Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

Coq5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171S-adenosyl-L-methionineUniRule annotation
Binding sitei171 – 1711S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
Gene namesi
Name:Coq5UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1310857. Coq5.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949MitochondrionSequence analysisAdd
BLAST
Chaini50 – 3272782-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialPRO_0000228631Add
BLAST

Proteomic databases

PaxDbiQ4G064.
PRIDEiQ4G064.

PTM databases

iPTMnetiQ4G064.
PhosphoSiteiQ4G064.

Expressioni

Gene expression databases

GenevisibleiQ4G064. RN.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001547.

Structurei

3D structure databases

ProteinModelPortaliQ4G064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2002S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ4G064.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG712TXJ.
PhylomeDBiQ4G064.
TreeFamiTF106217.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4G064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRSCVLW SYCGHGWSRL AGDCRLPGFR RSWLGATLSA RSLSQEKRAA
60 70 80 90 100
ETHFGFETVS EKEKGGKVYQ VFQSVARKYD LMNDMMSLGI HRAWKDLLIR
110 120 130 140 150
KMHPLPGTQL LDVAGGTGDI AFRFLSYVQT QHERKQRRQL RTRQNLSWEE
160 170 180 190 200
IARKYQSKED PLGGSLVMVC DINREMLKVG KQKALARGHT AGLAWVLGDA
210 220 230 240 250
EELPFDDDRF DVYTIAFGIR NVTHIDRALQ EAHRVLKPGG RFLCLEFSQV
260 270 280 290 300
NDPLISRLYD LYSFQVIPVI GEVIAGDWKS YQYLVESIRK FPNQEEFKDM
310 320
IEDAGFQKVT YESLTSGIVA IHSGFKL
Length:327
Mass (Da):37,301
Last modified:August 30, 2005 - v1
Checksum:i7D3D9EF85E28731A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098719 mRNA. Translation: AAH98719.1.
RefSeqiNP_001034111.1. NM_001039022.1.
UniGeneiRn.143996.

Genome annotation databases

EnsembliENSRNOT00000001546; ENSRNOP00000001547; ENSRNOG00000001171.
GeneIDi304542.
KEGGirno:304542.
UCSCiRGD:1310857. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098719 mRNA. Translation: AAH98719.1.
RefSeqiNP_001034111.1. NM_001039022.1.
UniGeneiRn.143996.

3D structure databases

ProteinModelPortaliQ4G064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001547.

PTM databases

iPTMnetiQ4G064.
PhosphoSiteiQ4G064.

Proteomic databases

PaxDbiQ4G064.
PRIDEiQ4G064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001546; ENSRNOP00000001547; ENSRNOG00000001171.
GeneIDi304542.
KEGGirno:304542.
UCSCiRGD:1310857. rat.

Organism-specific databases

CTDi84274.
RGDi1310857. Coq5.

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ4G064.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG712TXJ.
PhylomeDBiQ4G064.
TreeFamiTF106217.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

PROiQ4G064.

Gene expression databases

GenevisibleiQ4G064. RN.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCOQ5_RAT
AccessioniPrimary (citable) accession number: Q4G064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 30, 2005
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.