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Q4G0N0

- GGTA1_HUMAN

UniProt

Q4G0N0 - GGTA1_HUMAN

Protein

Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase

Gene

GGTA1P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. gamma-glutamyltransferase activity Source: UniProtKB
    2. transferase activity, transferring hexosyl groups Source: InterPro

    GO - Biological processi

    1. glutathione metabolic process Source: UniProtKB
    2. leukotriene biosynthetic process Source: UniProtKB
    3. protein galactosylation at cell surface Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase
    Alternative name(s):
    Glycoprotein alpha-galactosyltransferase 1 pseudogene
    Gene namesi
    Name:GGTA1P
    Synonyms:GGTA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4253. GGTA1P.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: UniProtKB
    2. Golgi cisterna Source: UniProtKB
    3. Golgi cisterna membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 100100Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferasePRO_0000333701Add
    BLAST

    Proteomic databases

    PRIDEiQ4G0N0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4G0N0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000362898.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G0N0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini28 – 10073LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 6 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309263.
    InParanoidiQ4G0N0.
    PhylomeDBiQ4G0N0.

    Family and domain databases

    InterProiIPR005076. Glyco_trans_6.
    [Graphical view]
    PANTHERiPTHR10462. PTHR10462. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4G0N0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVKGKVILS MLVVSTVIIV FWEFINSTEG SFLWIYHSKN PEVDDSSAQK    50
    GWWFLSWFNN GIHNYQQGEE DIDKEKGREE TKGRKMTQQS FGYGTGLIQT 100
    Length:100
    Mass (Da):11,568
    Last modified:October 5, 2010 - v2
    Checksum:iCA551358C2C8EE94
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411P → R in BC045756. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305838 mRNA. Translation: AAL09374.1.
    AL359644 Genomic DNA. No translation available.
    BC045756 mRNA. No translation available.
    UniGeneiHs.97469.

    Genome annotation databases

    UCSCiuc004bll.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305838 mRNA. Translation: AAL09374.1 .
    AL359644 Genomic DNA. No translation available.
    BC045756 mRNA. No translation available.
    UniGenei Hs.97469.

    3D structure databases

    ProteinModelPortali Q4G0N0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000362898.

    Proteomic databases

    PRIDEi Q4G0N0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc004bll.1. human.

    Organism-specific databases

    GeneCardsi GC09M124208.
    HGNCi HGNC:4253. GGTA1P.
    MIMi 104175. gene.
    neXtProti NX_Q4G0N0.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309263.
    InParanoidi Q4G0N0.
    PhylomeDBi Q4G0N0.

    Miscellaneous databases

    PROi Q4G0N0.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q4G0N0.

    Family and domain databases

    InterProi IPR005076. Glyco_trans_6.
    [Graphical view ]
    PANTHERi PTHR10462. PTHR10462. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A complete alpha1,3-galactosyltransferase gene is present in the human genome and partially transcribed."
      Lanteri M., Giordanengo V., Vidal F., Gaudray P., Lefebvre J.-C.
      Glycobiology 12:785-792(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGGTA1_HUMAN
    AccessioniPrimary (citable) accession number: Q4G0N0
    Secondary accession number(s): A2JVH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. According to PubMed:12499400, the human GGTA1 gene is an expressed pseudogene encoding non-functional truncated proteins containing the first four translated exons but missing the two catalytic exons. Although all exons expected to encode a functional GGTA1 of 371 residues are present in the human genome, all transcripts described encode truncated proteins that result from prematurely terminated transcription at the level of a strong transcriptional stop signal in the middle of intron 7. The premature transcriptional arrest of human GGTA1 gene leads to an ectopic splicing event and to the connection of a short intronic sequence downstream from translated exons.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3