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Q4G0A6

- F188B_HUMAN

UniProt

Q4G0A6 - F188B_HUMAN

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Protein
Protein FAM188B
Gene
FAM188B, C7orf67
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM188B
Gene namesi
Name:FAM188B
Synonyms:C7orf67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21916. FAM188B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Protein FAM188B
PRO_0000320590Add
BLAST

Proteomic databases

MaxQBiQ4G0A6.
PaxDbiQ4G0A6.
PRIDEiQ4G0A6.

PTM databases

PhosphoSiteiQ4G0A6.

Expressioni

Gene expression databases

BgeeiQ4G0A6.
GenevestigatoriQ4G0A6.

Organism-specific databases

HPAiHPA019475.
HPA030129.
HPA030130.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265299.

Structurei

3D structure databases

ProteinModelPortaliQ4G0A6.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM188 family.

Phylogenomic databases

eggNOGiNOG282176.
HOGENOMiHOG000111604.
InParanoidiQ4G0A6.
OMAiNWNGSDP.
OrthoDBiEOG7GJ6CM.
PhylomeDBiQ4G0A6.
TreeFamiTF323996.

Family and domain databases

InterProiIPR025257. DUF4205.
[Graphical view]
PfamiPF13898. DUF4205. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G0A6-1 [UniParc]FASTAAdd to Basket

« Hide

MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV    50
LHLEFLYKEN KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV 100
PKKNNKVPSR CSETTLVNIY DLSDEDAGWR TSLSETSKAR HDNLDGDVLG 150
NFVSSKRPPH KSKPMQTVPG ETPVLTSAWE KIDKLHSEPS LDVKRMGENS 200
RPKSGLIVRG MMSGPIASSP QDSFHRHYLR RSSPSSSSTQ PQEESRKVPE 250
LFVCTQQDIL ASSNSSPSRT SLGQLSELTV ERQKTTASSP PHLPSKRLPP 300
WDRARPRDPS EDTPAVDGST DTDRMPLKLY LPGGNSRMTQ ERLERAFKRQ 350
GSQPAPVRKN QLLPSDKVDG ELGALRLEDV EDELIREEVI LSPVPSVLKL 400
QTASKPIDLS VAKEIKTLLF GSSFCCFNEE WKLQSFSFSN TASLKYGIVQ 450
NKGGPCGVLA AVQGCVLQKL LFEGDSKADC AQGLQPSDAH RTRCLVLALA 500
DIVWRAGGRE RAVVALASRT QQFSPTGKYK ADGVLETLTL HSLTCYEDLV 550
TFLQQSIHQF EVGPYGCILL TLSAILSRST ELIRQDFDVP TSHLIGAHGY 600
CTQELVNLLL TGKAVSNVFN DVVELDSGDG NITLLRGIAA RSDIGFLSLF 650
EHYNMCQVGC FLKTPRFPIW VVCSESHFSI LFSLQPGLLR DWRTERLFDL 700
YYYDGLANQQ EQIRLTIDTT QTISEDTDND LVPPLELCIR TKWKGASVNW 750
NGSDPIL 757
Length:757
Mass (Da):84,372
Last modified:May 18, 2010 - v2
Checksum:i1DAB6CAE92042C8E
GO

Sequence cautioni

The sequence BAB15327.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAQ10898.1 differs from that shown. Reason: Frameshift at position 617.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831D → A.
Corresponds to variant rs34357272 [ dbSNP | Ensembl ].
VAR_039212
Natural varianti262 – 2621S → L.
Corresponds to variant rs17159453 [ dbSNP | Ensembl ].
VAR_039213
Natural varianti322 – 3221T → M.3 Publications
Corresponds to variant rs12701034 [ dbSNP | Ensembl ].
VAR_039214
Natural varianti324 – 3241R → K.
Corresponds to variant rs35897481 [ dbSNP | Ensembl ].
VAR_039215
Natural varianti355 – 3551A → V.
Corresponds to variant rs12672119 [ dbSNP | Ensembl ].
VAR_039216
Natural varianti465 – 4651C → Y.
Corresponds to variant rs34970833 [ dbSNP | Ensembl ].
VAR_062248
Natural varianti655 – 6551M → V.
Corresponds to variant rs10216063 [ dbSNP | Ensembl ].
VAR_039217

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461R → G in AAQ10898. 1 Publication
Sequence conflicti483 – 4831G → A in AAQ10898. 1 Publication
Sequence conflicti632 – 6321I → F in AAQ10898. 1 Publication
Sequence conflicti647 – 6471L → F in AAQ10898. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF538962 mRNA. Translation: AAQ10898.1. Frameshift.
AC004691 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93970.1.
BC098569 mRNA. Translation: AAH98569.1.
AK026027 mRNA. Translation: BAB15327.1. Sequence problems.
CCDSiCCDS43565.1.
RefSeqiNP_115598.2. NM_032222.2.
UniGeneiHs.660192.

Genome annotation databases

EnsembliENST00000265299; ENSP00000265299; ENSG00000106125.
GeneIDi84182.
KEGGihsa:84182.
UCSCiuc003tbt.3. human.

Polymorphism databases

DMDMi296434499.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF538962 mRNA. Translation: AAQ10898.1 . Frameshift.
AC004691 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93970.1 .
BC098569 mRNA. Translation: AAH98569.1 .
AK026027 mRNA. Translation: BAB15327.1 . Sequence problems.
CCDSi CCDS43565.1.
RefSeqi NP_115598.2. NM_032222.2.
UniGenei Hs.660192.

3D structure databases

ProteinModelPortali Q4G0A6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000265299.

PTM databases

PhosphoSitei Q4G0A6.

Polymorphism databases

DMDMi 296434499.

Proteomic databases

MaxQBi Q4G0A6.
PaxDbi Q4G0A6.
PRIDEi Q4G0A6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265299 ; ENSP00000265299 ; ENSG00000106125 .
GeneIDi 84182.
KEGGi hsa:84182.
UCSCi uc003tbt.3. human.

Organism-specific databases

CTDi 84182.
GeneCardsi GC07P030813.
HGNCi HGNC:21916. FAM188B.
HPAi HPA019475.
HPA030129.
HPA030130.
neXtProti NX_Q4G0A6.
PharmGKBi PA165618038.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282176.
HOGENOMi HOG000111604.
InParanoidi Q4G0A6.
OMAi NWNGSDP.
OrthoDBi EOG7GJ6CM.
PhylomeDBi Q4G0A6.
TreeFami TF323996.

Miscellaneous databases

GeneWikii C7orf67.
GenomeRNAii 84182.
NextBioi 73563.
PROi Q4G0A6.

Gene expression databases

Bgeei Q4G0A6.
Genevestigatori Q4G0A6.

Family and domain databases

InterProi IPR025257. DUF4205.
[Graphical view ]
Pfami PF13898. DUF4205. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ding P., Han W., Xia D., Li X., Song Q., Zhang Y., Ma D.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-322.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-322.
    Tissue: Chondrosarcoma and Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-451, VARIANT MET-322.

Entry informationi

Entry nameiF188B_HUMAN
AccessioniPrimary (citable) accession number: Q4G0A6
Secondary accession number(s): Q71AZ7, Q9H6D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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