Q4G0F5 (VP26B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar protein sorting-associated protein 26B

Alternative name(s):
Vesicle protein sorting 26B

Gene names

Name:

VPS26B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network By similarity.
Subunit structure	Probable component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS35 By similarity.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein. Note: Does not localize to endosomes By similarity.
Sequence similarities	Belongs to the VPS26 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Membrane
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW vacuolar transport Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosol Inferred from sequence or structural similarity PubMed 11102511. Source: UniProtKB retromer complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Vacuolar protein sorting-associated protein 26B		PRO_0000247089
Amino acid modifications
	Modified residue	302	1	Phosphoserine Ref.7
	Modified residue	304	1	Phosphoserine Ref.4
	Modified residue	319	1	Phosphoserine Ref.5
Experimental info
	Sequence conflict	55	1	K → R in AAH98386. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q4G0F5 [UniParc]. Last modified July 25, 2006. Version 2. Checksum: 1C07D0ABA7797A12	FASTA	336	39,155
	10 20 30 40 50 60 MSFFGFGQSV EVEILLNDAE SRKRAEHKTE DGKKEKYFLF YDGETVSGKV SLALKNPNKR 70 80 90 100 110 120 LEHQGIKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIT QSQAFDFEFT HVEKPYESYT 130 140 150 160 170 180 GQNVKLRYFL RATISRRLND VVKEMDIVVH TLSTYPELNS SIKMEVGIED CLHIEFEYNK 190 200 210 220 230 240 SKYHLKDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR 250 260 270 280 290 300 GESIPIRLFL AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR 310 320 330 KSMSHQAAIA SQRFEGTTSL GEVRTPSQLS DNNCRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Kim N.-S., Shon H.-Y., Oh J.-H., Lee J.-Y., Kim J.-M., Hahn Y., Park H.-S., Kim S., Kim Y.S. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye, Lung and Placenta.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[4]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF452718 mRNA. Translation: AAP13353.1. BC009747 mRNA. Translation: AAH09747.1. BC014128 mRNA. Translation: AAH14128.1. BC098386 mRNA. Translation: AAH98386.1.
IPI	IPI00059264.
RefSeq	NP_443107.1. NM_052875.3.
UniGene	Hs.334684.
3D structure databases
ProteinModelPortal	Q4G0F5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q4G0F5. 1 interaction.
STRING	9606.ENSP00000281187.
PTM databases
PhosphoSite	Q4G0F5.
Polymorphism databases
DMDM	110816482.
Proteomic databases
PaxDb	Q4G0F5.
PeptideAtlas	Q4G0F5.
PRIDE	Q4G0F5.
Protocols and materials databases
DNASU	112936.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281187; ENSP00000281187; ENSG00000151502.
GeneID	112936.
KEGG	hsa:112936.
UCSC	uc001qhe.3. human.
Organism-specific databases
CTD	112936.
GeneCards	GC11P134094.
HGNC	HGNC:28119. VPS26B.
HPA	HPA038172.
MIM	610027. gene.
neXtProt	NX_Q4G0F5.
PharmGKB	PA128394747.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG256244.
HOGENOM	HOG000191799.
HOVERGEN	HBG082914.
InParanoid	Q4G0F5.
OMA	FFSFGQS.
OrthoDB	EOG4X6C8P.
PhylomeDB	Q4G0F5.
Gene expression databases
ArrayExpress	Q4G0F5.
Bgee	Q4G0F5.
CleanEx	HS_VPS26B.
Genevestigator	Q4G0F5.
GermOnline	ENSG00000151502. Homo sapiens.
Family and domain databases
InterPro	IPR005377. VPS26. [Graphical view]
Pfam	PF03643. Vps26. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VPS26B. human.
GenomeRNAi	112936.
NextBio	78701.
SOURCE	Search...

Entry information

Entry name

VP26B_HUMAN

Accession

Primary (citable) accession number: Q4G0F5
Secondary accession number(s): Q96A55

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	May 1, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.