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Q4G0F5

- VP26B_HUMAN

UniProt

Q4G0F5 - VP26B_HUMAN

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Protein

Vacuolar protein sorting-associated protein 26B

Gene

VPS26B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network.By similarity

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 26B
Alternative name(s):
Vesicle protein sorting 26B
Gene namesi
Name:VPS26B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:28119. VPS26B.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein
Note: Does not localize to endosomes.By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. intracellular membrane-bounded organelle Source: HPA
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Vacuolar protein sorting-associated protein 26BPRO_0000247089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei302 – 3021Phosphoserine1 Publication
Modified residuei304 – 3041Phosphoserine1 Publication
Modified residuei319 – 3191Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ4G0F5.
PaxDbiQ4G0F5.
PeptideAtlasiQ4G0F5.
PRIDEiQ4G0F5.

PTM databases

PhosphoSiteiQ4G0F5.

Expressioni

Gene expression databases

BgeeiQ4G0F5.
CleanExiHS_VPS26B.
GenevestigatoriQ4G0F5.

Organism-specific databases

HPAiHPA038172.

Interactioni

Subunit structurei

Probable component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS35 (By similarity).By similarity

Protein-protein interaction databases

BioGridi125215. 15 interactions.
IntActiQ4G0F5. 1 interaction.
STRINGi9606.ENSP00000281187.

Structurei

3D structure databases

ProteinModelPortaliQ4G0F5.
SMRiQ4G0F5. Positions 9-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VPS26 family.Curated

Phylogenomic databases

eggNOGiNOG256244.
GeneTreeiENSGT00390000002588.
HOGENOMiHOG000191799.
HOVERGENiHBG082914.
InParanoidiQ4G0F5.
KOiK18466.
OMAiFDRGNHY.
OrthoDBiEOG7NW699.
PhylomeDBiQ4G0F5.
TreeFamiTF300907.

Family and domain databases

InterProiIPR028934. Vps26-related.
[Graphical view]
PfamiPF03643. Vps26. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0F5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFFGFGQSV EVEILLNDAE SRKRAEHKTE DGKKEKYFLF YDGETVSGKV
60 70 80 90 100
SLALKNPNKR LEHQGIKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIT
110 120 130 140 150
QSQAFDFEFT HVEKPYESYT GQNVKLRYFL RATISRRLND VVKEMDIVVH
160 170 180 190 200
TLSTYPELNS SIKMEVGIED CLHIEFEYNK SKYHLKDVIV GKIYFLLVRI
210 220 230 240 250
KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR GESIPIRLFL
260 270 280 290 300
AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR
310 320 330
KSMSHQAAIA SQRFEGTTSL GEVRTPSQLS DNNCRQ
Length:336
Mass (Da):39,155
Last modified:July 25, 2006 - v2
Checksum:i1C07D0ABA7797A12
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551K → R in AAH98386. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF452718 mRNA. Translation: AAP13353.1.
BC009747 mRNA. Translation: AAH09747.1.
BC014128 mRNA. Translation: AAH14128.1.
BC098386 mRNA. Translation: AAH98386.1.
CCDSiCCDS8495.1.
RefSeqiNP_443107.1. NM_052875.3.
UniGeneiHs.334684.

Genome annotation databases

EnsembliENST00000281187; ENSP00000281187; ENSG00000151502.
ENST00000525095; ENSP00000434162; ENSG00000151502.
GeneIDi112936.
KEGGihsa:112936.
UCSCiuc001qhe.3. human.

Polymorphism databases

DMDMi110816482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF452718 mRNA. Translation: AAP13353.1 .
BC009747 mRNA. Translation: AAH09747.1 .
BC014128 mRNA. Translation: AAH14128.1 .
BC098386 mRNA. Translation: AAH98386.1 .
CCDSi CCDS8495.1.
RefSeqi NP_443107.1. NM_052875.3.
UniGenei Hs.334684.

3D structure databases

ProteinModelPortali Q4G0F5.
SMRi Q4G0F5. Positions 9-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125215. 15 interactions.
IntActi Q4G0F5. 1 interaction.
STRINGi 9606.ENSP00000281187.

PTM databases

PhosphoSitei Q4G0F5.

Polymorphism databases

DMDMi 110816482.

Proteomic databases

MaxQBi Q4G0F5.
PaxDbi Q4G0F5.
PeptideAtlasi Q4G0F5.
PRIDEi Q4G0F5.

Protocols and materials databases

DNASUi 112936.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281187 ; ENSP00000281187 ; ENSG00000151502 .
ENST00000525095 ; ENSP00000434162 ; ENSG00000151502 .
GeneIDi 112936.
KEGGi hsa:112936.
UCSCi uc001qhe.3. human.

Organism-specific databases

CTDi 112936.
GeneCardsi GC11P134094.
HGNCi HGNC:28119. VPS26B.
HPAi HPA038172.
MIMi 610027. gene.
neXtProti NX_Q4G0F5.
PharmGKBi PA128394747.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256244.
GeneTreei ENSGT00390000002588.
HOGENOMi HOG000191799.
HOVERGENi HBG082914.
InParanoidi Q4G0F5.
KOi K18466.
OMAi FDRGNHY.
OrthoDBi EOG7NW699.
PhylomeDBi Q4G0F5.
TreeFami TF300907.

Miscellaneous databases

ChiTaRSi VPS26B. human.
GeneWikii VPS26B.
GenomeRNAii 112936.
NextBioi 78701.
PROi Q4G0F5.
SOURCEi Search...

Gene expression databases

Bgeei Q4G0F5.
CleanExi HS_VPS26B.
Genevestigatori Q4G0F5.

Family and domain databases

InterProi IPR028934. Vps26-related.
[Graphical view ]
Pfami PF03643. Vps26. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kim N.-S., Shon H.-Y., Oh J.-H., Lee J.-Y., Kim J.-M., Hahn Y., Park H.-S., Kim S., Kim Y.S.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye, Lung and Placenta.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVP26B_HUMAN
AccessioniPrimary (citable) accession number: Q4G0F5
Secondary accession number(s): Q96A55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3