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Protein

KIF1-binding protein

Gene

Kbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
KIF1-binding protein
Gene namesi
Name:Kbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1593126. LOC606294.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617KIF1-binding proteinPRO_0000334517Add
BLAST

Proteomic databases

PaxDbiQ4G074.
PRIDEiQ4G074.

PTM databases

PhosphoSiteiQ4G074.

Interactioni

Subunit structurei

Interacts with KIF1B. Interacts with STMN2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000444.

Family & Domainsi

Sequence similaritiesi

Belongs to the KIF1-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410IE53. Eukaryota.
ENOG410XSW1. LUCA.
HOGENOMiHOG000047429.
HOVERGENiHBG108054.
InParanoidiQ4G074.
PhylomeDBiQ4G074.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR022083. KBP.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR20956:SF0. PTHR20956:SF0. 2 hits.
PfamiPF12309. KBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4G074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAPGPEIR EKFQAALALS RVELHKNPEK EPYKSKYGAR ALLEEVRALL
60 70 80 90 100
GPAPEDDDER AADDGPVDQA LGAGEPRDAE GPGAQRALRL AVVEFHLGVN
110 120 130 140 150
HIDTEELSAG EEHLVRCLSL LRPYRLSLGC VSLFIQAQNN LGILWSEREE
160 170 180 190 200
IETARTYLES SEALYNQYMK EIGSPPLDPT EHFLPEEEKL TEQERSKRFE
210 220 230 240 250
KVYTHNLYYL AQVYQHMEMF EKAAHYCHST LKRQLEHNAY HPMEWAINAA
260 270 280 290 300
TLSQFYINKL CFMEARHCLS AANVIFGQTG KITATEDTPE VEGDMPELYH
310 320 330 340 350
QRKGEIARCW IKYCLTLMQN AQLSMQDNIG ELDLDKQSEL RALRRKELDE
360 370 380 390 400
EESVRKRAVQ FGTGELRDAI SAVEEKVRYL RPLDFEEARE LFLLGQHYVY
410 420 430 440 450
EAKEFFQIDG YVTDHIEVVQ DHSALFKVLA FFEADMERRC KMHKRRIAML
460 470 480 490 500
EPLIVDLNPQ YYQLVNRQIQ FEIAHAYYDM MDLKVAIADK LREPDSHTVK
510 520 530 540 550
KINSLNQSAL KYYQLFLDSL RDPNKVFPEH IGEDVLRPAM LAKFRVARLY
560 570 580 590 600
GKIITADPKK ELENLATSLE HYKFIVDYCE THPEAAQEIE VELELSKEMV
610
SLLPTKMERF RAKMALT
Length:617
Mass (Da):71,296
Last modified:August 30, 2005 - v1
Checksum:i2D82AAEA658B6301
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098692 mRNA. Translation: AAH98692.1.
RefSeqiNP_001026797.1. NM_001031627.1.
UniGeneiRn.100975.

Genome annotation databases

GeneIDi606294.
KEGGirno:606294.
UCSCiRGD:1593126. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098692 mRNA. Translation: AAH98692.1.
RefSeqiNP_001026797.1. NM_001031627.1.
UniGeneiRn.100975.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000444.

PTM databases

PhosphoSiteiQ4G074.

Proteomic databases

PaxDbiQ4G074.
PRIDEiQ4G074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi606294.
KEGGirno:606294.
UCSCiRGD:1593126. rat.

Organism-specific databases

CTDi26128.
RGDi1593126. LOC606294.

Phylogenomic databases

eggNOGiENOG410IE53. Eukaryota.
ENOG410XSW1. LUCA.
HOGENOMiHOG000047429.
HOVERGENiHBG108054.
InParanoidiQ4G074.
PhylomeDBiQ4G074.

Miscellaneous databases

PROiQ4G074.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR022083. KBP.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR20956:SF0. PTHR20956:SF0. 2 hits.
PfamiPF12309. KBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation."
    Alves M.M., Burzynski G., Delalande J.M., Osinga J., van der Goot A., Dolga A.M., de Graaff E., Brooks A.S., Metzger M., Eisel U.L., Shepherd I., Eggen B.J., Hofstra R.M.
    Hum. Mol. Genet. 19:3642-3651(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKBP_RAT
AccessioniPrimary (citable) accession number: Q4G074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 30, 2005
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.