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Q4G073 (TRDMT_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (cytosine(38)-C(5))-methyltransferase

EC=2.1.1.204
Alternative name(s):
DNA (cytosine-5)-methyltransferase-like protein 2
Short name=Dnmt2
Gene names
Name:Trdmt1
Synonyms:Dnmt2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) By similarity.

Catalytic activity

S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Contains 1 SAM-dependent MTase C5-type domain.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentNucleus
   LigandRNA-binding
S-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA methylation

Inferred from electronic annotation. Source: InterPro

response to amphetamine

Inferred from expression pattern PubMed 15542706. Source: RGD

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391tRNA (cytosine(38)-C(5))-methyltransferase
PRO_0000249870

Regions

Domain4 – 391388SAM-dependent MTase C5-type

Sites

Active site791 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4G073 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 58768BA5BBD4E37C

FASTA39144,070
        10         20         30         40         50         60 
MEPLRVLELY SGIGGMHHAL RESRVPAHVV AAIDVSTVAN EVYKHNFPHT HLLAKTIEGI 

        70         80         90        100        110        120 
SLEEFDKLSF NMILMSPPCQ PFTRIGLQGD MSDRRTNSFL YILDILPRLQ KLPKYILLEN 

       130        140        150        160        170        180 
VKGFEVSSTR GLLIQTMEAC GFQYQEFLLS PSSLGIPNSR LRYFLIAKLQ SEPLCFQAPG 

       190        200        210        220        230        240 
QILMEFPNSG TVQPQEYAVV EEGKLRVRTR EPDVCLDSSS TQCSGQDSIL FKHETAADID 

       250        260        270        280        290        300 
RKRQQDSDLS VQMLKGFLED GDTAQYLLPA KSLLRYALLL DIVKPTSRRS MCFTKGYGSY 

       310        320        330        340        350        360 
IEGTGSVLQT AEDVQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN LLGFPPEFGF 

       370        380        390 
PEKTTVKQRY RLLGNSLNVH VVSKLLTVLC E 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC098700 mRNA. Translation: AAH98700.1.
RefSeqNP_001026813.1. NM_001031643.1.
UniGeneRn.115.

3D structure databases

ProteinModelPortalQ4G073.
SMRQ4G073. Positions 2-391.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000038279.

Proteomic databases

PaxDbQ4G073.
PRIDEQ4G073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000038651; ENSRNOP00000038279; ENSRNOG00000026132.
GeneID291324.
KEGGrno:291324.
UCSCRGD:1306292. rat.

Organism-specific databases

CTD1787.
RGD1306292. Trdmt1.

Phylogenomic databases

eggNOGCOG0270.
GeneTreeENSGT00390000016416.
HOGENOMHOG000265038.
HOVERGENHBG051385.
InParanoidQ4G073.
KOK15336.
OMATCCFTRG.
OrthoDBEOG7PZRZ4.
PhylomeDBQ4G073.
TreeFamTF300024.

Gene expression databases

GenevestigatorQ4G073.

Family and domain databases

InterProIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025813. DNA/tRNA_C5-MeTrfase.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSPR00105. C5METTRFRASE.
TIGRFAMsTIGR00675. dcm. 1 hit.
PROSITEPS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio632414.
PROQ4G073.

Entry information

Entry nameTRDMT_RAT
AccessionPrimary (citable) accession number: Q4G073
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: August 30, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families