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Q4G073

- TRDMT_RAT

UniProt

Q4G073 - TRDMT_RAT

Protein

tRNA (cytosine(38)-C(5))-methyltransferase

Gene

Trdmt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. methyltransferase activity Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA methylation Source: InterPro
    2. response to amphetamine Source: RGD
    3. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (cytosine(38)-C(5))-methyltransferase (EC:2.1.1.204)
    Alternative name(s):
    DNA (cytosine-5)-methyltransferase-like protein 2
    Short name:
    Dnmt2
    Gene namesi
    Name:Trdmt1
    Synonyms:Dnmt2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1306292. Trdmt1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391tRNA (cytosine(38)-C(5))-methyltransferasePRO_0000249870Add
    BLAST

    Proteomic databases

    PaxDbiQ4G073.
    PRIDEiQ4G073.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4G073.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000038279.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4G073.
    SMRiQ4G073. Positions 2-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 391388SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0270.
    GeneTreeiENSGT00390000016416.
    HOGENOMiHOG000265038.
    HOVERGENiHBG051385.
    InParanoidiQ4G073.
    KOiK15336.
    OMAiFGVPYSR.
    OrthoDBiEOG7PZRZ4.
    PhylomeDBiQ4G073.
    TreeFamiTF300024.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025813. DNA/tRNA_C5-MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4G073-1 [UniParc]FASTAAdd to Basket

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    MEPLRVLELY SGIGGMHHAL RESRVPAHVV AAIDVSTVAN EVYKHNFPHT    50
    HLLAKTIEGI SLEEFDKLSF NMILMSPPCQ PFTRIGLQGD MSDRRTNSFL 100
    YILDILPRLQ KLPKYILLEN VKGFEVSSTR GLLIQTMEAC GFQYQEFLLS 150
    PSSLGIPNSR LRYFLIAKLQ SEPLCFQAPG QILMEFPNSG TVQPQEYAVV 200
    EEGKLRVRTR EPDVCLDSSS TQCSGQDSIL FKHETAADID RKRQQDSDLS 250
    VQMLKGFLED GDTAQYLLPA KSLLRYALLL DIVKPTSRRS MCFTKGYGSY 300
    IEGTGSVLQT AEDVQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN 350
    LLGFPPEFGF PEKTTVKQRY RLLGNSLNVH VVSKLLTVLC E 391
    Length:391
    Mass (Da):44,070
    Last modified:August 30, 2005 - v1
    Checksum:i58768BA5BBD4E37C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098700 mRNA. Translation: AAH98700.1.
    RefSeqiNP_001026813.1. NM_001031643.1.
    UniGeneiRn.115.

    Genome annotation databases

    EnsembliENSRNOT00000038651; ENSRNOP00000038279; ENSRNOG00000026132.
    GeneIDi291324.
    KEGGirno:291324.
    UCSCiRGD:1306292. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098700 mRNA. Translation: AAH98700.1 .
    RefSeqi NP_001026813.1. NM_001031643.1.
    UniGenei Rn.115.

    3D structure databases

    ProteinModelPortali Q4G073.
    SMRi Q4G073. Positions 2-391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000038279.

    Proteomic databases

    PaxDbi Q4G073.
    PRIDEi Q4G073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000038651 ; ENSRNOP00000038279 ; ENSRNOG00000026132 .
    GeneIDi 291324.
    KEGGi rno:291324.
    UCSCi RGD:1306292. rat.

    Organism-specific databases

    CTDi 1787.
    RGDi 1306292. Trdmt1.

    Phylogenomic databases

    eggNOGi COG0270.
    GeneTreei ENSGT00390000016416.
    HOGENOMi HOG000265038.
    HOVERGENi HBG051385.
    InParanoidi Q4G073.
    KOi K15336.
    OMAi FGVPYSR.
    OrthoDBi EOG7PZRZ4.
    PhylomeDBi Q4G073.
    TreeFami TF300024.

    Miscellaneous databases

    NextBioi 632414.
    PROi Q4G073.

    Gene expression databases

    Genevestigatori Q4G073.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025813. DNA/tRNA_C5-MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiTRDMT_RAT
    AccessioniPrimary (citable) accession number: Q4G073
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3