ID   TRDMT_RAT               Reviewed;         391 AA.
AC   Q4G073;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=tRNA (cytosine-5-)-methyltransferase;
DE            EC=2.1.1.29;
DE   AltName: Full=DNA (cytosine-5)-methyltransferase-like protein 2;
DE            Short=Dnmt2;
GN   Name=Trdmt1; Synonyms=Dnmt2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Specifically methylates cytosine 38 in the anticodon
CC       loop of tRNA(Asp) (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing 5-methylcytosine.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the C5-methyltransferase family.
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DR   EMBL; BC098700; AAH98700.1; -; mRNA.
DR   IPI; IPI00363164; -.
DR   RefSeq; NP_001026813.1; -.
DR   UniGene; Rn.115; -.
DR   Ensembl; ENSRNOG00000026132; Rattus norvegicus.
DR   GeneID; 291324; -.
DR   KEGG; rno:291324; -.
DR   NMPDR; fig|10116.3.peg.13667; -.
DR   RGD; 1306292; Trdmt1.
DR   HOVERGEN; Q4G073; -.
DR   OMA; Q4G073; YFTPREV.
DR   BRENDA; 2.1.1.29; 248.
DR   NextBio; 632414; -.
DR   ArrayExpress; Q4G073; -.
DR   GermOnline; ENSRNOG00000026132; Rattus norvegicus.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016428; F:tRNA (cytosine-5-)-methyltransferase activity; IEA:EC.
DR   GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR   GO; GO:0001975; P:response to amphetamine; IEP:RGD.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR001525; C5_DNA_meth.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   PANTHER; PTHR10629; C5_DNA_meth; 1.
DR   Pfam; PF00145; DNA_methylase; 2.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   PROSITE; PS00094; C5_MTASE_1; FALSE_NEG.
DR   PROSITE; PS00095; C5_MTASE_2; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Nucleus; RNA-binding; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   CHAIN         1    391       tRNA (cytosine-5-)-methyltransferase.
FT                                /FTId=PRO_0000249870.
FT   ACT_SITE     79     79       By similarity.
SQ   SEQUENCE   391 AA;  44070 MW;  58768BA5BBD4E37C CRC64;
     MEPLRVLELY SGIGGMHHAL RESRVPAHVV AAIDVSTVAN EVYKHNFPHT HLLAKTIEGI
     SLEEFDKLSF NMILMSPPCQ PFTRIGLQGD MSDRRTNSFL YILDILPRLQ KLPKYILLEN
     VKGFEVSSTR GLLIQTMEAC GFQYQEFLLS PSSLGIPNSR LRYFLIAKLQ SEPLCFQAPG
     QILMEFPNSG TVQPQEYAVV EEGKLRVRTR EPDVCLDSSS TQCSGQDSIL FKHETAADID
     RKRQQDSDLS VQMLKGFLED GDTAQYLLPA KSLLRYALLL DIVKPTSRRS MCFTKGYGSY
     IEGTGSVLQT AEDVQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN LLGFPPEFGF
     PEKTTVKQRY RLLGNSLNVH VVSKLLTVLC E
//