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Q4G0M1 (F132B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM132B
Alternative name(s):
Complement C1q tumor necrosis factor-related protein 15
Myonectin
Gene names
Name:FAM132B
Synonyms:C1QTNF15, CTRP15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake By similarity.

Subunit structure

Homodimer; disulfide-linked. May form heteromeric complexes with C1QTNF2 and FAM132A and, to a lesser extent, with C1QTNF5 and C1QTNF10 By similarity.

Subcellular location

Secreted By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the FAM132 family.

Contains 1 C1q domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 354326Protein FAM132B
PRO_0000340250

Regions

Domain199 – 354156C1q
Compositional bias111 – 12919Pro-rich
Compositional bias177 – 1804Poly-Asp

Experimental info

Sequence conflict220 – 22910ALHELGVYYL → SRGDHPCPSQ in AAH47423. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q4G0M1 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: F336BBFC1068FF52

FASTA35437,279
        10         20         30         40         50         60 
MAPARRPAGA RLLLVYAGLL AAAAAGLGSP EPGAPSRSRA RREPPPGNEL PRGPGESRAG 

        70         80         90        100        110        120 
PAARPPEPTA ERAHSVDPRD AWMLFVRQSD KGVNGKKRSR GKAKKLKFGL PGPPGPPGPQ 

       130        140        150        160        170        180 
GPPGPIIPPE ALLKEFQLLL KGAVRQRERA EPEPCTCGPA GPVAASLAPV SATAGEDDDD 

       190        200        210        220        230        240 
VVGDVLALLA APLAPGPRAP RVEAAFLCRL RRDALVERRA LHELGVYYLP DAEGAFRRGP 

       250        260        270        280        290        300 
GLNLTSGQYR APVAGFYALA ATLHVALGEP PRRGPPRPRD HLRLLICIQS RCQRNASLEA 

       310        320        330        340        350 
IMGLESSSEL FTISVNGVLY LQMGQWTSVF LDNASGCSLT VRSGSHFSAV LLGV 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 220-354.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC016757 Genomic DNA. No translation available.
BC047423 mRNA. Translation: AAH47423.1.
RefSeqNP_001278761.1. NM_001291832.1.
UniGeneHs.24951.
Hs.742300.

3D structure databases

ProteinModelPortalQ4G0M1.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM190359335.

Proteomic databases

MaxQBQ4G0M1.
PaxDbQ4G0M1.
PRIDEQ4G0M1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000546354; ENSP00000442304; ENSG00000178752.
GeneID151176.

Organism-specific databases

GeneCardsGC02P239067.
HGNCHGNC:26727. FAM132B.
MIM615099. gene.
neXtProtNX_Q4G0M1.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42889.
HOGENOMHOG000112436.
HOVERGENHBG107865.
InParanoidQ4G0M1.
OMAGSHFSAI.
OrthoDBEOG7XSTFH.
PhylomeDBQ4G0M1.
TreeFamTF331282.

Gene expression databases

BgeeQ4G0M1.
CleanExHS_FAM132B.
GenevestigatorQ4G0M1.

Family and domain databases

InterProIPR001073. C1q.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ4G0M1.
SOURCESearch...

Entry information

Entry nameF132B_HUMAN
AccessionPrimary (citable) accession number: Q4G0M1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM