Q4G075 (ILEUA_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte elastase inhibitor A

Alternative name(s):
Serine protease inhibitor EIA
Serpin B1a

Gene names

Name:

Serpinb1a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulates the activity of the neutrophil proteases By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the serpin family. Ov-serpin subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of protein catabolic process Inferred from electronic annotation. Source: Compara regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Leukocyte elastase inhibitor A		PRO_0000289123
Sites
	Site	344 – 345	2	Reactive bond By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4G075 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 2335D7C019FF849C	FASTA	379	42,727
	10 20 30 40 50 60 MEQLSSANSL FALELFHTLS ESSPTGNIFF SPFSISSALA MVFLGTKGTT AAQLSKTFHF 70 80 90 100 110 120 DSVEDVHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF LPEFLTSTQK MYGADLAPVD 130 140 150 160 170 180 FQHASEDARK EINQWVKGQT EGKIPELLAV GVVDSMTKLV LVNAIYFKGM WEEKFMKQDT 190 200 210 220 230 240 TDAPFRLNKK NTKSVKMMYQ KKKFFFGYIS DLKCKVLEMP YQGGELSMVI LLPEDIEDES 250 260 270 280 290 300 TGLKKIEEQI TLEKLREWTK RENLENIDVH VKLPRFKIEE SYILNSNLGR LGLQDLFNSS 310 320 330 340 350 360 KADLSGMSGS RDLFISKIVH KAFVEVNEEG TEAAAATAGI ATFCMLLPEE EFTADHPFIF 370 FIRHNPTANV LFLGRVCSP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098686 mRNA. Translation: AAH98686.1.
IPI	IPI00779473.
RefSeq	NP_001026812.1. NM_001031642.1.
UniGene	Rn.103402.
3D structure databases
HSSP	HSSP built from PDB template 1F0C based on UniProtKB P07385.
ProteinModelPortal	Q4G075.
SMR	Q4G075. Positions 1-327, 349-379.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000056600.
Protein family/group databases
MEROPS	I04.049.
Proteomic databases
PaxDb	Q4G075.
PRIDE	Q4G075.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000059854; ENSRNOP00000056600; ENSRNOG00000016581.
GeneID	291091.
KEGG	rno:291091.
UCSC	RGD:1306203. rat.
Organism-specific databases
CTD	66222.
RGD	1306203. Serpinb1a.
Phylogenomic databases
eggNOG	COG4826.
GeneTree	ENSGT00700000104334.
HOGENOM	HOG000238519.
HOVERGEN	HBG005957.
KO	K13963.
OrthoDB	EOG49KFQS.
Gene expression databases
Genevestigator	Q4G075.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR015557. Protease_inhib_serpin_B1. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit. PTHR11461:SF66. PTHR11461:SF66. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	632107.

Entry information

Entry name

ILEUA_RAT

Accession

Primary (citable) accession number: Q4G075

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program