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Q4G0A6

- F188B_HUMAN

UniProt

Q4G0A6 - F188B_HUMAN

Protein

Protein FAM188B

Gene

FAM188B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM188B
    Gene namesi
    Name:FAM188B
    Synonyms:C7orf67
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21916. FAM188B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165618038.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 757757Protein FAM188BPRO_0000320590Add
    BLAST

    Proteomic databases

    MaxQBiQ4G0A6.
    PaxDbiQ4G0A6.
    PRIDEiQ4G0A6.

    PTM databases

    PhosphoSiteiQ4G0A6.

    Expressioni

    Gene expression databases

    BgeeiQ4G0A6.
    GenevestigatoriQ4G0A6.

    Organism-specific databases

    HPAiHPA019475.
    HPA030129.
    HPA030130.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000265299.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G0A6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM188 family.Curated

    Phylogenomic databases

    eggNOGiNOG282176.
    HOGENOMiHOG000111604.
    InParanoidiQ4G0A6.
    OMAiNWNGSDP.
    OrthoDBiEOG7GJ6CM.
    PhylomeDBiQ4G0A6.
    TreeFamiTF323996.

    Family and domain databases

    InterProiIPR025257. DUF4205.
    [Graphical view]
    PfamiPF13898. DUF4205. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4G0A6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV    50
    LHLEFLYKEN KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV 100
    PKKNNKVPSR CSETTLVNIY DLSDEDAGWR TSLSETSKAR HDNLDGDVLG 150
    NFVSSKRPPH KSKPMQTVPG ETPVLTSAWE KIDKLHSEPS LDVKRMGENS 200
    RPKSGLIVRG MMSGPIASSP QDSFHRHYLR RSSPSSSSTQ PQEESRKVPE 250
    LFVCTQQDIL ASSNSSPSRT SLGQLSELTV ERQKTTASSP PHLPSKRLPP 300
    WDRARPRDPS EDTPAVDGST DTDRMPLKLY LPGGNSRMTQ ERLERAFKRQ 350
    GSQPAPVRKN QLLPSDKVDG ELGALRLEDV EDELIREEVI LSPVPSVLKL 400
    QTASKPIDLS VAKEIKTLLF GSSFCCFNEE WKLQSFSFSN TASLKYGIVQ 450
    NKGGPCGVLA AVQGCVLQKL LFEGDSKADC AQGLQPSDAH RTRCLVLALA 500
    DIVWRAGGRE RAVVALASRT QQFSPTGKYK ADGVLETLTL HSLTCYEDLV 550
    TFLQQSIHQF EVGPYGCILL TLSAILSRST ELIRQDFDVP TSHLIGAHGY 600
    CTQELVNLLL TGKAVSNVFN DVVELDSGDG NITLLRGIAA RSDIGFLSLF 650
    EHYNMCQVGC FLKTPRFPIW VVCSESHFSI LFSLQPGLLR DWRTERLFDL 700
    YYYDGLANQQ EQIRLTIDTT QTISEDTDND LVPPLELCIR TKWKGASVNW 750
    NGSDPIL 757
    Length:757
    Mass (Da):84,372
    Last modified:May 18, 2010 - v2
    Checksum:i1DAB6CAE92042C8E
    GO

    Sequence cautioni

    The sequence BAB15327.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAQ10898.1 differs from that shown. Reason: Frameshift at position 617.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461R → G in AAQ10898. 1 PublicationCurated
    Sequence conflicti483 – 4831G → A in AAQ10898. 1 PublicationCurated
    Sequence conflicti632 – 6321I → F in AAQ10898. 1 PublicationCurated
    Sequence conflicti647 – 6471L → F in AAQ10898. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti183 – 1831D → A.
    Corresponds to variant rs34357272 [ dbSNP | Ensembl ].
    VAR_039212
    Natural varianti262 – 2621S → L.
    Corresponds to variant rs17159453 [ dbSNP | Ensembl ].
    VAR_039213
    Natural varianti322 – 3221T → M.3 Publications
    Corresponds to variant rs12701034 [ dbSNP | Ensembl ].
    VAR_039214
    Natural varianti324 – 3241R → K.
    Corresponds to variant rs35897481 [ dbSNP | Ensembl ].
    VAR_039215
    Natural varianti355 – 3551A → V.
    Corresponds to variant rs12672119 [ dbSNP | Ensembl ].
    VAR_039216
    Natural varianti465 – 4651C → Y.
    Corresponds to variant rs34970833 [ dbSNP | Ensembl ].
    VAR_062248
    Natural varianti655 – 6551M → V.
    Corresponds to variant rs10216063 [ dbSNP | Ensembl ].
    VAR_039217

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF538962 mRNA. Translation: AAQ10898.1. Frameshift.
    AC004691 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93970.1.
    BC098569 mRNA. Translation: AAH98569.1.
    AK026027 mRNA. Translation: BAB15327.1. Sequence problems.
    CCDSiCCDS43565.1.
    RefSeqiNP_115598.2. NM_032222.2.
    UniGeneiHs.660192.

    Genome annotation databases

    EnsembliENST00000265299; ENSP00000265299; ENSG00000106125.
    GeneIDi84182.
    KEGGihsa:84182.
    UCSCiuc003tbt.3. human.

    Polymorphism databases

    DMDMi296434499.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF538962 mRNA. Translation: AAQ10898.1 . Frameshift.
    AC004691 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93970.1 .
    BC098569 mRNA. Translation: AAH98569.1 .
    AK026027 mRNA. Translation: BAB15327.1 . Sequence problems.
    CCDSi CCDS43565.1.
    RefSeqi NP_115598.2. NM_032222.2.
    UniGenei Hs.660192.

    3D structure databases

    ProteinModelPortali Q4G0A6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000265299.

    PTM databases

    PhosphoSitei Q4G0A6.

    Polymorphism databases

    DMDMi 296434499.

    Proteomic databases

    MaxQBi Q4G0A6.
    PaxDbi Q4G0A6.
    PRIDEi Q4G0A6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265299 ; ENSP00000265299 ; ENSG00000106125 .
    GeneIDi 84182.
    KEGGi hsa:84182.
    UCSCi uc003tbt.3. human.

    Organism-specific databases

    CTDi 84182.
    GeneCardsi GC07P030813.
    HGNCi HGNC:21916. FAM188B.
    HPAi HPA019475.
    HPA030129.
    HPA030130.
    neXtProti NX_Q4G0A6.
    PharmGKBi PA165618038.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282176.
    HOGENOMi HOG000111604.
    InParanoidi Q4G0A6.
    OMAi NWNGSDP.
    OrthoDBi EOG7GJ6CM.
    PhylomeDBi Q4G0A6.
    TreeFami TF323996.

    Miscellaneous databases

    GeneWikii C7orf67.
    GenomeRNAii 84182.
    NextBioi 73563.
    PROi Q4G0A6.

    Gene expression databases

    Bgeei Q4G0A6.
    Genevestigatori Q4G0A6.

    Family and domain databases

    InterProi IPR025257. DUF4205.
    [Graphical view ]
    Pfami PF13898. DUF4205. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ding P., Han W., Xia D., Li X., Song Q., Zhang Y., Ma D.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-322.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-322.
      Tissue: Chondrosarcoma and Testis.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-451, VARIANT MET-322.

    Entry informationi

    Entry nameiF188B_HUMAN
    AccessioniPrimary (citable) accession number: Q4G0A6
    Secondary accession number(s): Q71AZ7, Q9H6D2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3