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Q4G075

- ILEUA_RAT

UniProt

Q4G075 - ILEUA_RAT

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Protein

Leukocyte elastase inhibitor A

Gene
Serpinb1a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulates the activity of the neutrophil proteases By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei344 – 3452Reactive bond By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of protein catabolic process Source: Ensembl
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte elastase inhibitor A
Alternative name(s):
Serine protease inhibitor EIA
Serpin B1a
Gene namesi
Name:Serpinb1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1306203. Serpinb1a.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Leukocyte elastase inhibitor APRO_0000289123Add
BLAST

Proteomic databases

PaxDbiQ4G075.
PRIDEiQ4G075.

Expressioni

Gene expression databases

GenevestigatoriQ4G075.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056600.

Structurei

3D structure databases

ProteinModelPortaliQ4G075.
SMRiQ4G075. Positions 1-327, 349-379.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00740000115232.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
KOiK13963.
OMAiNTRFAVE.
OrthoDBiEOG7327PB.
PhylomeDBiQ4G075.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF142. PTHR11461:SF142. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G075-1 [UniParc]FASTAAdd to Basket

« Hide

MEQLSSANSL FALELFHTLS ESSPTGNIFF SPFSISSALA MVFLGTKGTT    50
AAQLSKTFHF DSVEDVHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF 100
LPEFLTSTQK MYGADLAPVD FQHASEDARK EINQWVKGQT EGKIPELLAV 150
GVVDSMTKLV LVNAIYFKGM WEEKFMKQDT TDAPFRLNKK NTKSVKMMYQ 200
KKKFFFGYIS DLKCKVLEMP YQGGELSMVI LLPEDIEDES TGLKKIEEQI 250
TLEKLREWTK RENLENIDVH VKLPRFKIEE SYILNSNLGR LGLQDLFNSS 300
KADLSGMSGS RDLFISKIVH KAFVEVNEEG TEAAAATAGI ATFCMLLPEE 350
EFTADHPFIF FIRHNPTANV LFLGRVCSP 379
Length:379
Mass (Da):42,727
Last modified:August 30, 2005 - v1
Checksum:i2335D7C019FF849C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098686 mRNA. Translation: AAH98686.1.
RefSeqiNP_001026812.1. NM_001031642.1.
UniGeneiRn.103402.

Genome annotation databases

EnsembliENSRNOT00000059854; ENSRNOP00000056600; ENSRNOG00000016581.
GeneIDi291091.
KEGGirno:291091.
UCSCiRGD:1306203. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098686 mRNA. Translation: AAH98686.1 .
RefSeqi NP_001026812.1. NM_001031642.1.
UniGenei Rn.103402.

3D structure databases

ProteinModelPortali Q4G075.
SMRi Q4G075. Positions 1-327, 349-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000056600.

Proteomic databases

PaxDbi Q4G075.
PRIDEi Q4G075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000059854 ; ENSRNOP00000056600 ; ENSRNOG00000016581 .
GeneIDi 291091.
KEGGi rno:291091.
UCSCi RGD:1306203. rat.

Organism-specific databases

CTDi 66222.
RGDi 1306203. Serpinb1a.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00740000115232.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
KOi K13963.
OMAi NTRFAVE.
OrthoDBi EOG7327PB.
PhylomeDBi Q4G075.
TreeFami TF352619.

Miscellaneous databases

NextBioi 632107.

Gene expression databases

Genevestigatori Q4G075.

Family and domain databases

InterProi IPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
PTHR11461:SF142. PTHR11461:SF142. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiILEUA_RAT
AccessioniPrimary (citable) accession number: Q4G075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 30, 2005
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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