponds to variant rs6768523 [ dbSNP | Ensembl ].
    VAR_033327
    Natural varianti705 – 7051T → I.1 Publication
    Corresponds to variant rs4434123 [ dbSNP | Ensembl ].
    VAR_033328
    Natural varianti732 – 7321Q → K.1 Publication
    Corresponds to variant rs6781844 [ dbSNP | Ensembl ].
    VAR_033329
    Natural varianti768 – 7681S → I.1 Publication
    Corresponds to variant rs9288938 [ dbSNP | Ensembl ].
    VAR_033330
    Natural varianti826 – 8261G → S.1 Publication
    Corresponds to variant rs28516377 [ dbSNP | Ensembl ].
    VAR_061369

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei294 – 34148Missing in isoform 2. 1 PublicationVSP_027010Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128084 mRNA. Translation: BAC87265.1.
    BC044801 mRNA. Translation: AAH44801.1.
    BK001328 mRNA. Translation: DAA01462.1. Sequence problems.
    CCDSiCCDS33817.1. [Q4G0N8-1]
    RefSeqiNP_898884.1. NM_183061.1. [Q4G0N8-1]
    UniGeneiHs.680112.

    Genome annotation databases

    EnsembliENST00000305815; ENSP00000306627; ENSG00000172139. [Q4G0N8-1]
    ENST00000487372; ENSP00000420688; ENSG00000172139. [Q4G0N8-2]
    GeneIDi285335.
    KEGGihsa:285335.
    UCSCiuc003dyu.3. human. [Q4G0N8-1]
    uc010hqc.3. human. [Q4G0N8-2]

    Polymorphism databases

    DMDMi158563886.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128084 mRNA. Translation: BAC87265.1 .
    BC044801 mRNA. Translation: AAH44801.1 .
    BK001328 mRNA. Translation: DAA01462.1 . Sequence problems.
    CCDSi CCDS33817.1. [Q4G0N8-1 ]
    RefSeqi NP_898884.1. NM_183061.1. [Q4G0N8-1 ]
    UniGenei Hs.680112.

    3D structure databases

    ProteinModelPortali Q4G0N8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000306627.

    Protein family/group databases

    TCDBi 2.A.36.7.5. the monovalent cation:proton antiporter-1 (cpa1) family.

    PTM databases

    PhosphoSitei Q4G0N8.

    Polymorphism databases

    DMDMi 158563886.

    Proteomic databases

    PaxDbi Q4G0N8.
    PRIDEi Q4G0N8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305815 ; ENSP00000306627 ; ENSG00000172139 . [Q4G0N8-1 ]
    ENST00000487372 ; ENSP00000420688 ; ENSG00000172139 . [Q4G0N8-2 ]
    GeneIDi 285335.
    KEGGi hsa:285335.
    UCSCi uc003dyu.3. human. [Q4G0N8-1 ]
    uc010hqc.3. human. [Q4G0N8-2 ]

    Organism-specific databases

    CTDi 285335.
    GeneCardsi GC03M111860.
    H-InvDB HIX0200547.
    HGNCi HGNC:31401. SLC9C1.
    HPAi HPA044853.
    MIMi 612738. gene.
    neXtProti NX_Q4G0N8.
    PharmGKBi PA134914619.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG126655.
    HOGENOMi HOG000169764.
    HOVERGENi HBG071202.
    InParanoidi Q4G0N8.
    KOi K14726.
    OMAi ASYQRQY.
    OrthoDBi EOG7N37BW.
    PhylomeDBi Q4G0N8.
    TreeFami TF328865.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    ChiTaRSi SLC9C1. human.
    GeneWikii SLC9A10.
    GenomeRNAii 285335.
    NextBioi 95448.
    PROi Q4G0N8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q4G0N8.
    CleanExi HS_SLC9A10.
    Genevestigatori Q4G0N8.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR028483. N/H_exchanger_10.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    PTHR10110:SF87. PTHR10110:SF87. 1 hit.
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-158; VAL-286; MET-348; VAL-364; ALA-424; ILE-705; LYS-732; ILE-768 AND SER-826.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
      Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
      BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiSL9C1_HUMAN
    AccessioniPrimary (citable) accession number: Q4G0N8
    Secondary accession number(s): Q6ZRP4, Q7RTP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3