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Q4G073

- TRDMT_RAT

UniProt

Q4G073 - TRDMT_RAT

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Protein
tRNA (cytosine(38)-C(5))-methyltransferase
Gene
Trdmt1, Dnmt2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) By similarity.

Catalytic activityi

S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791 By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA methylation Source: InterPro
  2. response to amphetamine Source: RGD
  3. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (cytosine(38)-C(5))-methyltransferase (EC:2.1.1.204)
Alternative name(s):
DNA (cytosine-5)-methyltransferase-like protein 2
Short name:
Dnmt2
Gene namesi
Name:Trdmt1
Synonyms:Dnmt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1306292. Trdmt1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391tRNA (cytosine(38)-C(5))-methyltransferase
PRO_0000249870Add
BLAST

Proteomic databases

PaxDbiQ4G073.
PRIDEiQ4G073.

Expressioni

Gene expression databases

GenevestigatoriQ4G073.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038279.

Structurei

3D structure databases

ProteinModelPortaliQ4G073.
SMRiQ4G073. Positions 2-391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 391388SAM-dependent MTase C5-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0270.
GeneTreeiENSGT00390000016416.
HOGENOMiHOG000265038.
HOVERGENiHBG051385.
InParanoidiQ4G073.
KOiK15336.
OMAiFGVPYSR.
OrthoDBiEOG7PZRZ4.
PhylomeDBiQ4G073.
TreeFamiTF300024.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025813. DNA/tRNA_C5-MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G073-1 [UniParc]FASTAAdd to Basket

« Hide

MEPLRVLELY SGIGGMHHAL RESRVPAHVV AAIDVSTVAN EVYKHNFPHT    50
HLLAKTIEGI SLEEFDKLSF NMILMSPPCQ PFTRIGLQGD MSDRRTNSFL 100
YILDILPRLQ KLPKYILLEN VKGFEVSSTR GLLIQTMEAC GFQYQEFLLS 150
PSSLGIPNSR LRYFLIAKLQ SEPLCFQAPG QILMEFPNSG TVQPQEYAVV 200
EEGKLRVRTR EPDVCLDSSS TQCSGQDSIL FKHETAADID RKRQQDSDLS 250
VQMLKGFLED GDTAQYLLPA KSLLRYALLL DIVKPTSRRS MCFTKGYGSY 300
IEGTGSVLQT AEDVQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN 350
LLGFPPEFGF PEKTTVKQRY RLLGNSLNVH VVSKLLTVLC E 391
Length:391
Mass (Da):44,070
Last modified:August 30, 2005 - v1
Checksum:i58768BA5BBD4E37C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098700 mRNA. Translation: AAH98700.1.
RefSeqiNP_001026813.1. NM_001031643.1.
UniGeneiRn.115.

Genome annotation databases

EnsembliENSRNOT00000038651; ENSRNOP00000038279; ENSRNOG00000026132.
GeneIDi291324.
KEGGirno:291324.
UCSCiRGD:1306292. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098700 mRNA. Translation: AAH98700.1 .
RefSeqi NP_001026813.1. NM_001031643.1.
UniGenei Rn.115.

3D structure databases

ProteinModelPortali Q4G073.
SMRi Q4G073. Positions 2-391.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000038279.

Proteomic databases

PaxDbi Q4G073.
PRIDEi Q4G073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000038651 ; ENSRNOP00000038279 ; ENSRNOG00000026132 .
GeneIDi 291324.
KEGGi rno:291324.
UCSCi RGD:1306292. rat.

Organism-specific databases

CTDi 1787.
RGDi 1306292. Trdmt1.

Phylogenomic databases

eggNOGi COG0270.
GeneTreei ENSGT00390000016416.
HOGENOMi HOG000265038.
HOVERGENi HBG051385.
InParanoidi Q4G073.
KOi K15336.
OMAi FGVPYSR.
OrthoDBi EOG7PZRZ4.
PhylomeDBi Q4G073.
TreeFami TF300024.

Miscellaneous databases

NextBioi 632414.
PROi Q4G073.

Gene expression databases

Genevestigatori Q4G073.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025813. DNA/tRNA_C5-MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiTRDMT_RAT
AccessioniPrimary (citable) accession number: Q4G073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: August 30, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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