Q4G072 (LPAR6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysophosphatidic acid receptor 6
Short name=LPA receptor 6
Short name=LPA-6

Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name=P2Y5
Purinergic receptor 5

Gene names

Name:	Lpar6
Synonyms:	P2ry5, P2y5

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Lysophosphatidic acid receptor 6		PRO_0000342665
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 56	10	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 90	13	Extracellular Potential
	Transmembrane	91 – 111	21	Helical; Name=3; Potential
	Topological domain	112 – 134	23	Cytoplasmic Potential
	Transmembrane	135 – 155	21	Helical; Name=4; Potential
	Topological domain	156 – 183	28	Extracellular Potential
	Transmembrane	184 – 204	21	Helical; Name=5; Potential
	Topological domain	205 – 230	26	Cytoplasmic Potential
	Transmembrane	231 – 251	21	Helical; Name=6; Potential
	Topological domain	252 – 272	21	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=7; Potential
	Topological domain	294 – 344	51	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Disulfide bond	89 ↔ 168		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4G072 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: AE959337B5C36ACD	FASTA	344	39,330
	10 20 30 40 50 60 MVSANGSHCP YDDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICALKVRN ETTTYMINLA 70 80 90 100 110 120 MSDLLFVFTL PFRIFYFATR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY 130 140 150 160 170 180 PFKSKTLRTK RNAKIVCIAV WFTVMGGSAP AVFFQSTHSQ GNNTSEACFE NFPAATWKTY 190 200 210 220 230 240 LSRIVIFIEI VGFFIPLILN VTCSSMVLRT LNKPVTLSRS KMNKTKVLKM IFVHLVIFCF 250 260 270 280 290 300 CFVPYNINLI LYSLVRTQTF VNCSVGAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN 310 320 330 340 SIKMKSWSVR RSDSRFSEVQ GTENFIQHNL QTLKNKIFDN ESAI

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098703 mRNA. Translation: AAH98703.1.
IPI	IPI00208388.
RefSeq	NP_001039308.1. NM_001045843.1.
UniGene	Rn.203876.
3D structure databases
ProteinModelPortal	Q4G072.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4G072.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000021430; ENSRNOP00000021430; ENSRNOG00000015577.
GeneID	691774.
KEGG	rno:691774.
NMPDR	fig|10116.3.peg.11686.
UCSC	BC098703. rat.
Organism-specific databases
CTD	10161.
RGD	1595950. Lpar6.
Phylogenomic databases
eggNOG	maNOG14545.
GeneTree	ENSGT00590000082782.
HOVERGEN	HBG101917.
InParanoid	Q4G072.
OMA	LYSLMRT.
OrthoDB	EOG4Q58PX.
PhylomeDB	Q4G072.
Gene expression databases
ArrayExpress	Q4G072.
Genevestigator	Q4G072.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002188. P2Y5_purnocptor. [Graphical view]
KO	K04273.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01067. P2Y5ORPHANR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	743763.

Entry information

Entry name

LPAR6_RAT

Accession

Primary (citable) accession number: Q4G072

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program