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Protein

Carboxylic ester hydrolase

Gene

CES2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

SABIO-RKQ4G0E9.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:CES2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Expressioni

Gene expression databases

BgeeiQ4G0E9.
ExpressionAtlasiQ4G0E9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ4G0E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000091866.
HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4G0E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PLTPCPVQTP RLGKALIHCW TDPGQPLGEQ QRVRRQRTET SEPTMRLHRL
60 70 80 90 100
RARLSAVACG LLLLLVRGQG QDSASPIRTT HTGQVLGSLV HVKGANAGVQ
110 120 130 140 150
TFLGIPFAKP PLGPLRFAPP EPPESWSGVR DGTTHPAMCL QDLTAVESEF
160 170 180 190 200
LSQFNMTFPS DSMSEDCLYL SIYTPAHSHE GSNLPVMVWI HGGALVFGMA
210 220 230 240 250
SLYDGSMLAA LENVVVVIIQ YRLGVLGFFS TGDKHATGNW GYLDQVAALR
260 270 280 290 300
WVQQNIAHFG GNPDRVTIFG ESAGGTSVSS LVVSPISQGL FHGAIMESGV
310 320 330 340 350
ALLPGLIASS ADVISTVVAN LSACDQVDSE ALVGCLRGKS KEEILAINKP
360 370 380 390 400
FKMIPGVVDG VFLPRHPQEL LASADFQPVP SIVGVNNNEF GWLIPKVMRI
410 420 430 440 450
YDTQKEMDRE ASQAALQKML TLLMLPPTFG DLLREEYIGD NGDPQTLQAQ
460 470 480 490 500
FQEMMADSMF VIPALQVAHF QCSRAPVYFY EFQHQPSWLK NIRPPHMKAD
510 520 530 540 550
HVKFTEEEEQ LSRKMMKYWA NFARNGNPNG EGLPHWPLFD QEEQYLQLNL
560 570 580
QPAVGRALKA HRLQFWKKAL PQKIQELEEP EERHTEL
Length:587
Mass (Da):64,920
Last modified:August 30, 2005 - v1
Checksum:i81FCB12A139A7580
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098417 mRNA. Translation: AAH98417.1.
UniGeneiHs.282975.

Genome annotation databases

UCSCiuc002eqq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098417 mRNA. Translation: AAH98417.1.
UniGeneiHs.282975.

3D structure databases

ProteinModelPortaliQ4G0E9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc002eqq.3. human.

Phylogenomic databases

HOGENOMiHOG000091866.
HOVERGENiHBG008839.

Enzyme and pathway databases

SABIO-RKQ4G0E9.

Miscellaneous databases

ChiTaRSiCES2. human.

Gene expression databases

BgeeiQ4G0E9.
ExpressionAtlasiQ4G0E9. baseline and differential.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.

Entry informationi

Entry nameiQ4G0E9_HUMAN
AccessioniPrimary (citable) accession number: Q4G0E9
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.