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Protein

tRNA (cytosine(38)-C(5))-methyltransferase

Gene

Trdmt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).By similarity

Catalytic activityi

S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34S-adenosyl-L-methionineBy similarity1
Binding sitei76S-adenosyl-L-methionineBy similarity1
Active sitei79PROSITE-ProRule annotation1
Binding sitei376S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

  • response to amphetamine Source: RGD

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (cytosine(38)-C(5))-methyltransferase (EC:2.1.1.204)
Alternative name(s):
DNA (cytosine-5)-methyltransferase-like protein 2
Short name:
Dnmt2
Gene namesi
Name:Trdmt1
Synonyms:Dnmt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1306292. Trdmt1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498701 – 391tRNA (cytosine(38)-C(5))-methyltransferaseAdd BLAST391

Proteomic databases

PaxDbiQ4G073.
PRIDEiQ4G073.

Expressioni

Gene expression databases

BgeeiENSRNOG00000026132.
GenevisibleiQ4G073. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038279.

Structurei

3D structure databases

ProteinModelPortaliQ4G073.
SMRiQ4G073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 391SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST388

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 15S-adenosyl-L-methionine bindingBy similarity3
Regioni57 – 58S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0919. Eukaryota.
COG0270. LUCA.
GeneTreeiENSGT00390000016416.
HOGENOMiHOG000265038.
HOVERGENiHBG051385.
InParanoidiQ4G073.
KOiK15336.
OMAiLRYFTPK.
OrthoDBiEOG091G0FXV.
PhylomeDBiQ4G073.
TreeFamiTF300024.

Family and domain databases

InterProiView protein in InterPro
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF00145. DNA_methylase. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiView protein in PROSITE
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4G073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLRVLELY SGIGGMHHAL RESRVPAHVV AAIDVSTVAN EVYKHNFPHT
60 70 80 90 100
HLLAKTIEGI SLEEFDKLSF NMILMSPPCQ PFTRIGLQGD MSDRRTNSFL
110 120 130 140 150
YILDILPRLQ KLPKYILLEN VKGFEVSSTR GLLIQTMEAC GFQYQEFLLS
160 170 180 190 200
PSSLGIPNSR LRYFLIAKLQ SEPLCFQAPG QILMEFPNSG TVQPQEYAVV
210 220 230 240 250
EEGKLRVRTR EPDVCLDSSS TQCSGQDSIL FKHETAADID RKRQQDSDLS
260 270 280 290 300
VQMLKGFLED GDTAQYLLPA KSLLRYALLL DIVKPTSRRS MCFTKGYGSY
310 320 330 340 350
IEGTGSVLQT AEDVQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN
360 370 380 390
LLGFPPEFGF PEKTTVKQRY RLLGNSLNVH VVSKLLTVLC E
Length:391
Mass (Da):44,070
Last modified:August 30, 2005 - v1
Checksum:i58768BA5BBD4E37C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098700 mRNA. Translation: AAH98700.1.
RefSeqiNP_001026813.1. NM_001031643.1.
UniGeneiRn.115.

Genome annotation databases

EnsembliENSRNOT00000038651; ENSRNOP00000038279; ENSRNOG00000026132.
GeneIDi291324.
KEGGirno:291324.
UCSCiRGD:1306292. rat.

Similar proteinsi

Entry informationi

Entry nameiTRDMT_RAT
AccessioniPrimary (citable) accession number: Q4G073
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: August 30, 2005
Last modified: August 30, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families