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Q4G075

- ILEUA_RAT

UniProt

Q4G075 - ILEUA_RAT

Protein

Leukocyte elastase inhibitor A

Gene

Serpinb1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Regulates the activity of the neutrophil proteases.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei344 – 3452Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of protein catabolic process Source: Ensembl
    3. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte elastase inhibitor A
    Alternative name(s):
    Serine protease inhibitor EIA
    Serpin B1a
    Gene namesi
    Name:Serpinb1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1306203. Serpinb1a.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Leukocyte elastase inhibitor APRO_0000289123Add
    BLAST

    Proteomic databases

    PaxDbiQ4G075.
    PRIDEiQ4G075.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4G075.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000056600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G075.
    SMRiQ4G075. Positions 1-327, 349-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115232.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    KOiK13963.
    OMAiNTRFAVE.
    OrthoDBiEOG7327PB.
    PhylomeDBiQ4G075.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR015557. Serpin_B1.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF142. PTHR11461:SF142. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4G075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQLSSANSL FALELFHTLS ESSPTGNIFF SPFSISSALA MVFLGTKGTT    50
    AAQLSKTFHF DSVEDVHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF 100
    LPEFLTSTQK MYGADLAPVD FQHASEDARK EINQWVKGQT EGKIPELLAV 150
    GVVDSMTKLV LVNAIYFKGM WEEKFMKQDT TDAPFRLNKK NTKSVKMMYQ 200
    KKKFFFGYIS DLKCKVLEMP YQGGELSMVI LLPEDIEDES TGLKKIEEQI 250
    TLEKLREWTK RENLENIDVH VKLPRFKIEE SYILNSNLGR LGLQDLFNSS 300
    KADLSGMSGS RDLFISKIVH KAFVEVNEEG TEAAAATAGI ATFCMLLPEE 350
    EFTADHPFIF FIRHNPTANV LFLGRVCSP 379
    Length:379
    Mass (Da):42,727
    Last modified:August 30, 2005 - v1
    Checksum:i2335D7C019FF849C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098686 mRNA. Translation: AAH98686.1.
    RefSeqiNP_001026812.1. NM_001031642.1.
    UniGeneiRn.103402.

    Genome annotation databases

    EnsembliENSRNOT00000059854; ENSRNOP00000056600; ENSRNOG00000016581.
    GeneIDi291091.
    KEGGirno:291091.
    UCSCiRGD:1306203. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098686 mRNA. Translation: AAH98686.1 .
    RefSeqi NP_001026812.1. NM_001031642.1.
    UniGenei Rn.103402.

    3D structure databases

    ProteinModelPortali Q4G075.
    SMRi Q4G075. Positions 1-327, 349-379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000056600.

    Proteomic databases

    PaxDbi Q4G075.
    PRIDEi Q4G075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000059854 ; ENSRNOP00000056600 ; ENSRNOG00000016581 .
    GeneIDi 291091.
    KEGGi rno:291091.
    UCSCi RGD:1306203. rat.

    Organism-specific databases

    CTDi 66222.
    RGDi 1306203. Serpinb1a.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115232.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    KOi K13963.
    OMAi NTRFAVE.
    OrthoDBi EOG7327PB.
    PhylomeDBi Q4G075.
    TreeFami TF352619.

    Miscellaneous databases

    NextBioi 632107.

    Gene expression databases

    Genevestigatori Q4G075.

    Family and domain databases

    InterProi IPR015557. Serpin_B1.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF142. PTHR11461:SF142. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiILEUA_RAT
    AccessioniPrimary (citable) accession number: Q4G075
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3