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Q4G0N0 (GGTA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase
Alternative name(s):
Glycoprotein alpha-galactosyltransferase 1 pseudogene
Gene names
Name:GGTA1P
Synonyms:GGTA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 6 family.

Caution

Could be the product of a pseudogene. According to Ref.1, the human GGTA1 gene is an expressed pseudogene encoding non-functional truncated proteins containing the first four translated exons but missing the two catalytic exons. Although all exons expected to encode a functional GGTA1 of 371 residues are present in the human genome, all transcripts described encode truncated proteins that result from prematurely terminated transcription at the level of a strong transcriptional stop signal in the middle of intron 7. The premature transcriptional arrest of human GGTA1 gene leads to an ectopic splicing event and to the connection of a short intronic sequence downstream from translated exons.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 100100Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase
PRO_0000333701

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain28 – 10073Lumenal Potential

Experimental info

Sequence conflict411P → R in BC045756. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q4G0N0 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: CA551358C2C8EE94

FASTA10011,568
        10         20         30         40         50         60 
MNVKGKVILS MLVVSTVIIV FWEFINSTEG SFLWIYHSKN PEVDDSSAQK GWWFLSWFNN 

        70         80         90        100 
GIHNYQQGEE DIDKEKGREE TKGRKMTQQS FGYGTGLIQT 

« Hide

References

« Hide 'large scale' references
[1]"A complete alpha1,3-galactosyltransferase gene is present in the human genome and partially transcribed."
Lanteri M., Giordanengo V., Vidal F., Gaudray P., Lefebvre J.-C.
Glycobiology 12:785-792(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF305838 mRNA. Translation: AAL09374.1.
AL359644 Genomic DNA. No translation available.
BC045756 mRNA. No translation available.
UniGeneHs.97469.

3D structure databases

ProteinModelPortalQ4G0N0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000362898.

Proteomic databases

PRIDEQ4G0N0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc004bll.1. human.

Organism-specific databases

GeneCardsGC09M124208.
HGNCHGNC:4253. GGTA1P.
MIM104175. gene.
neXtProtNX_Q4G0N0.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309263.
InParanoidQ4G0N0.

Gene expression databases

GenevestigatorQ4G0N0.

Family and domain databases

InterProIPR005076. Glyco_trans_6.
[Graphical view]
PANTHERPTHR10462. PTHR10462. 1 hit.
ProtoNetSearch...

Other

PROQ4G0N0.
SOURCESearch...

Entry information

Entry nameGGTA1_HUMAN
AccessionPrimary (citable) accession number: Q4G0N0
Secondary accession number(s): A2JVH9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 5, 2010
Last modified: February 19, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM