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Protein

Erythroferrone

Gene

ERFE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Erythroferrone
Alternative name(s):
Complement C1q tumor necrosis factor-related protein 15
Myonectin
Gene namesi
Name:ERFE
Synonyms:C1QTNF15, CTRP15, FAM132B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26727. ERFE.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178752.

Polymorphism and mutation databases

DMDMi190359335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000034025029 – 354ErythroferroneAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ4G0M1.
PaxDbiQ4G0M1.
PRIDEiQ4G0M1.

PTM databases

iPTMnetiQ4G0M1.
PhosphoSitePlusiQ4G0M1.

Expressioni

Gene expression databases

BgeeiENSG00000178752.
CleanExiHS_FAM132B.
ExpressionAtlasiQ4G0M1. baseline and differential.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form heteromeric complexes with C1QTNF2 and FAM132A and, to a lesser extent, with C1QTNF5 and C1QTNF10.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127350. 3 interactors.
STRINGi9606.ENSP00000442304.

Structurei

3D structure databases

ProteinModelPortaliQ4G0M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 354C1qPROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 129Pro-richAdd BLAST19
Compositional biasi177 – 180Poly-Asp4

Sequence similaritiesi

Belongs to the adipolin/erythroferrone family.Curated
Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ2E. Eukaryota.
ENOG410YGMD. LUCA.
GeneTreeiENSGT00390000007846.
HOGENOMiHOG000112436.
HOVERGENiHBG107865.
InParanoidiQ4G0M1.
OMAiGSHFSAI.
OrthoDBiEOG091G0HNK.
PhylomeDBiQ4G0M1.
TreeFamiTF331282.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4G0M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPARRPAGA RLLLVYAGLL AAAAAGLGSP EPGAPSRSRA RREPPPGNEL
60 70 80 90 100
PRGPGESRAG PAARPPEPTA ERAHSVDPRD AWMLFVRQSD KGVNGKKRSR
110 120 130 140 150
GKAKKLKFGL PGPPGPPGPQ GPPGPIIPPE ALLKEFQLLL KGAVRQRERA
160 170 180 190 200
EPEPCTCGPA GPVAASLAPV SATAGEDDDD VVGDVLALLA APLAPGPRAP
210 220 230 240 250
RVEAAFLCRL RRDALVERRA LHELGVYYLP DAEGAFRRGP GLNLTSGQYR
260 270 280 290 300
APVAGFYALA ATLHVALGEP PRRGPPRPRD HLRLLICIQS RCQRNASLEA
310 320 330 340 350
IMGLESSSEL FTISVNGVLY LQMGQWTSVF LDNASGCSLT VRSGSHFSAV

LLGV
Length:354
Mass (Da):37,279
Last modified:June 10, 2008 - v2
Checksum:iF336BBFC1068FF52
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220 – 229ALHELGVYYL → SRGDHPCPSQ in AAH47423 (PubMed:15489334).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF984314 mRNA. Translation: AHL84165.1.
AC016757 Genomic DNA. No translation available.
BC047423 mRNA. Translation: AAH47423.1.
CCDSiCCDS77548.1.
RefSeqiNP_001278761.1. NM_001291832.1.
UniGeneiHs.24951.
Hs.742300.

Genome annotation databases

EnsembliENST00000546354; ENSP00000442304; ENSG00000178752.
GeneIDi151176.
KEGGihsa:151176.
UCSCiuc061udn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF984314 mRNA. Translation: AHL84165.1.
AC016757 Genomic DNA. No translation available.
BC047423 mRNA. Translation: AAH47423.1.
CCDSiCCDS77548.1.
RefSeqiNP_001278761.1. NM_001291832.1.
UniGeneiHs.24951.
Hs.742300.

3D structure databases

ProteinModelPortaliQ4G0M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127350. 3 interactors.
STRINGi9606.ENSP00000442304.

PTM databases

iPTMnetiQ4G0M1.
PhosphoSitePlusiQ4G0M1.

Polymorphism and mutation databases

DMDMi190359335.

Proteomic databases

MaxQBiQ4G0M1.
PaxDbiQ4G0M1.
PRIDEiQ4G0M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000546354; ENSP00000442304; ENSG00000178752.
GeneIDi151176.
KEGGihsa:151176.
UCSCiuc061udn.1. human.

Organism-specific databases

CTDi151176.
GeneCardsiFAM132B.
HGNCiHGNC:26727. ERFE.
MIMi615099. gene.
neXtProtiNX_Q4G0M1.
OpenTargetsiENSG00000178752.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ2E. Eukaryota.
ENOG410YGMD. LUCA.
GeneTreeiENSGT00390000007846.
HOGENOMiHOG000112436.
HOVERGENiHBG107865.
InParanoidiQ4G0M1.
OMAiGSHFSAI.
OrthoDBiEOG091G0HNK.
PhylomeDBiQ4G0M1.
TreeFamiTF331282.

Miscellaneous databases

GenomeRNAii151176.
PROiQ4G0M1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178752.
CleanExiHS_FAM132B.
ExpressionAtlasiQ4G0M1. baseline and differential.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERFE_HUMAN
AccessioniPrimary (citable) accession number: Q4G0M1
Secondary accession number(s): W8S2M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 30, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.