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Protein

Lysophosphatidic acid receptor 6

Gene

Lpar6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events
R-RNO-417957 P2Y receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
Gene namesi
Name:Lpar6
Synonyms:P2ry5, P2y5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1595950 Lpar6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 56CytoplasmicSequence analysis10
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 90ExtracellularSequence analysisAdd BLAST13
Transmembranei91 – 111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini112 – 134CytoplasmicSequence analysisAdd BLAST23
Transmembranei135 – 155Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini156 – 183ExtracellularSequence analysisAdd BLAST28
Transmembranei184 – 204Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini205 – 230CytoplasmicSequence analysisAdd BLAST26
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 272ExtracellularSequence analysisAdd BLAST21
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 344CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003426651 – 344Lysophosphatidic acid receptor 6Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4G072
PRIDEiQ4G072

PTM databases

PhosphoSitePlusiQ4G072

Expressioni

Gene expression databases

BgeeiENSRNOG00000015577
GenevisibleiQ4G072 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021430

Structurei

3D structure databases

ProteinModelPortaliQ4G072
SMRiQ4G072
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00910000143980
HOGENOMiHOG000231307
HOVERGENiHBG101917
InParanoidiQ4G072
KOiK04273
OMAiFRIFYFA
OrthoDBiEOG091G0D67
PhylomeDBiQ4G072
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4G072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSANGSHCP YDDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICALKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFATR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCIAV WFTVMGGSAP
160 170 180 190 200
AVFFQSTHSQ GNNTSEACFE NFPAATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLRT LNKPVTLSRS KMNKTKVLKM IFVHLVIFCF CFVPYNINLI
260 270 280 290 300
LYSLVRTQTF VNCSVGAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKSWSVR RSDSRFSEVQ GTENFIQHNL QTLKNKIFDN ESAI
Length:344
Mass (Da):39,330
Last modified:August 30, 2005 - v1
Checksum:iAE959337B5C36ACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098703 mRNA Translation: AAH98703.1
RefSeqiNP_001039308.1, NM_001045843.1
UniGeneiRn.203876

Genome annotation databases

EnsembliENSRNOT00000021430; ENSRNOP00000021430; ENSRNOG00000015577
GeneIDi691774
KEGGirno:691774
UCSCiRGD:1595950 rat

Similar proteinsi

Entry informationi

Entry nameiLPAR6_RAT
AccessioniPrimary (citable) accession number: Q4G072
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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