Q4G0A6 (F188B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM188B

Gene names

Name:	FAM188B
Synonyms:	C7orf67

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	757 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the FAM188 family.
Sequence caution	The sequence AAQ10898.1 differs from that shown. Reason: Frameshift at position 617. The sequence BAB15327.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 757	757	Protein FAM188B		PRO_0000320590
Natural variations
	Natural variant	183	1	D → A. Corresponds to variant rs34357272 [ dbSNP | Ensembl ].		VAR_039212
	Natural variant	262	1	S → L. Corresponds to variant rs17159453 [ dbSNP | Ensembl ].		VAR_039213
	Natural variant	322	1	T → M. Ref.3 Ref.4 Ref.5 Corresponds to variant rs12701034 [ dbSNP | Ensembl ].		VAR_039214
	Natural variant	324	1	R → K. Corresponds to variant rs35897481 [ dbSNP | Ensembl ].		VAR_039215
	Natural variant	355	1	A → V. Corresponds to variant rs12672119 [ dbSNP | Ensembl ].		VAR_039216
	Natural variant	465	1	C → Y. Corresponds to variant rs34970833 [ dbSNP | Ensembl ].		VAR_062248
	Natural variant	655	1	M → V. Corresponds to variant rs10216063 [ dbSNP | Ensembl ].		VAR_039217
Experimental info
	Sequence conflict	246	1	R → G in AAQ10898. Ref.1
	Sequence conflict	483	1	G → A in AAQ10898. Ref.1
	Sequence conflict	632	1	I → F in AAQ10898. Ref.1
	Sequence conflict	647	1	L → F in AAQ10898. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q4G0A6 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 1DAB6CAE92042C8E	FASTA	757	84,372
	10 20 30 40 50 60 MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV LHLEFLYKEN 70 80 90 100 110 120 KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV PKKNNKVPSR CSETTLVNIY 130 140 150 160 170 180 DLSDEDAGWR TSLSETSKAR HDNLDGDVLG NFVSSKRPPH KSKPMQTVPG ETPVLTSAWE 190 200 210 220 230 240 KIDKLHSEPS LDVKRMGENS RPKSGLIVRG MMSGPIASSP QDSFHRHYLR RSSPSSSSTQ 250 260 270 280 290 300 PQEESRKVPE LFVCTQQDIL ASSNSSPSRT SLGQLSELTV ERQKTTASSP PHLPSKRLPP 310 320 330 340 350 360 WDRARPRDPS EDTPAVDGST DTDRMPLKLY LPGGNSRMTQ ERLERAFKRQ GSQPAPVRKN 370 380 390 400 410 420 QLLPSDKVDG ELGALRLEDV EDELIREEVI LSPVPSVLKL QTASKPIDLS VAKEIKTLLF 430 440 450 460 470 480 GSSFCCFNEE WKLQSFSFSN TASLKYGIVQ NKGGPCGVLA AVQGCVLQKL LFEGDSKADC 490 500 510 520 530 540 AQGLQPSDAH RTRCLVLALA DIVWRAGGRE RAVVALASRT QQFSPTGKYK ADGVLETLTL 550 560 570 580 590 600 HSLTCYEDLV TFLQQSIHQF EVGPYGCILL TLSAILSRST ELIRQDFDVP TSHLIGAHGY 610 620 630 640 650 660 CTQELVNLLL TGKAVSNVFN DVVELDSGDG NITLLRGIAA RSDIGFLSLF EHYNMCQVGC 670 680 690 700 710 720 FLKTPRFPIW VVCSESHFSI LFSLQPGLLR DWRTERLFDL YYYDGLANQQ EQIRLTIDTT 730 740 750 QTISEDTDND LVPPLELCIR TKWKGASVNW NGSDPIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ding P., Han W., Xia D., Li X., Song Q., Zhang Y., Ma D. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-322.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-322. Tissue: Chondrosarcoma and Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-451, VARIANT MET-322.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF538962 mRNA. Translation: AAQ10898.1. Frameshift. AC004691 Genomic DNA. No translation available. CH471073 Genomic DNA. Translation: EAW93970.1. BC098569 mRNA. Translation: AAH98569.1. AK026027 mRNA. Translation: BAB15327.1. Sequence problems.
IPI	IPI00396306.
RefSeq	NP_115598.2. NM_032222.2.
UniGene	Hs.660192.
3D structure databases
ProteinModelPortal	Q4G0A6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000265299.
PTM databases
PhosphoSite	Q4G0A6.
Polymorphism databases
DMDM	296434499.
Proteomic databases
PaxDb	Q4G0A6.
PRIDE	Q4G0A6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265299; ENSP00000265299; ENSG00000106125.
GeneID	84182.
KEGG	hsa:84182.
UCSC	uc003tbt.3. human.
Organism-specific databases
CTD	84182.
GeneCards	GC07P030813.
HGNC	HGNC:21916. FAM188B.
HPA	HPA019475. HPA030129. HPA030130.
neXtProt	NX_Q4G0A6.
PharmGKB	PA165618038.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG282176.
HOGENOM	HOG000111604.
InParanoid	Q4G0A6.
OMA	ENPLKTS.
OrthoDB	EOG4Z62ND.
Gene expression databases
Bgee	Q4G0A6.
Genevestigator	Q4G0A6.
Family and domain databases
InterPro	IPR025257. DUF4205. [Graphical view]
Pfam	PF13898. DUF4205. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84182.
NextBio	73563.

Entry information

Entry name

F188B_HUMAN

Accession

Primary (citable) accession number: Q4G0A6
Secondary accession number(s): Q71AZ7, Q9H6D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.