Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4G0A6 (F188B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM188B
Gene names
Name:FAM188B
Synonyms:C7orf67
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM188 family.

Sequence caution

The sequence AAQ10898.1 differs from that shown. Reason: Frameshift at position 617.

The sequence BAB15327.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757Protein FAM188B
PRO_0000320590

Natural variations

Natural variant1831D → A.
Corresponds to variant rs34357272 [ dbSNP | Ensembl ].
VAR_039212
Natural variant2621S → L.
Corresponds to variant rs17159453 [ dbSNP | Ensembl ].
VAR_039213
Natural variant3221T → M. Ref.3 Ref.4 Ref.5
Corresponds to variant rs12701034 [ dbSNP | Ensembl ].
VAR_039214
Natural variant3241R → K.
Corresponds to variant rs35897481 [ dbSNP | Ensembl ].
VAR_039215
Natural variant3551A → V.
Corresponds to variant rs12672119 [ dbSNP | Ensembl ].
VAR_039216
Natural variant4651C → Y.
Corresponds to variant rs34970833 [ dbSNP | Ensembl ].
VAR_062248
Natural variant6551M → V.
Corresponds to variant rs10216063 [ dbSNP | Ensembl ].
VAR_039217

Experimental info

Sequence conflict2461R → G in AAQ10898. Ref.1
Sequence conflict4831G → A in AAQ10898. Ref.1
Sequence conflict6321I → F in AAQ10898. Ref.1
Sequence conflict6471L → F in AAQ10898. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q4G0A6 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 1DAB6CAE92042C8E

FASTA75784,372
        10         20         30         40         50         60 
MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV LHLEFLYKEN 

        70         80         90        100        110        120 
KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV PKKNNKVPSR CSETTLVNIY 

       130        140        150        160        170        180 
DLSDEDAGWR TSLSETSKAR HDNLDGDVLG NFVSSKRPPH KSKPMQTVPG ETPVLTSAWE 

       190        200        210        220        230        240 
KIDKLHSEPS LDVKRMGENS RPKSGLIVRG MMSGPIASSP QDSFHRHYLR RSSPSSSSTQ 

       250        260        270        280        290        300 
PQEESRKVPE LFVCTQQDIL ASSNSSPSRT SLGQLSELTV ERQKTTASSP PHLPSKRLPP 

       310        320        330        340        350        360 
WDRARPRDPS EDTPAVDGST DTDRMPLKLY LPGGNSRMTQ ERLERAFKRQ GSQPAPVRKN 

       370        380        390        400        410        420 
QLLPSDKVDG ELGALRLEDV EDELIREEVI LSPVPSVLKL QTASKPIDLS VAKEIKTLLF 

       430        440        450        460        470        480 
GSSFCCFNEE WKLQSFSFSN TASLKYGIVQ NKGGPCGVLA AVQGCVLQKL LFEGDSKADC 

       490        500        510        520        530        540 
AQGLQPSDAH RTRCLVLALA DIVWRAGGRE RAVVALASRT QQFSPTGKYK ADGVLETLTL 

       550        560        570        580        590        600 
HSLTCYEDLV TFLQQSIHQF EVGPYGCILL TLSAILSRST ELIRQDFDVP TSHLIGAHGY 

       610        620        630        640        650        660 
CTQELVNLLL TGKAVSNVFN DVVELDSGDG NITLLRGIAA RSDIGFLSLF EHYNMCQVGC 

       670        680        690        700        710        720 
FLKTPRFPIW VVCSESHFSI LFSLQPGLLR DWRTERLFDL YYYDGLANQQ EQIRLTIDTT 

       730        740        750 
QTISEDTDND LVPPLELCIR TKWKGASVNW NGSDPIL 

« Hide

References

« Hide 'large scale' references
[1]Ding P., Han W., Xia D., Li X., Song Q., Zhang Y., Ma D.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-322.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-322.
Tissue: Chondrosarcoma and Testis.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-451, VARIANT MET-322.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF538962 mRNA. Translation: AAQ10898.1. Frameshift.
AC004691 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93970.1.
BC098569 mRNA. Translation: AAH98569.1.
AK026027 mRNA. Translation: BAB15327.1. Sequence problems.
RefSeqNP_115598.2. NM_032222.2.
UniGeneHs.660192.

3D structure databases

ProteinModelPortalQ4G0A6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000265299.

PTM databases

PhosphoSiteQ4G0A6.

Polymorphism databases

DMDM296434499.

Proteomic databases

PaxDbQ4G0A6.
PRIDEQ4G0A6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265299; ENSP00000265299; ENSG00000106125.
GeneID84182.
KEGGhsa:84182.
UCSCuc003tbt.3. human.

Organism-specific databases

CTD84182.
GeneCardsGC07P030813.
HGNCHGNC:21916. FAM188B.
HPAHPA019475.
HPA030129.
HPA030130.
neXtProtNX_Q4G0A6.
PharmGKBPA165618038.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282176.
HOGENOMHOG000111604.
InParanoidQ4G0A6.
OMANWNGSDP.
OrthoDBEOG7GJ6CM.
PhylomeDBQ4G0A6.
TreeFamTF323996.

Gene expression databases

BgeeQ4G0A6.
GenevestigatorQ4G0A6.

Family and domain databases

InterProIPR025257. DUF4205.
[Graphical view]
PfamPF13898. DUF4205. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC7orf67.
GenomeRNAi84182.
NextBio73563.
PROQ4G0A6.

Entry information

Entry nameF188B_HUMAN
AccessionPrimary (citable) accession number: Q4G0A6
Secondary accession number(s): Q71AZ7, Q9H6D2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM