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Q4G0N0

- GGTA1_HUMAN

UniProt

Q4G0N0 - GGTA1_HUMAN

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Protein

Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase

Gene

GGTA1P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. gamma-glutamyltransferase activity Source: UniProtKB
  2. transferase activity, transferring hexosyl groups Source: InterPro

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
  2. leukotriene biosynthetic process Source: UniProtKB
  3. protein galactosylation at cell surface Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase
Alternative name(s):
Glycoprotein alpha-galactosyltransferase 1 pseudogene
Gene namesi
Name:GGTA1P
Synonyms:GGTA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4253. GGTA1P.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: UniProtKB
  2. Golgi cisterna Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferasePRO_0000333701Add
BLAST

Proteomic databases

PRIDEiQ4G0N0.

Expressioni

Gene expression databases

GenevestigatoriQ4G0N0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362898.

Structurei

3D structure databases

ProteinModelPortaliQ4G0N0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Topological domaini28 – 10073LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309263.
InParanoidiQ4G0N0.
PhylomeDBiQ4G0N0.

Family and domain databases

InterProiIPR005076. Glyco_trans_6.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4G0N0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVKGKVILS MLVVSTVIIV FWEFINSTEG SFLWIYHSKN PEVDDSSAQK
60 70 80 90 100
GWWFLSWFNN GIHNYQQGEE DIDKEKGREE TKGRKMTQQS FGYGTGLIQT
Length:100
Mass (Da):11,568
Last modified:October 5, 2010 - v2
Checksum:iCA551358C2C8EE94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411P → R in BC045756. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305838 mRNA. Translation: AAL09374.1.
AL359644 Genomic DNA. No translation available.
BC045756 mRNA. No translation available.
UniGeneiHs.97469.

Genome annotation databases

UCSCiuc004bll.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305838 mRNA. Translation: AAL09374.1 .
AL359644 Genomic DNA. No translation available.
BC045756 mRNA. No translation available.
UniGenei Hs.97469.

3D structure databases

ProteinModelPortali Q4G0N0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362898.

Proteomic databases

PRIDEi Q4G0N0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc004bll.1. human.

Organism-specific databases

GeneCardsi GC09M124208.
HGNCi HGNC:4253. GGTA1P.
MIMi 104175. gene.
neXtProti NX_Q4G0N0.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309263.
InParanoidi Q4G0N0.
PhylomeDBi Q4G0N0.

Miscellaneous databases

PROi Q4G0N0.
SOURCEi Search...

Gene expression databases

Genevestigatori Q4G0N0.

Family and domain databases

InterProi IPR005076. Glyco_trans_6.
[Graphical view ]
PANTHERi PTHR10462. PTHR10462. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A complete alpha1,3-galactosyltransferase gene is present in the human genome and partially transcribed."
    Lanteri M., Giordanengo V., Vidal F., Gaudray P., Lefebvre J.-C.
    Glycobiology 12:785-792(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGGTA1_HUMAN
AccessioniPrimary (citable) accession number: Q4G0N0
Secondary accession number(s): A2JVH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. According to PubMed:12499400, the human GGTA1 gene is an expressed pseudogene encoding non-functional truncated proteins containing the first four translated exons but missing the two catalytic exons. Although all exons expected to encode a functional GGTA1 of 371 residues are present in the human genome, all transcripts described encode truncated proteins that result from prematurely terminated transcription at the level of a strong transcriptional stop signal in the middle of intron 7. The premature transcriptional arrest of human GGTA1 gene leads to an ectopic splicing event and to the connection of a short intronic sequence downstream from translated exons.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3