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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

Coq5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117S-adenosyl-L-methionineUniRule annotation1
Binding sitei171S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
Gene namesi
Name:Coq5UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1310857. Coq5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionUniRule annotationAdd BLAST49
ChainiPRO_000022863150 – 3272-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialAdd BLAST278

Proteomic databases

PaxDbiQ4G064.
PRIDEiQ4G064.

PTM databases

iPTMnetiQ4G064.
PhosphoSitePlusiQ4G064.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001171.
GenevisibleiQ4G064. RN.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001547.

Structurei

3D structure databases

ProteinModelPortaliQ4G064.
SMRiQ4G064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 200S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ4G064.
KOiK06127.
OMAiVRNFENL.
OrthoDBiEOG091G0G2Z.
PhylomeDBiQ4G064.
TreeFamiTF106217.

Family and domain databases

HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
PfamiView protein in Pfam
PF01209. Ubie_methyltran. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiView protein in PROSITE
PS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4G064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRSCVLW SYCGHGWSRL AGDCRLPGFR RSWLGATLSA RSLSQEKRAA
60 70 80 90 100
ETHFGFETVS EKEKGGKVYQ VFQSVARKYD LMNDMMSLGI HRAWKDLLIR
110 120 130 140 150
KMHPLPGTQL LDVAGGTGDI AFRFLSYVQT QHERKQRRQL RTRQNLSWEE
160 170 180 190 200
IARKYQSKED PLGGSLVMVC DINREMLKVG KQKALARGHT AGLAWVLGDA
210 220 230 240 250
EELPFDDDRF DVYTIAFGIR NVTHIDRALQ EAHRVLKPGG RFLCLEFSQV
260 270 280 290 300
NDPLISRLYD LYSFQVIPVI GEVIAGDWKS YQYLVESIRK FPNQEEFKDM
310 320
IEDAGFQKVT YESLTSGIVA IHSGFKL
Length:327
Mass (Da):37,301
Last modified:August 30, 2005 - v1
Checksum:i7D3D9EF85E28731A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098719 mRNA. Translation: AAH98719.1.
RefSeqiNP_001034111.1. NM_001039022.1.
UniGeneiRn.143996.

Genome annotation databases

EnsembliENSRNOT00000001546; ENSRNOP00000001547; ENSRNOG00000001171.
GeneIDi304542.
KEGGirno:304542.
UCSCiRGD:1310857. rat.

Similar proteinsi

Entry informationi

Entry nameiCOQ5_RAT
AccessioniPrimary (citable) accession number: Q4G064
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 30, 2005
Last modified: September 27, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families