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Protein

Leukocyte elastase inhibitor A

Gene

Serpinb1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the activity of the neutrophil proteases.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei344 – 345Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte elastase inhibitor A
Alternative name(s):
Serine protease inhibitor EIA
Serpin B1a
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1306203 Serpinb1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891231 – 379Leukocyte elastase inhibitor AAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4G075
PRIDEiQ4G075

PTM databases

iPTMnetiQ4G075
PhosphoSitePlusiQ4G075

Expressioni

Gene expression databases

BgeeiENSRNOG00000016581
GenevisibleiQ4G075 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056600

Structurei

3D structure databases

ProteinModelPortaliQ4G075
SMRiQ4G075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ4G075
KOiK13963
OMAiAESFHQV
OrthoDBiEOG091G0ION
PhylomeDBiQ4G075
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR015557 Serpin_B1
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF180 PTHR11461:SF180, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q4G075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLSSANSL FALELFHTLS ESSPTGNIFF SPFSISSALA MVFLGTKGTT
60 70 80 90 100
AAQLSKTFHF DSVEDVHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF
110 120 130 140 150
LPEFLTSTQK MYGADLAPVD FQHASEDARK EINQWVKGQT EGKIPELLAV
160 170 180 190 200
GVVDSMTKLV LVNAIYFKGM WEEKFMKQDT TDAPFRLNKK NTKSVKMMYQ
210 220 230 240 250
KKKFFFGYIS DLKCKVLEMP YQGGELSMVI LLPEDIEDES TGLKKIEEQI
260 270 280 290 300
TLEKLREWTK RENLENIDVH VKLPRFKIEE SYILNSNLGR LGLQDLFNSS
310 320 330 340 350
KADLSGMSGS RDLFISKIVH KAFVEVNEEG TEAAAATAGI ATFCMLLPEE
360 370
EFTADHPFIF FIRHNPTANV LFLGRVCSP
Length:379
Mass (Da):42,727
Last modified:August 30, 2005 - v1
Checksum:i2335D7C019FF849C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098686 mRNA Translation: AAH98686.1
RefSeqiNP_001026812.1, NM_001031642.1
UniGeneiRn.103402

Genome annotation databases

EnsembliENSRNOT00000059854; ENSRNOP00000056600; ENSRNOG00000016581
GeneIDi291091
KEGGirno:291091
UCSCiRGD:1306203 rat

Similar proteinsi

Entry informationi

Entry nameiILEUA_RAT
AccessioniPrimary (citable) accession number: Q4G075
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 30, 2005
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health