Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4G0F5

- VP26B_HUMAN

UniProt

Q4G0F5 - VP26B_HUMAN

Protein

Vacuolar protein sorting-associated protein 26B

Gene

VPS26B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network.By similarity

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 26B
    Alternative name(s):
    Vesicle protein sorting 26B
    Gene namesi
    Name:VPS26B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:28119. VPS26B.

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein
    Note: Does not localize to endosomes.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. intracellular membrane-bounded organelle Source: HPA
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394747.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Vacuolar protein sorting-associated protein 26BPRO_0000247089Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei302 – 3021Phosphoserine1 Publication
    Modified residuei304 – 3041Phosphoserine1 Publication
    Modified residuei319 – 3191Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ4G0F5.
    PaxDbiQ4G0F5.
    PeptideAtlasiQ4G0F5.
    PRIDEiQ4G0F5.

    PTM databases

    PhosphoSiteiQ4G0F5.

    Expressioni

    Gene expression databases

    BgeeiQ4G0F5.
    CleanExiHS_VPS26B.
    GenevestigatoriQ4G0F5.

    Organism-specific databases

    HPAiHPA038172.

    Interactioni

    Subunit structurei

    Probable component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS35 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125215. 7 interactions.
    IntActiQ4G0F5. 1 interaction.
    STRINGi9606.ENSP00000281187.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G0F5.
    SMRiQ4G0F5. Positions 9-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the VPS26 family.Curated

    Phylogenomic databases

    eggNOGiNOG256244.
    HOGENOMiHOG000191799.
    HOVERGENiHBG082914.
    InParanoidiQ4G0F5.
    OMAiFDRGNHY.
    OrthoDBiEOG7NW699.
    PhylomeDBiQ4G0F5.
    TreeFamiTF300907.

    Family and domain databases

    InterProiIPR028934. Vps26-related.
    [Graphical view]
    PfamiPF03643. Vps26. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4G0F5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFFGFGQSV EVEILLNDAE SRKRAEHKTE DGKKEKYFLF YDGETVSGKV    50
    SLALKNPNKR LEHQGIKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIT 100
    QSQAFDFEFT HVEKPYESYT GQNVKLRYFL RATISRRLND VVKEMDIVVH 150
    TLSTYPELNS SIKMEVGIED CLHIEFEYNK SKYHLKDVIV GKIYFLLVRI 200
    KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR GESIPIRLFL 250
    AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR 300
    KSMSHQAAIA SQRFEGTTSL GEVRTPSQLS DNNCRQ 336
    Length:336
    Mass (Da):39,155
    Last modified:July 25, 2006 - v2
    Checksum:i1C07D0ABA7797A12
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551K → R in AAH98386. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF452718 mRNA. Translation: AAP13353.1.
    BC009747 mRNA. Translation: AAH09747.1.
    BC014128 mRNA. Translation: AAH14128.1.
    BC098386 mRNA. Translation: AAH98386.1.
    CCDSiCCDS8495.1.
    RefSeqiNP_443107.1. NM_052875.3.
    UniGeneiHs.334684.

    Genome annotation databases

    EnsembliENST00000281187; ENSP00000281187; ENSG00000151502.
    ENST00000525095; ENSP00000434162; ENSG00000151502.
    GeneIDi112936.
    KEGGihsa:112936.
    UCSCiuc001qhe.3. human.

    Polymorphism databases

    DMDMi110816482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF452718 mRNA. Translation: AAP13353.1 .
    BC009747 mRNA. Translation: AAH09747.1 .
    BC014128 mRNA. Translation: AAH14128.1 .
    BC098386 mRNA. Translation: AAH98386.1 .
    CCDSi CCDS8495.1.
    RefSeqi NP_443107.1. NM_052875.3.
    UniGenei Hs.334684.

    3D structure databases

    ProteinModelPortali Q4G0F5.
    SMRi Q4G0F5. Positions 9-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125215. 7 interactions.
    IntActi Q4G0F5. 1 interaction.
    STRINGi 9606.ENSP00000281187.

    PTM databases

    PhosphoSitei Q4G0F5.

    Polymorphism databases

    DMDMi 110816482.

    Proteomic databases

    MaxQBi Q4G0F5.
    PaxDbi Q4G0F5.
    PeptideAtlasi Q4G0F5.
    PRIDEi Q4G0F5.

    Protocols and materials databases

    DNASUi 112936.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281187 ; ENSP00000281187 ; ENSG00000151502 .
    ENST00000525095 ; ENSP00000434162 ; ENSG00000151502 .
    GeneIDi 112936.
    KEGGi hsa:112936.
    UCSCi uc001qhe.3. human.

    Organism-specific databases

    CTDi 112936.
    GeneCardsi GC11P134094.
    HGNCi HGNC:28119. VPS26B.
    HPAi HPA038172.
    MIMi 610027. gene.
    neXtProti NX_Q4G0F5.
    PharmGKBi PA128394747.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256244.
    HOGENOMi HOG000191799.
    HOVERGENi HBG082914.
    InParanoidi Q4G0F5.
    OMAi FDRGNHY.
    OrthoDBi EOG7NW699.
    PhylomeDBi Q4G0F5.
    TreeFami TF300907.

    Miscellaneous databases

    ChiTaRSi VPS26B. human.
    GeneWikii VPS26B.
    GenomeRNAii 112936.
    NextBioi 78701.
    PROi Q4G0F5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q4G0F5.
    CleanExi HS_VPS26B.
    Genevestigatori Q4G0F5.

    Family and domain databases

    InterProi IPR028934. Vps26-related.
    [Graphical view ]
    Pfami PF03643. Vps26. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kim N.-S., Shon H.-Y., Oh J.-H., Lee J.-Y., Kim J.-M., Hahn Y., Park H.-S., Kim S., Kim Y.S.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye, Lung and Placenta.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVP26B_HUMAN
    AccessioniPrimary (citable) accession number: Q4G0F5
    Secondary accession number(s): Q96A55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3