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Protein

tRNA (cytosine(38)-C(5))-methyltransferase

Gene

Trdmt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).By similarity

Catalytic activityi

S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW
  3. tRNA methyltransferase activity Source: Ensembl

GO - Biological processi

  1. DNA methylation Source: InterPro
  2. response to amphetamine Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (cytosine(38)-C(5))-methyltransferase (EC:2.1.1.204)
Alternative name(s):
DNA (cytosine-5)-methyltransferase-like protein 2
Short name:
Dnmt2
Gene namesi
Name:Trdmt1
Synonyms:Dnmt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1306292. Trdmt1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391tRNA (cytosine(38)-C(5))-methyltransferasePRO_0000249870Add
BLAST

Proteomic databases

PaxDbiQ4G073.
PRIDEiQ4G073.

Expressioni

Gene expression databases

GenevestigatoriQ4G073.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038279.

Structurei

3D structure databases

ProteinModelPortaliQ4G073.
SMRiQ4G073. Positions 2-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 391388SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0270.
GeneTreeiENSGT00390000016416.
HOGENOMiHOG000265038.
HOVERGENiHBG051385.
InParanoidiQ4G073.
KOiK15336.
OMAiPDSKRCC.
OrthoDBiEOG7PZRZ4.
PhylomeDBiQ4G073.
TreeFamiTF300024.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLRVLELY SGIGGMHHAL RESRVPAHVV AAIDVSTVAN EVYKHNFPHT
60 70 80 90 100
HLLAKTIEGI SLEEFDKLSF NMILMSPPCQ PFTRIGLQGD MSDRRTNSFL
110 120 130 140 150
YILDILPRLQ KLPKYILLEN VKGFEVSSTR GLLIQTMEAC GFQYQEFLLS
160 170 180 190 200
PSSLGIPNSR LRYFLIAKLQ SEPLCFQAPG QILMEFPNSG TVQPQEYAVV
210 220 230 240 250
EEGKLRVRTR EPDVCLDSSS TQCSGQDSIL FKHETAADID RKRQQDSDLS
260 270 280 290 300
VQMLKGFLED GDTAQYLLPA KSLLRYALLL DIVKPTSRRS MCFTKGYGSY
310 320 330 340 350
IEGTGSVLQT AEDVQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN
360 370 380 390
LLGFPPEFGF PEKTTVKQRY RLLGNSLNVH VVSKLLTVLC E
Length:391
Mass (Da):44,070
Last modified:August 30, 2005 - v1
Checksum:i58768BA5BBD4E37C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098700 mRNA. Translation: AAH98700.1.
RefSeqiNP_001026813.1. NM_001031643.1.
UniGeneiRn.115.

Genome annotation databases

EnsembliENSRNOT00000038651; ENSRNOP00000038279; ENSRNOG00000026132.
GeneIDi291324.
KEGGirno:291324.
UCSCiRGD:1306292. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098700 mRNA. Translation: AAH98700.1.
RefSeqiNP_001026813.1. NM_001031643.1.
UniGeneiRn.115.

3D structure databases

ProteinModelPortaliQ4G073.
SMRiQ4G073. Positions 2-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038279.

Proteomic databases

PaxDbiQ4G073.
PRIDEiQ4G073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038651; ENSRNOP00000038279; ENSRNOG00000026132.
GeneIDi291324.
KEGGirno:291324.
UCSCiRGD:1306292. rat.

Organism-specific databases

CTDi1787.
RGDi1306292. Trdmt1.

Phylogenomic databases

eggNOGiCOG0270.
GeneTreeiENSGT00390000016416.
HOGENOMiHOG000265038.
HOVERGENiHBG051385.
InParanoidiQ4G073.
KOiK15336.
OMAiPDSKRCC.
OrthoDBiEOG7PZRZ4.
PhylomeDBiQ4G073.
TreeFamiTF300024.

Miscellaneous databases

NextBioi632414.
PROiQ4G073.

Gene expression databases

GenevestigatoriQ4G073.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiTRDMT_RAT
AccessioniPrimary (citable) accession number: Q4G073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: August 30, 2005
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.