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Q4G0F5 (VP26B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar protein sorting-associated protein 26B
Alternative name(s):
Vesicle protein sorting 26B
Gene names
Name:VPS26B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network By similarity.

Subunit structure

Probable component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS35 By similarity.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein. Note: Does not localize to endosomes By similarity.

Sequence similarities

Belongs to the VPS26 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Vacuolar protein sorting-associated protein 26B
PRO_0000247089

Amino acid modifications

Modified residue3021Phosphoserine Ref.8
Modified residue3041Phosphoserine Ref.5
Modified residue3191Phosphoserine Ref.6

Experimental info

Sequence conflict551K → R in AAH98386. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q4G0F5 [UniParc].

Last modified July 25, 2006. Version 2.
Checksum: 1C07D0ABA7797A12

FASTA33639,155
        10         20         30         40         50         60 
MSFFGFGQSV EVEILLNDAE SRKRAEHKTE DGKKEKYFLF YDGETVSGKV SLALKNPNKR 

        70         80         90        100        110        120 
LEHQGIKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIT QSQAFDFEFT HVEKPYESYT 

       130        140        150        160        170        180 
GQNVKLRYFL RATISRRLND VVKEMDIVVH TLSTYPELNS SIKMEVGIED CLHIEFEYNK 

       190        200        210        220        230        240 
SKYHLKDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR 

       250        260        270        280        290        300 
GESIPIRLFL AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR 

       310        320        330 
KSMSHQAAIA SQRFEGTTSL GEVRTPSQLS DNNCRQ 

« Hide

References

« Hide 'large scale' references
[1]Kim N.-S., Shon H.-Y., Oh J.-H., Lee J.-Y., Kim J.-M., Hahn Y., Park H.-S., Kim S., Kim Y.S.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye, Lung and Placenta.
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF452718 mRNA. Translation: AAP13353.1.
BC009747 mRNA. Translation: AAH09747.1.
BC014128 mRNA. Translation: AAH14128.1.
BC098386 mRNA. Translation: AAH98386.1.
RefSeqNP_443107.1. NM_052875.3.
UniGeneHs.334684.

3D structure databases

ProteinModelPortalQ4G0F5.
SMRQ4G0F5. Positions 9-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125215. 7 interactions.
IntActQ4G0F5. 1 interaction.
STRING9606.ENSP00000281187.

PTM databases

PhosphoSiteQ4G0F5.

Polymorphism databases

DMDM110816482.

Proteomic databases

PaxDbQ4G0F5.
PeptideAtlasQ4G0F5.
PRIDEQ4G0F5.

Protocols and materials databases

DNASU112936.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281187; ENSP00000281187; ENSG00000151502.
ENST00000525095; ENSP00000434162; ENSG00000151502.
GeneID112936.
KEGGhsa:112936.
UCSCuc001qhe.3. human.

Organism-specific databases

CTD112936.
GeneCardsGC11P134094.
HGNCHGNC:28119. VPS26B.
HPAHPA038172.
MIM610027. gene.
neXtProtNX_Q4G0F5.
PharmGKBPA128394747.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256244.
HOGENOMHOG000191799.
HOVERGENHBG082914.
InParanoidQ4G0F5.
OMAFDRGNHY.
OrthoDBEOG7NW699.
PhylomeDBQ4G0F5.
TreeFamTF300907.

Gene expression databases

BgeeQ4G0F5.
CleanExHS_VPS26B.
GenevestigatorQ4G0F5.

Family and domain databases

InterProIPR005377. VPS26.
IPR028934. Vps26-related.
[Graphical view]
PANTHERPTHR12233:SF1. PTHR12233:SF1. 1 hit.
PfamPF03643. Vps26. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVPS26B. human.
GeneWikiVPS26B.
GenomeRNAi112936.
NextBio78701.
PROQ4G0F5.
SOURCESearch...

Entry information

Entry nameVP26B_HUMAN
AccessionPrimary (citable) accession number: Q4G0F5
Secondary accession number(s): Q96A55
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM