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Protein

Lysophosphatidic acid receptor 6

Gene

Lpar6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
Gene namesi
Name:Lpar6
Synonyms:P2ry5, P2y5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1595950. Lpar6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 5610CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9013ExtracellularSequence analysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini112 – 13423CytoplasmicSequence analysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini156 – 18328ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini205 – 23026CytoplasmicSequence analysisAdd
BLAST
Transmembranei231 – 25121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini252 – 27221ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 34451CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Lysophosphatidic acid receptor 6PRO_0000342665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4G072.

PTM databases

PhosphoSiteiQ4G072.

Expressioni

Gene expression databases

GenevisibleiQ4G072. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021430.

Structurei

3D structure databases

ProteinModelPortaliQ4G072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ4G072.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG71VSSZ.
PhylomeDBiQ4G072.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4G072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSANGSHCP YDDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICALKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFATR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCIAV WFTVMGGSAP
160 170 180 190 200
AVFFQSTHSQ GNNTSEACFE NFPAATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLRT LNKPVTLSRS KMNKTKVLKM IFVHLVIFCF CFVPYNINLI
260 270 280 290 300
LYSLVRTQTF VNCSVGAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKSWSVR RSDSRFSEVQ GTENFIQHNL QTLKNKIFDN ESAI
Length:344
Mass (Da):39,330
Last modified:August 30, 2005 - v1
Checksum:iAE959337B5C36ACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098703 mRNA. Translation: AAH98703.1.
RefSeqiNP_001039308.1. NM_001045843.1.
UniGeneiRn.203876.

Genome annotation databases

EnsembliENSRNOT00000021430; ENSRNOP00000021430; ENSRNOG00000015577.
GeneIDi691774.
KEGGirno:691774.
UCSCiRGD:1595950. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098703 mRNA. Translation: AAH98703.1.
RefSeqiNP_001039308.1. NM_001045843.1.
UniGeneiRn.203876.

3D structure databases

ProteinModelPortaliQ4G072.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021430.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ4G072.

Proteomic databases

PaxDbiQ4G072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021430; ENSRNOP00000021430; ENSRNOG00000015577.
GeneIDi691774.
KEGGirno:691774.
UCSCiRGD:1595950. rat.

Organism-specific databases

CTDi10161.
RGDi1595950. Lpar6.

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ4G072.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG71VSSZ.
PhylomeDBiQ4G072.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-417957. P2Y receptors.

Miscellaneous databases

NextBioi743763.
PROiQ4G072.

Gene expression databases

GenevisibleiQ4G072. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiLPAR6_RAT
AccessioniPrimary (citable) accession number: Q4G072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 30, 2005
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.