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Protein

Acetyl-coenzyme A synthetase

Gene

ACSS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
Name:ACSS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ4G0E8.
PeptideAtlasiQ4G0E8.
PRIDEiQ4G0E8.

Expressioni

Gene expression databases

BgeeiENSG00000131069.
GenevisibleiQ4G0E8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000253382.

Structurei

3D structure databases

ProteinModelPortaliQ4G0E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 479460AMP-bindingInterPro annotationAdd
BLAST
Domaini488 – 56679AMP-binding_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGATTNICY NVLDRNVHEK KLGDKVAFYW EGNEPGETTQ ITYHQLLVQV
60 70 80 90 100
CQFSNVLRKQ GIQKGDRVAI YMPMIPELVV AMLACARIGA LHSIVFAGFS
110 120 130 140 150
SESLCERILD SSCSLLITTD AFYRGEKLVN LKELADEALQ KCQEKGFPVR
160 170 180 190 200
CCIVVKHLGR AELGMGDSTS QSPPIKRSCP DVQISWNQGI DLWWHELMQE
210 220 230 240 250
AGDECEPEWC DAEDPLFILY TSGSTGKPKG VVHTVGGYML YVATTFKYVF
260 270 280 290 300
DFHAEDVFWC TADIGWITGH SYVTYGPLAN GATSVLFEGI PTYPDVNRLW
310 320 330 340 350
SIVDKYKVTK FYTAPTAIRL LMKFGDEPVT KHSRASLQVL GTVGEPINPE
360 370 380 390 400
AWLWYHRVVG AQRCPIVDTF WQTETGGHML TPLPGATPMK PGSATFPFFG
410 420 430 440 450
VAPAILNESG EELEGEAEGY LVFKQPWPGI MRTVYGNHER FETTYFKKFP
460 470 480 490 500
GYYVTGDGCQ RDQDGYYWIT GRIDDMLNVS GHLLSTAEVE SALVEHEAVA
510 520 530 540 550
EAAVVGHPHP VKGECLYCFV TLCDGHTFSP KLTEELKKQI REKIGPIATP
560 570 580 590 600
DYIQNAPGLP KTRSGKIMRR VLRKIAQNDH DLGDMSTVAD PSVISHLFSH

RCLTIQ
Length:606
Mass (Da):67,619
Last modified:February 20, 2007 - v1
Checksum:i393EFB50EF974ADB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098422 mRNA. Translation: AAH98422.1.
RefSeqiNP_001229322.1. NM_001242393.1.
UniGeneiHs.517034.

Genome annotation databases

GeneIDi55902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098422 mRNA. Translation: AAH98422.1.
RefSeqiNP_001229322.1. NM_001242393.1.
UniGeneiHs.517034.

3D structure databases

ProteinModelPortaliQ4G0E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000253382.

Proteomic databases

PaxDbiQ4G0E8.
PeptideAtlasiQ4G0E8.
PRIDEiQ4G0E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi55902.

Organism-specific databases

CTDi55902.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.

Miscellaneous databases

ChiTaRSiACSS2. human.
GenomeRNAii55902.

Gene expression databases

BgeeiENSG00000131069.
GenevisibleiQ4G0E8. HS.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4G0E8_HUMAN
AccessioniPrimary (citable) accession number: Q4G0E8
Secondary accession number(s): A6NLR6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.